Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 143
- +12 vs. Q3 2021
- Shares held
- 54.2M
- −955.4K (−1.7%) vs. Q3 2021
- Total value
- $347.5M
- +$26.3M (+8.2%) vs. Q3 2021
- New holders
- 29
- 51 more added
- Sold out
- 17
- 46 more reduced
3 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Dark Forest Capital Management LP | 22 | $0 | 0.00% | −403−94.8% | Reduced |
| Glassman Wealth Services | 45 | $0 | 0.00% | +45 | New |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Kelly Financial Services LLC | 250 | $1.61K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 324 | $2.00K | 0.00% | +324 | New |
| Quadrant Capital Group LLC | 436 | $3.00K | 0.00% | +346+384.4% | Added |
| Russell Investments Group, Ltd. | 705 | $4.00K | 0.00% | −1,805−71.9% | Reduced |
| Harbour Investments, Inc. | 800 | $5.00K | 0.00% | −2,005−71.5% | Reduced |
| AdvisorNet Financial, Inc | 700 | $5.00K | 0.00% | −100−12.5% | Reduced |
| Ikarian Capital, LLC | 785 | $5.00K | 0.00% | +785 | New |
| Captrust Financial Advisors | 1,000 | $6.00K | 0.00% | −125−11.1% | Reduced |
| Future Financial Wealth Managment LLC | 900 | $6.00K | 0.00% | +900 | New |
| American Portfolios Advisors | 1,000 | $6.43K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 800 | $7.00K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 1,060 | $7.80K | 0.00% | +1,060 | New |
| Point72 Hong Kong Ltd | 1,258 | $8.00K | 0.00% | −9,516−88.3% | Reduced |
| Signaturefd, LLC | 1,768 | $11.0K | 0.00% | −129−6.8% | Reduced |
| US Bancorp | 2,758 | $18.0K | 0.00% | +646+30.6% | Added |
| Great West Life Assurance Co | 3,017 | $19.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 3,000 | $19.0K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,800 | $24.0K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 4,100 | $26.0K | 0.00% | +400+10.8% | Added |
| Snowden Capital Advisors LLC | 4,093 | $26.0K | 0.00% | +4,093 | New |
| Advisor Group Holdings, Inc. | 5,132 | $33.0K | 0.00% | −16,103−75.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,977 | $38.0K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 6,100 | $39.0K | 0.00% | +5,792+1,880.5% | Added |
| Ameritas Investment Partners, Inc. | 6,194 | $40.0K | 0.00% | 00.0% | Unchanged |
| Belvedere Trading LLC | 5,371 | $44.0K | 0.01% | +5,371 | New |
| Marshall Wace, LLP | 9,006 | $57.0K | 0.00% | +9,006 | New |
| Walleye Trading LLC | 9,098 | $59.0K | 0.00% | +9,098 | New |
| Principal Financial Group Inc | 12,172 | $78.0K | 0.00% | −18,193−59.9% | Reduced |
| Janus Henderson Group PLC | 12,162 | $78.0K | 0.00% | +12,162 | New |
| E Fund Management Co., Ltd. | 12,391 | $80.0K | 0.00% | −8,131−39.6% | Reduced |
| Graham Capital Management, L.P. | 12,618 | $81.0K | 0.00% | +12,618 | New |
| American Trust | 12,554 | $81.0K | 0.01% | +12,554 | New |
| Amalgamated Bank | 12,712 | $82.0K | 0.00% | −349−2.7% | Reduced |
| Metropolitan Life Insurance Co | 12,980 | $83.5K | 0.00% | +1,445+12.5% | Added |
| XTX Topco Ltd | 13,051 | $84.0K | 0.05% | −3,221−19.8% | Reduced |
| Creative Planning | 13,100 | $84.0K | 0.00% | −3,000−18.6% | Reduced |
| Teacher Retirement System of Texas | 13,107 | $84.0K | 0.00% | +13,107 | New |
| Commonwealth Equity Services, LLC | 13,690 | $88.0K | 0.00% | +950+7.5% | Added |
| Walleye Capital LLC | 13,903 | $89.0K | 0.00% | +13,903 | New |
| BNP Paribas Arbitrage, SA | 14,424 | $92.7K | 0.00% | −453,817−96.9% | Reduced |
| State of Wyoming | 14,427 | $93.0K | 0.04% | +925+6.9% | Added |
| Fox Run Management, L.L.C. | 15,443 | $99.0K | 0.06% | +15,443 | New |
| First Republic Investment Management, Inc. | 16,684 | $107.0K | 0.00% | −630−3.6% | Reduced |
| Arizona State Retirement System | 18,288 | $118.0K | 0.00% | +1,924+11.8% | Added |
| Assenagon Asset Management S.A. | 19,366 | $125.0K | 0.00% | +19,366 | New |
| Tower Research Capital LLC (TRC) | 19,738 | $127.0K | 0.00% | −6,263−24.1% | Reduced |
| Baird Financial Group, Inc. | 19,817 | $127.0K | 0.00% | +2,137+12.1% | Added |
| North Star Investment Management Corp. | 20,000 | $129.0K | 0.01% | +20,000 | New |
| Price T Rowe Associates Inc | 20,412 | $131.0K | 0.00% | −24,500−54.6% | Reduced |
| Prelude Capital Management, LLC | 21,000 | $135.0K | 0.01% | 00.0% | Unchanged |
| Moors & Cabot, Inc. | 21,550 | $139.0K | 0.01% | +400+1.9% | Added |
| SG Americas Securities, LLC | 23,716 | $152.0K | 0.00% | −18,483−43.8% | Reduced |
| Dimensional Fund Advisors LP | 23,570 | $152.0K | 0.00% | 00.0% | Unchanged |
| Bridgefront Capital, LLC | 24,396 | $157.0K | 0.15% | +3,450+16.5% | Added |
| ProShare Advisors LLC | 26,371 | $170.0K | 0.00% | +1,026+4.0% | Added |
| MetLife Investment Management | 27,007 | $173.7K | 0.00% | +17,452+182.6% | Added |
| Engineers Gate Manager LP | 28,200 | $181.0K | 0.01% | −32,599−53.6% | Reduced |
| Voya Investment Management LLC | 28,866 | $186.0K | 0.00% | −754−2.5% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 29,883 | $192.0K | 0.00% | −4,216−12.4% | Reduced |
| Royal Bank of Canada | 31,077 | $200.0K | 0.00% | +4,398+16.5% | Added |
| Lazard Asset Management LLC | 31,543 | $202.0K | 0.00% | +31,543 | New |
| Invesco Ltd. | 31,568 | $203.0K | 0.00% | −2,589−7.6% | Reduced |
| Legal & General Group Plc | 31,845 | $205.0K | 0.00% | +1,796+6.0% | Added |
| Spearhead Capital Advisors, LLC | 34,459 | $222.0K | 0.03% | +801+2.4% | Added |
| American International Group, Inc. | 38,262 | $246.0K | 0.00% | −1,144−2.9% | Reduced |
| Manufacturers Life Insurance Company, The | 38,301 | $246.0K | 0.00% | −872−2.2% | Reduced |
| Allspring Global Investments Holdings, LLC | 38,544 | $247.0K | 0.00% | +38,544 | New |
| Patriot Financial Group Insurance Agency, LLC | 38,750 | $249.0K | 0.04% | +34,750+868.8% | Added |
| GFG Capital, LLC | 41,400 | $266.0K | 0.08% | −11,750−22.1% | Reduced |
| Golden State Equity Partners | 41,850 | $269.0K | 0.14% | +11,897+39.7% | Added |
| New York State Common Retirement Fund | 42,594 | $274.0K | 0.00% | −166−0.4% | Reduced |
| Virginia Retirement Systems Et Al | 43,100 | $277.0K | 0.00% | −79,200−64.8% | Reduced |
| Ensign Peak Advisors, Inc | 43,380 | $279.0K | 0.00% | +43,380 | New |
| Deutsche Bank AG | 47,966 | $308.0K | 0.00% | −176,670−78.6% | Reduced |
| DuPont Capital Management Corp | 52,402 | $337.0K | 0.01% | −20,893−28.5% | Reduced |
| State Board of Administration of Florida Retirement System | 53,075 | $341.0K | 0.00% | −160.0% | Reduced |
| Simplex Trading, LLC | 58,733 | $377.0K | 0.01% | +58,733 | New |
| Dynamic Technology Lab Private Ltd | 61,045 | $392.0K | 0.04% | +61,045 | New |
| Credit Suisse AG | 62,143 | $398.0K | 0.00% | −23,471−27.4% | Reduced |
| Susquehanna Fundamental Investments, LLC | 62,544 | $402.0K | 0.01% | −81,726−56.6% | Reduced |
| Wells Fargo & Company | 65,868 | $424.0K | 0.00% | +40,478+159.4% | Added |
| Algert Global LLC | 78,239 | $503.0K | 0.06% | −9,300−10.6% | Reduced |
| Jump Financial, LLC | 85,615 | $551.0K | 0.03% | +85,615 | New |
| Renaissance Technologies LLC | 85,900 | $552.0K | 0.00% | −409,500−82.7% | Reduced |
| UBS Asset Management Americas Inc | 91,721 | $589.8K | 0.00% | +7,328+8.7% | Added |
| Rhumbline Advisers | 94,710 | $609.0K | 0.00% | −1,481−1.5% | Reduced |
| State of Wisconsin Investment Board | 95,800 | $616.0K | 0.00% | +400+0.4% | Added |
| California State Teachers Retirement System | 96,698 | $622.0K | 0.00% | +8,747+9.9% | Added |
| ExodusPoint Capital Management, LP | 108,896 | $700.0K | 0.01% | +78,976+264.0% | Added |
| Alliancebernstein L.P. | 115,830 | $745.0K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 120,114 | $772.0K | 0.01% | +73,460+157.5% | Added |
| Squarepoint Ops LLC | 124,274 | $799.0K | 0.00% | +124,274 | New |
| AlphaCentric Advisors LLC | 140,000 | $900.0K | 0.26% | +4,000+2.9% | Added |
| Swiss National Bank | 149,450 | $961.0K | 0.00% | +17,800+13.5% | Added |
| D. E. Shaw & Co., Inc. | 176,051 | $1.13M | 0.00% | +176,051 | New |
| Barclays PLC | 181,752 | $1.17M | 0.00% | +49,363+37.3% | Added |