Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 6 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Septerna, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 71
- +1 vs. Q4 2024
- Shares held
- 45.3M
- +1.19M (+2.7%) vs. Q4 2024
- Total value
- $262.2M
- −$747.8M (−74.0%) vs. Q4 2024
- New holders
- 20
- 25 more added
- Sold out
- 19
- 12 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Simplex Trading, LLC | 30 | $0 | 0.00% | +30 | New |
| Covestor Ltd | 6 | $0 | 0.00% | +6 | New |
| National Bank of Canada | 8 | $46 | 0.00% | +8 | New |
| Nisa Investment Advisors, LLC | 134 | $776 | 0.00% | +134 | New |
| Sterling Capital Management LLC | 157 | $909 | 0.00% | −109−41.0% | Reduced |
| CWM, LLC | 282 | $2.00K | 0.00% | +282 | New |
| GAMMA Investing LLC | 434 | $2.51K | 0.00% | +419+2,793.3% | Added |
| Royal Bank of Canada | 802 | $4.00K | 0.00% | −596−42.6% | Reduced |
| Amalgamated Bank | 634 | $4.00K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 1,149 | $6.65K | 0.00% | −1,102−49.0% | Reduced |
| Tower Research Capital LLC (TRC) | 1,788 | $10.4K | 0.00% | +695+63.6% | Added |
| Legal & General Group Plc | 1,840 | $10.7K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,944 | $11.3K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 2,900 | $16.8K | 0.00% | +1,500+107.1% | Added |
| STRS Ohio | 3,400 | $19.7K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 3,555 | $20.6K | 0.00% | +3,555 | New |
| KLP Kapitalforvaltning AS | 8,400 | $48.6K | 0.00% | +8,400 | New |
| JPMorgan Chase & Co | 8,786 | $50.9K | 0.00% | −29,229−76.9% | Reduced |
| Corebridge Financial, Inc. | 9,102 | $52.7K | 0.00% | −134−1.5% | Reduced |
| Wells Fargo & Company | 10,869 | $62.9K | 0.00% | +218+2.0% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 10,987 | $63.6K | 0.00% | +468+4.4% | Added |
| Bank of America Corp | 11,559 | $66.9K | 0.00% | −67,185−85.3% | Reduced |
| Invesco Ltd. | 12,202 | $70.6K | 0.00% | +48+0.4% | Added |
| Chicago Partners Investment Group LLC | 10,954 | $77.2K | 0.00% | +10,954 | New |
| Deutsche Bank AG | 15,968 | $92.5K | 0.00% | +5,549+53.3% | Added |
| Gsa Capital Partners LLP | 18,299 | $106.0K | 0.01% | +18,299 | New |
| Stoneridge Investment Partners LLC | 18,477 | $107.0K | 0.09% | +18,477 | New |
| Lindbrook Capital, LLC | 21,000 | $121.6K | 0.01% | 00.0% | Unchanged |
| Barclays PLC | 22,733 | $131.6K | 0.00% | −6,052−21.0% | Reduced |
| Price T Rowe Associates Inc | 22,957 | $133.0K | 0.00% | −495,631−95.6% | Reduced |
| Rhumbline Advisers | 23,318 | $135.0K | 0.00% | +3,323+16.6% | Added |
| Nuveen, LLC | 23,961 | $138.7K | 0.00% | +23,961 | New |
| Susquehanna International Group, LLP | 25,209 | $146.0K | 0.00% | +25,209 | New |
| Swiss National Bank | 30,100 | $174.3K | 0.00% | +30,100 | New |
| Alyeska Investment Group, L.P. | 35,000 | $202.7K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 37,350 | $216.3K | 0.01% | +37,350 | New |
| Citigroup Inc | 38,055 | $220.3K | 0.00% | +23,422+160.1% | Added |
| Bank of New York Mellon Corp | 38,376 | $222.2K | 0.00% | +283+0.7% | Added |
| California State Teachers Retirement System | 44,362 | $256.9K | 0.00% | +42,992+3,138.1% | Added |
| FMR LLC | 49,778 | $288.2K | 0.00% | −953,180−95.0% | Reduced |
| Rangeley Capital, LLC | 52,950 | $306.6K | 0.35% | +52,950 | New |
| Stonepine Capital Management, LLC | 68,084 | $394.2K | 0.46% | +68,084 | New |
| Two Sigma Investments, LP | 74,841 | $433.3K | 0.00% | +74,841 | New |
| Morgan Stanley | 91,044 | $527.1K | 0.00% | +49,133+117.2% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 102,749 | $594.9K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 118,451 | $685.8K | 0.00% | −21,165−15.2% | Reduced |
| Logos Global Management LP | 134,202 | $777.0K | 0.14% | 00.0% | Unchanged |
| Northern Trust Corp | 158,040 | $915.1K | 0.00% | +10,264+6.9% | Added |
| UBS Group AG | 239,930 | $1.39M | 0.00% | +131,477+121.2% | Added |
| State Street Corp | 344,604 | $2.00M | 0.00% | +71,828+26.3% | Added |
| Geode Capital Management, LLC | 409,640 | $2.37M | 0.00% | +29,063+7.6% | Added |
| Millennium Management LLC | 436,564 | $2.53M | 0.00% | +436,564 | New |
| Casdin Capital, LLC | 553,268 | $3.20M | 0.26% | 00.0% | Unchanged |
| Woodline Partners LP | 582,585 | $3.37M | 0.02% | +282,585+94.2% | Added |
| ADAR1 Capital Management, LLC | 720,848 | $4.17M | 0.80% | +720,848 | New |
| Soleus Capital Management, L.P. | 751,353 | $4.35M | 0.34% | +75,944+11.2% | Added |
| Sio Capital Management, LLC | 788,670 | $4.57M | 1.38% | +516,983+190.3% | Added |
| Checkpoint Capital L.P. | 824,878 | $4.78M | 2.62% | +824,878 | New |
| Vanguard Group Inc | 995,044 | $5.76M | 0.00% | +10,012+1.0% | Added |
| Catalio Capital Management, LP | 1,024,245 | $5.93M | 1.47% | 00.0% | Unchanged |
| BlackRock, Inc. | 1,258,313 | $7.29M | 0.00% | −418,822−25.0% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $7.74M | 0.12% | +227,500+20.5% | Added |
| Goldman Sachs Group Inc | 1,449,399 | $8.39M | 0.00% | −224,958−13.4% | Reduced |
| Deep Track Capital, LP | 1,912,929 | $11.1M | 0.36% | 00.0% | Unchanged |
| Siren, L.L.C. | 2,202,514 | $12.8M | 0.72% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 3,122,608 | $18.1M | 0.17% | +533,055+20.6% | Added |
| Samsara BioCapital, LLC | 3,149,128 | $18.2M | 3.25% | +380,608+13.7% | Added |
| TRV GP VI, LLC | 4,211,659 | $24.4M | 58.10% | +1,059,203+33.6% | Added |
| BVF Inc | 4,396,124 | $25.5M | 1.04% | +1,944,100+79.3% | Added |
| TRV GP V, LLC | 6,215,591 | $36.0M | 28.77% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $40.5M | 0.68% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 0 | $0 | 0.00% | −1,096,302−100.0% | Sold out |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −861,814−100.0% | Sold out |
| Perceptive Advisors LLC | 0 | $0 | 0.00% | −750,000−100.0% | Sold out |
| Cormorant Asset Management, LP | 0 | $0 | 0.00% | −560,000−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −404,882−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |
| ArrowMark Colorado Holdings LLC | 0 | $0 | 0.00% | −147,886−100.0% | Sold out |
| TD Asset Management Inc | 0 | $0 | 0.00% | −69,460−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −26,208−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −22,695−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −22,095−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −20,204−100.0% | Sold out |
| M&T Bank Corp | 0 | $0 | 0.00% | −16,394−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −12,118−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −11,555−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Zimmer Partners, LP | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −8,095−100.0% | Sold out |
| The PNC Financial Services Group, Inc. | 0 | $0 | 0.00% | −2,680−100.0% | Sold out |
| Nuveen Asset Management, LLC | – | – | – | – | Not filed |