Praxis Precision Medicines, Inc.
PRAX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001689548
No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 311 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.
Key figures
- Market capClose on Nov 9, 2026
- $9.30B
- Insider buysOpen market, last 90 days
- 0
- Insider sellsOpen market, last 90 days
- 0
- 13F holdersQ2 2026, +22 vs. previous quarter
- 311
- 13F valueReported value at the end of Q2 2026
- $11.3B
- Superinvestors holdingAt the end of Q2 2026
- 0
Price chart
Financials
See financial statementsFrom SEC filings, in USD.
- Revenue, FY2025
- $0
- −100.0% year over year
- Net income, FY2025
- -$303.3M
- No comparable prior period
- Free cash flow, FY2025
- -$249.1M
- No comparable prior period
- Revenue, Q3 FY2026
- –
- No comparable prior period
Short interest
See short dataFrom FINRA, settlement date Oct 15, 2026.
- Short interest
- 3.92M
- Shares sold short
- Change
- −266.3K
- −6.4% vs. previous
- Days to cover
- 7.41
- At average daily volume
Superinvestors holding PRAX, Q2 2026
Go to the superinvestors tabNo superinvestor reported holding PRAX at the end of Q2 2026.
Latest insider trades
See all insider tradesOpen-market purchases and sales by Praxis Precision Medicines, Inc. insiders from Form 4, newest first.
| Filed (ET) | Trade date | Filing delay | Insider | Transaction | Shares | Avg price | Value | Holding change | Flags |
|---|---|---|---|---|---|---|---|---|---|
| Jun 26, 2026 (view filing) | Jun 24 | 2 days | DeSimone JillDirector | SSale | −11.6K | $311.32 | −$3.61M | −83.2%2.34K after | 12 lots10b5-1 |
| Nov 21, 2025 (view filing) | Nov 20 | 1 day | Nemiroff AlexGeneral Counsel and Secretary | SSale | −25.1K | $193.08 | −$4.85M | −54.7%20.8K after | 4 lots |
| Nov 21, 2025 (view filing) | Nov 20 | 1 day | Mastrocola LaurenPrincipal Accounting Officer | SSale | −13.6K | $192.08 | −$2.61M | −56.6%10.4K after | 2 lots |
| Oct 17, 2025 (view filing)4:10 PM ET | Oct 16 | 1 day | Atchinson Robert and 2 others10% Owner | SSaleCommon Stock, $0.0001 par value per share ("Common Stock") | +12.6K | $90.00 | +$1.13M | +0.5%2.36M after | |
| Oct 17, 2025 (view filing)4:10 PM ET | Oct 16 | 1 day | Atchinson Robert and 2 others10% Owner | SSale | +301.3K | $106.42 | +$32.1M | +17.1%2.06M after | 9 lots |
| Nov 15, 2024 (view filing) | Nov 14 | 1 day | Nemiroff AlexGeneral Counsel and Secretary | SSale | −8.24K | $80.20 | −$660.8K | −44.4%10.3K after | |
| Nov 15, 2024 (view filing) | Nov 14 | 1 day | Mastrocola LaurenPrincipal Accounting Officer | SSale | −5.19K | $81.78 | −$424.3K | −48.0%5.61K after | |
| Oct 10, 2023 (view filing) | Oct 5 | 5 days | DeSimone JillDirector | PPurchase | +14.5K | $1.75 | +$25.4K | New position14.5K after | |
| Jun 27, 2023 (view filing) | Jun 27 | Same day | Souza MarcioChief Executive Officer | PPurchase | +10.0K | $1.06 | +$10.6K | +28.6%45.0K after | |
| Apr 6, 2023 (view filing) | Mar 24 | 13 days | Kelly Timothy EdwinChief Financial Officer | PPurchase | +8.00K | $0.87 | +$6.96K | +20.8%46.4K after | Amended |
Top 10 13F holders, Q2 2026
See all 311 holdersThe largest institutional positions in Praxis Precision Medicines, Inc. at the end of Q2 2026; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Jupiter Topco LLC | 3,421,374 | $1.15B | 0.47% | +3,421,374 | New |
| FMR LLC | 2,316,907 | $775.7M | 0.03% | +155,964+7.2% | Added |
| BlackRock, Inc. | 2,292,585 | $767.5M | 0.01% | −32,344−1.4% | Reduced |
| Perceptive Advisors LLC | 2,035,986 | $681.6M | 10.58% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 1,753,198 | $587.0M | 2.94% | 00.0% | Unchanged |
| Orbis Allan Gray Ltd | 1,529,788 | $512.2M | 1.76% | −942,692−38.1% | Reduced |
| Vanguard Portfolio Management LLC | 1,335,185 | $447.0M | 0.02% | +578,437+76.4% | Added |
| Vanguard Capital Management LLC | 1,235,299 | $413.6M | 0.01% | +13,355+1.1% | Added |
| State Street Corp | 1,026,443 | $343.7M | 0.01% | +142,205+16.1% | Added |
| Adage Capital Partners GP, L.L.C. | 1,015,480 | $340.0M | 0.48% | +199,741+24.5% | Added |
Holders of 5% or more of PRAX
See all 6 holders and filingsHolders whose latest Schedule 13D or 13G filing reports 5% or more of Praxis Precision Medicines, Inc..
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Janus Henderson Group PLC | 13G/A | 12.30%2.76M shares | −0.10 ppfrom 12.40% | Feb 11, 20226 filings | Nov 14, 2025 | SEC |
| FMR LLC | 13G/A | 9.20%2.57M shares | +1.50 ppfrom 7.70% | Feb 8, 20217 filings | Nov 5, 2026 | SEC |
| Perceptive Advisors LLC | 13G/A | 7.20%2.00M shares | +0.51 ppfrom 6.69% | Sep 23, 20245 filings | Feb 17, 2026 | SEC |
| Baker Bros. Advisors LP | 13G | 6.30%1.75M shares | New | May 15, 20261 filing | May 15, 2026 | SEC |
| Orbis Investment Management Ltd | 13G/A | 5.50%1.53M shares | −3.40 ppfrom 8.90% | Feb 17, 20263 filings | Aug 14, 2026 | SEC |
Politician trades
All politician trades in PRAX1 member of Congress reported 2 trades in Praxis Precision Medicines, Inc. since 2020. Newest filings:
| Filed | Politician | Type | Amount |
|---|---|---|---|
| Oct 12, 2026 |  Gilbert Ray Cisneros, Jr. House · CA | Buy | $1K-$15K |
| Sep 4, 2026 | Gilbert Ray Cisneros, Jr. House · CA | Buy | $1K-$15K |
House · CA · Oct 12, 2026
Buy$1K-$15K
House · CA · Sep 4, 2026
Buy$1K-$15K