Praxis Precision Medicines, Inc.
PRAX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001689548
No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.
Holders of 5% or more of PRAX
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Praxis Precision Medicines, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Janus Henderson Group PLC | 13G/A | 12.30%2.76M shares | −0.10 ppfrom 12.40% | May 14, 20254 filings | Nov 14, 2025 | SEC |
| Adage Capital Management, L.P. | 13G/A | 11.28%2.37M shares | +1.59 ppfrom 9.69% | May 12, 20253 filings | Sep 2, 2025 | SEC |
| Point72 Asset Management, L.P. | 13G/A | 9.60%2.07M shares | +2.30 ppfrom 7.30% | Feb 14, 20254 filings | Nov 14, 2025 | SEC |
| Perceptive Advisors LLC | 13G | 6.69%1.36M shares | +1.89 ppfrom 4.80% | Feb 14, 20253 filings | Jul 22, 2025 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
26 Schedule 13D and 13G filings on Praxis Precision Medicines, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Nov 14, 20254:00 PM ET | Point72 Asset Management, L.P.and 5 others | 13G/A | 9.60%2.07M shares | +2.30 ppfrom 7.30% | Sep 30, 2025 | SEC |
| Nov 14, 20251:08 PM ET | Cormorant Asset Management, LPand 1 other | 13G/A | 4.00%1.00M shares | −3.72 ppfrom 7.72%Below 5% | Sep 30, 2025 | SEC |
| Nov 14, 202512:19 PM ET | Price T Rowe Associates Inc | 13G/A | 4.80%1.00M shares | –Below 5% | Sep 30, 2025 | SEC |
| Nov 14, 202511:55 AM ET | Janus Henderson Group PLCand 1 other | 13G/A | 12.30%2.76M shares | −0.10 ppfrom 12.40% | Sep 30, 2025 | SEC |
| Nov 7, 20251:19 PM ET | Morgan Stanleyand 1 other | 13G/A | 2.90%618.0K shares | −3.30 ppfrom 6.20%Below 5% | Sep 30, 2025 | SEC |
| Sep 2, 20254:06 PM ET | Adage Capital Management, L.P.and 2 others | 13G/A | 11.28%2.37M shares | +1.59 ppfrom 9.69% | Aug 31, 2025 | SEC |
| Aug 14, 20255:01 PM ET | Point72 Asset Management, L.P.and 5 others | 13G/A | 7.30%1.53M shares | +1.50 ppfrom 5.80% | Jun 30, 2025 | SEC |
| Aug 14, 20253:03 PM ET | Cormorant Asset Management, LPand 1 other | 13G/A | 7.72%1.63M shares | −0.85 ppfrom 8.57% | Jun 30, 2025 | SEC |
| Aug 14, 202511:00 AM ET | Janus Henderson Group PLCand 1 other | 13G/A | 12.40%2.53M shares | +1.10 ppfrom 11.30% | Jun 30, 2025 | SEC |
| Aug 12, 20259:02 AM ET | Adage Capital Management, L.P.and 2 others | 13G/A | 9.69%1.97M shares | +1.05 ppfrom 8.64% | Jun 30, 2025 | SEC |
| Aug 5, 20255:00 PM ET | Soleus Capital Master Fund, L.P.and 5 others | 13G/A | 4.60%966.7K shares | −0.40 ppfrom 5.00%Below 5% | Jun 30, 2025 | SEC |
| Jul 22, 20259:58 AM ET | Perceptive Advisors LLCand 2 others | 13G | 6.69%1.36M shares | +1.89 ppfrom 4.80% | Jul 15, 2025 | SEC |
| Jun 6, 202512:00 PM ET | Janus Henderson Group PLCand 1 other | 13G/A | 11.30%2.30M shares | +3.70 ppfrom 7.60% | May 30, 2025 | SEC |
| May 15, 20255:45 PM ET | Venrock Healthcare Capital Partners III, L.P.and 6 others | 13G/A | 4.90%1.02M shares | −1.20 ppfrom 6.10%Below 5% | Mar 31, 2025 | SEC |
| May 15, 20254:35 PM ET | Point72 Asset Management, L.P.and 5 others | 13G/A | 5.80%1.21M shares | −0.50 ppfrom 6.30% | Mar 31, 2025 | SEC |
| May 15, 20254:30 PM ET | Perceptive Advisors LLCand 2 others | 13G/A | 4.80%980.9K shares | −4.70 ppfrom 9.50%Below 5% | Mar 31, 2025 | SEC |
| May 15, 20253:01 PM ET | Cormorant Asset Management, LPand 1 other | 13G/A | 8.57%1.75M shares | −0.51 ppfrom 9.08% | Mar 31, 2025 | SEC |
| May 14, 202511:47 AM ET | Janus Henderson Group PLC | 13G | 7.60%1.54M shares | New | Mar 31, 2025 | SEC |
| May 13, 202511:32 AM ET | Capital Research Global Investors | 13G/A | 4.20%853.7K shares | –Below 5% | Mar 31, 2025 | SEC |
| May 12, 20259:05 AM ET | Adage Capital Management, L.P.and 2 others | 13G | 8.64%1.74M shares | New | Mar 31, 2025 | SEC |
| Mar 19, 20255:00 PM ET | Soleus Capital Master Fund, L.P.and 5 others | 13G | 5.00%1.02M shares | New | Mar 18, 2025 | SEC |
| Feb 14, 20256:08 PM ET | Venrock Healthcare Capital Partners III, L.P.and 6 others | 13G/A | 6.10%1.19M shares | – | Dec 31, 2024 | SEC |
| Feb 14, 20254:15 PM ET | Perceptive Advisors LLCand 2 others | 13G/A | 9.50%1.83M shares | – | Dec 31, 2024 | SEC |
| Feb 14, 20254:10 PM ET | Point72 Asset Management, L.P.and 5 others | 13G/A | 6.30%1.25M shares | – | Dec 31, 2024 | SEC |
| Feb 14, 20253:03 PM ET | Cormorant Asset Management, LPand 1 other | 13G/A | 9.08%1.69M shares | – | Dec 31, 2024 | SEC |
| Feb 5, 202510:10 AM ET | Morgan Stanleyand 1 other | 13G | 6.20%1.16M shares | New | Dec 31, 2024 | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Praxis Precision Medicines, Inc. shares.
No Form 144 notices for Praxis Precision Medicines, Inc. are on file.