Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 150
- +16 vs. Q1 2022
- Shares held
- 67.1M
- −737.9K (−1.1%) vs. Q1 2022
- Total value
- $302.8M
- −$195.8M (−39.3%) vs. Q1 2022
- New holders
- 28
- 40 more added
- Sold out
- 12
- 58 more reduced
5 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Allworth Financial LP | 100 | $0 | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 90 | $0 | 0.00% | 00.0% | Unchanged |
| Ellevest, Inc. | 20 | $0 | 0.00% | −7−25.9% | Reduced |
| Quent Capital, LLC | 30 | $0 | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 199 | $1.00K | 0.00% | −877−81.5% | Reduced |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Lindbrook Capital, LLC | 235 | $1.00K | 0.00% | +235 | New |
| Kelly Financial Services LLC | 250 | $1.13K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $3.00K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 1,000 | $4.00K | 0.00% | −23,729−96.0% | Reduced |
| Rockefeller Capital Management L.P. | 900 | $4.00K | 0.00% | −2,500−73.5% | Reduced |
| Money Concepts Capital Corp | 800 | $4.00K | 0.00% | −70−8.0% | Reduced |
| Nisa Investment Advisors, LLC | 800 | $4.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $4.00K | 0.00% | +800 | New |
| Captrust Financial Advisors | 1,000 | $5.00K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 1,219 | $5.00K | 0.00% | +1,219 | New |
| TD Waterhouse Canada Inc. | 1,060 | $5.00K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 1,426 | $7.00K | 0.00% | −1,803−55.8% | Reduced |
| PEAK6 Investments LLC | 4,552 | $8.15K | 0.00% | +4,552 | New |
| Founders Capital Management | 2,000 | $9.00K | 0.01% | −1,000−33.3% | Reduced |
| Metropolitan Life Insurance Co | 2,658 | $12.0K | 0.00% | −2,154−44.8% | Reduced |
| The PNC Financial Services Group, Inc. | 3,000 | $14.0K | 0.00% | −800−21.1% | Reduced |
| Great West Life Assurance Co | 3,017 | $14.0K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 3,644 | $16.0K | 0.00% | +2+0.1% | Added |
| Federated Hermes, Inc. | 4,941 | $22.0K | 0.00% | +4,941 | New |
| Banque Cantonale Vaudoise | 5,000 | $23.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $27.0K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 6,871 | $30.0K | 0.00% | +6,871 | New |
| Wells Fargo & Company | 6,851 | $31.0K | 0.00% | −34,025−83.2% | Reduced |
| Running Point Capital Advisors, LLC | 10,000 | $45.0K | 0.03% | 00.0% | Unchanged |
| PDT Partners, LLC | 10,234 | $46.0K | 0.00% | −20,544−66.7% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,390 | $47.0K | 0.00% | −251−2.4% | Reduced |
| State of Wyoming | 10,606 | $48.0K | 0.03% | −4,510−29.8% | Reduced |
| Teacher Retirement System of Texas | 10,857 | $49.0K | 0.00% | −3,120−22.3% | Reduced |
| Creative Planning | 11,600 | $52.0K | 0.00% | −1,500−11.5% | Reduced |
| Amalgamated Bank | 11,818 | $53.0K | 0.00% | +96+0.8% | Added |
| Prelude Capital Management, LLC | 11,793 | $53.0K | 0.00% | +11,793 | New |
| Quantbot Technologies LP | 12,053 | $54.0K | 0.00% | −41,247−77.4% | Reduced |
| American Trust | 11,922 | $54.0K | 0.00% | −466−3.8% | Reduced |
| Mackenzie Financial Corp | 11,922 | $54.0K | 0.00% | +11,922 | New |
| Jump Financial, LLC | 12,140 | $54.0K | 0.00% | +12,140 | New |
| Janus Henderson Group PLC | 12,220 | $55.0K | 0.00% | +57+0.5% | Added |
| Snowden Capital Advisors LLC | 12,200 | $55.0K | 0.00% | −93−0.8% | Reduced |
| First Republic Investment Management, Inc. | 12,341 | $56.0K | 0.00% | −492−3.8% | Reduced |
| Commonwealth Equity Services, LLC | 12,990 | $58.0K | 0.00% | −100−0.8% | Reduced |
| Royal Bank of Canada | 13,321 | $59.0K | 0.00% | −3,246−19.6% | Reduced |
| Virtu Financial LLC | 13,137 | $59.0K | 0.01% | +13,137 | New |
| ProShare Advisors LLC | 14,744 | $66.0K | 0.00% | −6,555−30.8% | Reduced |
| Aquatic Capital Management LLC | 16,100 | $73.0K | 0.02% | +16,100 | New |
| Baird Financial Group, Inc. | 16,923 | $76.0K | 0.00% | −114−0.7% | Reduced |
| Arizona State Retirement System | 18,474 | $83.0K | 0.00% | +95+0.5% | Added |
| Los Angeles Capital Management LLC | 18,680 | $84.0K | 0.00% | 00.0% | Unchanged |
| Man Group plc | – | $85.0K | 0.00% | – | – |
| Principal Financial Group Inc | 20,299 | $91.0K | 0.00% | +7,195+54.9% | Added |
| Moors & Cabot, Inc. | 21,150 | $95.0K | 0.01% | −400−1.9% | Reduced |
| AQR Capital Management LLC | 22,622 | $102.0K | 0.00% | −5,208−18.7% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 22,541 | $102.0K | 0.00% | +22,541 | New |
| Marshall Wace, LLP | 23,000 | $103.0K | 0.00% | +23,000 | New |
| MetLife Investment Management | 23,213 | $104.7K | 0.00% | −18,559−44.4% | Reduced |
| Allspring Global Investments Holdings, LLC | 25,116 | $113.0K | 0.00% | −23,602−48.4% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 25,522 | $115.0K | 0.00% | −2,356−8.5% | Reduced |
| CSS LLC | 25,728 | $116.0K | 0.01% | +2,300+9.8% | Added |
| Voya Investment Management LLC | 28,866 | $130.0K | 0.00% | −1,897−6.2% | Reduced |
| Tower Research Capital LLC (TRC) | 29,096 | $131.0K | 0.00% | +22,576+346.3% | Added |
| Point72 Hong Kong Ltd | 29,111 | $131.0K | 0.01% | +28,640+6,080.7% | Added |
| Manufacturers Life Insurance Company, The | 29,827 | $134.5K | 0.00% | +329+1.1% | Added |
| Invesco Ltd. | 31,095 | $141.0K | 0.00% | −451−1.4% | Reduced |
| Legal & General Group Plc | 33,575 | $151.0K | 0.00% | +1,730+5.4% | Added |
| American International Group, Inc. | 35,660 | $161.0K | 0.00% | −85−0.2% | Reduced |
| DuPont Capital Management Corp | 36,455 | $164.0K | 0.01% | +13,728+60.4% | Added |
| Price T Rowe Associates Inc | 37,670 | $170.0K | 0.00% | +11,372+43.2% | Added |
| GFG Capital, LLC | 41,400 | $187.0K | 0.06% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 43,380 | $196.0K | 0.00% | 00.0% | Unchanged |
| Arrowstreet Capital, Limited Partnership | 44,753 | $202.0K | 0.00% | +44,753 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 45,978 | $207.0K | 0.00% | +45,978 | New |
| New York State Common Retirement Fund | 48,874 | $220.0K | 0.00% | −3,551−6.8% | Reduced |
| HRT Financial LP | 49,034 | $221.0K | 0.00% | +49,034 | New |
| Engineers Gate Manager LP | 48,928 | $221.0K | 0.01% | +48,928 | New |
| Caxton Associates LP | 50,993 | $230.0K | 0.03% | +50,993 | New |
| Prudential Financial Inc | 51,500 | $232.0K | 0.00% | +51,500 | New |
| XTX Topco Ltd | 51,606 | $233.0K | 0.10% | +37,177+257.7% | Added |
| E Fund Management Co., Ltd. | 52,671 | $238.0K | 0.02% | +12,089+29.8% | Added |
| State Board of Administration of Florida Retirement System | 53,075 | $239.0K | 0.00% | 00.0% | Unchanged |
| Tudor Investment Corp Et Al | 54,513 | $246.0K | 0.01% | +54,513 | New |
| D. E. Shaw & Co., Inc. | 58,500 | $264.0K | 0.00% | +24,387+71.5% | Added |
| New York Life Investment Management LLC | 63,275 | $285.0K | 0.00% | +63,275 | New |
| UBS Asset Management Americas Inc | 71,271 | $321.4K | 0.00% | +9,151+14.7% | Added |
| State of Wisconsin Investment Board | 72,844 | $329.0K | 0.00% | −22,956−24.0% | Reduced |
| Dynamic Technology Lab Private Ltd | 78,720 | $355.0K | 0.04% | +78,720 | New |
| Barclays PLC | 81,925 | $369.0K | 0.00% | −5,799−6.6% | Reduced |
| Balyasny Asset Management LLC | 86,059 | $388.0K | 0.00% | −256,425−74.9% | Reduced |
| California State Teachers Retirement System | 90,482 | $408.0K | 0.00% | +741+0.8% | Added |
| SG Americas Securities, LLC | 91,233 | $411.0K | 0.01% | +91,233 | New |
| Rhumbline Advisers | 91,430 | $412.0K | 0.00% | +12,307+15.6% | Added |
| Trexquant Investment LP | 96,131 | $434.0K | 0.02% | +67,023+230.3% | Added |
| Russell Investments Group, Ltd. | 109,095 | $491.0K | 0.00% | +48,349+79.6% | Added |
| FMR LLC | 112,517 | $507.0K | 0.00% | −1,455−1.3% | Reduced |
| Alliancebernstein L.P. | 118,030 | $532.0K | 0.00% | +2,000+1.7% | Added |
| Credit Suisse AG | 138,696 | $626.0K | 0.00% | +538+0.4% | Added |
| Algert Global LLC | 141,590 | $639.0K | 0.05% | +141,590 | New |