Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Septerna, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 122
- +40 vs. Q3 2025
- Shares held
- 45.6M
- +1.04M (+2.3%) vs. Q3 2025
- Total value
- $1.27B
- +$432.9M (+51.7%) vs. Q3 2025
- New holders
- 45
- 31 more added
- Sold out
- 5
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $195.0M | 2.00% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $173.3M | 40.38% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,809,470 | $134.1M | 0.91% | −110,426−2.2% | Reduced |
| TRV GP VI, LLC | 4,211,659 | $117.4M | 79.05% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $87.8M | 9.06% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 2,715,129 | $75.7M | 0.01% | +1,260,409+86.6% | Added |
| Siren, L.L.C. | 2,000,000 | $55.8M | 1.66% | −202,514−9.2% | Reduced |
| BlackRock, Inc. | 1,801,328 | $50.2M | 0.00% | +341,533+23.4% | Added |
| BVF Inc | 1,720,782 | $48.0M | 1.61% | −2,295,008−57.1% | Reduced |
| Vanguard Group Inc | 1,508,195 | $42.0M | 0.00% | −10,562−0.7% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $37.3M | 0.37% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 1,157,611 | $32.3M | 2.41% | −18,880−1.6% | Reduced |
| First Light Asset Management, LLC | 620,811 | $17.3M | 1.32% | +620,811 | New |
| VR Adviser, LLC | 610,808 | $17.0M | 0.84% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 572,734 | $16.0M | 0.00% | +27,033+5.0% | Added |
| Casdin Capital, LLC | 553,268 | $15.4M | 0.96% | 00.0% | Unchanged |
| Primecap Management Co | 546,100 | $15.2M | 0.01% | +546,100 | New |
| State Street Corp | 540,028 | $15.1M | 0.00% | +121,068+28.9% | Added |
| Perceptive Advisors LLC | 433,160 | $12.1M | 0.22% | −108,290−20.0% | Reduced |
| Woodline Partners LP | 385,310 | $10.7M | 0.04% | +102,725+36.4% | Added |
| Soleus Capital Management, L.P. | 383,368 | $10.7M | 0.45% | +365,108+1,999.5% | Added |
| Catalio Capital Management, LP | 294,360 | $8.21M | 1.45% | 00.0% | Unchanged |
| Marshall Wace, LLP | 226,901 | $6.33M | 0.01% | +226,901 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $6.21M | 0.01% | 00.0% | Unchanged |
| Kalehua Capital Management LLC | 194,544 | $5.42M | 5.36% | +194,544 | New |
| Charles Schwab Investment Management Inc | 187,241 | $5.22M | 0.00% | +337+0.2% | Added |
| Invesco Ltd. | 162,014 | $4.52M | 0.00% | −15,056−8.5% | Reduced |
| Northern Trust Corp | 154,196 | $4.30M | 0.00% | −13,149−7.9% | Reduced |
| Millennium Management LLC | 107,463 | $3.00M | 0.00% | −276,737−72.0% | Reduced |
| Morgan Stanley | 103,985 | $2.90M | 0.00% | +49,527+90.9% | Added |
| Two Sigma Investments, LP | 92,809 | $2.59M | 0.00% | +475+0.5% | Added |
| Federated Hermes, Inc. | 78,905 | $2.20M | 0.00% | +78,905 | New |
| HighVista Strategies LLC | 78,682 | $2.19M | 0.56% | +78,682 | New |
| Citadel Advisors LLC | 75,945 | $2.12M | 0.00% | +75,945 | New |
| UBS Group AG | 68,817 | $1.92M | 0.00% | +9,771+16.5% | Added |
| JPMorgan Chase & Co | 68,338 | $1.91M | 0.00% | +59,602+682.3% | Added |
| Rangeley Capital, LLC | 65,800 | $1.83M | 1.58% | −22,200−25.2% | Reduced |
| Jacobs Levy Equity Management, Inc | 61,370 | $1.71M | 0.01% | +25,592+71.5% | Added |
| Bank of New York Mellon Corp | 55,332 | $1.54M | 0.00% | +3,701+7.2% | Added |
| American Century Companies Inc | 50,689 | $1.41M | 0.00% | +25,406+100.5% | Added |
| Longaeva Partners L.P. | 49,902 | $1.39M | 0.17% | −7,162−12.6% | Reduced |
| Numerai GP LLC | 45,866 | $1.28M | 0.15% | +45,866 | New |
| Jane Street Group, LLC | 44,070 | $1.23M | 0.00% | +44,070 | New |
| Trexquant Investment LP | 44,005 | $1.23M | 0.01% | +44,005 | New |
| Barclays PLC | 38,147 | $1.06M | 0.00% | +8,045+26.7% | Added |
| ExodusPoint Capital Management, LP | 37,867 | $1.06M | 0.01% | +37,867 | New |
| Bank of America Corp | 37,594 | $1.05M | 0.00% | −13,901−27.0% | Reduced |
| Alyeska Investment Group, L.P. | 35,000 | $975.8K | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 34,944 | $974.2K | 0.02% | +34,944 | New |
| Acadian Asset Management LLC | 30,877 | $858.0K | 0.00% | +30,877 | New |
| Wells Fargo & Company | 26,529 | $739.6K | 0.00% | +6,382+31.7% | Added |
| Rhumbline Advisers | 26,419 | $736.6K | 0.00% | −1,185−4.3% | Reduced |
| Nuveen, LLC | 25,798 | $719.2K | 0.00% | +1,837+7.7% | Added |
| Two Sigma Advisers, LP | 25,700 | $716.5K | 0.00% | +5,000+24.2% | Added |
| Price T Rowe Associates Inc | 25,443 | $710.0K | 0.00% | −1,981−7.2% | Reduced |
| Logos Global Management LP | 23,548 | $656.5K | 0.04% | −60,000−71.8% | Reduced |
| XTX Topco Ltd | 23,315 | $650.0K | 0.02% | +23,315 | New |
| VARCOV Co. | 22,634 | $631.0K | 0.25% | +22,634 | New |
| Alliancebernstein L.P. | 19,600 | $546.4K | 0.00% | −2,500−11.3% | Reduced |
| Tudor Investment Corp Et Al | 18,053 | $503.3K | 0.00% | +18,053 | New |
| Franklin Resources Inc | 16,852 | $469.8K | 0.00% | +16,852 | New |
| Russell Investments Group, Ltd. | 15,310 | $426.8K | 0.00% | +13,414+707.5% | Added |
| Deutsche Bank AG | 14,879 | $414.8K | 0.00% | +744+5.3% | Added |
| Squarepoint Ops LLC | 14,847 | $413.9K | 0.00% | +14,847 | New |
| STRS Ohio | 14,600 | $407.0K | 0.00% | +14,600 | New |
| Los Angeles Capital Management LLC | 18,550 | $398.6K | 0.00% | +18,550 | New |
| Ameriprise Financial Inc | 14,090 | $392.8K | 0.00% | +14,090 | New |
| MetLife Investment Management | 13,685 | $381.5K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 13,283 | $370.3K | 0.00% | +13,283 | New |
| Advisor Group Holdings, Inc. | 12,693 | $353.9K | 0.00% | −170−1.3% | Reduced |
| Seven Fleet Capital Management LP | 11,445 | $319.1K | 0.22% | +11,445 | New |
| Dynamic Technology Lab Private Ltd | 10,810 | $301.0K | 0.07% | +10,810 | New |
| PharVision Advisers, LLC | 10,739 | $299.4K | 0.15% | −1,193−10.0% | Reduced |
| Public Employees Retirement System of Ohio | 10,594 | $295.4K | 0.00% | +10,594 | New |
| Virtus Investment Advisers, Inc. | 10,457 | $291.5K | 0.08% | +10,457 | New |
| China Universal Asset Management Co., Ltd. | 10,296 | $287.1K | 0.02% | +10,296 | New |
| Baader Bank INC | 10,000 | $278.8K | 0.02% | +10,000 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 9,934 | $277.0K | 0.00% | +143+1.5% | Added |
| Atom Investors LP | 9,791 | $273.0K | 0.02% | +9,791 | New |
| Citigroup Inc | 9,561 | $266.6K | 0.00% | +9,312+3,739.8% | Added |
| Graham Capital Management, L.P. | 8,971 | $250.1K | 0.01% | +8,971 | New |
| Jump Financial, LLC | 8,399 | $234.2K | 0.00% | +8,399 | New |
| Bank of Nova Scotia | 8,300 | $231.4K | 0.00% | +8,300 | New |
| AQR Capital Management LLC | 7,826 | $218.2K | 0.00% | +7,826 | New |
| New York State Common Retirement Fund | 5,600 | $156.1K | 0.00% | +2,700+93.1% | Added |
| BNP Paribas Arbitrage, SA | 5,449 | $151.9K | 0.00% | +1,294+31.1% | Added |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $144.3K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 3,571 | $99.6K | 0.00% | +3,571 | New |
| FMR LLC | 3,307 | $92.2K | 0.00% | −131−3.8% | Reduced |
| Caitong International Asset Management Co., Ltd | 3,170 | $88.4K | 0.02% | +3,170 | New |
| Mirae Asset Global Investments Co., Ltd. | 2,176 | $60.7K | 0.00% | +2,176 | New |
| Tower Research Capital LLC (TRC) | 2,156 | $60.1K | 0.00% | +1,197+124.8% | Added |
| Ameritas Investment Partners, Inc. | 1,944 | $54.2K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 1,945 | $54.2K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 1,941 | $54.0K | 0.03% | −1,679−46.4% | Reduced |
| California State Teachers Retirement System | 1,316 | $36.7K | 0.00% | −55−4.0% | Reduced |
| Global Retirement Partners, LLC | 1,256 | $35.0K | 0.00% | +1,256 | New |
| Sterling Capital Management LLC | 1,232 | $34.3K | 0.00% | −243−16.5% | Reduced |
| Signaturefd, LLC | 989 | $27.6K | 0.00% | +23+2.4% | Added |
| Group One Trading, L.P. | 944 | $26.3K | 0.00% | −745−44.1% | Reduced |