Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 138
- +6 vs. Q1 2023
- Shares held
- 81.5M
- −5.97M (−6.8%) vs. Q1 2023
- Total value
- $145.0M
- −$195.1M (−57.4%) vs. Q1 2023
- New holders
- 30
- 43 more added
- Sold out
- 24
- 42 more reduced
Compare with Q1 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 138 | $0 | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 104 | $186 | 0.00% | +104 | New |
| Kelly Financial Services LLC | 250 | $448 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 500 | $895 | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 1,000 | $1.00K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $1.25K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 800 | $1.43K | 0.00% | −60−7.0% | Reduced |
| TD Waterhouse Canada Inc. | 1,060 | $1.90K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $2.33K | 0.00% | +500+62.5% | Added |
| Group One Trading, L.P. | 1,493 | $2.67K | 0.00% | −1,617−52.0% | Reduced |
| China Universal Asset Management Co., Ltd. | 1,494 | $2.67K | 0.00% | −42−2.7% | Reduced |
| MB, Levis & Associates, LLC | 1,500 | $2.69K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $3.58K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $5.37K | 0.00% | 00.0% | Unchanged |
| PEAK6 Investments LLC | 4,552 | $8.15K | 0.00% | −10,448−69.7% | Reduced |
| Ameritas Investment Partners, Inc. | 6,194 | $11.1K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 6,242 | $11.2K | 0.00% | +1,972+46.2% | Added |
| Advisor Group Holdings, Inc. | 7,079 | $12.5K | 0.00% | −1,827−20.5% | Reduced |
| Janney Montgomery Scott LLC | 10,000 | $18.0K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 11,418 | $20.4K | 0.00% | −266−2.3% | Reduced |
| Creative Planning | 11,600 | $20.8K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 12,279 | $22.3K | 0.00% | 00.0% | Unchanged |
| ELCO Management Co., LLC | 13,474 | $24.1K | 0.02% | +13,474 | New |
| Two Sigma Securities, LLC | 13,480 | $24.1K | 0.00% | +13,480 | New |
| Baird Financial Group, Inc. | 13,800 | $24.7K | 0.00% | −13,175−48.8% | Reduced |
| Engineers Gate Manager LP | 13,925 | $24.9K | 0.00% | +13,925 | New |
| SG Americas Securities, LLC | 14,868 | $27.0K | 0.00% | −20,996−58.5% | Reduced |
| Banque Cantonale Vaudoise | 15,000 | $27.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 15,431 | $28.0K | 0.00% | +4,860+46.0% | Added |
| Prelude Capital Management, LLC | 15,933 | $28.5K | 0.00% | −26,494−62.4% | Reduced |
| Sawtooth Solutions, LLC | 15,966 | $28.6K | 0.00% | +15,966 | New |
| Bleakley Financial Group, LLC | 15,966 | $28.6K | 0.00% | +15,966 | New |
| Snowden Capital Advisors LLC | 16,200 | $29.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 17,466 | $31.3K | 0.00% | −1,877−9.7% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,134 | $32.5K | 0.00% | +9,813+117.9% | Added |
| New York State Common Retirement Fund | 18,959 | $33.9K | 0.00% | −115−0.6% | Reduced |
| Dynamic Technology Lab Private Ltd | 18,799 | $34.0K | 0.00% | +18,799 | New |
| Mariner, LLC | 19,984 | $35.8K | 0.00% | −8,072−28.8% | Reduced |
| ProShare Advisors LLC | 22,107 | $39.6K | 0.00% | +5,086+29.9% | Added |
| Great West Life Assurance Co | 23,069 | $42.0K | 0.00% | −6,365−21.6% | Reduced |
| Teacher Retirement System of Texas | 27,840 | $50.0K | 0.00% | −5,214−15.8% | Reduced |
| Arizona State Retirement System | 28,807 | $51.6K | 0.00% | −2,283−7.3% | Reduced |
| State Board of Administration of Florida Retirement System | 32,155 | $57.6K | 0.00% | +5,140+19.0% | Added |
| Centiva Capital, LP | 32,700 | $58.5K | 0.00% | +32,700 | New |
| Redwood Wealth Management Group, LLC | 32,730 | $58.6K | 0.06% | 00.0% | Unchanged |
| Principal Financial Group Inc | 32,838 | $58.8K | 0.00% | −16,024−32.8% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 33,931 | $60.7K | 0.01% | +33,931 | New |
| Dark Forest Capital Management LP | 34,943 | $62.5K | 0.01% | +34,943 | New |
| Kennedy Investment Group | 35,000 | $62.6K | 0.04% | +15,000+75.0% | Added |
| Weiss Multi-Strategy Advisers LLC | 35,559 | $64.0K | 0.00% | −3,753−9.5% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 37,490 | $67.1K | 0.00% | −149,960−80.0% | Reduced |
| Janus Henderson Group PLC | 38,053 | $68.3K | 0.00% | −61−0.2% | Reduced |
| Citigroup Inc | 38,246 | $68.5K | 0.00% | −691,781−94.8% | Reduced |
| Voya Investment Management LLC | 45,471 | $81.4K | 0.00% | +16,605+57.5% | Added |
| Manufacturers Life Insurance Company, The | 47,088 | $84.3K | 0.00% | +18,328+63.7% | Added |
| Wells Fargo & Company | 47,217 | $84.5K | 0.00% | −120,424−71.8% | Reduced |
| Quantbot Technologies LP | 54,397 | $97.4K | 0.01% | +6,200+12.9% | Added |
| American International Group, Inc. | 54,514 | $97.6K | 0.00% | +16,938+45.1% | Added |
| Invesco Ltd. | 54,541 | $97.6K | 0.00% | +11,312+26.2% | Added |
| Laurion Capital Management LP | 57,146 | $102.3K | 0.00% | +57,146 | New |
| MetLife Investment Management | 60,235 | $107.8K | 0.00% | +18,952+45.9% | Added |
| Graham Capital Management, L.P. | 62,414 | $111.7K | 0.00% | +62,414 | New |
| Exchange Traded Concepts, LLC | 66,422 | $118.9K | 0.00% | +66,422 | New |
| Price T Rowe Associates Inc | 68,108 | $122.0K | 0.00% | +7,642+12.6% | Added |
| Royal Bank of Canada | 77,297 | $139.0K | 0.00% | +14,545+23.2% | Added |
| Boothbay Fund Management, LLC | 81,736 | $146.3K | 0.01% | +20,326+33.1% | Added |
| Alps Advisors Inc | 83,803 | $150.0K | 0.00% | +83,803 | New |
| Point72 Middle East FZE | 85,933 | $153.8K | 0.01% | +85,933 | New |
| Susquehanna International Group, LLP | 89,007 | $159.3K | 0.00% | −206,177−69.8% | Reduced |
| JPMorgan Chase & Co | 89,431 | $160.1K | 0.00% | −101,237−53.1% | Reduced |
| Virginia Retirement Systems Et Al | 92,000 | $164.7K | 0.00% | −40,600−30.6% | Reduced |
| Legal & General Group Plc | 93,279 | $167.0K | 0.00% | +44,768+92.3% | Added |
| Russell Investments Group, Ltd. | 95,455 | $170.9K | 0.00% | +1,075+1.1% | Added |
| Acadian Asset Management LLC | 98,946 | $177.0K | 0.00% | +98,946 | New |
| Credit Suisse AG | 108,539 | $194.3K | 0.00% | −44,054−28.9% | Reduced |
| California State Teachers Retirement System | 127,890 | $228.9K | 0.00% | +4,683+3.8% | Added |
| Rhumbline Advisers | 134,585 | $240.9K | 0.00% | +30,294+29.0% | Added |
| Putnam Investments LLC | 147,803 | $264.6K | 0.00% | +27,035+22.4% | Added |
| Cubist Systematic Strategies, LLC | 160,004 | $286.4K | 0.00% | +160,004 | New |
| AQR Capital Management LLC | 164,038 | $293.6K | 0.00% | +83,525+103.7% | Added |
| Atom Investors LP | 184,619 | $330.5K | 0.13% | +184,619 | New |
| DAFNA Capital Management LLC | 192,678 | $344.9K | 0.09% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 91,628 | $356.4K | 0.00% | 00.0% | Unchanged |
| Swiss National Bank | 223,350 | $399.8K | 0.00% | −8,200−3.5% | Reduced |
| HRT Financial LP | 225,518 | $403.0K | 0.00% | +225,518 | New |
| Alliancebernstein L.P. | 234,430 | $419.6K | 0.00% | +56,600+31.8% | Added |
| Ergoteles LLC | 237,400 | $424.9K | 0.02% | +237,400 | New |
| Two Sigma Advisers, LP | 260,200 | $465.8K | 0.00% | −141,300−35.2% | Reduced |
| FMR LLC | 266,091 | $476.3K | 0.00% | +151,104+131.4% | Added |
| Birchview Capital, LP | 291,332 | $521.5K | 0.39% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 304,343 | $544.8K | 0.00% | +81,632+36.7% | Added |
| Bank of America Corp | 336,439 | $602.2K | 0.00% | −1,821,342−84.4% | Reduced |
| Two Sigma Investments, LP | 347,555 | $622.1K | 0.00% | +347,555 | New |
| Ameriprise Financial Inc | 360,145 | $644.7K | 0.00% | +102,289+39.7% | Added |
| Parkwood LLC | 1,000,000 | $669.0K | 0.12% | +1,000,000 | New |
| Macquarie Group Ltd | 380,000 | $680.0K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 383,848 | $687.1K | 0.12% | +383,848 | New |
| Ikarian Capital, LLC | 400,000 | $716.0K | 0.25% | +100,000+33.3% | Added |
| Morgan Stanley | 422,316 | $755.9K | 0.00% | −304,374−41.9% | Reduced |
| UBS Group AG | 437,610 | $783.3K | 0.00% | +275,169+169.4% | Added |