Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 341
- +20 vs. Q3 2021
- Shares held
- 123.2M
- +1.71M (+1.4%) vs. Q3 2021
- Total value
- $3.75B
- −$326.3M (−8.0%) vs. Q3 2021
- New holders
- 59
- 106 more added
- Sold out
- 39
- 119 more reduced
5 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,181,502 | $644.6M | 0.05% | +9,3480.0% | Added |
| Price T Rowe Associates Inc | 12,490,280 | $380.1M | 0.03% | +752,959+6.4% | Added |
| Vanguard Group Inc | 12,007,076 | $365.4M | 0.01% | +207,067+1.8% | Added |
| Bellevue Group AG | 10,355,123 | $315.1M | 3.25% | +1,007,197+10.8% | Added |
| BlackRock Inc. | 8,539,282 | $259.8M | 0.01% | +419,429+5.2% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 7,083,256 | $215.5M | 0.65% | −1,428,128−16.8% | Reduced |
| Clearbridge Investments, LLC | 5,882,982 | $179.0M | 0.12% | −1,444,340−19.7% | Reduced |
| State Street Corp | 3,906,375 | $118.9M | 0.01% | +385,061+10.9% | Added |
| Geode Capital Management, LLC | 1,825,226 | $55.5M | 0.01% | +52,459+3.0% | Added |
| First Trust Advisors LP | 1,680,012 | $51.1M | 0.05% | −5370.0% | Reduced |
| Millennium Management LLC | 1,623,138 | $49.4M | 0.05% | +1,340,284+473.8% | Added |
| Thrivent Financial for Lutherans | 1,533,999 | $46.7M | 0.09% | +146,235+10.5% | Added |
| Jacobs Levy Equity Management, Inc | 1,407,388 | $42.8M | 0.29% | +216,152+18.1% | Added |
| Camber Capital Management LP | 1,390,000 | $42.3M | 1.63% | −1,110,000−44.4% | Reduced |
| JPMorgan Chase & Co | 1,268,652 | $38.6M | 0.00% | −1,147,661−47.5% | Reduced |
| Citadel Advisors LLC | 1,221,571 | $37.2M | 0.04% | +171,714+16.4% | Added |
| Swedbank AB | 1,117,339 | $34.1M | 0.06% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 1,093,439 | $33.3M | 0.01% | +23,707+2.2% | Added |
| Candriam Luxembourg S.C.A. | 936,635 | $28.5M | 0.18% | +210,276+28.9% | Added |
| Norges Bank | 831,219 | $25.3M | 0.01% | −315,699−27.5% | Reduced |
| Wells Fargo & Company | 810,966 | $24.7M | 0.01% | −42,404−5.0% | Reduced |
| TD Asset Management Inc | 743,164 | $22.6M | 0.02% | +321,200+76.1% | Added |
| Northern Trust Corp | 660,890 | $20.1M | 0.00% | +5,469+0.8% | Added |
| Privium Fund Management B.V. | 630,199 | $19.2M | 3.83% | +630,199 | New |
| Bank of America Corp | 612,835 | $18.6M | 0.00% | −97,282−13.7% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 605,902 | $18.4M | 0.01% | −79,758−11.6% | Reduced |
| Bank of Nova Scotia | 601,883 | $18.3M | 0.03% | +589,568+4,787.4% | Added |
| Two Sigma Investments, LP | 594,885 | $18.1M | 0.04% | +280,751+89.4% | Added |
| Nikko Asset Management Americas, Inc. | 605,902 | $17.9M | 0.09% | −69,399−10.3% | Reduced |
| Goldman Sachs Group Inc | 589,298 | $17.9M | 0.00% | −12,538−2.1% | Reduced |
| Bank of New York Mellon Corp | 556,577 | $16.9M | 0.00% | −3,989−0.7% | Reduced |
| Pinnacle Associates Ltd | 541,044 | $16.5M | 0.28% | −2,182−0.4% | Reduced |
| Two Sigma Advisers, LP | 497,411 | $15.1M | 0.04% | +65,200+15.1% | Added |
| Royal Bank of Canada | 480,648 | $14.6M | 0.00% | −8,913−1.8% | Reduced |
| Morgan Stanley | 464,885 | $14.1M | 0.00% | −33,051−6.6% | Reduced |
| Woodline Partners LP | 411,454 | $12.5M | 0.18% | +5,993+1.5% | Added |
| Altrinsic Global Advisors LLC | 399,392 | $12.2M | 0.39% | −45,495−10.2% | Reduced |
| Dimensional Fund Advisors LP | 386,691 | $11.8M | 0.00% | +30,852+8.7% | Added |
| Eversept Partners, LP | 384,789 | $11.7M | 0.97% | −65,712−14.6% | Reduced |
| Nomura Holdings Inc | 372,480 | $11.3M | 0.07% | −4,268−1.1% | Reduced |
| Stifel Financial Corp | 357,948 | $10.9M | 0.01% | −18,271−4.9% | Reduced |
| International Biotechnology Trust PLC | 355,088 | $10.8M | 2.41% | +310,307+692.9% | Added |
| Nuveen Asset Management, LLC | 351,476 | $10.7M | 0.00% | −277,000−44.1% | Reduced |
| Barclays PLC | 329,938 | $10.0M | 0.01% | −353−0.1% | Reduced |
| Sio Capital Management, LLC | 322,566 | $9.82M | 2.99% | +322,566 | New |
| Baillie Gifford & Co | 315,820 | $9.61M | 0.01% | +13,817+4.6% | Added |
| BNP Paribas Arbitrage, SA | 306,253 | $9.32M | 0.02% | +280,521+1,090.2% | Added |
| Hudson Bay Capital Management LP | 305,000 | $9.28M | 0.10% | +40,000+15.1% | Added |
| Dowling & Yahnke LLC | 302,421 | $9.20M | 0.44% | −1000.0% | Reduced |
| Natixis | 300,797 | $9.15M | 0.03% | +300,797 | New |
| Cubist Systematic Strategies, LLC | 297,182 | $9.04M | 0.09% | +210,428+242.6% | Added |
| California Public Employees Retirement System | 284,424 | $8.65M | 0.01% | −3,704−1.3% | Reduced |
| Sicart Associates LLC | 282,531 | $8.63M | 2.25% | −8,723−3.0% | Reduced |
| Swiss National Bank | 279,300 | $8.50M | 0.01% | −600−0.2% | Reduced |
| Voloridge Investment Management, LLC | 266,845 | $8.12M | 0.04% | +266,845 | New |
| Raymond James & Associates | 257,985 | $7.85M | 0.01% | −43,464−14.4% | Reduced |
| Bank of Montreal | 229,407 | $7.17M | 0.00% | −20,297−8.1% | Reduced |
| Renaissance Technologies LLC | 230,814 | $7.02M | 0.01% | +133,100+136.2% | Added |
| Parametric Portfolio Associates LLC | 225,106 | $6.85M | 0.00% | −6,400−2.8% | Reduced |
| Morningstar Investment Services LLC | 219,432 | $6.68M | 0.07% | +5,291+2.5% | Added |
| Sector Gamma AS | 209,537 | $6.38M | 1.50% | −54,333−20.6% | Reduced |
| Susquehanna International Group, LLP | 204,255 | $6.21M | 0.01% | +30,089+17.3% | Added |
| MUFG Securities EMEA plc | 200,000 | $6.09M | 0.13% | +200,000 | New |
| Russell Investments Group, Ltd. | 194,145 | $5.91M | 0.01% | −37,720−16.3% | Reduced |
| UBS Group AG | 193,589 | $5.89M | 0.00% | +60,777+45.8% | Added |
| Balyasny Asset Management LLC | 193,120 | $5.88M | 0.03% | +51,105+36.0% | Added |
| Rafferty Asset Management, LLC | 189,639 | $5.77M | 0.03% | +92,902+96.0% | Added |
| Citigroup Inc | 186,047 | $5.66M | 0.01% | +64,983+53.7% | Added |
| California State Teachers Retirement System | 184,004 | $5.60M | 0.01% | −41,987−18.6% | Reduced |
| UBS Asset Management Americas Inc | 183,752 | $5.59M | 0.00% | +3,087+1.7% | Added |
| Pictet Asset Management SA | 183,087 | $5.57M | 0.01% | +47,391+34.9% | Added |
| Tudor Investment Corp Et Al | 178,386 | $5.43M | 0.10% | −23,227−11.5% | Reduced |
| Credit Suisse AG | 176,767 | $5.38M | 0.00% | −5,895−3.2% | Reduced |
| Majedie Asset Management Ltd | 175,508 | $5.35M | 0.41% | 00.0% | Unchanged |
| Tekla Capital Management LLC | 175,680 | $5.35M | 0.17% | −146,841−45.5% | Reduced |
| State Board of Administration of Florida Retirement System | 173,260 | $5.27M | 0.01% | +11,322+7.0% | Added |
| Tocqueville Asset Management L.P. | 170,405 | $5.18M | 0.07% | +1,875+1.1% | Added |
| Alps Advisors Inc | 163,424 | $4.97M | 0.06% | +163,424 | New |
| D. E. Shaw & Co., Inc. | 160,659 | $4.89M | 0.01% | +34,553+27.4% | Added |
| Legal & General Group Plc | 158,344 | $4.82M | 0.00% | −9,077−5.4% | Reduced |
| Sonora Investment Management Group, LLC | 156,790 | $4.77M | 0.55% | +156,790 | New |
| New York State Common Retirement Fund | 153,800 | $4.68M | 0.00% | −87,359−36.2% | Reduced |
| BLB&B Advisors, LLC | 150,935 | $4.59M | 0.30% | −5,265−3.4% | Reduced |
| Rhumbline Advisers | 139,749 | $4.25M | 0.01% | +1,386+1.0% | Added |
| Peregrine Capital Management LLC | 139,721 | $4.25M | 0.09% | +3,934+2.9% | Added |
| Invesco Ltd. | 132,242 | $4.02M | 0.00% | −9,113−6.4% | Reduced |
| Jump Financial, LLC | 120,500 | $3.67M | 0.23% | +120,500 | New |
| Private Advisor Group, LLC | 115,742 | $3.52M | 0.03% | +71,637+162.4% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 112,525 | $3.42M | 0.02% | +76,989+216.7% | Added |
| DekaBank Deutsche Girozentrale | 109,476 | $3.35M | 0.01% | +1,900+1.8% | Added |
| Wolverine Trading, LLC | 108,529 | $3.31M | 0.04% | +1,651+1.5% | Added |
| Alliancebernstein L.P. | 103,214 | $3.14M | 0.00% | +34,763+50.8% | Added |
| Allspring Global Investments Holdings, LLC | 98,574 | $3.00M | 0.00% | +98,574 | New |
| State of New Jersey Common Pension Fund D | 95,234 | $2.90M | 0.01% | +8,018+9.2% | Added |
| Envestnet Asset Management Inc | 91,292 | $2.78M | 0.00% | −11,130−10.9% | Reduced |
| LPL Financial LLC | 88,666 | $2.70M | 0.00% | +5,051+6.0% | Added |
| AXA S.A. | 87,900 | $2.67M | 0.01% | +30,700+53.7% | Added |
| Gateway Investment Advisers LLC | 85,103 | $2.59M | 0.02% | +46,971+123.2% | Added |
| Davenport & Co LLC | 84,663 | $2.58M | 0.02% | −37,640−30.8% | Reduced |
| Public Employees Retirement System of Ohio | 84,661 | $2.58M | 0.01% | −2,783−3.2% | Reduced |