Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Septerna, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +31 vs. Q1 2026
- Shares held
- 47.2M
- +2.41M (+5.4%) vs. Q1 2026
- Total value
- $1.58B
- +$504.7M (+46.8%) vs. Q1 2026
- New holders
- 47
- 49 more added
- Sold out
- 16
- 32 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Silver Grove Financial Group, Inc. | 1 | $33 | 0.00% | +1 | New |
| Allworth Financial LP | 1 | $34 | 0.00% | −16−94.1% | Reduced |
| Global Retirement Partners, LLC | 3 | $100 | 0.00% | +3 | New |
| SJS Investment Consulting Inc. | 6 | $201 | 0.00% | +6 | New |
| National Bank of Canada | 7 | $234 | 0.00% | +7 | New |
| Ameritas Advisory Services, LLC | 18 | $603 | 0.00% | +18 | New |
| Fortitude Family Office, LLC | 20 | $670 | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 30 | $1.00K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 45 | $1.51K | 0.00% | +2+4.7% | Added |
| Cornerstone Financial Management LLC | 52 | $1.74K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 55 | $1.84K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 64 | $2.14K | 0.00% | −4−5.9% | Reduced |
| Caitong International Asset Management Co., Ltd | 77 | $2.58K | 0.00% | +39+102.6% | Added |
| Aster Capital Management (DIFC) Ltd | 102 | $3.42K | 0.00% | +102 | New |
| Massmutual Trust Co FSB | 104 | $3.48K | 0.00% | −31−23.0% | Reduced |
| UBS Asset Management Americas Inc | 155 | $5.19K | 0.00% | 00.0% | Unchanged |
| N.E.W. Advisory Services LLC | 180 | $6.03K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 196 | $6.56K | 0.00% | −8−3.9% | Reduced |
| Sterling Capital Management LLC | 200 | $6.70K | 0.00% | −512−71.9% | Reduced |
| US Bancorp | 220 | $7.37K | 0.00% | +23+11.7% | Added |
| SRS Capital Advisors, Inc. | 236 | $7.90K | 0.00% | +236 | New |
| Versant Capital Management, Inc | 261 | $8.74K | 0.00% | 00.0% | Unchanged |
| Pinnacle Wealth Planning Services, Inc. | 322 | $10.8K | 0.00% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 362 | $12.1K | 0.00% | +362 | New |
| Nikko Asset Management Americas, Inc. | 507 | $16.9K | 0.00% | +507 | New |
| Quantbot Technologies LP | 515 | $17.2K | 0.00% | +515 | New |
| Nisa Investment Advisors, LLC | 768 | $25.7K | 0.00% | −73−8.7% | Reduced |
| GF Fund Management Co. Ltd. | 950 | $31.8K | 0.00% | −56−5.6% | Reduced |
| Signaturefd, LLC | 966 | $32.4K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 971 | $32.5K | 0.00% | +463+91.1% | Added |
| Tower Research Capital LLC (TRC) | 1,059 | $35.5K | 0.00% | +342+47.7% | Added |
| GAMMA Investing LLC | 1,119 | $37.5K | 0.00% | +9+0.8% | Added |
| Steward Partners Investment Advisory, LLC | 1,325 | $44.4K | 0.00% | +1,325 | New |
| New York State Teachers Retirement System | 1,946 | $65.0K | 0.00% | +1,946 | New |
| Ameritas Investment Partners, Inc. | 1,944 | $65.1K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,016 | $67.5K | 0.00% | −319−13.7% | Reduced |
| Royal Bank of Canada | 2,098 | $70.0K | 0.00% | +2,098 | New |
| Covestor Ltd | 2,123 | $72.0K | 0.04% | −137−6.1% | Reduced |
| KLP Kapitalforvaltning AS | 2,500 | $83.7K | 0.00% | 00.0% | Unchanged |
| Vanguard Investments Australia, Ltd. | 3,895 | $130.4K | 0.00% | 00.0% | Unchanged |
| Chung Wu Investment Group, LLC | 4,800 | $160.8K | 0.11% | +4,800 | New |
| State of Wisconsin Investment Board | 6,095 | $204.1K | 0.00% | +6,095 | New |
| Captrust Financial Advisors | 6,211 | $208.0K | 0.00% | +6,211 | New |
| Manufacturers Life Insurance Company, The | 6,304 | $211.1K | 0.00% | +6,304 | New |
| Citadel Advisors LLC | 6,350 | $212.7K | 0.00% | +6,350 | New |
| Police & Firemen's Retirement System of New Jersey | 6,527 | $218.6K | 0.00% | +1,352+26.1% | Added |
| Winton Group Ltd | 7,182 | $240.5K | 0.01% | −1,660−18.8% | Reduced |
| Occudo Quantitative Strategies LP | 7,191 | $240.8K | 0.01% | +7,191 | New |
| Rangeley Capital, LLC | 7,200 | $241.1K | 0.24% | −32,600−81.9% | Reduced |
| CIBC Bancorp USA Inc. | 7,222 | $241.9K | 0.00% | +7,222 | New |
| Quantinno Capital Management LP | 7,330 | $245.5K | 0.00% | +7,330 | New |
| Vanguard Asset Management, Ltd | 7,420 | $248.5K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 7,636 | $255.7K | 0.00% | +7,636 | New |
| First Trust Advisors LP | 7,739 | $259.2K | 0.00% | +7,739 | New |
| New York State Common Retirement Fund | 8,500 | $284.7K | 0.00% | +2,900+51.8% | Added |
| Canada Pension Plan Investment Board | 8,900 | $298.1K | 0.00% | +8,900 | New |
| Virtus Investment Advisers, Inc. | 9,102 | $304.8K | 0.07% | −1,617−15.1% | Reduced |
| Gotham Asset Management, LLC | 9,322 | $312.2K | 0.00% | +9,322 | New |
| Massachusetts Financial Services Co | 9,982 | $334.3K | 0.00% | −400−3.9% | Reduced |
| Legal & General Group Plc | 10,062 | $337.0K | 0.00% | +4,327+75.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 10,193 | $341.4K | 0.00% | +172+1.7% | Added |
| China Universal Asset Management Co., Ltd. | 10,774 | $360.8K | 0.02% | −1,172−9.8% | Reduced |
| California State Teachers Retirement System | 10,866 | $363.9K | 0.00% | +9,709+839.2% | Added |
| Man Group plc | 11,469 | $384.1K | 0.00% | −389−3.3% | Reduced |
| Advisor Group Holdings, Inc. | 12,594 | $421.8K | 0.00% | −104−0.8% | Reduced |
| MetLife Investment Management | 12,880 | $431.4K | 0.00% | −805−5.9% | Reduced |
| Verdad Advisers, LP | 12,970 | $434.4K | 0.42% | +12,970 | New |
| Virginia Retirement Systems Et Al | 13,300 | $445.4K | 0.00% | +13,300 | New |
| AQR Capital Management LLC | 15,397 | $515.6K | 0.00% | +22+0.1% | Added |
| Vanguard Global Advisers, LLC | 16,247 | $544.1K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 16,379 | $548.5K | 0.06% | +16,379 | New |
| Los Angeles Capital Management LLC | 16,597 | $555.8K | 0.00% | +2,383+16.8% | Added |
| BNP Paribas Arbitrage, SA | 16,946 | $567.5K | 0.00% | +11,585+216.1% | Added |
| Engineers Gate Manager LP | 17,350 | $581.1K | 0.01% | +822+5.0% | Added |
| Aquatic Capital Management LLC | 17,427 | $583.6K | 0.02% | +17,427 | New |
| Citigroup Inc | 17,808 | $596.4K | 0.00% | +8,613+93.7% | Added |
| Franklin Resources Inc | 18,607 | $623.1K | 0.00% | +18,607 | New |
| Wells Fargo & Company | 19,684 | $659.2K | 0.00% | +9,815+99.5% | Added |
| Swiss National Bank | 19,800 | $663.1K | 0.00% | −2,300−10.4% | Reduced |
| Jump Financial, LLC | 20,200 | $676.5K | 0.01% | −32,811−61.9% | Reduced |
| Acadian Asset Management LLC | 20,996 | $701.0K | 0.00% | −9,982−32.2% | Reduced |
| Fred Alger Management, LLC | 20,958 | $701.9K | 0.00% | +20,958 | New |
| STRS Ohio | 21,000 | $703.3K | 0.00% | +3,800+22.1% | Added |
| Squarepoint Ops LLC | 21,219 | $710.6K | 0.00% | +3,136+17.3% | Added |
| Alliancebernstein L.P. | 29,900 | $718.5K | 0.00% | +10,300+52.6% | Added |
| Deutsche Bank AG | 21,873 | $732.5K | 0.00% | +5,030+29.9% | Added |
| Fox Run Management, L.L.C. | 22,038 | $738.1K | 0.12% | +22,038 | New |
| FMR LLC | 23,240 | $778.3K | 0.00% | −206−0.9% | Reduced |
| Logos Global Management LP | 23,548 | $788.6K | 0.03% | 00.0% | Unchanged |
| Invesco Ltd. | 24,094 | $806.9K | 0.00% | −58,774−70.9% | Reduced |
| Trexquant Investment LP | 25,645 | $858.9K | 0.01% | −9,656−27.4% | Reduced |
| Rhumbline Advisers | 27,636 | $925.5K | 0.00% | +1,032+3.9% | Added |
| Tudor Investment Corp Et Al | 28,966 | $970.1K | 0.00% | +28,966 | New |
| HighVista Strategies LLC | 29,337 | $982.5K | 0.22% | +29,337 | New |
| Brevan Howard Capital Management LP | 29,452 | $986.3K | 0.01% | +29,452 | New |
| Alyeska Investment Group, L.P. | 35,000 | $1.17M | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 35,323 | $1.18M | 0.00% | +7,247+25.8% | Added |
| Bank of America Corp | 35,875 | $1.20M | 0.00% | +9,902+38.1% | Added |
| Caption Management, LLC | 38,006 | $1.27M | 0.04% | +38,006 | New |
| Russell Investments Group, Ltd. | 40,209 | $1.35M | 0.00% | +28,694+249.2% | Added |