Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Septerna, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 71
- +71 vs. Q3 2024
- Shares held
- 44.1M
- +44.1M vs. Q3 2024
- Total value
- $1.01B
- +$1.01B vs. Q3 2024
- New holders
- 71
- 0 more added
- Sold out
- 0
- 0 more reduced
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $160.2M | 2.13% | +6,995,858 | New |
| TRV GP V, LLC | 6,215,591 | $142.3M | 48.42% | +6,215,591 | New |
| TRV GP VI, LLC | 3,152,456 | $72.2M | 61.75% | +3,152,456 | New |
| Samsara BioCapital, LLC | 2,768,520 | $63.4M | 8.70% | +2,768,520 | New |
| Driehaus Capital Management LLC | 2,589,553 | $59.3M | 0.49% | +2,589,553 | New |
| BVF Inc | 2,452,024 | $56.2M | 1.90% | +2,452,024 | New |
| Siren, L.L.C. | 2,202,514 | $50.4M | 2.23% | +2,202,514 | New |
| Deep Track Capital, LP | 1,912,929 | $43.8M | 1.64% | +1,912,929 | New |
| BlackRock, Inc. | 1,677,135 | $38.4M | 0.00% | +1,677,135 | New |
| Goldman Sachs Group Inc | 1,674,357 | $38.3M | 0.01% | +1,674,357 | New |
| Avoro Capital Advisors LLC | 1,110,000 | $25.4M | 0.36% | +1,110,000 | New |
| Janus Henderson Group PLC | 1,096,302 | $25.1M | 0.01% | +1,096,302 | New |
| Catalio Capital Management, LP | 1,024,245 | $23.5M | 5.13% | +1,024,245 | New |
| FMR LLC | 1,002,958 | $23.0M | 0.00% | +1,002,958 | New |
| Vanguard Group Inc | 985,032 | $22.6M | 0.00% | +985,032 | New |
| Deerfield Management Company, L.P. (Series C) | 861,814 | $19.7M | 0.38% | +861,814 | New |
| Perceptive Advisors LLC | 750,000 | $17.2M | 0.48% | +750,000 | New |
| Soleus Capital Management, L.P. | 675,409 | $15.5M | 1.17% | +675,409 | New |
| Cormorant Asset Management, LP | 560,000 | $12.8M | 0.70% | +560,000 | New |
| Casdin Capital, LLC | 553,268 | $12.7M | 0.85% | +553,268 | New |
| Price T Rowe Associates Inc | 518,588 | $11.9M | 0.00% | +518,588 | New |
| Citadel Advisors LLC | 404,882 | $9.27M | 0.01% | +404,882 | New |
| Geode Capital Management, LLC | 380,577 | $8.72M | 0.00% | +380,577 | New |
| Adage Capital Partners GP, L.L.C. | 300,000 | $6.87M | 0.01% | +300,000 | New |
| Woodline Partners LP | 300,000 | $6.87M | 0.05% | +300,000 | New |
| State Street Corp | 272,776 | $6.25M | 0.00% | +272,776 | New |
| Sio Capital Management, LLC | 271,687 | $6.22M | 1.75% | +271,687 | New |
| ArrowMark Colorado Holdings LLC | 147,886 | $3.39M | 0.05% | +147,886 | New |
| Northern Trust Corp | 147,776 | $3.38M | 0.00% | +147,776 | New |
| Charles Schwab Investment Management Inc | 139,616 | $3.20M | 0.00% | +139,616 | New |
| Logos Global Management LP | 134,202 | $3.07M | 0.36% | +134,202 | New |
| UBS Group AG | 108,453 | $2.48M | 0.00% | +108,453 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 102,749 | $2.35M | 0.00% | +102,749 | New |
| Bank of America Corp | 78,744 | $1.80M | 0.00% | +78,744 | New |
| TD Asset Management Inc | 69,460 | $1.59M | 0.00% | +69,460 | New |
| Morgan Stanley | 41,911 | $959.8K | 0.00% | +41,911 | New |
| Bank of New York Mellon Corp | 38,093 | $872.3K | 0.00% | +38,093 | New |
| JPMorgan Chase & Co | 38,015 | $870.5K | 0.00% | +38,015 | New |
| Alyeska Investment Group, L.P. | 35,000 | $801.5K | 0.00% | +35,000 | New |
| Barclays PLC | 28,785 | $659.2K | 0.00% | +28,785 | New |
| Jane Street Group, LLC | 26,208 | $600.2K | 0.00% | +26,208 | New |
| Nuveen Asset Management, LLC | 23,961 | $548.7K | 0.00% | +23,961 | New |
| Verition Fund Management LLC | 22,695 | $519.7K | 0.00% | +22,695 | New |
| Manufacturers Life Insurance Company, The | 22,095 | $506.0K | 0.00% | +22,095 | New |
| Lindbrook Capital, LLC | 21,000 | $480.9K | 0.04% | +21,000 | New |
| Walleye Capital LLC | 20,204 | $462.7K | 0.00% | +20,204 | New |
| Rhumbline Advisers | 19,995 | $457.9K | 0.00% | +19,995 | New |
| M&T Bank Corp | 16,394 | $375.7K | 0.00% | +16,394 | New |
| Citigroup Inc | 14,633 | $335.1K | 0.00% | +14,633 | New |
| Invesco Ltd. | 12,154 | $278.3K | 0.00% | +12,154 | New |
| UBS Oconnor LLC | 12,118 | $277.5K | 0.01% | +12,118 | New |
| MetLife Investment Management | 11,555 | $264.6K | 0.00% | +11,555 | New |
| Wells Fargo & Company | 10,651 | $243.9K | 0.00% | +10,651 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 10,519 | $240.9K | 0.00% | +10,519 | New |
| Deutsche Bank AG | 10,419 | $238.6K | 0.00% | +10,419 | New |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 10,000 | $229.0K | 0.00% | +10,000 | New |
| Zimmer Partners, LP | 10,000 | $229.0K | 0.00% | +10,000 | New |
| Corebridge Financial, Inc. | 9,236 | $211.5K | 0.00% | +9,236 | New |
| SG Americas Securities, LLC | 8,095 | $185.0K | 0.00% | +8,095 | New |
| STRS Ohio | 3,400 | $77.9K | 0.00% | +3,400 | New |
| The PNC Financial Services Group, Inc. | 2,680 | $61.4K | 0.00% | +2,680 | New |
| BNP Paribas Arbitrage, SA | 2,251 | $51.5K | 0.00% | +2,251 | New |
| Ameritas Investment Partners, Inc. | 1,944 | $44.5K | 0.00% | +1,944 | New |
| Legal & General Group Plc | 1,840 | $42.1K | 0.00% | +1,840 | New |
| New York State Common Retirement Fund | 1,400 | $32.1K | 0.00% | +1,400 | New |
| Royal Bank of Canada | 1,398 | $32.0K | 0.00% | +1,398 | New |
| California State Teachers Retirement System | 1,370 | $31.4K | 0.00% | +1,370 | New |
| Tower Research Capital LLC (TRC) | 1,093 | $25.0K | 0.00% | +1,093 | New |
| Amalgamated Bank | 634 | $15.0K | 0.00% | +634 | New |
| Sterling Capital Management LLC | 266 | $6.09K | 0.00% | +266 | New |
| GAMMA Investing LLC | 15 | $344 | 0.00% | +15 | New |