Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 23,642,990 | $934.1M | 0.05% | +29,405+0.1% | Added |
| Vanguard Group Inc | 16,714,846 | $660.4M | 0.01% | +330,912+2.0% | Added |
| T. Rowe Price Investment Management, Inc. | 16,048,721 | $634.1M | 0.40% | −126,812−0.8% | Reduced |
| Capital World Investors | 12,540,188 | $495.5M | 0.07% | +178,194+1.4% | Added |
| BlackRock, Inc. | 10,896,937 | $430.5M | 0.01% | −367,505−3.3% | Reduced |
| Bellevue Group AG | 7,853,198 | $310.3M | 6.84% | 00.0% | Unchanged |
| Wellington Management Group LLP | 6,345,776 | $250.7M | 0.05% | −2,070,645−24.6% | Reduced |
| Deep Track Capital, LP | 4,891,544 | $193.3M | 6.21% | +327,337+7.2% | Added |
| State Street Corp | 4,530,398 | $179.0M | 0.01% | −314,735−6.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 3,800,000 | $150.1M | 0.25% | +2,724,400+253.3% | Added |
| Price T Rowe Associates Inc | 3,126,073 | $123.5M | 0.01% | −138,961−4.3% | Reduced |
| Tweedy, Browne Co LLC | 2,891,948 | $114.3M | 10.60% | −91,570−3.1% | Reduced |
| Geode Capital Management, LLC | 2,891,095 | $114.2M | 0.01% | +48,141+1.7% | Added |
| Two Sigma Advisers, LP | 2,667,611 | $105.4M | 0.22% | +575,600+27.5% | Added |
| Millennium Management LLC | 2,649,527 | $104.7M | 0.09% | +2,014,157+317.0% | Added |
| BVF Inc | 1,913,385 | $75.6M | 2.70% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 1,788,367 | $70.7M | 0.13% | +102,514+6.1% | Added |
| UBS Group AG | 1,529,323 | $60.4M | 0.01% | −361,279−19.1% | Reduced |
| Citadel Advisors LLC | 1,494,981 | $59.1M | 0.05% | −1,985,081−57.0% | Reduced |
| Charles Schwab Investment Management Inc | 1,487,818 | $58.8M | 0.01% | +44,189+3.1% | Added |
| Macquarie Group Ltd | 1,434,073 | $56.7M | 0.07% | −233,121−14.0% | Reduced |
| Morgan Stanley | 1,362,209 | $53.8M | 0.00% | +218,028+19.1% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,350,879 | $53.4M | 0.13% | +154,487+12.9% | Added |
| TD Asset Management Inc | 1,104,690 | $43.6M | 0.04% | +4,224+0.4% | Added |
| Polar Capital Holdings Plc | 1,000,000 | $39.5M | 0.21% | +1,000,000 | New |
| Bank of America Corp | 995,890 | $39.3M | 0.00% | +228,458+29.8% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 900,318 | $35.6M | 0.26% | −100,209−10.0% | Reduced |
| Voloridge Investment Management, LLC | 854,634 | $33.8M | 0.12% | +477,430+126.6% | Added |
| Northern Trust Corp | 814,250 | $32.2M | 0.00% | −20,597−2.5% | Reduced |
| Royal Bank of Canada | 799,912 | $31.6M | 0.01% | +183,831+29.8% | Added |
| UBS Asset Management Americas Inc | 791,072 | $31.3M | 0.01% | +131,637+20.0% | Added |
| Goldman Sachs Group Inc | 777,940 | $30.7M | 0.00% | +125,422+19.2% | Added |
| Balyasny Asset Management LLC | 768,648 | $30.4M | 0.07% | +768,648 | New |
| Hudson Bay Capital Management LP | 750,000 | $29.6M | 0.19% | −299,900−28.6% | Reduced |
| Woodline Partners LP | 732,813 | $29.0M | 0.15% | +732,813 | New |
| Candriam Luxembourg S.C.A. | 724,740 | $28.6M | 0.17% | −268,964−27.1% | Reduced |
| Groupama Asset Managment | 660,957 | $26.8M | 0.44% | +91,746+16.1% | Added |
| Teacher Retirement System of Texas | 668,273 | $26.4M | 0.11% | +167,822+33.5% | Added |
| Pictet Asset Management Holding SA | 608,640 | $24.2M | 0.02% | −9,910−1.6% | Reduced |
| Eversept Partners, LP | 588,900 | $23.3M | 2.34% | +71,879+13.9% | Added |
| Barclays PLC | 583,266 | $23.0M | 0.01% | +229,329+64.8% | Added |
| AXA S.A. | 566,883 | $22.4M | 0.06% | +397+0.1% | Added |
| Bank of New York Mellon Corp | 527,188 | $20.8M | 0.00% | −17,445−3.2% | Reduced |
| Massachusetts Financial Services Co | 519,184 | $20.5M | 0.01% | +519,184 | New |
| Great Point Partners LLC | 500,000 | $19.8M | 12.84% | +250,000+100.0% | Added |
| Vestal Point Capital, LP | 500,000 | $19.8M | 1.04% | +500,000 | New |
| Pinnacle Associates Ltd | 494,539 | $19.5M | 0.28% | −113,978−18.7% | Reduced |
| Bank of Montreal | 483,289 | $19.1M | 0.01% | −299,546−38.3% | Reduced |
| American Century Companies Inc | 472,749 | $18.7M | 0.01% | +355,981+304.9% | Added |
| Norges Bank | 450,254 | $17.8M | 0.00% | −407,974−47.5% | Reduced |
| C WorldWide Group Holding A/S | 450,000 | $17.8M | 0.24% | +50,000+12.5% | Added |
| Schonfeld Strategic Advisors LLC | 449,206 | $17.7M | 0.13% | −111,153−19.8% | Reduced |
| GW&K Investment Management, LLC | 448,830 | $17.7M | 0.16% | +266,521+146.2% | Added |
| Standard Life Aberdeen plc | 406,694 | $16.2M | 0.03% | −39,503−8.9% | Reduced |
| Legal & General Group Plc | 404,366 | $16.0M | 0.00% | +65,904+19.5% | Added |
| Great Lakes Advisors, LLC | 399,646 | $15.8M | 0.13% | +399,646 | New |
| JPMorgan Chase & Co | 394,978 | $15.6M | 0.00% | −26,533−6.3% | Reduced |
| Ameriprise Financial Inc | 368,119 | $14.5M | 0.00% | +7,931+2.2% | Added |
| Artisan Partners Limited Partnership | 354,962 | $14.0M | 0.02% | +151,784+74.7% | Added |
| Citigroup Inc | 340,977 | $13.5M | 0.01% | −85,503−20.0% | Reduced |
| Sovran Advisors, LLC | 321,913 | $13.3M | 1.39% | −6,991−2.1% | Reduced |
| Point72 Asset Management, L.P. | 292,647 | $11.6M | 0.03% | +5,443+1.9% | Added |
| Swiss National Bank | 288,600 | $11.4M | 0.01% | +13,300+4.8% | Added |
| Sector Gamma AS | 285,842 | $11.3M | 3.69% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 270,714 | $10.7M | 0.01% | +117,200+76.3% | Added |
| Privium Fund Management B.V. | 267,594 | $10.7M | 2.31% | 00.0% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. | 265,793 | $10.5M | 0.04% | +136,520+105.6% | Added |
| Invesco Ltd. | 256,235 | $10.1M | 0.00% | −618,599−70.7% | Reduced |
| Nuveen, LLC | 245,085 | $9.68M | 0.00% | −63,692−20.6% | Reduced |
| CI Private Wealth, LLC | 237,840 | $9.40M | 0.01% | +707+0.3% | Added |
| Verition Fund Management LLC | 232,687 | $9.19M | 0.05% | +180,400+345.0% | Added |
| Orion Investment Co | 217,370 | $8.59M | 3.06% | +2,080+1.0% | Added |
| Raymond James Financial Inc | 210,592 | $8.32M | 0.00% | +61,902+41.6% | Added |
| Wells Fargo & Company | 209,857 | $8.29M | 0.00% | −46,376−18.1% | Reduced |
| California Public Employees Retirement System | 201,993 | $7.98M | 0.01% | +10,989+5.8% | Added |
| Edmond de Rothschild Holding S.A. | 197,600 | $7.81M | 0.12% | +73,400+59.1% | Added |
| Stifel Financial Corp | 196,357 | $7.76M | 0.01% | −4,585−2.3% | Reduced |
| Tocqueville Asset Management L.P. | 187,345 | $7.40M | 0.11% | −500.0% | Reduced |
| Sicart Associates LLC | 185,296 | $7.32M | 2.56% | −350−0.2% | Reduced |
| Rhenman & Partners Asset Management AB | 182,000 | $7.19M | 0.91% | +101,000+124.7% | Added |
| Rhumbline Advisers | 181,599 | $7.17M | 0.01% | −6,617−3.5% | Reduced |
| BNP Paribas Arbitrage, SA | 177,762 | $7.02M | 0.01% | −130,531−42.3% | Reduced |
| Sonora Investment Management Group, LLC | 163,172 | $6.45M | 0.48% | +9,025+5.9% | Added |
| Alyeska Investment Group, L.P. | 159,008 | $6.28M | 0.02% | +159,008 | New |
| Aquatic Capital Management LLC | 158,086 | $6.25M | 0.13% | +1,929+1.2% | Added |
| State Board of Administration of Florida Retirement System | 153,895 | $6.08M | 0.01% | +1,580+1.0% | Added |
| BLB&B Advisors, LLC | 151,550 | $5.99M | 0.28% | −650−0.4% | Reduced |
| Tang Capital Management LLC | 150,000 | $5.93M | 0.30% | 00.0% | Unchanged |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 149,839 | $5.92M | 0.01% | +5,969+4.1% | Added |
| ADAR1 Capital Management, LLC | 148,461 | $5.87M | 0.95% | +148,461 | New |
| J. Goldman & Co LP | 147,682 | $5.83M | 0.18% | −160,088−52.0% | Reduced |
| California State Teachers Retirement System | 145,104 | $5.73M | 0.01% | +12,866+9.7% | Added |
| Rafferty Asset Management, LLC | 144,770 | $5.72M | 0.02% | −31,478−17.9% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 139,739 | $5.52M | 0.00% | −2,694−1.9% | Reduced |
| Nikko Asset Management Americas, Inc. | 139,739 | $5.52M | 0.06% | −2,694−1.9% | Reduced |
| Squarepoint Ops LLC | 134,395 | $5.31M | 0.01% | −170,978−56.0% | Reduced |
| Kennedy Capital Management, Inc. | 132,045 | $5.22M | 0.12% | −18,379−12.2% | Reduced |
| Trexquant Investment LP | 128,869 | $5.09M | 0.06% | +128,869 | New |
| Exome Asset Management LLC | 121,116 | $4.79M | 3.95% | −14,500−10.7% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 116,000 | $4.58M | 0.01% | +116,000 | New |