Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 23,613,585 | $712.4M | 0.05% | +924,094+4.1% | Added |
| Vanguard Group Inc | 16,383,934 | $494.3M | 0.01% | −88,605−0.5% | Reduced |
| T. Rowe Price Investment Management, Inc. | 16,175,533 | $488.0M | 0.32% | +2,006,334+14.2% | Added |
| Capital World Investors | 12,361,994 | $373.0M | 0.06% | +896,581+7.8% | Added |
| BlackRock, Inc. | 11,264,442 | $339.8M | 0.01% | −401,106−3.4% | Reduced |
| Wellington Management Group LLP | 8,416,421 | $253.9M | 0.05% | −255,727−2.9% | Reduced |
| Bellevue Group AG | 7,853,198 | $236.9M | 5.31% | −15,502−0.2% | Reduced |
| State Street Corp | 4,845,133 | $146.2M | 0.01% | −581,280−10.7% | Reduced |
| Deep Track Capital, LP | 4,564,207 | $137.7M | 4.46% | +2,630,279+136.0% | Added |
| Citadel Advisors LLC | 3,480,062 | $105.0M | 0.10% | +1,314,146+60.7% | Added |
| Price T Rowe Associates Inc | 3,265,034 | $98.5M | 0.01% | −561,905−14.7% | Reduced |
| Tweedy, Browne Co LLC | 2,983,518 | $90.0M | 7.98% | −265,345−8.2% | Reduced |
| Geode Capital Management, LLC | 2,842,954 | $85.8M | 0.01% | +155,706+5.8% | Added |
| OrbiMed Advisors LLC | 2,540,136 | $76.6M | 1.84% | −277,211−9.8% | Reduced |
| Two Sigma Advisers, LP | 2,092,011 | $63.1M | 0.14% | +742,800+55.1% | Added |
| BVF Inc | 1,913,385 | $57.7M | 2.35% | +1,913,385 | New |
| UBS Group AG | 1,890,602 | $57.0M | 0.01% | −27,006−1.4% | Reduced |
| Two Sigma Investments, LP | 1,685,853 | $50.9M | 0.11% | +764,414+83.0% | Added |
| Macquarie Group Ltd | 1,667,194 | $50.3M | 0.06% | −102,549−5.8% | Reduced |
| Charles Schwab Investment Management Inc | 1,443,629 | $43.6M | 0.01% | −37,811−2.6% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,196,392 | $36.1M | 0.10% | +116,051+10.7% | Added |
| Morgan Stanley | 1,144,181 | $34.5M | 0.00% | −185,748−14.0% | Reduced |
| TD Asset Management Inc | 1,100,466 | $33.2M | 0.03% | +50,476+4.8% | Added |
| Adage Capital Partners GP, L.L.C. | 1,075,600 | $32.5M | 0.06% | +800,600+291.1% | Added |
| Hudson Bay Capital Management LP | 1,049,900 | $31.7M | 0.20% | +228,700+27.8% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 1,000,527 | $30.2M | 0.30% | −24,733−2.4% | Reduced |
| Candriam Luxembourg S.C.A. | 993,704 | $30.0M | 0.19% | +143,880+16.9% | Added |
| Invesco Ltd. | 874,834 | $26.4M | 0.01% | +86,235+10.9% | Added |
| Norges Bank | 858,228 | $25.9M | 0.00% | −856,534−50.0% | Reduced |
| Northern Trust Corp | 834,847 | $25.2M | 0.00% | −5,424−0.6% | Reduced |
| Bank of Montreal | 782,835 | $23.6M | 0.01% | +470,689+150.8% | Added |
| Bank of America Corp | 767,432 | $23.2M | 0.00% | +344,571+81.5% | Added |
| Camber Capital Management LP | 725,000 | $21.9M | 1.36% | +100,000+16.0% | Added |
| UBS Asset Management Americas Inc | 659,435 | $19.9M | 0.01% | +39,794+6.4% | Added |
| Goldman Sachs Group Inc | 652,518 | $19.7M | 0.00% | +274,310+72.5% | Added |
| Pictet Asset Management Holding SA | 618,550 | $19.2M | 0.02% | −2,248−0.4% | Reduced |
| Millennium Management LLC | 635,370 | $19.2M | 0.02% | −138,845−17.9% | Reduced |
| Royal Bank of Canada | 616,081 | $18.6M | 0.00% | −27,111−4.2% | Reduced |
| Pinnacle Associates Ltd | 608,517 | $18.4M | 0.27% | +60,875+11.1% | Added |
| Groupama Asset Managment | 569,211 | $18.2M | 0.36% | +52,020+10.1% | Added |
| AXA S.A. | 566,486 | $17.1M | 0.06% | −38,859−6.4% | Reduced |
| Schonfeld Strategic Advisors LLC | 560,359 | $16.9M | 0.11% | +188,978+50.9% | Added |
| Bank of New York Mellon Corp | 544,633 | $16.4M | 0.00% | −71,438−11.6% | Reduced |
| Eversept Partners, LP | 517,021 | $15.6M | 1.77% | +302,069+140.5% | Added |
| Teacher Retirement System of Texas | 500,451 | $15.1M | 0.06% | +434,659+660.7% | Added |
| Standard Life Aberdeen plc | 446,197 | $13.5M | 0.03% | +44,696+11.1% | Added |
| Citigroup Inc | 426,480 | $12.9M | 0.01% | +257,325+152.1% | Added |
| JPMorgan Chase & Co | 421,511 | $12.7M | 0.00% | +5,592+1.3% | Added |
| C WorldWide Group Holding A/S | 400,000 | $12.1M | 0.15% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 377,204 | $11.4M | 0.04% | +60,261+19.0% | Added |
| Ameriprise Financial Inc | 360,188 | $10.9M | 0.00% | −27,260−7.0% | Reduced |
| Baker Bros. Advisors LP | 357,915 | $10.8M | 0.12% | 00.0% | Unchanged |
| Barclays PLC | 353,937 | $10.7M | 0.00% | −242,135−40.6% | Reduced |
| Legal & General Group Plc | 338,462 | $10.2M | 0.00% | +170,382+101.4% | Added |
| Sovran Advisors, LLC | 328,904 | $9.34M | 1.21% | +157,092+91.4% | Added |
| Nuveen, LLC | 308,777 | $9.32M | 0.00% | +308,777 | New |
| BNP Paribas Arbitrage, SA | 308,293 | $9.30M | 0.01% | +53,772+21.1% | Added |
| J. Goldman & Co LP | 307,770 | $9.29M | 0.33% | −299,729−49.3% | Reduced |
| Squarepoint Ops LLC | 305,373 | $9.21M | 0.02% | +138,905+83.4% | Added |
| Point72 Asset Management, L.P. | 287,204 | $8.66M | 0.02% | +287,204 | New |
| Sector Gamma AS | 285,842 | $8.62M | 2.76% | +50,000+21.2% | Added |
| Swiss National Bank | 275,300 | $8.31M | 0.01% | −3,900−1.4% | Reduced |
| Privium Fund Management B.V. | 267,594 | $8.07M | 2.10% | +800+0.3% | Added |
| Wells Fargo & Company | 256,233 | $7.73M | 0.00% | −74,776−22.6% | Reduced |
| Great Point Partners LLC | 250,000 | $7.54M | 4.10% | −255,007−50.5% | Reduced |
| CI Private Wealth, LLC | 237,133 | $7.15M | 0.01% | −2,030−0.8% | Reduced |
| Nomura Holdings Inc | 236,426 | $7.13M | 0.04% | −120,829−33.8% | Reduced |
| Orion Investment Co | 215,290 | $6.50M | 2.67% | −710−0.3% | Reduced |
| Artisan Partners Limited Partnership | 203,178 | $6.13M | 0.01% | −49,457−19.6% | Reduced |
| Stifel Financial Corp | 200,942 | $6.06M | 0.01% | −10,551−5.0% | Reduced |
| California Public Employees Retirement System | 191,004 | $5.76M | 0.00% | −1,126−0.6% | Reduced |
| Rhumbline Advisers | 188,216 | $5.68M | 0.01% | −3,677−1.9% | Reduced |
| Tocqueville Asset Management L.P. | 187,395 | $5.65M | 0.09% | −164,745−46.8% | Reduced |
| Sicart Associates LLC | 185,646 | $5.60M | 1.94% | −175−0.1% | Reduced |
| GW&K Investment Management, LLC | 182,309 | $5.50M | 0.05% | −4,911−2.6% | Reduced |
| Rafferty Asset Management, LLC | 176,248 | $5.32M | 0.02% | −61,089−25.7% | Reduced |
| Susquehanna Fundamental Investments, LLC | 158,609 | $4.79M | 0.08% | −54,406−25.5% | Reduced |
| Aquatic Capital Management LLC | 156,157 | $4.71M | 0.12% | −73,859−32.1% | Reduced |
| Sonora Investment Management Group, LLC | 154,147 | $4.65M | 0.37% | +5,371+3.6% | Added |
| Renaissance Technologies LLC | 153,514 | $4.63M | 0.01% | −52,000−25.3% | Reduced |
| State Board of Administration of Florida Retirement System | 152,315 | $4.60M | 0.01% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 152,200 | $4.59M | 0.23% | +150+0.1% | Added |
| Kennedy Capital Management, Inc. | 150,424 | $4.54M | 0.11% | −72,854−32.6% | Reduced |
| Tang Capital Management LLC | 150,000 | $4.53M | 0.25% | 00.0% | Unchanged |
| Raymond James Financial Inc | 148,690 | $4.49M | 0.00% | +43,071+40.8% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 143,870 | $4.34M | 0.01% | +143,870 | New |
| Sumitomo Mitsui Trust Holdings, Inc. | 142,433 | $4.30M | 0.00% | −14,224−9.1% | Reduced |
| Nikko Asset Management Americas, Inc. | 142,433 | $4.30M | 0.06% | −14,224−9.1% | Reduced |
| Exome Asset Management LLC | 135,616 | $4.09M | 3.66% | +74,249+121.0% | Added |
| California State Teachers Retirement System | 132,238 | $3.99M | 0.00% | −1,664−1.2% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 129,273 | $3.90M | 0.02% | +3,884+3.1% | Added |
| Edmond de Rothschild Holding S.A. | 124,200 | $3.75M | 0.07% | +124,200 | New |
| American Century Companies Inc | 116,768 | $3.52M | 0.00% | +116,768 | New |
| State of Wisconsin Investment Board | 108,316 | $3.27M | 0.01% | +7,085+7.0% | Added |
| Neuberger Berman Group LLC | 102,473 | $3.09M | 0.00% | +5,842+6.0% | Added |
| Alliancebernstein L.P. | 100,749 | $3.04M | 0.00% | +48,613+93.2% | Added |
| PDT Partners, LLC | 96,056 | $2.90M | 0.21% | +67,062+231.3% | Added |
| DekaBank Deutsche Girozentrale | 93,807 | $2.87M | 0.01% | 00.0% | Unchanged |
| DCF Advisers, LLC | 95,000 | $2.87M | 1.54% | +12,118+14.6% | Added |
| Walleye Capital LLC | 94,990 | $2.87M | 0.03% | +78,735+484.4% | Added |