Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Regions Financial Corp | 6,122 | $459.7K | 0.00% | +33+0.5% | Added |
| Cypress Capital, LLC | 6,000 | $450.5K | 0.13% | −4,000−40.0% | Reduced |
| Frank, Rimerman Advisors LLC | 5,781 | $434.1K | 0.03% | 00.0% | Unchanged |
| Tema ETFs LLC | 5,673 | $426.0K | 0.03% | −2,884−33.7% | Reduced |
| Robeco Institutional Asset Management B.V. | 5,660 | $425.0K | 0.00% | +5,660 | New |
| Coldstream Capital Management Inc | 5,653 | $424.5K | 0.01% | −966−14.6% | Reduced |
| Cynosure Management, LLC | 5,614 | $421.6K | 0.05% | +5,614 | New |
| Mesirow Financial Investment Management, Inc. | 5,460 | $410.0K | 0.01% | +5,460 | New |
| Resources Investment Advisors, LLC. | 5,390 | $404.7K | 0.00% | +384+7.7% | Added |
| Granite Investment Partners, LLC | 5,345 | $401.4K | 0.02% | +539+11.2% | Added |
| Virtu Financial LLC | 5,342 | $401.0K | 0.02% | +5,342 | New |
| Vontobel Holding Ltd. | 5,240 | $393.5K | 0.00% | 00.0% | Unchanged |
| Atria Investments LLC | 5,227 | $392.5K | 0.00% | −428−7.6% | Reduced |
| US Bancorp | 5,047 | $379.0K | 0.00% | −94−1.8% | Reduced |
| CIBC Asset Management Inc | 5,017 | $376.7K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 5,000 | $375.4K | 0.00% | −293−5.5% | Reduced |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $375.4K | 0.04% | 00.0% | Unchanged |
| Lighthouse Investment Partners, LLC | 4,970 | $373.2K | 0.01% | −8,112−62.0% | Reduced |
| Farallon Capital Management, L.L.C. | 4,800 | $360.4K | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 4,786 | $359.4K | 0.00% | −152−3.1% | Reduced |
| North Dakota State Investment Board | 4,623 | $347.1K | 0.02% | −857−15.6% | Reduced |
| Vise Technologies, Inc. | 4,305 | $340.6K | 0.01% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 4,466 | $335.4K | 0.01% | +1,203+36.9% | Added |
| Checchi Capital Advisers, LLC | 4,429 | $332.6K | 0.02% | +157+3.7% | Added |
| Credit Agricole S A | 4,410 | $331.1K | 0.00% | 00.0% | Unchanged |
| Kestra Advisory Services, LLC | 4,372 | $328.3K | 0.00% | −79−1.8% | Reduced |
| R Squared Ltd | 4,359 | $327.3K | 0.18% | +4,359 | New |
| Prospera Financial Services Inc | 4,341 | $325.9K | 0.01% | −418−8.8% | Reduced |
| Pinnacle Wealth Planning Services, Inc. | 4,213 | $316.4K | 0.03% | +349+9.0% | Added |
| Rockefeller Capital Management L.P. | 4,155 | $312.0K | 0.00% | +1,429+52.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 4,273 | $309.9K | 0.00% | −61−1.4% | Reduced |
| Inspire Advisors, LLC | 4,120 | $309.4K | 0.03% | −731−15.1% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 4,125 | $308.5K | 0.00% | −4,131−50.0% | Reduced |
| Intrust Bank NA | 4,056 | $304.6K | 0.02% | +4,056 | New |
| Optas, LLC | 4,034 | $302.9K | 0.05% | +4,034 | New |
| Prime Capital Investment Advisors, LLC | 3,971 | $298.2K | 0.00% | −10−0.3% | Reduced |
| Congress Asset Management Co | 3,946 | $296.3K | 0.00% | +3,946 | New |
| Sanctuary Advisors, LLC | 3,918 | $294.2K | 0.00% | −584−13.0% | Reduced |
| Axq Capital, LP | 3,846 | $288.8K | 0.04% | +3,846 | New |
| HighTower Advisors, LLC | 3,797 | $285.1K | 0.00% | −1,325−25.9% | Reduced |
| Mackenzie Financial Corp | 3,795 | $285.0K | 0.00% | −96−2.5% | Reduced |
| Anb Bank | 3,769 | $283.0K | 0.11% | +576+18.0% | Added |
| CWM, LLC | 3,717 | $279.1K | 0.00% | −1,332−26.4% | Reduced |
| Steward Partners Investment Advisory, LLC | 3,639 | $273.3K | 0.00% | +2,570+240.4% | Added |
| Berkshire Asset Management LLC | 3,637 | $273.1K | 0.01% | +7+0.2% | Added |
| GF Fund Management Co. Ltd. | 3,637 | $273.1K | 0.00% | +454+14.3% | Added |
| Marex Group plc | 3,610 | $271.1K | 0.00% | +86+2.4% | Added |
| Westfield Capital Management Co LP | 3,502 | $263.0K | 0.00% | +345+10.9% | Added |
| Everhart Financial Group, Inc. | 3,470 | $260.6K | 0.02% | +5+0.1% | Added |
| Perigon Wealth Management, LLC | 3,430 | $257.6K | 0.00% | +3,430 | New |
| Eurizon Capital SGR S.p.A. | 3,514 | $256.1K | 0.00% | +200+6.0% | Added |
| Mitchell & Pahl Private Wealth, LLC | 3,261 | $244.9K | 0.10% | −118−3.5% | Reduced |
| Nwam LLC | 3,238 | $243.1K | 0.01% | 00.0% | Unchanged |
| Crossmark Global Holdings, Inc. | 3,199 | $240.2K | 0.00% | +97+3.1% | Added |
| MML Investors Services, LLC | 3,173 | $238.3K | 0.00% | −91−2.8% | Reduced |
| Gsa Capital Partners LLP | 3,172 | $238.0K | 0.01% | +3,172 | New |
| Raab & Moskowitz Asset Management LLC | 3,115 | $233.9K | 0.05% | 00.0% | Unchanged |
| Campbell & CO Investment Adviser LLC | 3,101 | $232.9K | 0.01% | +317+11.4% | Added |
| QRG Capital Management, Inc. | 3,094 | $232.3K | 0.00% | +3,094 | New |
| Venturi Wealth Management, LLC | 3,061 | $229.9K | 0.01% | 00.0% | Unchanged |
| Larson Financial Group LLC | 3,031 | $227.6K | 0.01% | +691+29.5% | Added |
| Argent Trust Co | 3,018 | $226.6K | 0.01% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 2,963 | $222.5K | 0.07% | +2,963 | New |
| HB Wealth Management, LLC | 2,926 | $219.7K | 0.00% | +4+0.1% | Added |
| Norden Group LLC | 2,889 | $216.9K | 0.02% | −46−1.6% | Reduced |
| Cambria Investment Management, L.P. | 2,885 | $216.6K | 0.01% | −799−21.7% | Reduced |
| National Asset Management, Inc. | 2,945 | $213.6K | 0.01% | −30−1.0% | Reduced |
| Blueshift Asset Management, LLC | 2,777 | $208.5K | 0.06% | −7,666−73.4% | Reduced |
| AlphaCore Capital LLC | 2,762 | $207.4K | 0.00% | +2,762 | New |
| Integrated Wealth Concepts LLC | 2,724 | $204.5K | 0.00% | +2,724 | New |
| Montis Financial, LLC | 2,700 | $202.7K | 0.04% | 00.0% | Unchanged |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 2,693 | $202.2K | 0.00% | −57−2.1% | Reduced |
| New York Life Investment Management LLC | 2,688 | $201.8K | 0.00% | +2,688 | New |
| Fideuram Asset Management (Ireland) dac | 2,213 | $181.6K | 0.02% | +2,213 | New |
| Ancora Advisors, LLC | 2,391 | $179.5K | 0.00% | +49+2.1% | Added |
| Signaturefd, LLC | 2,078 | $156.0K | 0.00% | +37+1.8% | Added |
| Group One Trading, L.P. | 1,892 | $142.1K | 0.00% | −1,886−49.9% | Reduced |
| Farther Finance Advisors, LLC | 1,883 | $141.5K | 0.00% | +684+57.0% | Added |
| Parallel Advisors, LLC | 1,883 | $141.4K | 0.00% | +1+0.1% | Added |
| Advisors Asset Management, Inc. | 1,878 | $141.0K | 0.00% | −957−33.8% | Reduced |
| EverSource Wealth Advisors, LLC | 1,794 | $134.7K | 0.00% | +657+57.8% | Added |
| GAMMA Investing LLC | 1,766 | $132.6K | 0.01% | +33+1.9% | Added |
| Versant Capital Management, Inc | 1,555 | $116.8K | 0.01% | +59+3.9% | Added |
| Sterling Capital Management LLC | 1,425 | $107.0K | 0.00% | −288−16.8% | Reduced |
| Smartleaf Asset Management LLC | 1,416 | $102.7K | 0.00% | +28+2.0% | Added |
| International Assets Investment Management, LLC | 1,221 | $91.7K | 0.01% | +4+0.3% | Added |
| Stephens Inc | 26,761 | $91.4K | 0.00% | +26,761 | New |
| Sunbelt Securities, Inc. | 1,014 | $76.1K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 950 | $71.3K | 0.00% | −64−6.3% | Reduced |
| MAI Capital Management | 940 | $70.6K | 0.00% | +40+4.4% | Added |
| Los Angeles Capital Management LLC | 700 | $52.6K | 0.00% | 00.0% | Unchanged |
| Root Financial Partners, LLC | 681 | $51.1K | 0.00% | −658−49.1% | Reduced |
| Huntington National Bank | 681 | $51.1K | 0.00% | −14−2.0% | Reduced |
| Quadrant Capital Group LLC | 616 | $46.3K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 604 | $45.4K | 0.00% | +604 | New |
| Archer Investment Corp | 600 | $45.1K | 0.01% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 573 | $43.0K | 0.00% | −40−6.5% | Reduced |
| Harbour Investments, Inc. | 546 | $41.0K | 0.00% | +318+139.5% | Added |
| Allworth Financial LP | 522 | $39.2K | 0.00% | −398−43.3% | Reduced |
| Bayforest Capital Ltd | 413 | $31.0K | 0.03% | −678−62.1% | Reduced |