Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Tyra Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +19 vs. Q3 2025
- Shares held
- 56.8M
- +1.36M (+2.4%) vs. Q3 2025
- Total value
- $1.49B
- +$717.9M (+92.5%) vs. Q3 2025
- New holders
- 29
- 43 more added
- Sold out
- 10
- 38 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 3 | $79 | 0.00% | −82−96.5% | Reduced |
| SBI Securities Co., Ltd. | 4 | $105 | 0.00% | −1−20.0% | Reduced |
| Clearstead Advisors, LLC | 29 | $759 | 0.00% | −96−76.8% | Reduced |
| EverSource Wealth Advisors, LLC | 42 | $1.10K | 0.00% | −2−4.5% | Reduced |
| Signaturefd, LLC | 43 | $1.13K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 55 | $1.45K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 60 | $1.58K | 0.00% | +49+445.5% | Added |
| Steward Partners Investment Advisory, LLC | 77 | $2.02K | 0.00% | +77 | New |
| Rockefeller Capital Management L.P. | 84 | $2.21K | 0.00% | +84 | New |
| Nisa Investment Advisors, LLC | 86 | $2.26K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $2.63K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 127 | $3.23K | 0.00% | +127 | New |
| Optiver Holding B.V. | 128 | $3.37K | 0.00% | −240−65.2% | Reduced |
| True Wealth Design, LLC | 142 | $3.73K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 146 | $3.84K | 0.00% | +8+5.8% | Added |
| Daiwa Securities Group Inc. | 173 | $5.00K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 208 | $5.47K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 331 | $8.70K | 0.00% | −543−62.1% | Reduced |
| GAMMA Investing LLC | 472 | $12.4K | 0.00% | +161+51.8% | Added |
| STRS Ohio | 700 | $18.4K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 742 | $19.0K | 0.00% | −414−35.8% | Reduced |
| Amalgamated Bank | 814 | $21.0K | 0.00% | +113+16.1% | Added |
| Versant Capital Management, Inc | 819 | $21.5K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,048 | $27.6K | 0.00% | −99−8.6% | Reduced |
| Advisor Group Holdings, Inc. | 1,188 | $31.2K | 0.00% | −4−0.3% | Reduced |
| Federated Hermes, Inc. | 1,297 | $34.1K | 0.00% | −858−39.8% | Reduced |
| Sterling Capital Management LLC | 1,488 | $39.1K | 0.00% | −174−10.5% | Reduced |
| CWM, LLC | 1,546 | $41.0K | 0.00% | +17+1.1% | Added |
| California State Teachers Retirement System | 1,595 | $41.9K | 0.00% | +122+8.3% | Added |
| Ameritas Investment Partners, Inc. | 1,991 | $52.3K | 0.00% | 00.0% | Unchanged |
| Chung Wu Investment Group, LLC | 2,000 | $52.6K | 0.04% | +2,000 | New |
| Quest Partners LLC | 2,139 | $56.2K | 0.00% | −27,921−92.9% | Reduced |
| Legal & General Group Plc | 2,367 | $62.2K | 0.00% | +175+8.0% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,594 | $68.2K | 0.00% | +534+25.9% | Added |
| Caitong International Asset Management Co., Ltd | 2,997 | $78.8K | 0.02% | +2,997 | New |
| Bellevue Group AG | 3,143 | $82.6K | 0.00% | +3,143 | New |
| Citigroup Inc | 3,817 | $100.3K | 0.00% | +2,110+123.6% | Added |
| Police & Firemen's Retirement System of New Jersey | 6,440 | $169.3K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 7,423 | $195.2K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 8,357 | $219.7K | 0.00% | +8,357 | New |
| China Universal Asset Management Co., Ltd. | 8,697 | $228.6K | 0.02% | −645−6.9% | Reduced |
| VARCOV Co. | 9,708 | $255.2K | 0.10% | +9,708 | New |
| Intech Investment Management LLC | 9,801 | $257.7K | 0.00% | −1,601−14.0% | Reduced |
| Baker Bros. Advisors LP | 10,607 | $278.9K | 0.00% | 00.0% | Unchanged |
| Bank of Nova Scotia | 11,100 | $291.8K | 0.00% | +11,100 | New |
| Virtus Investment Advisers, Inc. | 11,756 | $309.1K | 0.08% | +741+6.7% | Added |
| FMR LLC | 12,563 | $330.3K | 0.00% | +34+0.3% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 12,908 | $338.6K | 0.00% | +1,591+14.1% | Added |
| Franklin Resources Inc | 12,970 | $341.0K | 0.00% | +12,970 | New |
| Russell Investments Group, Ltd. | 12,996 | $341.7K | 0.00% | +255+2.0% | Added |
| Price T Rowe Associates Inc | 14,432 | $380.0K | 0.00% | +1,631+12.7% | Added |
| MetLife Investment Management | 15,356 | $403.7K | 0.00% | +725+5.0% | Added |
| Rafferty Asset Management, LLC | 15,455 | $406.3K | 0.00% | +15,455 | New |
| Deutsche Bank AG | 16,377 | $430.6K | 0.00% | +894+5.8% | Added |
| Public Employees Retirement System of Ohio | 18,542 | $487.5K | 0.00% | −6,420−25.7% | Reduced |
| Victory Capital Management Inc | 18,790 | $494.0K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 19,603 | $515.4K | 0.00% | +19,603 | New |
| Auour Investments LLC | 21,020 | $552.6K | 0.18% | 00.0% | Unchanged |
| PSP Research LLC | 21,853 | $574.5K | 0.50% | +21,853 | New |
| AQR Capital Management LLC | 28,631 | $752.7K | 0.00% | +562+2.0% | Added |
| Fisher Asset Management, LLC | 28,800 | $757.2K | 0.00% | +28,800 | New |
| Canada Pension Plan Investment Board | 28,900 | $759.8K | 0.00% | +28,900 | New |
| Wells Fargo & Company | 29,049 | $763.7K | 0.00% | +10,579+57.3% | Added |
| Voya Investment Management LLC | 29,887 | $785.7K | 0.00% | +29,887 | New |
| XTX Topco Ltd | 30,414 | $799.6K | 0.02% | −3,286−9.8% | Reduced |
| Alliancebernstein L.P. | 31,990 | $841.0K | 0.00% | −1,270−3.8% | Reduced |
| HighVista Strategies LLC | 35,086 | $922.4K | 0.24% | −30,726−46.7% | Reduced |
| Bank of America Corp | 38,310 | $1.01M | 0.00% | −96,009−71.5% | Reduced |
| Rhumbline Advisers | 38,790 | $1.02M | 0.00% | −1,846−4.5% | Reduced |
| State of Wisconsin Investment Board | 39,023 | $1.03M | 0.00% | +9,375+31.6% | Added |
| PDT Partners, LLC | 42,284 | $1.11M | 0.07% | −1,026−2.4% | Reduced |
| ExodusPoint Capital Management, LP | 42,791 | $1.12M | 0.01% | +42,791 | New |
| Alps Advisors Inc | 43,827 | $1.15M | 0.01% | +19,127+77.4% | Added |
| Y-Intercept (Hong Kong) Ltd | 45,942 | $1.21M | 0.03% | +45,942 | New |
| American Century Companies Inc | 46,227 | $1.22M | 0.00% | +7,815+20.3% | Added |
| Algert Global LLC | 46,870 | $1.23M | 0.02% | +46,870 | New |
| Nuveen, LLC | 47,349 | $1.24M | 0.00% | −33,092−41.1% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 48,644 | $1.28M | 0.02% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 54,424 | $1.43M | 0.00% | +42,210+345.6% | Added |
| Ameriprise Financial Inc | 54,625 | $1.44M | 0.00% | −32,482−37.3% | Reduced |
| Susquehanna International Group, LLP | 55,135 | $1.45M | 0.00% | +55,135 | New |
| Superstring Capital Management LP | 58,677 | $1.54M | 0.83% | +58,677 | New |
| UBS Group AG | 58,856 | $1.55M | 0.00% | −288−0.5% | Reduced |
| Two Sigma Advisers, LP | 58,900 | $1.55M | 0.00% | −54,300−48.0% | Reduced |
| Bank of New York Mellon Corp | 60,901 | $1.60M | 0.00% | +3,739+6.5% | Added |
| JPMorgan Chase & Co | 71,175 | $1.87M | 0.00% | −3,054−4.1% | Reduced |
| Kalehua Capital Management LLC | 74,465 | $1.96M | 1.94% | +74,465 | New |
| Barclays PLC | 76,309 | $2.01M | 0.00% | +19,183+33.6% | Added |
| Seven Fleet Capital Management LP | 79,560 | $2.09M | 1.42% | +79,560 | New |
| Oppenheimer & Co Inc | 84,726 | $2.23M | 0.03% | +2,488+3.0% | Added |
| Investment Counsel Co of Nevada | 85,020 | $2.24M | 4.80% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 95,640 | $2.51M | 0.00% | +55,961+141.0% | Added |
| Wellington Management Group LLP | 104,305 | $2.74M | 0.00% | +21,434+25.9% | Added |
| Two Sigma Investments, LP | 107,023 | $2.81M | 0.00% | −92,415−46.3% | Reduced |
| Millennium Management LLC | 114,388 | $3.01M | 0.00% | −29,628−20.6% | Reduced |
| Morgan Stanley | 118,898 | $3.13M | 0.00% | −203,245−63.1% | Reduced |
| BNP Paribas Arbitrage, SA | 120,278 | $3.16M | 0.00% | −8,603−6.7% | Reduced |
| Soleus Capital Management, L.P. | 125,000 | $3.29M | 0.14% | +125,000 | New |
| Invesco Ltd. | 129,435 | $3.40M | 0.00% | +113,925+734.5% | Added |