Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Tyra Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +19 vs. Q3 2025
- Shares held
- 56.8M
- +1.36M (+2.4%) vs. Q3 2025
- Total value
- $1.49B
- +$717.9M (+92.5%) vs. Q3 2025
- New holders
- 29
- 43 more added
- Sold out
- 10
- 38 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Quest Partners LLC | 2,139 | $56.2K | 0.00% | −27,921−92.9% | Reduced |
| Chung Wu Investment Group, LLC | 2,000 | $52.6K | 0.04% | +2,000 | New |
| Ameritas Investment Partners, Inc. | 1,991 | $52.3K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 1,595 | $41.9K | 0.00% | +122+8.3% | Added |
| CWM, LLC | 1,546 | $41.0K | 0.00% | +17+1.1% | Added |
| Sterling Capital Management LLC | 1,488 | $39.1K | 0.00% | −174−10.5% | Reduced |
| Federated Hermes, Inc. | 1,297 | $34.1K | 0.00% | −858−39.8% | Reduced |
| Advisor Group Holdings, Inc. | 1,188 | $31.2K | 0.00% | −4−0.3% | Reduced |
| GF Fund Management Co. Ltd. | 1,048 | $27.6K | 0.00% | −99−8.6% | Reduced |
| Versant Capital Management, Inc | 819 | $21.5K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 814 | $21.0K | 0.00% | +113+16.1% | Added |
| Royal Bank of Canada | 742 | $19.0K | 0.00% | −414−35.8% | Reduced |
| STRS Ohio | 700 | $18.4K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 472 | $12.4K | 0.00% | +161+51.8% | Added |
| Tower Research Capital LLC (TRC) | 331 | $8.70K | 0.00% | −543−62.1% | Reduced |
| The PNC Financial Services Group, Inc. | 208 | $5.47K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 173 | $5.00K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 146 | $3.84K | 0.00% | +8+5.8% | Added |
| True Wealth Design, LLC | 142 | $3.73K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 128 | $3.37K | 0.00% | −240−65.2% | Reduced |
| Smartleaf Asset Management LLC | 127 | $3.23K | 0.00% | +127 | New |
| Allworth Financial LP | 100 | $2.63K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 86 | $2.26K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 84 | $2.21K | 0.00% | +84 | New |
| Steward Partners Investment Advisory, LLC | 77 | $2.02K | 0.00% | +77 | New |
| Farther Finance Advisors, LLC | 60 | $1.58K | 0.00% | +49+445.5% | Added |
| Rothschild Investment LLC | 55 | $1.45K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 43 | $1.13K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 42 | $1.10K | 0.00% | −2−4.5% | Reduced |
| Clearstead Advisors, LLC | 29 | $759 | 0.00% | −96−76.8% | Reduced |
| SBI Securities Co., Ltd. | 4 | $105 | 0.00% | −1−20.0% | Reduced |
| SRS Capital Advisors, Inc. | 3 | $79 | 0.00% | −82−96.5% | Reduced |
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Walleye Capital LLC | 0 | $0 | 0.00% | −297,808−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −170,100−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −111,293−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −62,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −44,680−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −31,101−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −15,758−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −10,761−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −9,542−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −49−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |