Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Septerna, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 89
- +19 vs. Q1 2025
- Shares held
- 44.4M
- −839.0K (−1.9%) vs. Q1 2025
- Total value
- $469.6M
- +$207.5M (+79.2%) vs. Q1 2025
- New holders
- 25
- 31 more added
- Sold out
- 6
- 19 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $73.9M | 1.25% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $65.7M | 39.66% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,680,431 | $49.5M | 0.40% | +1,557,823+49.9% | Added |
| BVF Inc | 4,396,124 | $46.5M | 1.66% | 00.0% | Unchanged |
| TRV GP VI, LLC | 4,211,659 | $44.5M | 69.32% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $33.3M | 6.81% | 00.0% | Unchanged |
| Siren, L.L.C. | 2,202,514 | $23.3M | 1.20% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,416,314 | $15.0M | 0.00% | −33,085−2.3% | Reduced |
| Vanguard Group Inc | 1,414,363 | $14.9M | 0.00% | +419,319+42.1% | Added |
| BlackRock, Inc. | 1,390,800 | $14.7M | 0.00% | +132,487+10.5% | Added |
| Avoro Capital Advisors LLC | 1,237,500 | $13.1M | 0.23% | −100,000−7.5% | Reduced |
| ADAR1 Capital Management, LLC | 847,227 | $8.96M | 1.45% | +126,379+17.5% | Added |
| Checkpoint Capital L.P. | 586,473 | $6.20M | 2.89% | −238,405−28.9% | Reduced |
| Sio Capital Management, LLC | 584,435 | $6.18M | 2.48% | −204,235−25.9% | Reduced |
| Casdin Capital, LLC | 553,268 | $5.85M | 0.53% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 541,450 | $5.72M | 0.21% | +541,450 | New |
| VR Adviser, LLC | 540,453 | $5.71M | 0.43% | +540,453 | New |
| Geode Capital Management, LLC | 487,956 | $5.16M | 0.00% | +78,316+19.1% | Added |
| State Street Corp | 369,992 | $3.91M | 0.00% | +25,388+7.4% | Added |
| Catalio Capital Management, LP | 294,360 | $3.11M | 0.65% | −729,885−71.3% | Reduced |
| Woodline Partners LP | 282,585 | $2.99M | 0.02% | −300,000−51.5% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $2.35M | 0.00% | +119,953+116.7% | Added |
| Susquehanna International Group, LLP | 166,506 | $1.76M | 0.00% | +141,297+560.5% | Added |
| Charles Schwab Investment Management Inc | 154,781 | $1.64M | 0.00% | +36,330+30.7% | Added |
| Northern Trust Corp | 154,344 | $1.63M | 0.00% | −3,696−2.3% | Reduced |
| Deep Track Capital, LP | 121,716 | $1.29M | 0.04% | −1,791,213−93.6% | Reduced |
| Logos Global Management LP | 109,202 | $1.15M | 0.15% | −25,000−18.6% | Reduced |
| Bank of America Corp | 99,213 | $1.05M | 0.00% | +87,654+758.3% | Added |
| Morgan Stanley | 84,860 | $897.0K | 0.00% | −6,184−6.8% | Reduced |
| Two Sigma Investments, LP | 77,642 | $820.7K | 0.00% | +2,801+3.7% | Added |
| Soleus Capital Management, L.P. | 75,456 | $797.6K | 0.06% | −675,897−90.0% | Reduced |
| UBS Group AG | 72,335 | $764.6K | 0.00% | −167,595−69.9% | Reduced |
| Rangeley Capital, LLC | 58,605 | $619.5K | 0.78% | +5,655+10.7% | Added |
| Nuveen, LLC | 57,971 | $612.8K | 0.00% | +34,010+141.9% | Added |
| Millennium Management LLC | 51,944 | $549.0K | 0.00% | −384,620−88.1% | Reduced |
| Bank of New York Mellon Corp | 48,489 | $512.5K | 0.00% | +10,113+26.4% | Added |
| Barclays PLC | 35,706 | $377.4K | 0.00% | +12,973+57.1% | Added |
| Alyeska Investment Group, L.P. | 35,000 | $369.9K | 0.00% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 28,700 | $303.4K | 0.00% | +28,700 | New |
| Rhumbline Advisers | 28,572 | $302.0K | 0.00% | +5,254+22.5% | Added |
| Price T Rowe Associates Inc | 24,902 | $264.0K | 0.00% | +1,945+8.5% | Added |
| Boothbay Fund Management, LLC | 24,142 | $255.2K | 0.01% | +24,142 | New |
| Gsa Capital Partners LLP | 23,527 | $249.0K | 0.02% | +5,228+28.6% | Added |
| Simplex Trading, LLC | 23,525 | $248.0K | 0.01% | +23,495+78,316.7% | Added |
| XTX Topco Ltd | 22,330 | $236.0K | 0.01% | −15,020−40.2% | Reduced |
| Alliancebernstein L.P. | 22,100 | $233.6K | 0.00% | +22,100 | New |
| Citadel Advisors LLC | 17,774 | $187.9K | 0.00% | +17,774 | New |
| Tudor Investment Corp Et Al | 16,761 | $177.2K | 0.00% | +16,761 | New |
| Wells Fargo & Company | 14,717 | $155.6K | 0.00% | +3,848+35.4% | Added |
| MetLife Investment Management | 13,685 | $144.7K | 0.00% | +13,685 | New |
| Congress Wealth Management LLC | 12,589 | $133.1K | 0.00% | +12,589 | New |
| Intech Investment Management LLC | 12,200 | $129.0K | 0.00% | +12,200 | New |
| Deutsche Bank AG | 12,123 | $128.1K | 0.00% | −3,845−24.1% | Reduced |
| Invesco Ltd. | 11,833 | $125.1K | 0.00% | −369−3.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 11,697 | $123.6K | 0.00% | +710+6.5% | Added |
| Squarepoint Ops LLC | 10,737 | $113.5K | 0.00% | +10,737 | New |
| Quadrature Capital Ltd | 10,125 | $107.3K | 0.00% | +10,125 | New |
| PharVision Advisers, LLC | 10,152 | $107.3K | 0.15% | +10,152 | New |
| JPMorgan Chase & Co | 10,101 | $106.8K | 0.00% | +1,315+15.0% | Added |
| Citigroup Inc | 7,173 | $75.8K | 0.00% | −30,882−81.2% | Reduced |
| Quarry LP | 3,601 | $38.1K | 0.01% | +3,601 | New |
| Police & Firemen's Retirement System of New Jersey | 3,555 | $37.6K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 3,400 | $35.9K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,900 | $30.7K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 2,485 | $26.3K | 0.00% | −47,293−95.0% | Reduced |
| Covestor Ltd | 2,324 | $24.0K | 0.01% | +2,318+38,633.3% | Added |
| Tower Research Capital LLC (TRC) | 2,225 | $23.5K | 0.00% | +437+24.4% | Added |
| BNP Paribas Arbitrage, SA | 2,210 | $23.4K | 0.00% | +1,061+92.3% | Added |
| Legal & General Group Plc | 1,945 | $20.6K | 0.00% | +105+5.7% | Added |
| Ameritas Investment Partners, Inc. | 1,944 | $20.5K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,840 | $19.0K | 0.00% | +1,038+129.4% | Added |
| California State Teachers Retirement System | 1,370 | $14.5K | 0.00% | −42,992−96.9% | Reduced |
| Signaturefd, LLC | 966 | $10.2K | 0.00% | +966 | New |
| CWM, LLC | 872 | $9.00K | 0.00% | +590+209.2% | Added |
| Group One Trading, L.P. | 789 | $8.34K | 0.00% | +789 | New |
| Amalgamated Bank | 634 | $7.00K | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 605 | $6.39K | 0.00% | +605 | New |
| GAMMA Investing LLC | 577 | $6.10K | 0.00% | +143+32.9% | Added |
| Sterling Capital Management LLC | 577 | $6.10K | 0.00% | +420+267.5% | Added |
| US Bancorp | 265 | $2.80K | 0.00% | +265 | New |
| Raymond James Financial Inc | 222 | $2.35K | 0.00% | +222 | New |
| Advisor Group Holdings, Inc. | 214 | $2.26K | 0.00% | +214 | New |
| Comerica Bank | 212 | $2.24K | 0.00% | +212 | New |
| Nisa Investment Advisors, LLC | 143 | $1.51K | 0.00% | +9+6.7% | Added |
| Fortitude Family Office, LLC | 71 | $750 | 0.00% | +71 | New |
| SBI Securities Co., Ltd. | 50 | $529 | 0.00% | +50 | New |
| Rothschild Investment LLC | 30 | $317 | 0.00% | +30 | New |
| EverSource Wealth Advisors, LLC | 22 | $233 | 0.00% | +22 | New |
| National Bank of Canada | 8 | $85 | 0.00% | 00.0% | Unchanged |
| Stonepine Capital Management, LLC | 0 | $0 | 0.00% | −68,084−100.0% | Sold out |
| Swiss National Bank | 0 | $0 | 0.00% | −30,100−100.0% | Sold out |
| Stoneridge Investment Partners LLC | 0 | $0 | 0.00% | −18,477−100.0% | Sold out |
| Chicago Partners Investment Group LLC | 0 | $0 | 0.00% | −10,954−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −9,102−100.0% | Sold out |
| KLP Kapitalforvaltning AS | 0 | $0 | 0.00% | −8,400−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |