Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Septerna, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 71
- +1 vs. Q4 2024
- Shares held
- 45.3M
- +1.19M (+2.7%) vs. Q4 2024
- Total value
- $262.2M
- −$747.8M (−74.0%) vs. Q4 2024
- New holders
- 20
- 25 more added
- Sold out
- 19
- 12 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $40.5M | 0.68% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $36.0M | 28.77% | 00.0% | Unchanged |
| BVF Inc | 4,396,124 | $25.5M | 1.04% | +1,944,100+79.3% | Added |
| TRV GP VI, LLC | 4,211,659 | $24.4M | 58.10% | +1,059,203+33.6% | Added |
| Samsara BioCapital, LLC | 3,149,128 | $18.2M | 3.25% | +380,608+13.7% | Added |
| Driehaus Capital Management LLC | 3,122,608 | $18.1M | 0.17% | +533,055+20.6% | Added |
| Siren, L.L.C. | 2,202,514 | $12.8M | 0.72% | 00.0% | Unchanged |
| Deep Track Capital, LP | 1,912,929 | $11.1M | 0.36% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,449,399 | $8.39M | 0.00% | −224,958−13.4% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $7.74M | 0.12% | +227,500+20.5% | Added |
| BlackRock, Inc. | 1,258,313 | $7.29M | 0.00% | −418,822−25.0% | Reduced |
| Catalio Capital Management, LP | 1,024,245 | $5.93M | 1.47% | 00.0% | Unchanged |
| Vanguard Group Inc | 995,044 | $5.76M | 0.00% | +10,012+1.0% | Added |
| Checkpoint Capital L.P. | 824,878 | $4.78M | 2.62% | +824,878 | New |
| Sio Capital Management, LLC | 788,670 | $4.57M | 1.38% | +516,983+190.3% | Added |
| Soleus Capital Management, L.P. | 751,353 | $4.35M | 0.34% | +75,944+11.2% | Added |
| ADAR1 Capital Management, LLC | 720,848 | $4.17M | 0.80% | +720,848 | New |
| Woodline Partners LP | 582,585 | $3.37M | 0.02% | +282,585+94.2% | Added |
| Casdin Capital, LLC | 553,268 | $3.20M | 0.26% | 00.0% | Unchanged |
| Millennium Management LLC | 436,564 | $2.53M | 0.00% | +436,564 | New |
| Geode Capital Management, LLC | 409,640 | $2.37M | 0.00% | +29,063+7.6% | Added |
| State Street Corp | 344,604 | $2.00M | 0.00% | +71,828+26.3% | Added |
| UBS Group AG | 239,930 | $1.39M | 0.00% | +131,477+121.2% | Added |
| Northern Trust Corp | 158,040 | $915.1K | 0.00% | +10,264+6.9% | Added |
| Logos Global Management LP | 134,202 | $777.0K | 0.14% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 118,451 | $685.8K | 0.00% | −21,165−15.2% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 102,749 | $594.9K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 91,044 | $527.1K | 0.00% | +49,133+117.2% | Added |
| Two Sigma Investments, LP | 74,841 | $433.3K | 0.00% | +74,841 | New |
| Stonepine Capital Management, LLC | 68,084 | $394.2K | 0.46% | +68,084 | New |
| Rangeley Capital, LLC | 52,950 | $306.6K | 0.35% | +52,950 | New |
| FMR LLC | 49,778 | $288.2K | 0.00% | −953,180−95.0% | Reduced |
| California State Teachers Retirement System | 44,362 | $256.9K | 0.00% | +42,992+3,138.1% | Added |
| Bank of New York Mellon Corp | 38,376 | $222.2K | 0.00% | +283+0.7% | Added |
| Citigroup Inc | 38,055 | $220.3K | 0.00% | +23,422+160.1% | Added |
| XTX Topco Ltd | 37,350 | $216.3K | 0.01% | +37,350 | New |
| Alyeska Investment Group, L.P. | 35,000 | $202.7K | 0.00% | 00.0% | Unchanged |
| Swiss National Bank | 30,100 | $174.3K | 0.00% | +30,100 | New |
| Susquehanna International Group, LLP | 25,209 | $146.0K | 0.00% | +25,209 | New |
| Nuveen, LLC | 23,961 | $138.7K | 0.00% | +23,961 | New |
| Rhumbline Advisers | 23,318 | $135.0K | 0.00% | +3,323+16.6% | Added |
| Price T Rowe Associates Inc | 22,957 | $133.0K | 0.00% | −495,631−95.6% | Reduced |
| Barclays PLC | 22,733 | $131.6K | 0.00% | −6,052−21.0% | Reduced |
| Lindbrook Capital, LLC | 21,000 | $121.6K | 0.01% | 00.0% | Unchanged |
| Stoneridge Investment Partners LLC | 18,477 | $107.0K | 0.09% | +18,477 | New |
| Gsa Capital Partners LLP | 18,299 | $106.0K | 0.01% | +18,299 | New |
| Deutsche Bank AG | 15,968 | $92.5K | 0.00% | +5,549+53.3% | Added |
| Chicago Partners Investment Group LLC | 10,954 | $77.2K | 0.00% | +10,954 | New |
| Invesco Ltd. | 12,202 | $70.6K | 0.00% | +48+0.4% | Added |
| Bank of America Corp | 11,559 | $66.9K | 0.00% | −67,185−85.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 10,987 | $63.6K | 0.00% | +468+4.4% | Added |
| Wells Fargo & Company | 10,869 | $62.9K | 0.00% | +218+2.0% | Added |
| Corebridge Financial, Inc. | 9,102 | $52.7K | 0.00% | −134−1.5% | Reduced |
| JPMorgan Chase & Co | 8,786 | $50.9K | 0.00% | −29,229−76.9% | Reduced |
| KLP Kapitalforvaltning AS | 8,400 | $48.6K | 0.00% | +8,400 | New |
| Police & Firemen's Retirement System of New Jersey | 3,555 | $20.6K | 0.00% | +3,555 | New |
| STRS Ohio | 3,400 | $19.7K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,900 | $16.8K | 0.00% | +1,500+107.1% | Added |
| Ameritas Investment Partners, Inc. | 1,944 | $11.3K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 1,840 | $10.7K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,788 | $10.4K | 0.00% | +695+63.6% | Added |
| BNP Paribas Arbitrage, SA | 1,149 | $6.65K | 0.00% | −1,102−49.0% | Reduced |
| Royal Bank of Canada | 802 | $4.00K | 0.00% | −596−42.6% | Reduced |
| Amalgamated Bank | 634 | $4.00K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 434 | $2.51K | 0.00% | +419+2,793.3% | Added |
| CWM, LLC | 282 | $2.00K | 0.00% | +282 | New |
| Sterling Capital Management LLC | 157 | $909 | 0.00% | −109−41.0% | Reduced |
| Nisa Investment Advisors, LLC | 134 | $776 | 0.00% | +134 | New |
| National Bank of Canada | 8 | $46 | 0.00% | +8 | New |
| Simplex Trading, LLC | 30 | $0 | 0.00% | +30 | New |
| Covestor Ltd | 6 | $0 | 0.00% | +6 | New |
| Janus Henderson Group PLC | 0 | $0 | 0.00% | −1,096,302−100.0% | Sold out |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −861,814−100.0% | Sold out |
| Perceptive Advisors LLC | 0 | $0 | 0.00% | −750,000−100.0% | Sold out |
| Cormorant Asset Management, LP | 0 | $0 | 0.00% | −560,000−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −404,882−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |
| ArrowMark Colorado Holdings LLC | 0 | $0 | 0.00% | −147,886−100.0% | Sold out |
| TD Asset Management Inc | 0 | $0 | 0.00% | −69,460−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −26,208−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −22,695−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −22,095−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −20,204−100.0% | Sold out |
| M&T Bank Corp | 0 | $0 | 0.00% | −16,394−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −12,118−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −11,555−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Zimmer Partners, LP | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −8,095−100.0% | Sold out |
| The PNC Financial Services Group, Inc. | 0 | $0 | 0.00% | −2,680−100.0% | Sold out |
| Nuveen Asset Management, LLC | – | – | – | – | Not filed |