Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 351
- +22 vs. Q1 2022
- Shares held
- 124.6M
- +27.5K (0.0%) vs. Q1 2022
- Total value
- $4.61B
- −$315.6K (0.0%) vs. Q1 2022
- New holders
- 53
- 89 more added
- Sold out
- 31
- 130 more reduced
4 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,269,560 | $787.4M | 0.08% | −51,326−0.2% | Reduced |
| Price T Rowe Associates Inc | 15,056,046 | $557.4M | 0.07% | +705,586+4.9% | Added |
| Vanguard Group Inc | 12,200,276 | $451.7M | 0.01% | +101,242+0.8% | Added |
| Bellevue Group AG | 9,776,528 | $361.9M | 5.12% | −141,545−1.4% | Reduced |
| BlackRock Inc. | 8,831,390 | $326.9M | 0.01% | +387,547+4.6% | Added |
| Clearbridge Investments, LLC | 6,005,818 | $222.3M | 0.21% | −470,215−7.3% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 4,701,297 | $171.7M | 1.02% | −1,470,011−23.8% | Reduced |
| State Street Corp | 4,202,874 | $155.6M | 0.01% | +172,228+4.3% | Added |
| Tweedy, Browne Co LLC | 2,726,778 | $100.9M | 4.13% | −198,324−6.8% | Reduced |
| Camber Capital Management LP | 2,700,000 | $100.0M | 4.34% | −300,000−10.0% | Reduced |
| Geode Capital Management, LLC | 1,865,133 | $69.0M | 0.01% | −32,359−1.7% | Reduced |
| First Trust Advisors LP | 1,596,055 | $59.1M | 0.07% | −20,235−1.3% | Reduced |
| Thrivent Financial for Lutherans | 1,276,783 | $47.3M | 0.13% | −284,730−18.2% | Reduced |
| BVF Inc | 1,276,574 | $47.3M | 2.28% | +1,276,574 | New |
| Charles Schwab Investment Management Inc | 1,154,025 | $42.7M | 0.01% | +16,198+1.4% | Added |
| Norges Bank | 1,118,341 | $41.4M | 0.01% | +332,780+42.4% | Added |
| Goldman Sachs Group Inc | 1,041,824 | $38.6M | 0.01% | +87,498+9.2% | Added |
| JPMorgan Chase & Co | 1,039,570 | $38.5M | 0.01% | −141,987−12.0% | Reduced |
| Swedbank AB | 1,022,281 | $37.8M | 0.09% | −95,058−8.5% | Reduced |
| TD Asset Management Inc | 803,664 | $29.8M | 0.03% | −16,500−2.0% | Reduced |
| Morgan Stanley | 737,977 | $27.3M | 0.00% | +218,500+42.1% | Added |
| Wells Fargo & Company | 723,995 | $26.8M | 0.01% | −118,289−14.0% | Reduced |
| Two Sigma Advisers, LP | 705,811 | $26.1M | 0.07% | +94,200+15.4% | Added |
| Bank of New York Mellon Corp | 665,316 | $24.6M | 0.01% | +116,069+21.1% | Added |
| Northern Trust Corp | 625,472 | $23.2M | 0.00% | −23,062−3.6% | Reduced |
| Jacobs Levy Equity Management, Inc | 616,766 | $22.8M | 0.18% | −1,001,501−61.9% | Reduced |
| Renaissance Technologies LLC | 614,814 | $22.8M | 0.03% | +479,900+355.7% | Added |
| Bank of America Corp | 608,552 | $22.5M | 0.00% | −153,606−20.2% | Reduced |
| Dimensional Fund Advisors LP | 585,048 | $21.7M | 0.01% | +231,567+65.5% | Added |
| Candriam Luxembourg S.C.A. | 570,692 | $21.1M | 0.17% | +71,145+14.2% | Added |
| Two Sigma Investments, LP | 560,031 | $20.7M | 0.07% | −220,225−28.2% | Reduced |
| Pinnacle Associates Ltd | 515,859 | $19.1M | 0.42% | −6,109−1.2% | Reduced |
| Citadel Advisors LLC | 480,143 | $17.8M | 0.02% | −764,381−61.4% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 468,116 | $17.3M | 0.01% | −131,500−21.9% | Reduced |
| OrbiMed Advisors LLC | 453,400 | $16.8M | 0.33% | +453,400 | New |
| Royal Bank of Canada | 428,423 | $15.9M | 0.00% | −16,079−3.6% | Reduced |
| Nikko Asset Management Americas, Inc. | 468,116 | $15.4M | 0.19% | −131,500−21.9% | Reduced |
| Nomura Holdings Inc | 375,977 | $14.3M | 0.13% | −18,177−4.6% | Reduced |
| Barclays PLC | 354,579 | $13.1M | 0.01% | +38,229+12.1% | Added |
| Nuveen Asset Management, LLC | 348,686 | $12.9M | 0.01% | +32,867+10.4% | Added |
| Assenagon Asset Management S.A. | 340,716 | $12.6M | 0.05% | −17,180−4.8% | Reduced |
| Invesco Ltd. | 325,985 | $12.1M | 0.00% | +185,993+132.9% | Added |
| Millennium Management LLC | 320,615 | $11.9M | 0.02% | +129,424+67.7% | Added |
| Baillie Gifford & Co | 311,015 | $11.5M | 0.01% | −37,848−10.8% | Reduced |
| Stifel Financial Corp | 306,320 | $11.3M | 0.02% | −34,246−10.1% | Reduced |
| Dowling & Yahnke LLC | 302,571 | $11.2M | 0.53% | 00.0% | Unchanged |
| Swiss National Bank | 299,300 | $11.1M | 0.01% | −1,200−0.4% | Reduced |
| Sicart Associates LLC | 288,751 | $10.7M | 3.33% | −16,031−5.3% | Reduced |
| California Public Employees Retirement System | 282,382 | $10.5M | 0.01% | −12,433−4.2% | Reduced |
| Bank of Montreal | 231,992 | $9.22M | 0.01% | −36,505−13.6% | Reduced |
| Raymond James & Associates | 246,449 | $9.12M | 0.01% | −10,277−4.0% | Reduced |
| Pictet Asset Management SA | 238,339 | $8.82M | 0.01% | +32,198+15.6% | Added |
| UBS Asset Management Americas Inc | 205,789 | $7.62M | 0.00% | −1,117−0.5% | Reduced |
| Tang Capital Management LLC | 200,000 | $7.40M | 1.12% | 00.0% | Unchanged |
| Caisse de Depot Et Placement du Quebec | 198,324 | $7.34M | 0.02% | +198,324 | New |
| Liontrust Investment Partners LLP | 194,492 | $7.20M | 0.10% | +194,492 | New |
| Altrinsic Global Advisors LLC | 186,454 | $6.90M | 0.28% | −21,704−10.4% | Reduced |
| Hudson Bay Capital Management LP | 185,000 | $6.85M | 0.07% | −25,000−11.9% | Reduced |
| Privium Fund Management B.V. | 180,107 | $6.67M | 2.26% | 00.0% | Unchanged |
| Tekla Capital Management LLC | 175,680 | $6.50M | 0.26% | 00.0% | Unchanged |
| Parkman Healthcare Partners LLC | 174,300 | $6.45M | 2.38% | +174,300 | New |
| UBS Group AG | 170,167 | $6.30M | 0.00% | −31,034−15.4% | Reduced |
| California State Teachers Retirement System | 169,414 | $6.27M | 0.01% | +1,052+0.6% | Added |
| Sector Gamma AS | 165,439 | $6.13M | 1.37% | −23,000−12.2% | Reduced |
| State Board of Administration of Florida Retirement System | 164,125 | $6.08M | 0.01% | −6,603−3.9% | Reduced |
| Legal & General Group Plc | 163,954 | $6.07M | 0.00% | +1,636+1.0% | Added |
| Tocqueville Asset Management L.P. | 162,605 | $6.02M | 0.11% | −4,900−2.9% | Reduced |
| AXA S.A. | 158,535 | $5.87M | 0.02% | +72,235+83.7% | Added |
| Sonora Investment Management Group, LLC | 156,323 | $5.79M | 0.55% | −938−0.6% | Reduced |
| Balyasny Asset Management LLC | 155,533 | $5.76M | 0.02% | +155,533 | New |
| Rhumbline Advisers | 154,502 | $5.72M | 0.01% | +20,942+15.7% | Added |
| Credit Suisse AG | 149,721 | $5.54M | 0.01% | −30,905−17.1% | Reduced |
| Cubist Systematic Strategies, LLC | 149,388 | $5.53M | 0.04% | +53,858+56.4% | Added |
| BLB&B Advisors, LLC | 149,250 | $5.53M | 0.44% | −495−0.3% | Reduced |
| Citigroup Inc | 149,131 | $5.52M | 0.01% | +67,795+83.4% | Added |
| New York State Common Retirement Fund | 146,825 | $5.43M | 0.01% | +250.0% | Added |
| Fred Alger Management, LLC | 146,656 | $5.43M | 0.03% | +146,656 | New |
| Private Advisor Group, LLC | 137,782 | $5.10M | 0.05% | −19,186−12.2% | Reduced |
| State of Wisconsin Investment Board | 137,233 | $5.08M | 0.01% | +22,782+19.9% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 131,983 | $4.89M | 0.03% | −25,210−16.0% | Reduced |
| Peregrine Capital Management LLC | 130,224 | $4.82M | 0.15% | −96−0.1% | Reduced |
| Schonfeld Strategic Advisors LLC | 130,023 | $4.81M | 0.05% | +74,480+134.1% | Added |
| Squarepoint Ops LLC | 129,940 | $4.81M | 0.04% | +111,046+587.7% | Added |
| Woodline Partners LP | 129,908 | $4.81M | 0.08% | −62,743−32.6% | Reduced |
| D. E. Shaw & Co., Inc. | 126,621 | $4.69M | 0.01% | +126,621 | New |
| DekaBank Deutsche Girozentrale | 124,776 | $4.65M | 0.01% | 00.0% | Unchanged |
| HRT Financial LP | 122,897 | $4.55M | 0.05% | +13,521+12.4% | Added |
| BNP Paribas Arbitrage, SA | 119,970 | $4.44M | 0.01% | +29,034+31.9% | Added |
| Kennedy Capital Management, Inc. | 119,682 | $4.43M | 0.12% | +109,834+1,115.3% | Added |
| Rafferty Asset Management, LLC | 119,283 | $4.42M | 0.04% | −59,511−33.3% | Reduced |
| Jump Financial, LLC | 114,857 | $4.25M | 0.18% | +5,030+4.6% | Added |
| Principal Financial Group Inc | 112,168 | $4.15M | 0.00% | +81,957+271.3% | Added |
| Eventide Asset Management, LLC | 110,000 | $4.07M | 0.09% | +110,000 | New |
| Russell Investments Group, Ltd. | 99,234 | $3.67M | 0.01% | −184,896−65.1% | Reduced |
| Gateway Investment Advisers LLC | 99,129 | $3.67M | 0.04% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 93,214 | $3.50M | 0.00% | +17,916+23.8% | Added |
| Bard Financial Services, Inc. | 93,445 | $3.46M | 0.32% | −5,575−5.6% | Reduced |
| Jane Street Group, LLC | 90,889 | $3.36M | 0.01% | +63,098+227.0% | Added |
| Eversept Partners, LP | 86,311 | $3.20M | 0.31% | −72,495−45.7% | Reduced |
| Alps Advisors Inc | 84,115 | $3.11M | 0.03% | −61,500−42.2% | Reduced |