Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 8 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.59B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Septerna, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +31 vs. Q1 2026
- Shares held
- 47.4M
- +2.41M (+5.4%) vs. Q1 2026
- Total value
- $1.59B
- +$506.5M (+46.8%) vs. Q1 2026
- New holders
- 47
- 49 more added
- Sold out
- 16
- 32 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.59B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.1M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $234.3M | 2.04% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $208.2M | 41.78% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,433,058 | $148.5M | 0.86% | +37,486+0.9% | Added |
| TRV GP VI, LLC | 4,211,659 | $141.0M | 60.72% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $105.5M | 8.66% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 3,062,766 | $102.6M | 0.01% | +156,339+5.4% | Added |
| BlackRock, Inc. | 1,932,088 | $64.7M | 0.00% | +109,914+6.0% | Added |
| Siren, L.L.C. | 1,900,000 | $63.6M | 1.29% | −100,000−5.0% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $44.8M | 0.40% | 00.0% | Unchanged |
| Jupiter Topco LLC | 1,307,500 | $43.7M | 0.02% | +1,307,500 | New |
| Vanguard Capital Management LLC | 1,221,673 | $40.9M | 0.00% | +24,711+2.1% | Added |
| Primecap Management Co | 1,167,382 | $39.1M | 0.02% | +118,548+11.3% | Added |
| First Light Asset Management, LLC | 963,260 | $32.3M | 1.96% | +230,400+31.4% | Added |
| ADAR1 Capital Management, LLC | 940,747 | $31.5M | 1.48% | −149,071−13.7% | Reduced |
| Geode Capital Management, LLC | 679,163 | $22.8M | 0.00% | +34,017+5.3% | Added |
| State Street Corp | 652,630 | $21.9M | 0.00% | +21,183+3.4% | Added |
| Loomis Sayles & Co L P | 624,752 | $20.9M | 0.03% | +624,752 | New |
| Casdin Capital, LLC | 553,268 | $18.5M | 0.93% | 00.0% | Unchanged |
| Catalio Capital Management, LP | 536,152 | $18.0M | 3.37% | +241,792+82.1% | Added |
| Algert Global LLC | 397,487 | $13.3M | 0.16% | +376,452+1,789.6% | Added |
| Kalehua Capital Management LLC | 389,088 | $13.0M | 4.16% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 350,442 | $11.7M | 0.02% | +113,763+48.1% | Added |
| Longaeva Partners L.P. | 298,171 | $9.99M | 0.29% | +223,604+299.9% | Added |
| Soleus Capital Management, L.P. | 275,000 | $9.21M | 0.32% | 00.0% | Unchanged |
| Vanguard Portfolio Management LLC | 230,184 | $7.71M | 0.00% | +35,141+18.0% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $7.46M | 0.01% | −1,293−0.6% | Reduced |
| Two Sigma Investments, LP | 220,885 | $7.40M | 0.01% | +145,518+193.1% | Added |
| Northern Trust Corp | 201,131 | $6.74M | 0.00% | +36,601+22.2% | Added |
| Charles Schwab Investment Management Inc | 187,041 | $6.26M | 0.00% | +5,461+3.0% | Added |
| Woodline Partners LP | 185,535 | $6.21M | 0.02% | +185,535 | New |
| Vanguard Fiduciary Trust Co | 165,656 | $5.55M | 0.00% | +11,172+7.2% | Added |
| Morgan Stanley | 134,377 | $4.50M | 0.00% | +23,847+21.6% | Added |
| UBS Group AG | 89,874 | $3.01M | 0.00% | −27,105−23.2% | Reduced |
| JPMorgan Chase & Co | 85,301 | $2.96M | 0.00% | +627+0.7% | Added |
| Federated Hermes, Inc. | 86,753 | $2.91M | 0.00% | −2,548−2.9% | Reduced |
| Lazard Asset Management LLC | 75,425 | $2.53M | 0.00% | +75,425 | New |
| Dimensional Fund Advisors LP | 75,309 | $2.52M | 0.00% | +75,309 | New |
| Arrowstreet Capital, Limited Partnership | 74,649 | $2.50M | 0.00% | +74,649 | New |
| Jacobs Levy Equity Management, Inc | 68,180 | $2.28M | 0.01% | +39,744+139.8% | Added |
| Hussman Strategic Advisors, Inc. | 63,000 | $2.11M | 0.49% | −42,000−40.0% | Reduced |
| American Century Companies Inc | 60,973 | $2.04M | 0.00% | −317−0.5% | Reduced |
| Bank of New York Mellon Corp | 56,176 | $1.88M | 0.00% | −2,533−4.3% | Reduced |
| XTX Topco Ltd | 54,489 | $1.82M | 0.02% | +17,766+48.4% | Added |
| Millennium Management LLC | 50,562 | $1.69M | 0.00% | −73,539−59.3% | Reduced |
| Barclays PLC | 49,821 | $1.67M | 0.00% | +27,107+119.3% | Added |
| Elmind Capital, LP | 49,444 | $1.66M | 0.42% | +49,444 | New |
| Nuveen, LLC | 48,229 | $1.62M | 0.00% | +19,053+65.3% | Added |
| Sofinnova Investments, Inc. | 47,506 | $1.59M | 0.08% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 46,483 | $1.56M | 0.00% | +46,483 | New |
| Jane Street Group, LLC | 45,552 | $1.53M | 0.00% | +45,552 | New |
| Voleon Capital Management LP | 44,435 | $1.49M | 0.03% | +44,435 | New |
| HRT Financial LP | 42,022 | $1.41M | 0.00% | +42,022 | New |
| Renaissance Technologies LLC | 41,419 | $1.39M | 0.00% | +3,719+9.9% | Added |
| Russell Investments Group, Ltd. | 40,209 | $1.35M | 0.00% | +28,694+249.2% | Added |
| Caption Management, LLC | 38,006 | $1.27M | 0.04% | +38,006 | New |
| Bank of America Corp | 35,875 | $1.20M | 0.00% | +9,902+38.1% | Added |
| Price T Rowe Associates Inc | 35,323 | $1.18M | 0.00% | +7,247+25.8% | Added |
| Alyeska Investment Group, L.P. | 35,000 | $1.17M | 0.00% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 29,452 | $986.3K | 0.01% | +29,452 | New |
| HighVista Strategies LLC | 29,337 | $982.5K | 0.22% | +29,337 | New |
| Tudor Investment Corp Et Al | 28,966 | $970.1K | 0.00% | +28,966 | New |
| Rhumbline Advisers | 27,636 | $925.5K | 0.00% | +1,032+3.9% | Added |
| Trexquant Investment LP | 25,645 | $858.9K | 0.01% | −9,656−27.4% | Reduced |
| Invesco Ltd. | 24,094 | $806.9K | 0.00% | −58,774−70.9% | Reduced |
| Logos Global Management LP | 23,548 | $788.6K | 0.03% | 00.0% | Unchanged |
| FMR LLC | 23,240 | $778.3K | 0.00% | −206−0.9% | Reduced |
| Fox Run Management, L.L.C. | 22,038 | $738.1K | 0.12% | +22,038 | New |
| Deutsche Bank AG | 21,873 | $732.5K | 0.00% | +5,030+29.9% | Added |
| Alliancebernstein L.P. | 29,900 | $718.5K | 0.00% | +10,300+52.6% | Added |
| Squarepoint Ops LLC | 21,219 | $710.6K | 0.00% | +3,136+17.3% | Added |
| STRS Ohio | 21,000 | $703.3K | 0.00% | +3,800+22.1% | Added |
| Fred Alger Management, LLC | 20,958 | $701.9K | 0.00% | +20,958 | New |
| Acadian Asset Management LLC | 20,996 | $701.0K | 0.00% | −9,982−32.2% | Reduced |
| Jump Financial, LLC | 20,200 | $676.5K | 0.01% | −32,811−61.9% | Reduced |
| Swiss National Bank | 19,800 | $663.1K | 0.00% | −2,300−10.4% | Reduced |
| Wells Fargo & Company | 19,684 | $659.2K | 0.00% | +9,815+99.5% | Added |
| Franklin Resources Inc | 18,607 | $623.1K | 0.00% | +18,607 | New |
| Citigroup Inc | 17,808 | $596.4K | 0.00% | +8,613+93.7% | Added |
| Aquatic Capital Management LLC | 17,427 | $583.6K | 0.02% | +17,427 | New |
| Engineers Gate Manager LP | 17,350 | $581.1K | 0.01% | +822+5.0% | Added |
| BNP Paribas Arbitrage, SA | 16,946 | $567.5K | 0.00% | +11,585+216.1% | Added |
| Los Angeles Capital Management LLC | 16,597 | $555.8K | 0.00% | +2,383+16.8% | Added |
| State of Wyoming | 16,379 | $548.5K | 0.06% | +16,379 | New |
| Vanguard Global Advisers, LLC | 16,247 | $544.1K | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 15,397 | $515.6K | 0.00% | +22+0.1% | Added |
| Virginia Retirement Systems Et Al | 13,300 | $445.4K | 0.00% | +13,300 | New |
| Verdad Advisers, LP | 12,970 | $434.4K | 0.42% | +12,970 | New |
| MetLife Investment Management | 12,880 | $431.4K | 0.00% | −805−5.9% | Reduced |
| Advisor Group Holdings, Inc. | 12,594 | $421.8K | 0.00% | −104−0.8% | Reduced |
| Man Group plc | 11,469 | $384.1K | 0.00% | −389−3.3% | Reduced |
| California State Teachers Retirement System | 10,866 | $363.9K | 0.00% | +9,709+839.2% | Added |
| China Universal Asset Management Co., Ltd. | 10,774 | $360.8K | 0.02% | −1,172−9.8% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 10,193 | $341.4K | 0.00% | +172+1.7% | Added |
| Legal & General Group Plc | 10,062 | $337.0K | 0.00% | +4,327+75.4% | Added |
| Massachusetts Financial Services Co | 9,982 | $334.3K | 0.00% | −400−3.9% | Reduced |
| Gotham Asset Management, LLC | 9,322 | $312.2K | 0.00% | +9,322 | New |
| Virtus Investment Advisers, Inc. | 9,102 | $304.8K | 0.07% | −1,617−15.1% | Reduced |
| Canada Pension Plan Investment Board | 8,900 | $298.1K | 0.00% | +8,900 | New |
| New York State Common Retirement Fund | 8,500 | $284.7K | 0.00% | +2,900+51.8% | Added |
| First Trust Advisors LP | 7,739 | $259.2K | 0.00% | +7,739 | New |