Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 143
- +12 vs. Q3 2021
- Shares held
- 54.2M
- −955.4K (−1.7%) vs. Q3 2021
- Total value
- $347.5M
- +$26.3M (+8.2%) vs. Q3 2021
- New holders
- 29
- 51 more added
- Sold out
- 17
- 46 more reduced
3 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Walleye Capital LLC | 13,903 | $89.0K | 0.00% | +13,903 | New |
| Commonwealth Equity Services, LLC | 13,690 | $88.0K | 0.00% | +950+7.5% | Added |
| XTX Topco Ltd | 13,051 | $84.0K | 0.05% | −3,221−19.8% | Reduced |
| Creative Planning | 13,100 | $84.0K | 0.00% | −3,000−18.6% | Reduced |
| Teacher Retirement System of Texas | 13,107 | $84.0K | 0.00% | +13,107 | New |
| Metropolitan Life Insurance Co | 12,980 | $83.5K | 0.00% | +1,445+12.5% | Added |
| Amalgamated Bank | 12,712 | $82.0K | 0.00% | −349−2.7% | Reduced |
| Graham Capital Management, L.P. | 12,618 | $81.0K | 0.00% | +12,618 | New |
| American Trust | 12,554 | $81.0K | 0.01% | +12,554 | New |
| E Fund Management Co., Ltd. | 12,391 | $80.0K | 0.00% | −8,131−39.6% | Reduced |
| Principal Financial Group Inc | 12,172 | $78.0K | 0.00% | −18,193−59.9% | Reduced |
| Janus Henderson Group PLC | 12,162 | $78.0K | 0.00% | +12,162 | New |
| Walleye Trading LLC | 9,098 | $59.0K | 0.00% | +9,098 | New |
| Marshall Wace, LLP | 9,006 | $57.0K | 0.00% | +9,006 | New |
| Belvedere Trading LLC | 5,371 | $44.0K | 0.01% | +5,371 | New |
| Ameritas Investment Partners, Inc. | 6,194 | $40.0K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 6,100 | $39.0K | 0.00% | +5,792+1,880.5% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,977 | $38.0K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 5,132 | $33.0K | 0.00% | −16,103−75.8% | Reduced |
| Rockefeller Capital Management L.P. | 4,100 | $26.0K | 0.00% | +400+10.8% | Added |
| Snowden Capital Advisors LLC | 4,093 | $26.0K | 0.00% | +4,093 | New |
| The PNC Financial Services Group, Inc. | 3,800 | $24.0K | 0.00% | 00.0% | Unchanged |
| Great West Life Assurance Co | 3,017 | $19.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 3,000 | $19.0K | 0.01% | 00.0% | Unchanged |
| US Bancorp | 2,758 | $18.0K | 0.00% | +646+30.6% | Added |
| Signaturefd, LLC | 1,768 | $11.0K | 0.00% | −129−6.8% | Reduced |
| Point72 Hong Kong Ltd | 1,258 | $8.00K | 0.00% | −9,516−88.3% | Reduced |
| TD Waterhouse Canada Inc. | 1,060 | $7.80K | 0.00% | +1,060 | New |
| Nisa Investment Advisors, LLC | 800 | $7.00K | 0.00% | 00.0% | Unchanged |
| American Portfolios Advisors | 1,000 | $6.43K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 1,000 | $6.00K | 0.00% | −125−11.1% | Reduced |
| Future Financial Wealth Managment LLC | 900 | $6.00K | 0.00% | +900 | New |
| Harbour Investments, Inc. | 800 | $5.00K | 0.00% | −2,005−71.5% | Reduced |
| AdvisorNet Financial, Inc | 700 | $5.00K | 0.00% | −100−12.5% | Reduced |
| Ikarian Capital, LLC | 785 | $5.00K | 0.00% | +785 | New |
| Russell Investments Group, Ltd. | 705 | $4.00K | 0.00% | −1,805−71.9% | Reduced |
| Quadrant Capital Group LLC | 436 | $3.00K | 0.00% | +346+384.4% | Added |
| Parallel Advisors, LLC | 324 | $2.00K | 0.00% | +324 | New |
| Kelly Financial Services LLC | 250 | $1.61K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Dark Forest Capital Management LP | 22 | $0 | 0.00% | −403−94.8% | Reduced |
| Glassman Wealth Services | 45 | $0 | 0.00% | +45 | New |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −200,412−100.0% | Sold out |
| Banque Cantonale Vaudoise | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −44,364−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −39,622−100.0% | Sold out |
| DekaBank Deutsche Girozentrale | 0 | $0 | 0.00% | −36,200−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| SG3 Management, LLC | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −17,613−100.0% | Sold out |
| ACT Capital Management, LLC | 0 | $0 | 0.00% | −14,000−100.0% | Sold out |
| Handelsbanken Fonder AB | 0 | $0 | 0.00% | −10,400−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −10,431−100.0% | Sold out |
| Atlas Private Wealth Advisors | 0 | $0 | 0.00% | −3,500−100.0% | Sold out |
| Tarbox Family Office, Inc. | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −1,725−100.0% | Sold out |
| Private Capital Group, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −753−100.0% | Sold out |
| Glen Eagle Advisors, LLC | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Delphi Management Partners VIII, L.L.C. | – | – | – | – | Not filed |
| First Mercantile Trust Co | – | – | – | – | Not filed |
| Berman Capital Advisors, LLC | – | – | – | – | Not filed |