Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Septerna, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 89
- +19 vs. Q1 2025
- Shares held
- 44.4M
- −839.0K (−1.9%) vs. Q1 2025
- Total value
- $469.6M
- +$207.5M (+79.2%) vs. Q1 2025
- New holders
- 25
- 31 more added
- Sold out
- 6
- 19 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| National Bank of Canada | 8 | $85 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 22 | $233 | 0.00% | +22 | New |
| Rothschild Investment LLC | 30 | $317 | 0.00% | +30 | New |
| SBI Securities Co., Ltd. | 50 | $529 | 0.00% | +50 | New |
| Fortitude Family Office, LLC | 71 | $750 | 0.00% | +71 | New |
| Nisa Investment Advisors, LLC | 143 | $1.51K | 0.00% | +9+6.7% | Added |
| Comerica Bank | 212 | $2.24K | 0.00% | +212 | New |
| Advisor Group Holdings, Inc. | 214 | $2.26K | 0.00% | +214 | New |
| Raymond James Financial Inc | 222 | $2.35K | 0.00% | +222 | New |
| US Bancorp | 265 | $2.80K | 0.00% | +265 | New |
| GAMMA Investing LLC | 577 | $6.10K | 0.00% | +143+32.9% | Added |
| Sterling Capital Management LLC | 577 | $6.10K | 0.00% | +420+267.5% | Added |
| Caitong International Asset Management Co., Ltd | 605 | $6.39K | 0.00% | +605 | New |
| Amalgamated Bank | 634 | $7.00K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 789 | $8.34K | 0.00% | +789 | New |
| CWM, LLC | 872 | $9.00K | 0.00% | +590+209.2% | Added |
| Signaturefd, LLC | 966 | $10.2K | 0.00% | +966 | New |
| California State Teachers Retirement System | 1,370 | $14.5K | 0.00% | −42,992−96.9% | Reduced |
| Royal Bank of Canada | 1,840 | $19.0K | 0.00% | +1,038+129.4% | Added |
| Ameritas Investment Partners, Inc. | 1,944 | $20.5K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 1,945 | $20.6K | 0.00% | +105+5.7% | Added |
| BNP Paribas Arbitrage, SA | 2,210 | $23.4K | 0.00% | +1,061+92.3% | Added |
| Tower Research Capital LLC (TRC) | 2,225 | $23.5K | 0.00% | +437+24.4% | Added |
| Covestor Ltd | 2,324 | $24.0K | 0.01% | +2,318+38,633.3% | Added |
| FMR LLC | 2,485 | $26.3K | 0.00% | −47,293−95.0% | Reduced |
| New York State Common Retirement Fund | 2,900 | $30.7K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 3,400 | $35.9K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 3,555 | $37.6K | 0.00% | 00.0% | Unchanged |
| Quarry LP | 3,601 | $38.1K | 0.01% | +3,601 | New |
| Citigroup Inc | 7,173 | $75.8K | 0.00% | −30,882−81.2% | Reduced |
| JPMorgan Chase & Co | 10,101 | $106.8K | 0.00% | +1,315+15.0% | Added |
| PharVision Advisers, LLC | 10,152 | $107.3K | 0.15% | +10,152 | New |
| Quadrature Capital Ltd | 10,125 | $107.3K | 0.00% | +10,125 | New |
| Squarepoint Ops LLC | 10,737 | $113.5K | 0.00% | +10,737 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 11,697 | $123.6K | 0.00% | +710+6.5% | Added |
| Invesco Ltd. | 11,833 | $125.1K | 0.00% | −369−3.0% | Reduced |
| Deutsche Bank AG | 12,123 | $128.1K | 0.00% | −3,845−24.1% | Reduced |
| Intech Investment Management LLC | 12,200 | $129.0K | 0.00% | +12,200 | New |
| Congress Wealth Management LLC | 12,589 | $133.1K | 0.00% | +12,589 | New |
| MetLife Investment Management | 13,685 | $144.7K | 0.00% | +13,685 | New |
| Wells Fargo & Company | 14,717 | $155.6K | 0.00% | +3,848+35.4% | Added |
| Tudor Investment Corp Et Al | 16,761 | $177.2K | 0.00% | +16,761 | New |
| Citadel Advisors LLC | 17,774 | $187.9K | 0.00% | +17,774 | New |
| Alliancebernstein L.P. | 22,100 | $233.6K | 0.00% | +22,100 | New |
| XTX Topco Ltd | 22,330 | $236.0K | 0.01% | −15,020−40.2% | Reduced |
| Simplex Trading, LLC | 23,525 | $248.0K | 0.01% | +23,495+78,316.7% | Added |
| Gsa Capital Partners LLP | 23,527 | $249.0K | 0.02% | +5,228+28.6% | Added |
| Boothbay Fund Management, LLC | 24,142 | $255.2K | 0.01% | +24,142 | New |
| Price T Rowe Associates Inc | 24,902 | $264.0K | 0.00% | +1,945+8.5% | Added |
| Rhumbline Advisers | 28,572 | $302.0K | 0.00% | +5,254+22.5% | Added |
| UBS Asset Management Americas Inc | 28,700 | $303.4K | 0.00% | +28,700 | New |
| Alyeska Investment Group, L.P. | 35,000 | $369.9K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 35,706 | $377.4K | 0.00% | +12,973+57.1% | Added |
| Bank of New York Mellon Corp | 48,489 | $512.5K | 0.00% | +10,113+26.4% | Added |
| Millennium Management LLC | 51,944 | $549.0K | 0.00% | −384,620−88.1% | Reduced |
| Nuveen, LLC | 57,971 | $612.8K | 0.00% | +34,010+141.9% | Added |
| Rangeley Capital, LLC | 58,605 | $619.5K | 0.78% | +5,655+10.7% | Added |
| UBS Group AG | 72,335 | $764.6K | 0.00% | −167,595−69.9% | Reduced |
| Soleus Capital Management, L.P. | 75,456 | $797.6K | 0.06% | −675,897−90.0% | Reduced |
| Two Sigma Investments, LP | 77,642 | $820.7K | 0.00% | +2,801+3.7% | Added |
| Morgan Stanley | 84,860 | $897.0K | 0.00% | −6,184−6.8% | Reduced |
| Bank of America Corp | 99,213 | $1.05M | 0.00% | +87,654+758.3% | Added |
| Logos Global Management LP | 109,202 | $1.15M | 0.15% | −25,000−18.6% | Reduced |
| Deep Track Capital, LP | 121,716 | $1.29M | 0.04% | −1,791,213−93.6% | Reduced |
| Northern Trust Corp | 154,344 | $1.63M | 0.00% | −3,696−2.3% | Reduced |
| Charles Schwab Investment Management Inc | 154,781 | $1.64M | 0.00% | +36,330+30.7% | Added |
| Susquehanna International Group, LLP | 166,506 | $1.76M | 0.00% | +141,297+560.5% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $2.35M | 0.00% | +119,953+116.7% | Added |
| Woodline Partners LP | 282,585 | $2.99M | 0.02% | −300,000−51.5% | Reduced |
| Catalio Capital Management, LP | 294,360 | $3.11M | 0.65% | −729,885−71.3% | Reduced |
| State Street Corp | 369,992 | $3.91M | 0.00% | +25,388+7.4% | Added |
| Geode Capital Management, LLC | 487,956 | $5.16M | 0.00% | +78,316+19.1% | Added |
| VR Adviser, LLC | 540,453 | $5.71M | 0.43% | +540,453 | New |
| Perceptive Advisors LLC | 541,450 | $5.72M | 0.21% | +541,450 | New |
| Casdin Capital, LLC | 553,268 | $5.85M | 0.53% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 584,435 | $6.18M | 2.48% | −204,235−25.9% | Reduced |
| Checkpoint Capital L.P. | 586,473 | $6.20M | 2.89% | −238,405−28.9% | Reduced |
| ADAR1 Capital Management, LLC | 847,227 | $8.96M | 1.45% | +126,379+17.5% | Added |
| Avoro Capital Advisors LLC | 1,237,500 | $13.1M | 0.23% | −100,000−7.5% | Reduced |
| BlackRock, Inc. | 1,390,800 | $14.7M | 0.00% | +132,487+10.5% | Added |
| Vanguard Group Inc | 1,414,363 | $14.9M | 0.00% | +419,319+42.1% | Added |
| Goldman Sachs Group Inc | 1,416,314 | $15.0M | 0.00% | −33,085−2.3% | Reduced |
| Siren, L.L.C. | 2,202,514 | $23.3M | 1.20% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $33.3M | 6.81% | 00.0% | Unchanged |
| TRV GP VI, LLC | 4,211,659 | $44.5M | 69.32% | 00.0% | Unchanged |
| BVF Inc | 4,396,124 | $46.5M | 1.66% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,680,431 | $49.5M | 0.40% | +1,557,823+49.9% | Added |
| TRV GP V, LLC | 6,215,591 | $65.7M | 39.66% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $73.9M | 1.25% | 00.0% | Unchanged |
| Stonepine Capital Management, LLC | 0 | $0 | 0.00% | −68,084−100.0% | Sold out |
| Swiss National Bank | 0 | $0 | 0.00% | −30,100−100.0% | Sold out |
| Stoneridge Investment Partners LLC | 0 | $0 | 0.00% | −18,477−100.0% | Sold out |
| Chicago Partners Investment Group LLC | 0 | $0 | 0.00% | −10,954−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −9,102−100.0% | Sold out |
| KLP Kapitalforvaltning AS | 0 | $0 | 0.00% | −8,400−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |