Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 52
- +2 vs. Q2 2025
- Shares held
- 2.98M
- −1.44M (−32.6%) vs. Q2 2025
- Total value
- $19.5M
- +$444.0K (+2.3%) vs. Q2 2025
- New holders
- 7
- 7 more added
- Sold out
- 5
- 20 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CIBC Private Wealth Group, LLC | 3 | $20 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 3 | $20 | 0.00% | 00.0% | Unchanged |
| Pittenger & Anderson Inc | 3 | $20 | 0.00% | +3 | New |
| Advisory Services Network, LLC | 12 | $78 | 0.00% | +12 | New |
| Bruce G. Allen Investments, LLC | 22 | $144 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $171 | 0.00% | −6−18.8% | Reduced |
| Activest Wealth Management | 66 | $432 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 74 | $484 | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 81 | $530 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 82 | $536 | 0.00% | −29,555−99.7% | Reduced |
| Harbour Investments, Inc. | 85 | $556 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 94 | $615 | 0.00% | −168,440−99.9% | Reduced |
| MB, Levis & Associates, LLC | 100 | $654 | 0.00% | 00.0% | Unchanged |
| Rise Advisors, LLC | 131 | $857 | 0.00% | +131 | New |
| Quent Capital, LLC | 231 | $1.51K | 0.00% | +231 | New |
| Advisor Group Holdings, Inc. | 346 | $2.41K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 513 | $3.35K | 0.00% | −6,527−92.7% | Reduced |
| JPMorgan Chase & Co | 550 | $3.60K | 0.00% | −255,893−99.8% | Reduced |
| FMR LLC | 679 | $4.44K | 0.00% | −86−11.2% | Reduced |
| Tower Research Capital LLC (TRC) | 1,089 | $7.12K | 0.00% | +239+28.1% | Added |
| TD Waterhouse Canada Inc. | 3,203 | $19.9K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 4,109 | $26.9K | 0.00% | −1,224−23.0% | Reduced |
| Simplex Trading, LLC | 5,862 | $38.0K | 0.00% | −2,371−28.8% | Reduced |
| Royal Bank of Canada | 6,734 | $44.0K | 0.00% | −695−9.4% | Reduced |
| Price T Rowe Associates Inc | 10,886 | $72.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 11,086 | $72.5K | 0.00% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 14,076 | $92.0K | 0.01% | +182+1.3% | Added |
| XTX Topco Ltd | 14,402 | $94.2K | 0.00% | +1,346+10.3% | Added |
| Belvedere Trading LLC | 14,563 | $95.2K | 0.01% | +14,563 | New |
| Northern Trust Corp | 18,876 | $123.4K | 0.00% | −34−0.2% | Reduced |
| Goldman Sachs Group Inc | 24,885 | $162.7K | 0.00% | −84,519−77.3% | Reduced |
| ADAR1 Capital Management, LLC | 25,000 | $163.5K | 0.02% | +25,000 | New |
| Morgan Stanley | 25,766 | $168.5K | 0.00% | +675+2.7% | Added |
| Baird Financial Group, Inc. | 25,932 | $169.6K | 0.00% | +15,400+146.2% | Added |
| Ikarian Capital, LLC | 27,257 | $178.3K | 0.04% | 00.0% | Unchanged |
| Birchview Capital, LP | 27,985 | $183.0K | 0.14% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 34,873 | $228.1K | 0.00% | −2,963−7.8% | Reduced |
| Susquehanna International Group, LLP | 35,339 | $231.1K | 0.00% | +35,339 | New |
| Silverback Asset Management LLC | 40,000 | $261.6K | 0.03% | −30,000−42.9% | Reduced |
| State Street Corp | 46,342 | $303.1K | 0.00% | +13,047+39.2% | Added |
| UBS Group AG | 59,685 | $390.3K | 0.00% | −102,215−63.1% | Reduced |
| Renaissance Technologies LLC | 64,714 | $423.2K | 0.00% | −1,100−1.7% | Reduced |
| Group One Trading, L.P. | 68,436 | $447.6K | 0.01% | −29,464−30.1% | Reduced |
| Geode Capital Management, LLC | 93,289 | $610.3K | 0.00% | +1,448+1.6% | Added |
| C WorldWide Group Holding A/S | 100,000 | $654.0K | 0.01% | 00.0% | Unchanged |
| Marshall Wace, LLP | 128,451 | $840.1K | 0.00% | 00.0% | Unchanged |
| Avidity Partners Management LP | 134,566 | $880.1K | 0.20% | 00.0% | Unchanged |
| Catalio Capital Management, LP | 142,984 | $935.1K | 0.17% | −3,029−2.1% | Reduced |
| BlackRock, Inc. | 231,951 | $1.52M | 0.00% | −4,690−2.0% | Reduced |
| Vanguard Group Inc | 408,222 | $2.67M | 0.00% | −110,047−21.2% | Reduced |
| Adage Capital Partners GP, L.L.C. | 421,322 | $2.76M | 0.00% | 00.0% | Unchanged |
| T. Rowe Price Investment Management, Inc. | 700,992 | $4.58M | 0.00% | −27,774−3.8% | Reduced |
| Eversept Partners, LP | 0 | $0 | 0.00% | −257,154−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −206,781−100.0% | Sold out |
| Palo Alto Investors LP | 0 | $0 | 0.00% | −187,911−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −31,847−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −90−100.0% | Sold out |