Tyra Biosciences, Inc.

TYRA

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001863127

SEC filings (opens in a new tab)

In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.

Q1 2025 vs. Q4 2024

How the institutions holding Tyra Biosciences, Inc. changed between Q4 2024 and Q1 2025.

All holders in Q1 2025 All holders in Q4 2024

13F holders of TYRA: Q4 2024 compared with Q1 2025
Measure	Q4 2024	Of which not filed for Q1 2025	Q1 2025	Change
Holders	113	2	117	+6
Shares	48.6M	4.11M	53.6M	+9.07M (+20.4%)
Value	$675.8M	$57.1M	$499.5M	−$119.2M (−19.3%)

2 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (22)

Institutions that held Tyra Biosciences, Inc. at the end of Q1 2025 but not at the end of Q4 2024.

Institutions new to TYRA in Q1 2025
Institution	Shares	Value	% of portfolio
Nextech Invest, Ltd.	4,055,861	$37.7M	8.77%
Commodore Capital LP	950,000	$8.84M	0.65%
Balyasny Asset Management LLC	243,244	$2.26M	0.01%
AXA S.A.	128,189	$1.19M	0.00%
Woodline Partners LP	100,108	$931.0K	0.01%
Nuveen, LLC	49,998	$465.0K	0.00%
Brevan Howard Capital Management LP	46,371	$431.3K	0.01%
Verition Fund Management LLC	42,174	$392.2K	0.00%
Jane Street Group, LLC	34,813	$323.8K	0.00%
ExodusPoint Capital Management, LP	30,235	$281.0K	0.00%
Caligan Partners LP	25,000	$232.5K	0.05%
Susquehanna International Group, LLP	23,526	$218.8K	0.00%
Intech Investment Management LLC	13,597	$126.5K	0.00%
Virtus Investment Advisers, Inc.	10,818	$100.6K	0.03%
Axq Capital, LP	10,302	$95.8K	0.04%
Zurcher Kantonalbank (Zurich Cantonalbank)	9,047	$84.1K	0.00%
Point72 Asia (Singapore) Pte. Ltd.	792	$7.37K	0.00%
Caitong International Asset Management Co., Ltd	503	$4.68K	0.00%
Daiwa Securities Group Inc.	173	$2.00K	0.00%
Allworth Financial LP	100	$1.01K	0.00%
Coldstream Capital Management Inc	28	$260	0.00%
EverSource Wealth Advisors, LLC	9	$84	0.00%

Sold out (16)

Institutions that held Tyra Biosciences, Inc. at the end of Q4 2024 and filed for Q1 2025 without it.

Institutions that sold out of TYRA in Q1 2025
Institution	Shares, Q4 2024	Value, Q4 2024
Boxer Capital Management, LLC	2,027,678	$28.2M
Adage Capital Partners GP, L.L.C.	200,000	$2.78M
Nantahala Capital Management, LLC	100,000	$1.39M
Susquehanna Fundamental Investments, LLC	39,093	$543.4K
PDT Partners, LLC	20,359	$283.0K
Squarepoint Ops LLC	18,216	$253.2K
Boothbay Fund Management, LLC	17,560	$244.1K
Manufacturers Life Insurance Company, The	13,368	$185.8K
Franklin Resources Inc	12,751	$177.2K
Virtus ETF Advisers LLC	4,686	$65.1K
R Squared Ltd	1,480	$20.6K
Aster Capital Management (DIFC) Ltd	214	$2.98K
Creative Planning	63	$876
GAMMA Investing LLC	26	$361
Signaturefd, LLC	24	$334
IFP Advisors, Inc	2	$28

Not filed for Q1 2025 yet (2)

Institutions that held Tyra Biosciences, Inc. at the end of Q4 2024 and haven't filed a 13F for Q1 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding TYRA in Q4 2024 that haven't filed for Q1 2025
Institution	Shares, Q4 2024	Value, Q4 2024
Nextech Invest AG	4,055,861	$56.4M
Nuveen Asset Management, LLC	49,998	$695.0K