Ionis Pharmaceuticals Inc

IONS

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0000874015

SEC filings (opens in a new tab)

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

Q2 2025 vs. Q1 2025

How the institutions holding Ionis Pharmaceuticals Inc changed between Q1 2025 and Q2 2025.

All holders in Q2 2025 All holders in Q1 2025

13F holders of IONS: Q1 2025 compared with Q2 2025
Measure	Q1 2025	Of which not filed for Q2 2025	Q2 2025	Change
Holders	344	2	363	+21
Shares	166.7M	7.15K	168.9M	+2.14M (+1.3%)
Value	$5.03B	$216.3K	$6.67B	+$1.64B (+32.6%)

2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (80)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q2 2025 but not at the end of Q1 2025.

Institutions new to IONS in Q2 2025
Institution	Shares	Value	% of portfolio
Polar Capital Holdings Plc	1,000,000	$39.5M	0.21%
Balyasny Asset Management LLC	768,648	$30.4M	0.07%
Woodline Partners LP	732,813	$29.0M	0.15%
Massachusetts Financial Services Co	519,184	$20.5M	0.01%
Vestal Point Capital, LP	500,000	$19.8M	1.04%
Great Lakes Advisors, LLC	399,646	$15.8M	0.13%
Alyeska Investment Group, L.P.	159,008	$6.28M	0.02%
ADAR1 Capital Management, LLC	148,461	$5.87M	0.95%
Trexquant Investment LP	128,869	$5.09M	0.06%
Healthcare of Ontario Pension Plan Trust Fund	116,000	$4.58M	0.01%
Superstring Capital Management LP	98,267	$3.88M	4.84%
Susquehanna Portfolio Strategies, LLC	92,900	$3.67M	0.08%
Marex Group plc	83,361	$3.29M	0.06%
Worldquant Millennium Advisors LLC	74,438	$2.94M	0.01%
First Trust Advisors LP	56,519	$2.23M	0.00%
Algert Global LLC	38,090	$1.50M	0.03%
Y-Intercept (Hong Kong) Ltd	37,649	$1.49M	0.04%
Engineers Gate Manager LP	33,118	$1.31M	0.02%
One Capital Management, LLC	29,865	$1.18M	0.04%
Future Fund LLC	29,595	$1.17M	0.52%
Entropy Technologies, LP	29,452	$1.16M	0.09%
Oxford Asset Management LLP	22,405	$885.2K	0.29%
Graham Capital Management, L.P.	20,935	$827.1K	0.03%
Assenagon Asset Management S.A.	17,654	$697.5K	0.00%
Fieldview Capital Management, LLC	17,306	$683.8K	0.10%
Corton Capital Inc.	14,424	$569.9K	0.66%
Vestmark Advisory Solutions, Inc.	14,341	$566.6K	0.01%
Gotham Asset Management, LLC	14,279	$564.2K	0.00%
Paloma Partners Management Co	12,557	$496.1K	0.11%
DnB Asset Management AS	12,271	$484.8K	0.00%
Vident Advisory, LLC	12,000	$474.1K	0.01%
Fox Run Management, L.L.C.	10,988	$434.1K	0.07%
Westfield Capital Management Co LP	9,561	$377.8K	0.00%
Perbak Capital Partners LLP	9,538	$376.8K	0.09%
Fred Alger Management, LLC	9,464	$373.9K	0.00%
Wealth Enhancement Advisory Services, LLC	7,915	$340.3K	0.00%
Aigen Investment Management, LP	8,298	$327.9K	0.04%
Atria Investments LLC	8,186	$323.4K	0.00%
M&T Bank Corp	7,651	$303.0K	0.00%
Jacobs Levy Equity Management, Inc	6,813	$269.2K	0.00%
Meeder Advisory Services, Inc.	6,644	$262.5K	0.01%
Frank, Rimerman Advisors LLC	5,763	$227.7K	0.02%
Wedmont Private Capital	5,282	$226.2K	0.01%
Brinker Capital Investments, LLC	5,600	$221.3K	0.00%
Savant Capital, LLC	5,570	$220.1K	0.00%
Franklin Resources Inc	5,556	$219.5K	0.00%
Castle Rock Wealth Management, LLC	5,122	$215.2K	0.05%
Callan Family Office, LLC	5,400	$213.4K	0.01%
HighTower Advisors, LLC	5,357	$211.7K	0.00%
Pinnacle Wealth Planning Services, Inc.	5,284	$208.8K	0.03%
Empowered Funds, LLC	5,067	$200.2K	0.00%
Wexford Capital LP	4,749	$187.6K	0.05%
STRS Ohio	3,714	$146.7K	0.00%
Allianz SE	2,100	$83.0K	0.00%
Harvest Fund Management Co., Ltd	1,829	$72.0K	0.00%
Capital Advisors, Ltd. LLC	295	$12.0K	0.00%
Global X Japan Co., Ltd.	259	$10.2K	0.00%
MTM Investment Management, LLC	258	$10.2K	0.00%
Westside Investment Management, Inc.	231	$9.23K	0.00%
Twin Peaks Wealth Advisors, LLC	215	$8.90K	0.00%
Atlantic Union Bankshares Corp	200	$7.90K	0.00%
Ameritas Advisory Services, LLC	146	$5.77K	0.00%
Geneos Wealth Management Inc.	139	$5.49K	0.00%
WPG Advisers, LLC	70	$2.77K	0.00%
Asset Dedication, LLC	59	$2.33K	0.00%
TD Private Client Wealth LLC	44	$1.74K	0.00%
Rossby Financial, LCC	34	$1.34K	0.00%
Hantz Financial Services, Inc.	36	$1.00K	0.00%
Principia Wealth Advisory, LLC	25	$988	0.00%
Cromwell Holdings LLC	18	$711	0.00%
Fortitude Family Office, LLC	17	$672	0.00%
Global Retirement Partners, LLC	16	$632	0.00%
Horizon Investments, LLC	15	$593	0.00%
Quaker Wealth Management, LLC	14	$554	0.00%
Cornerstone Planning Group LLC	12	$517	0.00%
Rothschild Investment LLC	10	$395	0.00%
Parkworth Wealth Management, Inc.	8	$316	0.00%
Kayne Anderson Rudnick Investment Management LLC	7	$277	0.00%
IMA Wealth, Inc.	5	$198	0.00%
WealthTrak Capital Management LLC	5	$198	0.00%

Sold out (59)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q1 2025 and filed for Q2 2025 without it.

Institutions that sold out of IONS in Q2 2025
Institution	Shares, Q1 2025	Value, Q1 2025
OrbiMed Advisors LLC	2,540,136	$76.6M
Camber Capital Management LP	725,000	$21.9M
Baker Bros. Advisors LP	357,915	$10.8M
Susquehanna Fundamental Investments, LLC	158,609	$4.79M
Susquehanna International Group, LLP	71,811	$2.17M
Sphera Funds Management Ltd.	63,821	$1.93M
Avidity Partners Management LP	60,000	$1.81M
Jane Street Group, LLC	54,117	$1.63M
Readystate Asset Management LP	46,394	$1.40M
Allostery Investments LP	35,000	$1.06M
Private Advisor Group, LLC	34,531	$1.04M
Liontrust Investment Partners LLP	30,390	$916.9K
Axq Capital, LP	30,104	$908.2K
ExodusPoint Capital Management, LP	26,261	$792.0K
HRT Financial LP	25,824	$779.0K
BlueCrest Capital Management Ltd	24,800	$748.2K
Castle Hook Partners LP	23,940	$722.3K
Toroso Investments, LLC	21,833	$658.7K
Bridgefront Capital, LLC	20,528	$619.3K
SG Americas Securities, LLC	20,050	$605.0K
NBT Bank N A	17,050	$514.4K
Virginia Retirement Systems Et Al	16,522	$498.5K
Twinbeech Capital LP	15,938	$480.8K
Point72 Hong Kong Ltd	12,862	$388.0K
XTX Topco Ltd	12,404	$374.2K
Intech Investment Management LLC	12,207	$368.3K
SIH Partners, LLLP	11,999	$362.0K
FORA Capital, LLC	11,570	$349.1K
Twin Tree Management, LP	11,385	$343.5K
Capula Management Ltd	10,382	$313.2K
Walleye Trading LLC	9,361	$282.4K
Amundi	3,873	$110.5K
Quarry LP	3,000	$90.5K
Corebridge Financial, Inc.	2,657	$80.2K
Sandia Investment Management LP	2,500	$75.4K
Coldstream Capital Management Inc	2,345	$70.8K
Point72 Asia (Singapore) Pte. Ltd.	2,082	$62.8K
Laurel Wealth Advisors LLC	600	$18.1K
Riverview Trust Co	476	$14.4K
Mather Group, LLC.	410	$12.4K
Quadrant Capital Group LLC	381	$11.5K
Oakworth Capital, Inc.	300	$9.05K
Ronald Blue Trust, Inc.	259	$7.81K
Newbridge Financial Services Group, Inc.	200	$6.03K
Whittier Trust Co	192	$5.79K
Smartleaf Asset Management LLC	131	$4.08K
Anderson Financial Strategies, LLC	121	$3.65K
First Horizon Advisors, Inc.	112	$3.38K
Picton Mahoney Asset Management	89	$3.00K
Dynamic Wealth Strategies, LLC	80	$2.41K
Blume Capital Management, Inc.	55	$1.66K
Quent Capital, LLC	53	$1.60K
Wolff Wiese Magana LLC	41	$1.24K
Avion Wealth	54	$1.00K
Caitong International Asset Management Co., Ltd	28	$845
Bokf, NA	18	$543
Hexagon Capital Partners LLC	9	$272
Umb Bank N A	6	$181
MV Capital Management, Inc.	3	$91

Not filed for Q2 2025 yet (2)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q1 2025 and haven't filed a 13F for Q2 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding IONS in Q1 2025 that haven't filed for Q2 2025
Institution	Shares, Q1 2025	Value, Q1 2025
Tanaka Capital Management Inc	6,714	$203.0K
Lindbrook Capital, LLC	440	$13.3K