Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 24,631,956 | $1.95B | 0.08% | +75,319+0.3% | Added |
| Capital World Investors | 21,669,226 | $1.72B | 0.20% | +482,857+2.3% | Added |
| BlackRock, Inc. | 10,704,660 | $848.8M | 0.01% | +262,184+2.5% | Added |
| Vanguard Portfolio Management LLC | 7,859,529 | $623.2M | 0.03% | +50,627+0.6% | Added |
| Wellington Management Group LLP | 7,651,415 | $606.7M | 0.10% | +1,259,599+19.7% | Added |
| Vanguard Capital Management LLC | 7,211,497 | $571.8M | 0.01% | +93,167+1.3% | Added |
| Two Sigma Investments, LP | 6,252,342 | $495.7M | 0.37% | +394,713+6.7% | Added |
| Royal Bank of Canada | 6,182,479 | $490.2M | 0.08% | +2,380,664+62.6% | Added |
| State Street Corp | 4,334,848 | $343.7M | 0.01% | +339,284+8.5% | Added |
| T. Rowe Price Investment Management, Inc. | 3,959,372 | $313.9M | 0.21% | −2,199,655−35.7% | Reduced |
| Geode Capital Management, LLC | 3,584,024 | $294.8M | 0.02% | −400,308−10.0% | Reduced |
| Price T Rowe Associates Inc | 3,184,500 | $252.5M | 0.03% | +159,249+5.3% | Added |
| JPMorgan Chase & Co | 2,671,717 | $216.2M | 0.01% | +308,150+13.0% | Added |
| Artisan Partners Limited Partnership | 2,640,024 | $209.3M | 0.34% | +581,716+28.3% | Added |
| Tweedy, Browne Co LLC | 2,280,311 | $180.8M | 13.70% | +4,686+0.2% | Added |
| Deep Track Capital, LP | 2,200,000 | $174.4M | 2.57% | +250,000+12.8% | Added |
| Goldman Sachs Group Inc | 2,109,945 | $167.3M | 0.02% | +410,098+24.1% | Added |
| Baker Bros. Advisors LP | 2,047,727 | $162.4M | 0.81% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $157.0M | 1.64% | 00.0% | Unchanged |
| American Century Companies Inc | 1,947,076 | $154.4M | 0.07% | +283,273+17.0% | Added |
| Franklin Resources Inc | 1,623,377 | $128.7M | 0.03% | +48,354+3.1% | Added |
| Charles Schwab Investment Management Inc | 1,605,054 | $127.3M | 0.02% | +21,788+1.4% | Added |
| Barclays PLC | 1,603,136 | $127.1M | 0.04% | +1,313,262+453.0% | Added |
| Pictet Asset Management Holding SA | 1,596,998 | $127.0M | 0.12% | +162,003+11.3% | Added |
| UBS Asset Management Americas Inc | 1,454,672 | $115.3M | 0.02% | −20,960−1.4% | Reduced |
| Polar Capital Holdings Plc | 1,454,021 | $115.3M | 0.33% | +624,510+75.3% | Added |
| Alyeska Investment Group, L.P. | 1,417,916 | $112.4M | 0.29% | +944,766+199.7% | Added |
| Nomura Asset Management International Inc. | 1,300,392 | $103.1M | 0.15% | +515,111+65.6% | Added |
| Morgan Stanley | 1,281,444 | $101.6M | 0.01% | +254,935+24.8% | Added |
| Invesco Ltd. | 1,120,707 | $88.9M | 0.01% | −156,651−12.3% | Reduced |
| Vanguard Fiduciary Trust Co | 1,060,845 | $84.1M | 0.02% | +36,468+3.6% | Added |
| Bellevue Group AG | 972,258 | $77.1M | 1.62% | −846,407−46.5% | Reduced |
| Groupama Asset Managment | 937,083 | $75.2M | 0.95% | +112,543+13.6% | Added |
| Northern Trust Corp | 913,610 | $72.4M | 0.01% | +45,431+5.2% | Added |
| Capital International Investors | 823,764 | $65.3M | 0.01% | +823,764 | New |
| Davern Capital Partners, LP | 798,709 | $63.3M | 10.80% | +411,806+106.4% | Added |
| Bank of America Corp | 790,990 | $62.7M | 0.00% | −49,608−5.9% | Reduced |
| Summit Partners Public Asset Management, LLC | 787,263 | $62.4M | 1.62% | −616,770−43.9% | Reduced |
| GW&K Investment Management, LLC | 746,966 | $59.2M | 0.46% | −32,383−4.2% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 734,219 | $58.2M | 0.06% | −173,314−19.1% | Reduced |
| Nuveen, LLC | 726,282 | $57.6M | 0.01% | +77,786+12.0% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 684,236 | $54.3M | 0.10% | −189,853−21.7% | Reduced |
| Eversept Partners, LP | 664,684 | $52.7M | 2.87% | +32,584+5.2% | Added |
| Voloridge Investment Management, LLC | 655,454 | $52.0M | 0.22% | −17,404−2.6% | Reduced |
| Massachusetts Financial Services Co | 651,816 | $51.7M | 0.02% | −14,300−2.1% | Reduced |
| Neuberger Berman Group LLC | 633,533 | $50.2M | 0.03% | +190,261+42.9% | Added |
| Arrowstreet Capital, Limited Partnership | 632,028 | $50.1M | 0.02% | −105,831−14.3% | Reduced |
| UBS Group AG | 624,874 | $49.5M | 0.01% | −183,569−22.7% | Reduced |
| TimesSquare Capital Management, LLC | 614,070 | $48.7M | 0.72% | +338,396+122.8% | Added |
| Eventide Asset Management, LLC | 575,000 | $45.6M | 0.61% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 566,000 | $44.9M | 0.70% | +62,000+12.3% | Added |
| Renaissance Technologies LLC | 559,414 | $44.4M | 0.06% | +253,865+83.1% | Added |
| Bank of New York Mellon Corp | 542,454 | $43.0M | 0.01% | +27,837+5.4% | Added |
| Teacher Retirement System of Texas | 522,317 | $41.4M | 0.11% | −1,615−0.3% | Reduced |
| Boone Capital Management LLC | 519,977 | $41.2M | 9.64% | +19,455+3.9% | Added |
| Jane Street Group, LLC | 503,647 | $39.9M | 0.03% | +311,829+162.6% | Added |
| New York State Common Retirement Fund | 500,050 | $39.6M | 0.05% | +149,636+42.7% | Added |
| BNP Paribas Arbitrage, SA | 454,649 | $36.0M | 0.02% | −24,811−5.2% | Reduced |
| Candriam Luxembourg S.C.A. | 445,019 | $35.3M | 0.16% | −39,034−8.1% | Reduced |
| First Trust Advisors LP | 427,197 | $33.9M | 0.02% | −41,166−8.8% | Reduced |
| Pinnacle Associates Ltd | 419,752 | $33.3M | 0.36% | −16,705−3.8% | Reduced |
| Nomura Holdings Inc | 402,192 | $31.9M | 0.13% | +288,112+252.6% | Added |
| Handelsbanken Fonder AB | 383,211 | $30.4M | 0.09% | +169,300+79.1% | Added |
| C WorldWide Group Holding A/S | 366,000 | $29.0M | 0.70% | 00.0% | Unchanged |
| TD Asset Management Inc | 340,548 | $27.0M | 0.02% | −189,406−35.7% | Reduced |
| Freestone Grove Partners LP | 339,967 | $27.0M | 0.18% | +339,967 | New |
| Qube Research & Technologies Ltd | 333,952 | $26.5M | 0.03% | +291,096+679.2% | Added |
| Capital Research Global Investors | 331,936 | $26.3M | 0.00% | +8,921+2.8% | Added |
| Capital Fund Management S.A. | 329,554 | $26.1M | 0.19% | +187,353+131.8% | Added |
| Alliancebernstein L.P. | 340,450 | $25.6M | 0.01% | −60,219−15.0% | Reduced |
| Carmignac Gestion | 321,000 | $25.5M | 0.33% | +268,000+505.7% | Added |
| Privium Fund Management B.V. | 319,924 | $25.4M | 4.66% | +29,900+10.3% | Added |
| Swiss National Bank | 315,000 | $25.0M | 0.01% | +10,500+3.4% | Added |
| Jump Financial, LLC | 306,330 | $24.3M | 0.22% | +99,655+48.2% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 300,770 | $23.8M | 0.15% | +12,054+4.2% | Added |
| Legal & General Group Plc | 299,184 | $23.7M | 0.00% | +4,505+1.5% | Added |
| D. E. Shaw & Co., Inc. | 297,041 | $23.6M | 0.01% | −132,558−30.9% | Reduced |
| Millennium Management LLC | 288,872 | $22.9M | 0.02% | −762,634−72.5% | Reduced |
| Davenport & Co LLC | 283,960 | $22.5M | 0.11% | +45,722+19.2% | Added |
| Standard Life Aberdeen plc | 277,400 | $22.0M | 0.03% | +163,557+143.7% | Added |
| California Public Employees Retirement System | 270,843 | $21.5M | 0.01% | +15,358+6.0% | Added |
| Tocqueville Asset Management L.P. | 251,215 | $19.9M | 0.26% | +31,995+14.6% | Added |
| Raymond James Financial Inc | 237,348 | $18.8M | 0.01% | +2,227+0.9% | Added |
| Citadel Advisors LLC | 236,284 | $18.7M | 0.01% | −706,250−74.9% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 233,499 | $18.5M | 0.03% | +13,847+6.3% | Added |
| Wells Fargo & Company | 226,213 | $17.9M | 0.00% | +36,360+19.2% | Added |
| Empowered Funds, LLC | 223,142 | $17.7M | 0.09% | +120,001+116.3% | Added |
| Orion Investment Co | 220,335 | $17.5M | 5.12% | −4,680−2.1% | Reduced |
| Life Cycle Investment Partners Ltd | 219,896 | $17.4M | 0.08% | +219,896 | New |
| Algert Global LLC | 206,853 | $16.4M | 0.19% | +90,290+77.5% | Added |
| Stifel Financial Corp | 202,983 | $16.1M | 0.01% | +6,280+3.2% | Added |
| CI Private Wealth, LLC | 196,661 | $15.6M | 0.02% | +620.0% | Added |
| Eagle Health Investments LP | 194,577 | $15.4M | 2.56% | +194,577 | New |
| HSBC Holdings PLC | 188,402 | $15.0M | 0.01% | +2,435+1.3% | Added |
| Sector Gamma AS | 189,468 | $15.0M | 3.26% | +20,000+11.8% | Added |
| California State Teachers Retirement System | 180,949 | $14.3M | 0.01% | +4,464+2.5% | Added |
| Polymer Capital Management (HK) LTD | 177,897 | $14.1M | 1.43% | +116,697+190.7% | Added |
| Deutsche Bank AG | 169,614 | $13.4M | 0.00% | +9,723+6.1% | Added |
| ADAR1 Capital Management, LLC | 166,286 | $13.2M | 0.62% | +5,948+3.7% | Added |
| Rhumbline Advisers | 164,911 | $13.1M | 0.01% | −8,529−4.9% | Reduced |