Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 6 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Septerna, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +4 vs. Q4 2025
- Shares held
- 45.7M
- +1.64M (+3.7%) vs. Q4 2025
- Total value
- $1.10B
- −$130.2M (−10.6%) vs. Q4 2025
- New holders
- 28
- 43 more added
- Sold out
- 24
- 30 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| MAI Capital Management | 6 | $145 | 0.00% | +6 | New |
| Quadrant Capital Group LLC | 7 | $169 | 0.00% | +7 | New |
| Farther Finance Advisors, LLC | 7 | $171 | 0.00% | +6+600.0% | Added |
| Allworth Financial LP | 17 | $409 | 0.00% | +17 | New |
| Fortitude Family Office, LLC | 20 | $481 | 0.00% | −51−71.8% | Reduced |
| Rothschild Investment LLC | 30 | $721 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 38 | $913 | 0.00% | −3,132−98.8% | Reduced |
| The PNC Financial Services Group, Inc. | 43 | $1.03K | 0.00% | −155−78.3% | Reduced |
| Cornerstone Financial Management LLC | 52 | $1.25K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 55 | $1.32K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 68 | $1.63K | 0.00% | +5+7.9% | Added |
| Massmutual Trust Co FSB | 135 | $3.24K | 0.00% | +72+114.3% | Added |
| UBS Asset Management Americas Inc | 155 | $3.73K | 0.00% | +155 | New |
| N.E.W. Advisory Services LLC | 180 | $4.33K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 197 | $4.73K | 0.00% | +7+3.7% | Added |
| Diadema Partners LP | 202 | $4.85K | 0.00% | +202 | New |
| Larson Financial Group LLC | 204 | $4.90K | 0.00% | +204 | New |
| Versant Capital Management, Inc | 261 | $6.27K | 0.00% | 00.0% | Unchanged |
| Pinnacle Wealth Planning Services, Inc. | 322 | $7.74K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 508 | $12.2K | 0.00% | +508 | New |
| Sterling Capital Management LLC | 712 | $17.1K | 0.00% | −520−42.2% | Reduced |
| Tower Research Capital LLC (TRC) | 717 | $17.2K | 0.00% | −1,439−66.7% | Reduced |
| Nisa Investment Advisors, LLC | 841 | $20.2K | 0.00% | +500+146.6% | Added |
| CWM, LLC | 894 | $21.5K | 0.00% | +6+0.7% | Added |
| Signaturefd, LLC | 966 | $23.2K | 0.00% | −23−2.3% | Reduced |
| GF Fund Management Co. Ltd. | 1,006 | $24.2K | 0.00% | +128+14.6% | Added |
| GAMMA Investing LLC | 1,110 | $26.7K | 0.00% | +194+21.2% | Added |
| California State Teachers Retirement System | 1,157 | $27.8K | 0.00% | −159−12.1% | Reduced |
| Ameritas Investment Partners, Inc. | 1,944 | $46.7K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 2,260 | $54.0K | 0.04% | +319+16.4% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,335 | $56.1K | 0.00% | +159+7.3% | Added |
| KLP Kapitalforvaltning AS | 2,500 | $60.1K | 0.00% | +2,500 | New |
| Public Employees Retirement System of Ohio | 3,374 | $81.1K | 0.00% | −7,220−68.2% | Reduced |
| Vanguard Investments Australia, Ltd. | 3,895 | $93.6K | 0.00% | +3,895 | New |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $124.4K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 5,361 | $128.8K | 0.00% | −88−1.6% | Reduced |
| New York State Common Retirement Fund | 5,600 | $134.6K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 5,735 | $137.8K | 0.00% | +3,790+194.9% | Added |
| Vanguard Asset Management, Ltd | 7,420 | $178.3K | 0.00% | +7,420 | New |
| Winton Group Ltd | 8,842 | $212.5K | 0.01% | +8,842 | New |
| Citigroup Inc | 9,195 | $221.0K | 0.00% | −366−3.8% | Reduced |
| Wells Fargo & Company | 9,869 | $237.2K | 0.00% | −16,660−62.8% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 10,021 | $240.8K | 0.00% | +87+0.9% | Added |
| Massachusetts Financial Services Co | 10,382 | $249.5K | 0.00% | +10,382 | New |
| Virtus Investment Advisers, Inc. | 10,719 | $257.6K | 0.07% | +262+2.5% | Added |
| Seven Fleet Capital Management LP | 11,445 | $275.0K | 0.09% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 11,515 | $276.7K | 0.00% | −3,795−24.8% | Reduced |
| Man Group plc | 11,858 | $284.9K | 0.00% | +11,858 | New |
| China Universal Asset Management Co., Ltd. | 11,946 | $287.1K | 0.02% | +1,650+16.0% | Added |
| Verition Fund Management LLC | 12,343 | $296.6K | 0.00% | +12,343 | New |
| Advisor Group Holdings, Inc. | 12,698 | $305.1K | 0.00% | +50.0% | Added |
| EntryPoint Capital, LLC | 12,776 | $307.0K | 0.09% | +12,776 | New |
| MetLife Investment Management | 13,685 | $328.9K | 0.00% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 14,214 | $341.6K | 0.00% | −4,336−23.4% | Reduced |
| Numerai GP LLC | 15,082 | $362.4K | 0.04% | −30,784−67.1% | Reduced |
| AQR Capital Management LLC | 15,375 | $369.5K | 0.00% | +7,549+96.5% | Added |
| Vanguard Global Advisers, LLC | 16,247 | $390.4K | 0.00% | +16,247 | New |
| Engineers Gate Manager LP | 16,528 | $397.2K | 0.00% | +16,528 | New |
| VARCOV Co. | 16,752 | $402.6K | 0.15% | −5,882−26.0% | Reduced |
| Deutsche Bank AG | 16,843 | $404.7K | 0.00% | +1,964+13.2% | Added |
| STRS Ohio | 17,200 | $413.3K | 0.00% | +2,600+17.8% | Added |
| Squarepoint Ops LLC | 18,083 | $434.5K | 0.00% | +3,236+21.8% | Added |
| Algert Global LLC | 21,035 | $505.5K | 0.01% | −13,909−39.8% | Reduced |
| Swiss National Bank | 22,100 | $531.1K | 0.00% | +22,100 | New |
| Barclays PLC | 22,714 | $545.8K | 0.00% | −15,433−40.5% | Reduced |
| Alliancebernstein L.P. | 19,600 | $546.4K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 23,446 | $563.4K | 0.00% | +20,139+609.0% | Added |
| Logos Global Management LP | 23,548 | $565.9K | 0.03% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 24,000 | $576.7K | 0.00% | +24,000 | New |
| Y-Intercept (Hong Kong) Ltd | 25,770 | $619.3K | 0.01% | +25,770 | New |
| Bank of America Corp | 25,973 | $624.1K | 0.00% | −11,621−30.9% | Reduced |
| Rhumbline Advisers | 26,604 | $639.3K | 0.00% | +185+0.7% | Added |
| Price T Rowe Associates Inc | 28,076 | $675.0K | 0.00% | +2,633+10.3% | Added |
| Jacobs Levy Equity Management, Inc | 28,436 | $683.3K | 0.00% | −32,934−53.7% | Reduced |
| Nuveen, LLC | 29,176 | $701.1K | 0.00% | +3,378+13.1% | Added |
| Acadian Asset Management LLC | 30,978 | $741.0K | 0.00% | +101+0.3% | Added |
| Alyeska Investment Group, L.P. | 35,000 | $841.0K | 0.00% | 00.0% | Unchanged |
| Trexquant Investment LP | 35,301 | $848.3K | 0.01% | −8,704−19.8% | Reduced |
| XTX Topco Ltd | 36,723 | $882.5K | 0.02% | +13,408+57.5% | Added |
| Renaissance Technologies LLC | 37,700 | $905.9K | 0.00% | +37,700 | New |
| Rangeley Capital, LLC | 39,800 | $956.4K | 1.03% | −26,000−39.5% | Reduced |
| Marshall Wace, LLP | 39,840 | $957.4K | 0.00% | −187,061−82.4% | Reduced |
| Sofinnova Investments, Inc. | 47,506 | $1.14M | 0.06% | +47,506 | New |
| Jump Financial, LLC | 53,011 | $1.27M | 0.02% | +44,612+531.2% | Added |
| Bank of New York Mellon Corp | 58,709 | $1.41M | 0.00% | +3,377+6.1% | Added |
| American Century Companies Inc | 61,290 | $1.47M | 0.00% | +10,601+20.9% | Added |
| Longaeva Partners L.P. | 74,567 | $1.79M | 0.09% | +24,665+49.4% | Added |
| Two Sigma Investments, LP | 75,367 | $1.81M | 0.00% | −17,442−18.8% | Reduced |
| JPMorgan Chase & Co | 84,674 | $1.97M | 0.00% | +16,336+23.9% | Added |
| Invesco Ltd. | 82,868 | $1.99M | 0.00% | −79,146−48.9% | Reduced |
| Federated Hermes, Inc. | 89,301 | $2.15M | 0.00% | +10,396+13.2% | Added |
| Checkpoint Capital L.P. | 100,300 | $2.41M | 0.86% | +100,300 | New |
| Hussman Strategic Advisors, Inc. | 105,000 | $2.52M | 0.55% | +105,000 | New |
| Morgan Stanley | 110,530 | $2.66M | 0.00% | +6,545+6.3% | Added |
| UBS Group AG | 116,979 | $2.81M | 0.00% | +48,162+70.0% | Added |
| Millennium Management LLC | 124,101 | $2.98M | 0.00% | +16,638+15.5% | Added |
| Vanguard Fiduciary Trust Co | 154,484 | $3.71M | 0.00% | +154,484 | New |
| Northern Trust Corp | 164,530 | $3.95M | 0.00% | +10,334+6.7% | Added |
| Charles Schwab Investment Management Inc | 181,580 | $4.36M | 0.00% | −5,661−3.0% | Reduced |
| Kalehua Capital Management LLC | 194,544 | $4.67M | 3.31% | 00.0% | Unchanged |