Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
Holders of 5% or more of SEPN
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Septerna, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Third Rock Ventures V, L.P. | 13G/A | 14.00%6.22M shares | 0.00 ppfrom 14.00% | Feb 13, 20252 filings | May 9, 2025 | SEC |
| Driehaus Capital Management LLC | 13G/A | 10.46%4.66M shares | +3.43 ppfrom 7.03% | Feb 14, 20253 filings | Jun 10, 2025 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
7 Schedule 13D and 13G filings on Septerna, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Aug 14, 20265:14 PM ET | Ra Capital Management, L.P.and 3 others | 13D/A | 11.80%5.53M shares | – | Aug 12, 2026 | SEC |
| Aug 14, 20267:32 AM ET | Driehaus Capital Management LLC | 13G/A | 9.83%4.43M shares | −0.63 ppfrom 10.46% | Jun 30, 2026 | SEC |
| Feb 17, 20264:25 PM ET | Biotechnology Value Fund L Pand 9 others | 13G/A | 3.80%1.72M shares | −6.10 ppfrom 9.90%Below 5% | Dec 31, 2025 | SEC |
| Jun 10, 202510:55 AM ET | Driehaus Capital Management LLC | 13G/A | 10.46%4.66M shares | +3.43 ppfrom 7.03% | May 31, 2025 | SEC |
| May 15, 20254:37 PM ET | Biotechnology Value Fund L Pand 9 others | 13G/A | 9.90%4.40M shares | – | Mar 31, 2025 | SEC |
| May 15, 20257:17 AM ET | Driehaus Capital Management LLC | 13G/A | 7.03%3.12M shares | +1.20 ppfrom 5.83% | Mar 31, 2025 | SEC |
| May 9, 20254:15 PM ET | Third Rock Ventures V, L.P.and 5 others | 13G/A | 14.00%6.22M shares | 0.00 ppfrom 14.00% | Mar 31, 2025 | SEC |
| Feb 14, 20257:48 AM ET | Driehaus Capital Management LLC | 13G | 5.83%2.59M shares | New | Dec 31, 2024 | SEC |
| Feb 13, 20254:15 PM ET | Third Rock Ventures V, L.P.and 5 others | 13G | 14.00%6.22M shares | New | Dec 31, 2024 | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Septerna, Inc. shares.
No Form 144 notices for Septerna, Inc. are on file.