Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Septerna, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 122
- +40 vs. Q3 2025
- Shares held
- 45.6M
- +1.04M (+2.3%) vs. Q3 2025
- Total value
- $1.27B
- +$432.9M (+51.7%) vs. Q3 2025
- New holders
- 45
- 31 more added
- Sold out
- 5
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Farther Finance Advisors, LLC | 1 | $28 | 0.00% | +1 | New |
| SRS Capital Advisors, Inc. | 3 | $84 | 0.00% | −60−95.2% | Reduced |
| Aster Capital Management (DIFC) Ltd | 20 | $558 | 0.00% | +20 | New |
| Rothschild Investment LLC | 30 | $836 | 0.00% | 00.0% | Unchanged |
| Cornerstone Financial Management LLC | 52 | $1.45K | 0.00% | +52 | New |
| SBI Securities Co., Ltd. | 55 | $1.53K | 0.00% | +5+10.0% | Added |
| EverSource Wealth Advisors, LLC | 63 | $1.76K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 63 | $1.76K | 0.00% | +63 | New |
| Fortitude Family Office, LLC | 71 | $1.98K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 149 | $4.00K | 0.00% | +149 | New |
| N.E.W. Advisory Services LLC | 180 | $5.02K | 0.00% | +180 | New |
| US Bancorp | 190 | $5.30K | 0.00% | −75−28.3% | Reduced |
| The PNC Financial Services Group, Inc. | 198 | $5.52K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 261 | $7.28K | 0.00% | 00.0% | Unchanged |
| Pinnacle Wealth Planning Services, Inc. | 322 | $8.98K | 0.00% | +322 | New |
| Nisa Investment Advisors, LLC | 341 | $9.51K | 0.00% | +198+138.5% | Added |
| Royal Bank of Canada | 628 | $18.0K | 0.00% | −455−42.0% | Reduced |
| Amalgamated Bank | 672 | $19.0K | 0.00% | +38+6.0% | Added |
| Quarry LP | 724 | $20.2K | 0.00% | −1,012−58.3% | Reduced |
| GF Fund Management Co. Ltd. | 878 | $24.5K | 0.00% | +878 | New |
| CWM, LLC | 888 | $25.0K | 0.00% | +4+0.5% | Added |
| GAMMA Investing LLC | 916 | $25.5K | 0.00% | +112+13.9% | Added |
| Group One Trading, L.P. | 944 | $26.3K | 0.00% | −745−44.1% | Reduced |
| Signaturefd, LLC | 989 | $27.6K | 0.00% | +23+2.4% | Added |
| Sterling Capital Management LLC | 1,232 | $34.3K | 0.00% | −243−16.5% | Reduced |
| Global Retirement Partners, LLC | 1,256 | $35.0K | 0.00% | +1,256 | New |
| California State Teachers Retirement System | 1,316 | $36.7K | 0.00% | −55−4.0% | Reduced |
| Covestor Ltd | 1,941 | $54.0K | 0.03% | −1,679−46.4% | Reduced |
| Legal & General Group Plc | 1,945 | $54.2K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,944 | $54.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 2,156 | $60.1K | 0.00% | +1,197+124.8% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,176 | $60.7K | 0.00% | +2,176 | New |
| Caitong International Asset Management Co., Ltd | 3,170 | $88.4K | 0.02% | +3,170 | New |
| FMR LLC | 3,307 | $92.2K | 0.00% | −131−3.8% | Reduced |
| Balyasny Asset Management LLC | 3,571 | $99.6K | 0.00% | +3,571 | New |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $144.3K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 5,449 | $151.9K | 0.00% | +1,294+31.1% | Added |
| New York State Common Retirement Fund | 5,600 | $156.1K | 0.00% | +2,700+93.1% | Added |
| AQR Capital Management LLC | 7,826 | $218.2K | 0.00% | +7,826 | New |
| Bank of Nova Scotia | 8,300 | $231.4K | 0.00% | +8,300 | New |
| Jump Financial, LLC | 8,399 | $234.2K | 0.00% | +8,399 | New |
| Graham Capital Management, L.P. | 8,971 | $250.1K | 0.01% | +8,971 | New |
| Citigroup Inc | 9,561 | $266.6K | 0.00% | +9,312+3,739.8% | Added |
| Atom Investors LP | 9,791 | $273.0K | 0.02% | +9,791 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 9,934 | $277.0K | 0.00% | +143+1.5% | Added |
| Baader Bank INC | 10,000 | $278.8K | 0.02% | +10,000 | New |
| China Universal Asset Management Co., Ltd. | 10,296 | $287.1K | 0.02% | +10,296 | New |
| Virtus Investment Advisers, Inc. | 10,457 | $291.5K | 0.08% | +10,457 | New |
| Public Employees Retirement System of Ohio | 10,594 | $295.4K | 0.00% | +10,594 | New |
| PharVision Advisers, LLC | 10,739 | $299.4K | 0.15% | −1,193−10.0% | Reduced |
| Dynamic Technology Lab Private Ltd | 10,810 | $301.0K | 0.07% | +10,810 | New |
| Seven Fleet Capital Management LP | 11,445 | $319.1K | 0.22% | +11,445 | New |
| Advisor Group Holdings, Inc. | 12,693 | $353.9K | 0.00% | −170−1.3% | Reduced |
| Intech Investment Management LLC | 13,283 | $370.3K | 0.00% | +13,283 | New |
| MetLife Investment Management | 13,685 | $381.5K | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 14,090 | $392.8K | 0.00% | +14,090 | New |
| Los Angeles Capital Management LLC | 18,550 | $398.6K | 0.00% | +18,550 | New |
| STRS Ohio | 14,600 | $407.0K | 0.00% | +14,600 | New |
| Squarepoint Ops LLC | 14,847 | $413.9K | 0.00% | +14,847 | New |
| Deutsche Bank AG | 14,879 | $414.8K | 0.00% | +744+5.3% | Added |
| Russell Investments Group, Ltd. | 15,310 | $426.8K | 0.00% | +13,414+707.5% | Added |
| Franklin Resources Inc | 16,852 | $469.8K | 0.00% | +16,852 | New |
| Tudor Investment Corp Et Al | 18,053 | $503.3K | 0.00% | +18,053 | New |
| Alliancebernstein L.P. | 19,600 | $546.4K | 0.00% | −2,500−11.3% | Reduced |
| VARCOV Co. | 22,634 | $631.0K | 0.25% | +22,634 | New |
| XTX Topco Ltd | 23,315 | $650.0K | 0.02% | +23,315 | New |
| Logos Global Management LP | 23,548 | $656.5K | 0.04% | −60,000−71.8% | Reduced |
| Price T Rowe Associates Inc | 25,443 | $710.0K | 0.00% | −1,981−7.2% | Reduced |
| Two Sigma Advisers, LP | 25,700 | $716.5K | 0.00% | +5,000+24.2% | Added |
| Nuveen, LLC | 25,798 | $719.2K | 0.00% | +1,837+7.7% | Added |
| Rhumbline Advisers | 26,419 | $736.6K | 0.00% | −1,185−4.3% | Reduced |
| Wells Fargo & Company | 26,529 | $739.6K | 0.00% | +6,382+31.7% | Added |
| Acadian Asset Management LLC | 30,877 | $858.0K | 0.00% | +30,877 | New |
| Algert Global LLC | 34,944 | $974.2K | 0.02% | +34,944 | New |
| Alyeska Investment Group, L.P. | 35,000 | $975.8K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 37,594 | $1.05M | 0.00% | −13,901−27.0% | Reduced |
| ExodusPoint Capital Management, LP | 37,867 | $1.06M | 0.01% | +37,867 | New |
| Barclays PLC | 38,147 | $1.06M | 0.00% | +8,045+26.7% | Added |
| Trexquant Investment LP | 44,005 | $1.23M | 0.01% | +44,005 | New |
| Jane Street Group, LLC | 44,070 | $1.23M | 0.00% | +44,070 | New |
| Numerai GP LLC | 45,866 | $1.28M | 0.15% | +45,866 | New |
| Longaeva Partners L.P. | 49,902 | $1.39M | 0.17% | −7,162−12.6% | Reduced |
| American Century Companies Inc | 50,689 | $1.41M | 0.00% | +25,406+100.5% | Added |
| Bank of New York Mellon Corp | 55,332 | $1.54M | 0.00% | +3,701+7.2% | Added |
| Jacobs Levy Equity Management, Inc | 61,370 | $1.71M | 0.01% | +25,592+71.5% | Added |
| Rangeley Capital, LLC | 65,800 | $1.83M | 1.58% | −22,200−25.2% | Reduced |
| JPMorgan Chase & Co | 68,338 | $1.91M | 0.00% | +59,602+682.3% | Added |
| UBS Group AG | 68,817 | $1.92M | 0.00% | +9,771+16.5% | Added |
| Citadel Advisors LLC | 75,945 | $2.12M | 0.00% | +75,945 | New |
| HighVista Strategies LLC | 78,682 | $2.19M | 0.56% | +78,682 | New |
| Federated Hermes, Inc. | 78,905 | $2.20M | 0.00% | +78,905 | New |
| Two Sigma Investments, LP | 92,809 | $2.59M | 0.00% | +475+0.5% | Added |
| Morgan Stanley | 103,985 | $2.90M | 0.00% | +49,527+90.9% | Added |
| Millennium Management LLC | 107,463 | $3.00M | 0.00% | −276,737−72.0% | Reduced |
| Northern Trust Corp | 154,196 | $4.30M | 0.00% | −13,149−7.9% | Reduced |
| Invesco Ltd. | 162,014 | $4.52M | 0.00% | −15,056−8.5% | Reduced |
| Charles Schwab Investment Management Inc | 187,241 | $5.22M | 0.00% | +337+0.2% | Added |
| Kalehua Capital Management LLC | 194,544 | $5.42M | 5.36% | +194,544 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $6.21M | 0.01% | 00.0% | Unchanged |
| Marshall Wace, LLP | 226,901 | $6.33M | 0.01% | +226,901 | New |