Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Septerna, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +4 vs. Q4 2025
- Shares held
- 45.7M
- +1.64M (+3.7%) vs. Q4 2025
- Total value
- $1.10B
- −$130.2M (−10.6%) vs. Q4 2025
- New holders
- 28
- 43 more added
- Sold out
- 24
- 30 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | $168.1M | 1.78% | 00.0% | Unchanged |
| TRV GP V, LLC | 6,215,591 | $149.4M | 37.25% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,395,572 | $105.6M | 0.78% | −413,898−8.6% | Reduced |
| TRV GP VI, LLC | 4,211,659 | $101.2M | 74.64% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 3,149,128 | $75.7M | 7.35% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 2,906,427 | $69.8M | 0.01% | +191,298+7.0% | Added |
| Siren, L.L.C. | 2,000,000 | $48.1M | 1.33% | 00.0% | Unchanged |
| BlackRock, Inc. | 1,822,174 | $43.8M | 0.00% | +20,846+1.2% | Added |
| BVF Inc | 1,353,249 | $32.5M | 1.04% | −367,533−21.4% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $32.1M | 0.32% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 1,196,962 | $28.8M | 0.00% | +1,196,962 | New |
| ADAR1 Capital Management, LLC | 1,089,818 | $26.2M | 1.57% | −67,793−5.9% | Reduced |
| Primecap Management Co | 1,048,834 | $25.2M | 0.02% | +502,734+92.1% | Added |
| Janus Henderson Group PLC | 890,754 | $21.3M | 0.01% | +890,754 | New |
| First Light Asset Management, LLC | 732,860 | $17.6M | 1.58% | +112,049+18.0% | Added |
| Geode Capital Management, LLC | 645,146 | $15.5M | 0.00% | +72,412+12.6% | Added |
| State Street Corp | 631,447 | $15.2M | 0.00% | +91,419+16.9% | Added |
| Casdin Capital, LLC | 553,268 | $13.3M | 1.01% | 00.0% | Unchanged |
| VR Adviser, LLC | 506,056 | $12.2M | 0.45% | −104,752−17.1% | Reduced |
| Catalio Capital Management, LP | 294,360 | $7.07M | 1.48% | 00.0% | Unchanged |
| Soleus Capital Management, L.P. | 275,000 | $6.61M | 0.27% | −108,368−28.3% | Reduced |
| Balyasny Asset Management LLC | 236,679 | $5.69M | 0.01% | +233,108+6,527.8% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 223,995 | $5.38M | 0.01% | +1,293+0.6% | Added |
| Vanguard Portfolio Management LLC | 195,043 | $4.69M | 0.00% | +195,043 | New |
| Kalehua Capital Management LLC | 194,544 | $4.67M | 3.31% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 181,580 | $4.36M | 0.00% | −5,661−3.0% | Reduced |
| Northern Trust Corp | 164,530 | $3.95M | 0.00% | +10,334+6.7% | Added |
| Vanguard Fiduciary Trust Co | 154,484 | $3.71M | 0.00% | +154,484 | New |
| Millennium Management LLC | 124,101 | $2.98M | 0.00% | +16,638+15.5% | Added |
| UBS Group AG | 116,979 | $2.81M | 0.00% | +48,162+70.0% | Added |
| Morgan Stanley | 110,530 | $2.66M | 0.00% | +6,545+6.3% | Added |
| Hussman Strategic Advisors, Inc. | 105,000 | $2.52M | 0.55% | +105,000 | New |
| Checkpoint Capital L.P. | 100,300 | $2.41M | 0.86% | +100,300 | New |
| Federated Hermes, Inc. | 89,301 | $2.15M | 0.00% | +10,396+13.2% | Added |
| Invesco Ltd. | 82,868 | $1.99M | 0.00% | −79,146−48.9% | Reduced |
| JPMorgan Chase & Co | 84,674 | $1.97M | 0.00% | +16,336+23.9% | Added |
| Two Sigma Investments, LP | 75,367 | $1.81M | 0.00% | −17,442−18.8% | Reduced |
| Longaeva Partners L.P. | 74,567 | $1.79M | 0.09% | +24,665+49.4% | Added |
| American Century Companies Inc | 61,290 | $1.47M | 0.00% | +10,601+20.9% | Added |
| Bank of New York Mellon Corp | 58,709 | $1.41M | 0.00% | +3,377+6.1% | Added |
| Jump Financial, LLC | 53,011 | $1.27M | 0.02% | +44,612+531.2% | Added |
| Sofinnova Investments, Inc. | 47,506 | $1.14M | 0.06% | +47,506 | New |
| Marshall Wace, LLP | 39,840 | $957.4K | 0.00% | −187,061−82.4% | Reduced |
| Rangeley Capital, LLC | 39,800 | $956.4K | 1.03% | −26,000−39.5% | Reduced |
| Renaissance Technologies LLC | 37,700 | $905.9K | 0.00% | +37,700 | New |
| XTX Topco Ltd | 36,723 | $882.5K | 0.02% | +13,408+57.5% | Added |
| Trexquant Investment LP | 35,301 | $848.3K | 0.01% | −8,704−19.8% | Reduced |
| Alyeska Investment Group, L.P. | 35,000 | $841.0K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 30,978 | $741.0K | 0.00% | +101+0.3% | Added |
| Nuveen, LLC | 29,176 | $701.1K | 0.00% | +3,378+13.1% | Added |
| Jacobs Levy Equity Management, Inc | 28,436 | $683.3K | 0.00% | −32,934−53.7% | Reduced |
| Price T Rowe Associates Inc | 28,076 | $675.0K | 0.00% | +2,633+10.3% | Added |
| Rhumbline Advisers | 26,604 | $639.3K | 0.00% | +185+0.7% | Added |
| Bank of America Corp | 25,973 | $624.1K | 0.00% | −11,621−30.9% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 25,770 | $619.3K | 0.01% | +25,770 | New |
| Adage Capital Partners GP, L.L.C. | 24,000 | $576.7K | 0.00% | +24,000 | New |
| Logos Global Management LP | 23,548 | $565.9K | 0.03% | 00.0% | Unchanged |
| FMR LLC | 23,446 | $563.4K | 0.00% | +20,139+609.0% | Added |
| Alliancebernstein L.P. | 19,600 | $546.4K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 22,714 | $545.8K | 0.00% | −15,433−40.5% | Reduced |
| Swiss National Bank | 22,100 | $531.1K | 0.00% | +22,100 | New |
| Algert Global LLC | 21,035 | $505.5K | 0.01% | −13,909−39.8% | Reduced |
| Squarepoint Ops LLC | 18,083 | $434.5K | 0.00% | +3,236+21.8% | Added |
| STRS Ohio | 17,200 | $413.3K | 0.00% | +2,600+17.8% | Added |
| Deutsche Bank AG | 16,843 | $404.7K | 0.00% | +1,964+13.2% | Added |
| VARCOV Co. | 16,752 | $402.6K | 0.15% | −5,882−26.0% | Reduced |
| Engineers Gate Manager LP | 16,528 | $397.2K | 0.00% | +16,528 | New |
| Vanguard Global Advisers, LLC | 16,247 | $390.4K | 0.00% | +16,247 | New |
| AQR Capital Management LLC | 15,375 | $369.5K | 0.00% | +7,549+96.5% | Added |
| Numerai GP LLC | 15,082 | $362.4K | 0.04% | −30,784−67.1% | Reduced |
| Los Angeles Capital Management LLC | 14,214 | $341.6K | 0.00% | −4,336−23.4% | Reduced |
| MetLife Investment Management | 13,685 | $328.9K | 0.00% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 12,776 | $307.0K | 0.09% | +12,776 | New |
| Advisor Group Holdings, Inc. | 12,698 | $305.1K | 0.00% | +50.0% | Added |
| Verition Fund Management LLC | 12,343 | $296.6K | 0.00% | +12,343 | New |
| China Universal Asset Management Co., Ltd. | 11,946 | $287.1K | 0.02% | +1,650+16.0% | Added |
| Man Group plc | 11,858 | $284.9K | 0.00% | +11,858 | New |
| Russell Investments Group, Ltd. | 11,515 | $276.7K | 0.00% | −3,795−24.8% | Reduced |
| Seven Fleet Capital Management LP | 11,445 | $275.0K | 0.09% | 00.0% | Unchanged |
| Virtus Investment Advisers, Inc. | 10,719 | $257.6K | 0.07% | +262+2.5% | Added |
| Massachusetts Financial Services Co | 10,382 | $249.5K | 0.00% | +10,382 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 10,021 | $240.8K | 0.00% | +87+0.9% | Added |
| Wells Fargo & Company | 9,869 | $237.2K | 0.00% | −16,660−62.8% | Reduced |
| Citigroup Inc | 9,195 | $221.0K | 0.00% | −366−3.8% | Reduced |
| Winton Group Ltd | 8,842 | $212.5K | 0.01% | +8,842 | New |
| Vanguard Asset Management, Ltd | 7,420 | $178.3K | 0.00% | +7,420 | New |
| Legal & General Group Plc | 5,735 | $137.8K | 0.00% | +3,790+194.9% | Added |
| New York State Common Retirement Fund | 5,600 | $134.6K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 5,361 | $128.8K | 0.00% | −88−1.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $124.4K | 0.00% | 00.0% | Unchanged |
| Vanguard Investments Australia, Ltd. | 3,895 | $93.6K | 0.00% | +3,895 | New |
| Public Employees Retirement System of Ohio | 3,374 | $81.1K | 0.00% | −7,220−68.2% | Reduced |
| KLP Kapitalforvaltning AS | 2,500 | $60.1K | 0.00% | +2,500 | New |
| Mirae Asset Global Investments Co., Ltd. | 2,335 | $56.1K | 0.00% | +159+7.3% | Added |
| Covestor Ltd | 2,260 | $54.0K | 0.04% | +319+16.4% | Added |
| Ameritas Investment Partners, Inc. | 1,944 | $46.7K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 1,157 | $27.8K | 0.00% | −159−12.1% | Reduced |
| GAMMA Investing LLC | 1,110 | $26.7K | 0.00% | +194+21.2% | Added |
| GF Fund Management Co. Ltd. | 1,006 | $24.2K | 0.00% | +128+14.6% | Added |
| Signaturefd, LLC | 966 | $23.2K | 0.00% | −23−2.3% | Reduced |