Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mather Group, LLC. | 410 | $30.8K | 0.00% | +410 | New |
| ORG Wealth Partners, LLC | 400 | $30.0K | 0.01% | 00.0% | Unchanged |
| Cassaday & Co Wealth Management LLC | 400 | $30.0K | 0.00% | +400 | New |
| Golden State Wealth Management, LLC | 376 | $28.2K | 0.00% | 00.0% | Unchanged |
| RWM Asset Management, LLC | 375 | $28.2K | 0.00% | +375 | New |
| Employees Retirement System of Texas | 378 | $28.0K | 0.00% | −976−72.1% | Reduced |
| CoreCap Advisors, LLC | 370 | $27.8K | 0.00% | 00.0% | Unchanged |
| Hilton Head Capital Partners, LLC | 353 | $26.5K | 0.01% | −246−41.1% | Reduced |
| Brown Brothers Harriman & Co | 341 | $25.6K | 0.00% | 00.0% | Unchanged |
| Wellington-Altus USA Inc. | 317 | $25.1K | 0.01% | −34−9.7% | Reduced |
| Salomon & Ludwin, LLC | 332 | $24.8K | 0.00% | 00.0% | Unchanged |
| Sound Income Strategies, LLC | 300 | $22.5K | 0.00% | +14+4.9% | Added |
| Eastern Bank | 300 | $22.5K | 0.00% | 00.0% | Unchanged |
| Steigerwald, Gordon & Koch Inc. | 295 | $22.2K | 0.00% | −85−22.4% | Reduced |
| Capital Advisors, Ltd. LLC | 295 | $22.0K | 0.00% | 00.0% | Unchanged |
| NBC Securities, Inc. | 273 | $20.5K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 258 | $19.4K | 0.00% | +8+3.2% | Added |
| MTM Investment Management, LLC | 258 | $19.4K | 0.01% | 00.0% | Unchanged |
| Harvest Fund Management Co., Ltd | 234 | $18.0K | 0.00% | −4,582−95.1% | Reduced |
| Westside Investment Management, Inc. | 231 | $17.3K | 0.00% | 00.0% | Unchanged |
| Cedar Mountain Advisors, LLC | 223 | $16.7K | 0.00% | +223 | New |
| Aster Capital Management (DIFC) Ltd | 550 | $16.6K | 0.01% | +535+3,566.7% | Added |
| Global Trust Asset Management, LLC | 218 | $16.4K | 0.01% | 00.0% | Unchanged |
| Umb Bank N A | 215 | $16.1K | 0.00% | +1+0.5% | Added |
| Twin Peaks Wealth Advisors, LLC | 215 | $16.1K | 0.00% | +215 | New |
| Elequin Capital LP | 208 | $15.6K | 0.00% | −503−70.7% | Reduced |
| MH & Associates Securities Management Corp | 200 | $15.0K | 0.01% | 00.0% | Unchanged |
| Atlantic Union Bankshares Corp | 200 | $15.0K | 0.00% | 00.0% | Unchanged |
| CX Institutional | 202 | $15.0K | 0.00% | +202 | New |
| E Fund Management (Hong Kong) Co., Ltd. | 195 | $14.6K | 0.01% | +195 | New |
| Covestor Ltd | 182 | $14.0K | 0.01% | −91−33.3% | Reduced |
| Basecamp Wealth Advisors LLC | 185 | $13.9K | 0.00% | 00.0% | Unchanged |
| Zions Bancorporation, National Association | 177 | $13.3K | 0.00% | −11−5.9% | Reduced |
| Owl Creek Wealth Partners LLC | 170 | $12.8K | 0.00% | +170 | New |
| FIL Ltd | 165 | $12.4K | 0.00% | +118+251.1% | Added |
| SBI Securities Co., Ltd. | 161 | $12.1K | 0.00% | −125−43.7% | Reduced |
| United Financial Planning Group LLC | 158 | $11.9K | 0.01% | +150+1,875.0% | Added |
| Meeder Asset Management Inc | 152 | $11.4K | 0.00% | −564−78.8% | Reduced |
| Strategic Wealth Partners, Ltd. | 150 | $11.3K | 0.00% | 00.0% | Unchanged |
| Wealth Preservation Advisors, LLC | 150 | $11.3K | 0.01% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 143 | $10.7K | 0.00% | +52+57.1% | Added |
| Global X Japan Co., Ltd. | 128 | $9.61K | 0.00% | −43−25.1% | Reduced |
| Spire Wealth Management | 125 | $9.39K | 0.00% | 00.0% | Unchanged |
| Bogart Wealth, LLC | 123 | $9.24K | 0.00% | −5−3.9% | Reduced |
| LRI Investments, LLC | 110 | $8.26K | 0.00% | 00.0% | Unchanged |
| Danske Bank A/S | 100 | $7.51K | 0.00% | −1,300−92.9% | Reduced |
| Main Street Group, LTD | 100 | $7.51K | 0.00% | +100 | New |
| Quent Capital, LLC | 99 | $7.43K | 0.00% | 00.0% | Unchanged |
| Bessemer Group Inc | 94 | $7.00K | 0.00% | −39−29.3% | Reduced |
| Keating Financial Advisory Services, Inc. | 90 | $6.76K | 0.00% | +74+462.5% | Added |
| TD Private Client Wealth LLC | 80 | $6.01K | 0.00% | −2−2.4% | Reduced |
| Orion Capital Management LLC | 80 | $6.01K | 0.00% | 00.0% | Unchanged |
| Rossby Financial, LCC | 74 | $5.56K | 0.00% | +25+51.0% | Added |
| Leonteq Securities AG | 73 | $5.48K | 0.00% | +10+15.9% | Added |
| Clear Investment Research, LLC | 71 | $5.33K | 0.01% | +71 | New |
| WPG Advisers, LLC | 70 | $5.26K | 0.00% | 00.0% | Unchanged |
| Private Wealth Management Group, LLC | 65 | $4.88K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 61 | $4.58K | 0.00% | 00.0% | Unchanged |
| First Horizon Corp | 56 | $4.21K | 0.00% | +31+124.0% | Added |
| MCF Advisors LLC | 50 | $3.75K | 0.00% | +50 | New |
| Triumph Capital Management | 50 | $3.75K | 0.00% | 00.0% | Unchanged |
| Crewe Advisors LLC | 48 | $3.60K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 48 | $3.60K | 0.00% | +48 | New |
| Horizon Investments, LLC | 48 | $3.60K | 0.00% | +26+118.2% | Added |
| Sachetta, LLC | 45 | $3.38K | 0.00% | 00.0% | Unchanged |
| Hantz Financial Services, Inc. | 36 | $3.00K | 0.00% | 00.0% | Unchanged |
| Highline Wealth Partners LLC | 38 | $2.85K | 0.00% | 00.0% | Unchanged |
| Transamerica Financial Advisors, Inc. | 33 | $2.48K | 0.00% | +33 | New |
| Principia Wealth Advisory, LLC | 32 | $2.40K | 0.00% | +6+23.1% | Added |
| Cheviot Value Management, LLC | 28 | $2.10K | 0.00% | 00.0% | Unchanged |
| Raffa Wealth Management, LLC | 28 | $2.10K | 0.00% | 00.0% | Unchanged |
| IMA Wealth, Inc. | 28 | $2.10K | 0.00% | +23+460.0% | Added |
| Bruce G. Allen Investments, LLC | 23 | $1.73K | 0.00% | 00.0% | Unchanged |
| TFC Financial Management | 21 | $1.58K | 0.00% | 00.0% | Unchanged |
| Aspect Partners, LLC | 20 | $1.50K | 0.00% | 00.0% | Unchanged |
| NBT Bank N A | 20 | $1.50K | 0.00% | +20 | New |
| Cromwell Holdings LLC | 18 | $1.35K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 17 | $1.28K | 0.00% | 00.0% | Unchanged |
| Quaker Wealth Management, LLC | 15 | $1.13K | 0.00% | +1+7.1% | Added |
| Cornerstone Financial Management LLC | 15 | $1.13K | 0.00% | 00.0% | Unchanged |
| Whipplewood Advisors, LLC | 15 | $1.13K | 0.00% | +15 | New |
| South State Corp. | 14 | $1.05K | 0.00% | 00.0% | Unchanged |
| Mascoma Wealth Management LLC | 14 | $1.05K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 13 | $976 | 0.00% | −6−31.6% | Reduced |
| Clearstead Advisors, LLC | 12 | $902 | 0.00% | −3−20.0% | Reduced |
| Cornerstone Planning Group LLC | 10 | $753 | 0.00% | +5+100.0% | Added |
| Kayne Anderson Rudnick Investment Management LLC | 7 | $526 | 0.00% | 00.0% | Unchanged |
| True Wealth Design, LLC | 7 | $526 | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 7 | $526 | 0.00% | 00.0% | Unchanged |
| American Capital Advisory, LLC | 7 | $526 | 0.00% | +5+250.0% | Added |
| Caitong International Asset Management Co., Ltd | 7 | $526 | 0.00% | +7 | New |
| Hughes Financial Services, LLC | 6 | $451 | 0.00% | +6 | New |
| Manchester Capital Management LLC | 5 | $376 | 0.00% | 00.0% | Unchanged |
| Dunhill Financial, LLC | 2 | $201 | 0.00% | −1−33.3% | Reduced |
| 3 Factor Indexing, LLC | 2 | $151 | 0.00% | +2 | New |
| Nisa Investment Advisors, LLC | 1 | $75 | 0.00% | 00.0% | Unchanged |
| Truvestments Capital LLC | 1 | $56 | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −3,052,111−100.0% | Sold out |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −557,174−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −120,577−100.0% | Sold out |