Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- −18 vs. Q2 2023
- Shares held
- 77.2M
- −4.32M (−5.3%) vs. Q2 2023
- Total value
- $102.8M
- −$42.2M (−29.1%) vs. Q2 2023
- New holders
- 16
- 40 more added
- Sold out
- 34
- 30 more reduced
Compare with Q2 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 138 | $0 | 0.00% | 00.0% | Unchanged |
| Sofos Investments, Inc. | 2 | $2 | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6 | $8 | 0.00% | −18,128−100.0% | Reduced |
| Kelly Financial Services LLC | 250 | $335 | 0.00% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 272 | $364 | 0.00% | +272 | New |
| Allworth Financial LP | 500 | $670 | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $938 | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 800 | $1.07K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $1.74K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $2.01K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1,605 | $2.15K | 0.00% | −36,641−95.8% | Reduced |
| TD Waterhouse Canada Inc. | 2,060 | $2.49K | 0.00% | +1,000+94.3% | Added |
| Founders Capital Management | 2,000 | $2.68K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 2,929 | $3.92K | 0.00% | +1,435+96.1% | Added |
| The PNC Financial Services Group, Inc. | 3,000 | $4.02K | 0.00% | 00.0% | Unchanged |
| PEAK6 Investments LLC | 4,552 | $6.10K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $8.30K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 6,242 | $8.36K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 6,944 | $9.30K | 0.00% | −135−1.9% | Reduced |
| Janney Montgomery Scott LLC | 10,000 | $13.0K | 0.00% | 00.0% | Unchanged |
| Neuberger Berman Group LLC | 11,234 | $15.1K | 0.00% | +11,234 | New |
| Victory Capital Management Inc | 11,436 | $15.3K | 0.00% | +18+0.2% | Added |
| Creative Planning | 11,600 | $15.5K | 0.00% | 00.0% | Unchanged |
| Brinker Capital Investments, LLC | 13,039 | $17.5K | 0.00% | +13,039 | New |
| Orion Portfolio Solutions, LLC | 13,039 | $17.5K | 0.00% | +13,039 | New |
| Legal & General Group Plc | 13,735 | $18.4K | 0.00% | −79,544−85.3% | Reduced |
| Baird Financial Group, Inc. | 13,800 | $18.5K | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 13,817 | $18.5K | 0.01% | +13,817 | New |
| Banque Cantonale Vaudoise | 15,000 | $20.0K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 14,964 | $20.1K | 0.00% | +14,964 | New |
| Amalgamated Bank | 15,431 | $21.0K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 18,591 | $25.0K | 0.00% | +3,723+25.0% | Added |
| Prudential Financial Inc | 19,415 | $26.0K | 0.00% | +19,415 | New |
| Nomura Holdings Inc | 19,433 | $26.0K | 0.00% | +19,433 | New |
| New York State Common Retirement Fund | 19,663 | $26.3K | 0.00% | +704+3.7% | Added |
| Simplex Trading, LLC | 21,506 | $28.0K | 0.00% | +21,506 | New |
| Quantbot Technologies LP | 21,699 | $29.1K | 0.00% | −32,698−60.1% | Reduced |
| Tower Research Capital LLC (TRC) | 22,144 | $29.7K | 0.00% | +4,678+26.8% | Added |
| ProShare Advisors LLC | 22,191 | $29.7K | 0.00% | +84+0.4% | Added |
| ELCO Management Co., LLC | 22,561 | $30.2K | 0.02% | +9,087+67.4% | Added |
| Wells Fargo & Company | 22,683 | $30.4K | 0.00% | −24,534−52.0% | Reduced |
| Brevan Howard Capital Management LP | 22,824 | $30.6K | 0.01% | +22,824 | New |
| California State Teachers Retirement System | 24,990 | $33.5K | 0.00% | −102,900−80.5% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 31,814 | $43.0K | 0.00% | −3,745−10.5% | Reduced |
| Redwood Wealth Management Group, LLC | 32,730 | $43.9K | 0.05% | 00.0% | Unchanged |
| Principal Financial Group Inc | 32,838 | $44.0K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 34,154 | $45.8K | 0.00% | +34,154 | New |
| Kennedy Investment Group | 35,000 | $46.9K | 0.03% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 35,200 | $47.2K | 0.00% | −225,000−86.5% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 35,279 | $47.3K | 0.00% | −2,211−5.9% | Reduced |
| Engineers Gate Manager LP | 38,962 | $52.2K | 0.00% | +25,037+179.8% | Added |
| State of Wyoming | 40,741 | $54.6K | 0.01% | +40,741 | New |
| Wade G W & Inc | 45,140 | $60.0K | 0.00% | +45,140 | New |
| HSBC Holdings PLC | 44,928 | $60.4K | 0.00% | +32,649+265.9% | Added |
| Voya Investment Management LLC | 45,471 | $60.9K | 0.00% | 00.0% | Unchanged |
| Centiva Capital, LP | 45,790 | $61.4K | 0.00% | +13,090+40.0% | Added |
| Manufacturers Life Insurance Company, The | 47,088 | $63.1K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 54,513 | $73.0K | 0.00% | +53,020+3,551.2% | Added |
| American International Group, Inc. | 56,523 | $75.7K | 0.00% | +2,009+3.7% | Added |
| Deutsche Bank AG | 58,231 | $78.0K | 0.00% | −1,534,953−96.3% | Reduced |
| MetLife Investment Management | 60,235 | $80.7K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 63,812 | $85.5K | 0.00% | +9,271+17.0% | Added |
| Royal Bank of Canada | 77,281 | $104.0K | 0.00% | −160.0% | Reduced |
| Boothbay Fund Management, LLC | 81,736 | $109.5K | 0.00% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 82,309 | $110.3K | 0.00% | +19,895+31.9% | Added |
| Alps Advisors Inc | 84,432 | $113.1K | 0.00% | +629+0.8% | Added |
| Exchange Traded Concepts, LLC | 86,484 | $115.9K | 0.00% | +20,062+30.2% | Added |
| Price T Rowe Associates Inc | 87,113 | $117.0K | 0.00% | +19,005+27.9% | Added |
| Russell Investments Group, Ltd. | 94,858 | $127.1K | 0.00% | −597−0.6% | Reduced |
| Point72 Middle East FZE | 95,138 | $127.5K | 0.01% | +9,205+10.7% | Added |
| J. Goldman & Co LP | 120,000 | $160.8K | 0.01% | −419,742−77.8% | Reduced |
| Woodline Partners LP | 134,112 | $179.7K | 0.00% | +134,112 | New |
| Susquehanna International Group, LLP | 137,809 | $184.7K | 0.00% | +48,802+54.8% | Added |
| Rhumbline Advisers | 138,157 | $185.1K | 0.00% | +3,572+2.7% | Added |
| Atom Investors LP | 190,825 | $255.7K | 0.06% | +6,206+3.4% | Added |
| DAFNA Capital Management LLC | 192,678 | $258.2K | 0.08% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 192,810 | $258.4K | 0.00% | −41,620−17.8% | Reduced |
| Charles Schwab Investment Management Inc | 258,909 | $346.9K | 0.00% | −45,434−14.9% | Reduced |
| FMR LLC | 266,447 | $357.0K | 0.00% | +356+0.1% | Added |
| Bridgeway Capital Management, LLC | 289,500 | $387.9K | 0.01% | +289,500 | New |
| XTX Topco Ltd | 310,065 | $415.5K | 0.07% | −73,783−19.2% | Reduced |
| Bank of America Corp | 352,622 | $472.5K | 0.00% | +16,183+4.8% | Added |
| Ameriprise Financial Inc | 356,978 | $478.4K | 0.00% | −3,167−0.9% | Reduced |
| Macquarie Group Ltd | 380,000 | $509.0K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 400,000 | $536.0K | 0.20% | 00.0% | Unchanged |
| Worth Venture Partners, LLC | 445,981 | $597.6K | 0.36% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 452,406 | $606.2K | 0.00% | −11,128−2.4% | Reduced |
| Parkwood LLC | 1,000,000 | $661.0K | 0.12% | 00.0% | Unchanged |
| AQR Capital Management LLC | 501,799 | $672.4K | 0.00% | +337,761+205.9% | Added |
| Silverarc Capital Management, LLC | 561,955 | $753.0K | 0.28% | +42,970+8.3% | Added |
| Gsa Capital Partners LLP | 568,298 | $762.0K | 0.07% | +568,298 | New |
| Birchview Capital, LP | 571,832 | $766.3K | 0.65% | +280,500+96.3% | Added |
| D. E. Shaw & Co., Inc. | 622,855 | $834.6K | 0.00% | +25,096+4.2% | Added |
| Bank of New York Mellon Corp | 653,650 | $875.9K | 0.00% | −6,966−1.1% | Reduced |
| Renaissance Technologies LLC | 730,400 | $979.0K | 0.00% | +63,000+9.4% | Added |
| Altium Capital Management LP | 740,000 | $991.6K | 0.57% | 00.0% | Unchanged |
| UBS Oconnor LLC | 876,710 | $1.17M | 0.02% | +270,000+44.5% | Added |
| UBS Group AG | 906,645 | $1.21M | 0.00% | +469,035+107.2% | Added |
| Northern Trust Corp | 985,732 | $1.32M | 0.00% | −83,362−7.8% | Reduced |
| Morgan Stanley | 1,044,471 | $1.40M | 0.00% | +622,155+147.3% | Added |