Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Septerna, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 82
- −6 vs. Q2 2025
- Shares held
- 44.5M
- +131.1K (+0.3%) vs. Q2 2025
- Total value
- $838.0M
- +$368.5M (+78.5%) vs. Q2 2025
- New holders
- 10
- 31 more added
- Sold out
- 16
- 17 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $131.6M | 1.62% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $116.9M | 33.07% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,919,896 | $92.5M | 0.66% | +239,465+5.1% | Added |
| TRV GP VI, LLC | 4,211,659 | $79.2M | 72.26% | 00.0% | Unchanged |
| BVF Inc | 4,015,790 | $75.5M | 3.06% | −380,334−8.7% | Reduced |
| Samsara BioCapital, LLC | 3,149,128 | $59.2M | 7.73% | 00.0% | Unchanged |
| Siren, L.L.C. | 2,202,514 | $41.4M | 1.62% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,518,757 | $28.6M | 0.00% | +104,394+7.4% | Added |
| BlackRock, Inc. | 1,459,795 | $27.5M | 0.00% | +68,995+5.0% | Added |
| Goldman Sachs Group Inc | 1,454,720 | $27.4M | 0.00% | +38,406+2.7% | Added |
| Avoro Capital Advisors LLC | 1,337,500 | $25.2M | 0.33% | +100,000+8.1% | Added |
| ADAR1 Capital Management, LLC | 1,176,491 | $22.1M | 2.19% | +329,264+38.9% | Added |
| VR Adviser, LLC | 610,808 | $11.5M | 0.65% | +70,355+13.0% | Added |
| Casdin Capital, LLC | 553,268 | $10.4M | 0.87% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 545,701 | $10.3M | 0.00% | +57,745+11.8% | Added |
| Perceptive Advisors LLC | 541,450 | $10.2M | 0.29% | 00.0% | Unchanged |
| State Street Corp | 418,960 | $7.88M | 0.00% | +48,968+13.2% | Added |
| Millennium Management LLC | 384,200 | $7.23M | 0.01% | +332,256+639.6% | Added |
| Catalio Capital Management, LP | 294,360 | $5.54M | 1.02% | 00.0% | Unchanged |
| Checkpoint Capital L.P. | 283,158 | $5.33M | 1.78% | −303,315−51.7% | Reduced |
| Woodline Partners LP | 282,585 | $5.32M | 0.03% | 00.0% | Unchanged |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $4.19M | 0.01% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 189,199 | $3.56M | 0.90% | −395,236−67.6% | Reduced |
| Charles Schwab Investment Management Inc | 186,904 | $3.52M | 0.00% | +32,123+20.8% | Added |
| Invesco Ltd. | 177,070 | $3.33M | 0.00% | +165,237+1,396.4% | Added |
| Northern Trust Corp | 167,345 | $3.15M | 0.00% | +13,001+8.4% | Added |
| Two Sigma Investments, LP | 92,334 | $1.74M | 0.00% | +14,692+18.9% | Added |
| Rangeley Capital, LLC | 88,000 | $1.66M | 1.56% | +29,395+50.2% | Added |
| Logos Global Management LP | 83,548 | $1.57M | 0.16% | −25,654−23.5% | Reduced |
| Walleye Capital LLC | 80,341 | $1.51M | 0.01% | +80,341 | New |
| UBS Group AG | 59,046 | $1.11M | 0.00% | −13,289−18.4% | Reduced |
| Longaeva Partners L.P. | 57,064 | $1.07M | 0.23% | +57,064 | New |
| Morgan Stanley | 54,458 | $1.02M | 0.00% | −30,402−35.8% | Reduced |
| Bank of New York Mellon Corp | 51,631 | $971.2K | 0.00% | +3,142+6.5% | Added |
| Bank of America Corp | 51,495 | $968.6K | 0.00% | −47,718−48.1% | Reduced |
| Jacobs Levy Equity Management, Inc | 35,778 | $673.0K | 0.00% | +35,778 | New |
| Alyeska Investment Group, L.P. | 35,000 | $658.4K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 30,102 | $566.2K | 0.00% | −5,604−15.7% | Reduced |
| Rhumbline Advisers | 27,604 | $519.2K | 0.00% | −968−3.4% | Reduced |
| Price T Rowe Associates Inc | 27,424 | $516.0K | 0.00% | +2,522+10.1% | Added |
| American Century Companies Inc | 25,283 | $475.6K | 0.00% | +25,283 | New |
| Nuveen, LLC | 23,961 | $450.7K | 0.00% | −34,010−58.7% | Reduced |
| Alliancebernstein L.P. | 22,100 | $415.7K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 20,700 | $389.4K | 0.00% | +20,700 | New |
| Wells Fargo & Company | 20,147 | $379.0K | 0.00% | +5,430+36.9% | Added |
| Verition Fund Management LLC | 20,131 | $378.7K | 0.00% | +20,131 | New |
| Soleus Capital Management, L.P. | 18,260 | $343.5K | 0.02% | −57,196−75.8% | Reduced |
| Deutsche Bank AG | 14,135 | $265.9K | 0.00% | +2,012+16.6% | Added |
| MetLife Investment Management | 13,685 | $257.4K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 12,863 | $242.0K | 0.00% | +12,649+5,910.7% | Added |
| PharVision Advisers, LLC | 11,932 | $224.4K | 0.13% | +1,780+17.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 9,791 | $184.2K | 0.00% | −1,906−16.3% | Reduced |
| JPMorgan Chase & Co | 8,736 | $164.3K | 0.00% | −1,365−13.5% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $97.3K | 0.00% | +1,620+45.6% | Added |
| BNP Paribas Arbitrage, SA | 4,155 | $78.2K | 0.00% | +1,945+88.0% | Added |
| Covestor Ltd | 3,620 | $68.0K | 0.04% | +1,296+55.8% | Added |
| FMR LLC | 3,438 | $64.7K | 0.00% | +953+38.4% | Added |
| New York State Common Retirement Fund | 2,900 | $54.5K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 1,945 | $36.6K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,944 | $36.6K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 1,896 | $35.7K | 0.00% | +1,896 | New |
| Quarry LP | 1,736 | $32.7K | 0.01% | −1,865−51.8% | Reduced |
| Group One Trading, L.P. | 1,689 | $31.8K | 0.00% | +900+114.1% | Added |
| Sterling Capital Management LLC | 1,475 | $27.7K | 0.00% | +898+155.6% | Added |
| California State Teachers Retirement System | 1,371 | $25.8K | 0.00% | +1+0.1% | Added |
| Royal Bank of Canada | 1,083 | $20.0K | 0.00% | −757−41.1% | Reduced |
| Signaturefd, LLC | 966 | $18.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 959 | $18.0K | 0.00% | −1,266−56.9% | Reduced |
| CWM, LLC | 884 | $17.0K | 0.00% | +12+1.4% | Added |
| GAMMA Investing LLC | 804 | $15.1K | 0.00% | +227+39.3% | Added |
| Amalgamated Bank | 634 | $12.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 265 | $4.99K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 261 | $4.91K | 0.00% | +261 | New |
| Citigroup Inc | 249 | $4.68K | 0.00% | −6,924−96.5% | Reduced |
| The PNC Financial Services Group, Inc. | 198 | $3.72K | 0.00% | +198 | New |
| Nisa Investment Advisors, LLC | 143 | $2.69K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 71 | $1.34K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 63 | $1.19K | 0.00% | +41+186.4% | Added |
| SRS Capital Advisors, Inc. | 63 | $1.19K | 0.00% | +63 | New |
| SBI Securities Co., Ltd. | 50 | $941 | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 30 | $564 | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 8 | $150 | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −166,506−100.0% | Sold out |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −121,716−100.0% | Sold out |
| UBS Asset Management Americas Inc | 0 | $0 | 0.00% | −28,700−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −24,142−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −23,527−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −23,525−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −22,330−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −17,774−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −16,761−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −10,737−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −10,125−100.0% | Sold out |
| STRS Ohio | 0 | $0 | 0.00% | −3,400−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −605−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −222−100.0% | Sold out |
| Comerica Bank | 0 | $0 | 0.00% | −212−100.0% | Sold out |
| Congress Wealth Management LLC | – | – | – | – | Not filed |