Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Septerna, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 82
- −6 vs. Q2 2025
- Shares held
- 44.5M
- +131.1K (+0.3%) vs. Q2 2025
- Total value
- $838.0M
- +$368.5M (+78.5%) vs. Q2 2025
- New holders
- 10
- 31 more added
- Sold out
- 16
- 17 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| National Bank of Canada | 8 | $150 | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 30 | $564 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 50 | $941 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 63 | $1.19K | 0.00% | +41+186.4% | Added |
| SRS Capital Advisors, Inc. | 63 | $1.19K | 0.00% | +63 | New |
| Fortitude Family Office, LLC | 71 | $1.34K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 143 | $2.69K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 198 | $3.72K | 0.00% | +198 | New |
| Citigroup Inc | 249 | $4.68K | 0.00% | −6,924−96.5% | Reduced |
| Versant Capital Management, Inc | 261 | $4.91K | 0.00% | +261 | New |
| US Bancorp | 265 | $4.99K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 634 | $12.0K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 804 | $15.1K | 0.00% | +227+39.3% | Added |
| CWM, LLC | 884 | $17.0K | 0.00% | +12+1.4% | Added |
| Tower Research Capital LLC (TRC) | 959 | $18.0K | 0.00% | −1,266−56.9% | Reduced |
| Signaturefd, LLC | 966 | $18.2K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,083 | $20.0K | 0.00% | −757−41.1% | Reduced |
| California State Teachers Retirement System | 1,371 | $25.8K | 0.00% | +1+0.1% | Added |
| Sterling Capital Management LLC | 1,475 | $27.7K | 0.00% | +898+155.6% | Added |
| Group One Trading, L.P. | 1,689 | $31.8K | 0.00% | +900+114.1% | Added |
| Quarry LP | 1,736 | $32.7K | 0.01% | −1,865−51.8% | Reduced |
| Russell Investments Group, Ltd. | 1,896 | $35.7K | 0.00% | +1,896 | New |
| Ameritas Investment Partners, Inc. | 1,944 | $36.6K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 1,945 | $36.6K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,900 | $54.5K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 3,438 | $64.7K | 0.00% | +953+38.4% | Added |
| Covestor Ltd | 3,620 | $68.0K | 0.04% | +1,296+55.8% | Added |
| BNP Paribas Arbitrage, SA | 4,155 | $78.2K | 0.00% | +1,945+88.0% | Added |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $97.3K | 0.00% | +1,620+45.6% | Added |
| JPMorgan Chase & Co | 8,736 | $164.3K | 0.00% | −1,365−13.5% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 9,791 | $184.2K | 0.00% | −1,906−16.3% | Reduced |
| PharVision Advisers, LLC | 11,932 | $224.4K | 0.13% | +1,780+17.5% | Added |
| Advisor Group Holdings, Inc. | 12,863 | $242.0K | 0.00% | +12,649+5,910.7% | Added |
| MetLife Investment Management | 13,685 | $257.4K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 14,135 | $265.9K | 0.00% | +2,012+16.6% | Added |
| Soleus Capital Management, L.P. | 18,260 | $343.5K | 0.02% | −57,196−75.8% | Reduced |
| Verition Fund Management LLC | 20,131 | $378.7K | 0.00% | +20,131 | New |
| Wells Fargo & Company | 20,147 | $379.0K | 0.00% | +5,430+36.9% | Added |
| Two Sigma Advisers, LP | 20,700 | $389.4K | 0.00% | +20,700 | New |
| Alliancebernstein L.P. | 22,100 | $415.7K | 0.00% | 00.0% | Unchanged |
| Nuveen, LLC | 23,961 | $450.7K | 0.00% | −34,010−58.7% | Reduced |
| American Century Companies Inc | 25,283 | $475.6K | 0.00% | +25,283 | New |
| Price T Rowe Associates Inc | 27,424 | $516.0K | 0.00% | +2,522+10.1% | Added |
| Rhumbline Advisers | 27,604 | $519.2K | 0.00% | −968−3.4% | Reduced |
| Barclays PLC | 30,102 | $566.2K | 0.00% | −5,604−15.7% | Reduced |
| Alyeska Investment Group, L.P. | 35,000 | $658.4K | 0.00% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 35,778 | $673.0K | 0.00% | +35,778 | New |
| Bank of America Corp | 51,495 | $968.6K | 0.00% | −47,718−48.1% | Reduced |
| Bank of New York Mellon Corp | 51,631 | $971.2K | 0.00% | +3,142+6.5% | Added |
| Morgan Stanley | 54,458 | $1.02M | 0.00% | −30,402−35.8% | Reduced |
| Longaeva Partners L.P. | 57,064 | $1.07M | 0.23% | +57,064 | New |
| UBS Group AG | 59,046 | $1.11M | 0.00% | −13,289−18.4% | Reduced |
| Walleye Capital LLC | 80,341 | $1.51M | 0.01% | +80,341 | New |
| Logos Global Management LP | 83,548 | $1.57M | 0.16% | −25,654−23.5% | Reduced |
| Rangeley Capital, LLC | 88,000 | $1.66M | 1.56% | +29,395+50.2% | Added |
| Two Sigma Investments, LP | 92,334 | $1.74M | 0.00% | +14,692+18.9% | Added |
| Northern Trust Corp | 167,345 | $3.15M | 0.00% | +13,001+8.4% | Added |
| Invesco Ltd. | 177,070 | $3.33M | 0.00% | +165,237+1,396.4% | Added |
| Charles Schwab Investment Management Inc | 186,904 | $3.52M | 0.00% | +32,123+20.8% | Added |
| Sio Capital Management, LLC | 189,199 | $3.56M | 0.90% | −395,236−67.6% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $4.19M | 0.01% | 00.0% | Unchanged |
| Woodline Partners LP | 282,585 | $5.32M | 0.03% | 00.0% | Unchanged |
| Checkpoint Capital L.P. | 283,158 | $5.33M | 1.78% | −303,315−51.7% | Reduced |
| Catalio Capital Management, LP | 294,360 | $5.54M | 1.02% | 00.0% | Unchanged |
| Millennium Management LLC | 384,200 | $7.23M | 0.01% | +332,256+639.6% | Added |
| State Street Corp | 418,960 | $7.88M | 0.00% | +48,968+13.2% | Added |
| Perceptive Advisors LLC | 541,450 | $10.2M | 0.29% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 545,701 | $10.3M | 0.00% | +57,745+11.8% | Added |
| Casdin Capital, LLC | 553,268 | $10.4M | 0.87% | 00.0% | Unchanged |
| VR Adviser, LLC | 610,808 | $11.5M | 0.65% | +70,355+13.0% | Added |
| ADAR1 Capital Management, LLC | 1,176,491 | $22.1M | 2.19% | +329,264+38.9% | Added |
| Avoro Capital Advisors LLC | 1,337,500 | $25.2M | 0.33% | +100,000+8.1% | Added |
| Goldman Sachs Group Inc | 1,454,720 | $27.4M | 0.00% | +38,406+2.7% | Added |
| BlackRock, Inc. | 1,459,795 | $27.5M | 0.00% | +68,995+5.0% | Added |
| Vanguard Group Inc | 1,518,757 | $28.6M | 0.00% | +104,394+7.4% | Added |
| Siren, L.L.C. | 2,202,514 | $41.4M | 1.62% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $59.2M | 7.73% | 00.0% | Unchanged |
| BVF Inc | 4,015,790 | $75.5M | 3.06% | −380,334−8.7% | Reduced |
| TRV GP VI, LLC | 4,211,659 | $79.2M | 72.26% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,919,896 | $92.5M | 0.66% | +239,465+5.1% | Added |
| TRV GP V, LLC | 6,215,591 | $116.9M | 33.07% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $131.6M | 1.62% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −166,506−100.0% | Sold out |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −121,716−100.0% | Sold out |
| UBS Asset Management Americas Inc | 0 | $0 | 0.00% | −28,700−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −24,142−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −23,527−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −23,525−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −22,330−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −17,774−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −16,761−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −10,737−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −10,125−100.0% | Sold out |
| STRS Ohio | 0 | $0 | 0.00% | −3,400−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −605−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −222−100.0% | Sold out |
| Comerica Bank | 0 | $0 | 0.00% | −212−100.0% | Sold out |
| Congress Wealth Management LLC | – | – | – | – | Not filed |