Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sicart Associates LLC | 160,694 | $12.7M | 3.12% | +1,282+0.8% | Added |
| HRT Financial LP | 156,798 | $12.4M | 0.02% | −95,452−37.8% | Reduced |
| Vanguard Asset Management, Ltd | 155,088 | $12.3M | 0.01% | +17,581+12.8% | Added |
| CSS LLC | 152,289 | $12.1M | 0.54% | +73,196+92.5% | Added |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 151,301 | $12.0M | 0.01% | −16,356−9.8% | Reduced |
| Adage Capital Partners GP, L.L.C. | 150,000 | $11.9M | 0.02% | +100,000+200.0% | Added |
| Colony Group, LLC | 147,917 | $11.7M | 0.01% | −17,627−10.6% | Reduced |
| Hudson Bay Capital Management LP | 145,000 | $11.5M | 0.05% | −150,100−50.9% | Reduced |
| Artia Global Partners LP | 144,376 | $11.4M | 2.18% | 00.0% | Unchanged |
| Fisher Asset Management, LLC | 137,184 | $10.9M | 0.00% | −4,360−3.1% | Reduced |
| HealthInvest Partners AB | 137,131 | $10.9M | 2.93% | +109,258+392.0% | Added |
| Lazard Asset Management LLC | 132,480 | $10.5M | 0.02% | +107,070+421.4% | Added |
| State Board of Administration of Florida Retirement System | 131,818 | $10.5M | 0.02% | −4,060−3.0% | Reduced |
| SEI Investments Co | 127,868 | $10.1M | 0.01% | −29,354−18.7% | Reduced |
| EFG International AG | 122,804 | $9.74M | 0.18% | +28,824+30.7% | Added |
| Gotham Asset Management, LLC | 121,252 | $9.61M | 0.02% | +22,284+22.5% | Added |
| Manufacturers Life Insurance Company, The | 120,678 | $9.57M | 0.01% | −28,860−19.3% | Reduced |
| Braidwell LP | 116,762 | $9.26M | 0.34% | −14,100−10.8% | Reduced |
| Norges Bank | 114,359 | $9.07M | 0.00% | +114,359 | New |
| SEB Asset Management AB | 114,334 | $9.07M | 0.03% | 00.0% | Unchanged |
| Edmond de Rothschild Holding S.A. | 113,320 | $8.99M | 0.12% | −23,870−17.4% | Reduced |
| Squarepoint Ops LLC | 109,379 | $8.67M | 0.02% | −585,897−84.3% | Reduced |
| Kennedy Capital Management, Inc. | 106,342 | $8.43M | 0.15% | −5,488−4.9% | Reduced |
| Envestnet Asset Management Inc | 98,124 | $7.78M | 0.00% | +4,742+5.1% | Added |
| Polygon Management Ltd. | 97,173 | $7.70M | 1.25% | +55,409+132.7% | Added |
| Swedbank AB | 95,666 | $7.59M | 0.01% | +63,413+196.6% | Added |
| State of Wisconsin Investment Board | 94,492 | $7.49M | 0.02% | −1,999−2.1% | Reduced |
| Public Employees Retirement Association of Colorado | 90,589 | $7.18M | 0.02% | +75,000+481.1% | Added |
| CenterBook Partners LP | 89,280 | $7.08M | 0.35% | −61,632−40.8% | Reduced |
| Exome Asset Management LLC | 88,177 | $6.99M | 4.31% | −21,887−19.9% | Reduced |
| Citigroup Inc | 86,746 | $6.88M | 0.00% | −59,795−40.8% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $6.78M | 0.01% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 84,748 | $6.72M | 0.00% | −182,467−68.3% | Reduced |
| Russell Investments Group, Ltd. | 81,319 | $6.45M | 0.01% | +18,400+29.2% | Added |
| Fred Alger Management, LLC | 78,932 | $6.26M | 0.02% | +50,480+177.4% | Added |
| China Universal Asset Management Co., Ltd. | 76,302 | $6.05M | 0.36% | −1,013−1.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 75,061 | $5.95M | 0.04% | +7,738+11.5% | Added |
| SG Americas Securities, LLC | 74,589 | $5.91M | 0.00% | +11,294+17.8% | Added |
| Erste Asset Management GmbH | 71,800 | $5.79M | 0.05% | 00.0% | Unchanged |
| Future Fund LLC | 71,362 | $5.66M | 1.62% | +12,630+21.5% | Added |
| Hillsdale Investment Management Inc. | 70,900 | $5.62M | 0.13% | 00.0% | Unchanged |
| Treasurer of the State of North Carolina | 70,021 | $5.55M | 0.01% | +2,320+3.4% | Added |
| Bank of Nova Scotia | 68,548 | $5.44M | 0.01% | +68,548 | New |
| Jupiter Topco LLC | 68,191 | $5.41M | 0.00% | +68,191 | New |
| Ameriprise Financial Inc | 67,705 | $5.37M | 0.00% | −592,439−89.7% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 67,374 | $5.34M | 0.11% | +67,374 | New |
| Great Lakes Advisors, LLC | 66,924 | $5.31M | 0.04% | −52,002−43.7% | Reduced |
| Voya Investment Management LLC | 66,303 | $5.26M | 0.00% | −2,833−4.1% | Reduced |
| Victory Capital Management Inc | 65,967 | $5.23M | 0.00% | −42,777−39.3% | Reduced |
| Vanguard Global Advisers, LLC | 65,858 | $5.22M | 0.00% | −6,053−8.4% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 65,077 | $5.16M | 0.01% | +4,838+8.0% | Added |
| Quantinno Capital Management LP | 64,914 | $5.15M | 0.01% | +9,412+17.0% | Added |
| Van Eck Associates Corp | 63,396 | $5.03M | 0.00% | +28,891+83.7% | Added |
| Thrivent Financial for Lutherans | 62,743 | $4.97M | 0.01% | +52,781+529.8% | Added |
| Panagora Asset Management Inc | 61,125 | $4.85M | 0.01% | +3,679+6.4% | Added |
| Stanley-Laman Group, Ltd. | 60,842 | $4.82M | 0.49% | +21,536+54.8% | Added |
| XTX Topco Ltd | 60,776 | $4.82M | 0.06% | −19,743−24.5% | Reduced |
| Schroder Investment Management Group | 58,865 | $4.75M | 0.00% | +58,865 | New |
| Rhenman & Partners Asset Management AB | 59,900 | $4.75M | 0.45% | −33,000−35.5% | Reduced |
| Sovran Advisors, LLC | 84,984 | $4.70M | 0.35% | +84,984 | New |
| Edgestream Partners, L.P. | 56,715 | $4.50M | 0.13% | −11,654−17.0% | Reduced |
| One Capital Management, LLC | 58,939 | $4.43M | 0.12% | 00.0% | Unchanged |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 53,795 | $4.27M | 0.13% | −474−0.9% | Reduced |
| Nicola Wealth Management Ltd. | 52,000 | $4.12M | 0.47% | 00.0% | Unchanged |
| KBC Group NV | 51,127 | $4.05M | 0.01% | +20,914+69.2% | Added |
| State of New Jersey Common Pension Fund D | 50,743 | $4.02M | 0.01% | −1,845−3.5% | Reduced |
| Creative Planning | 50,554 | $4.01M | 0.00% | −1,674−3.2% | Reduced |
| Campbell & CO Investment Adviser LLC | 49,632 | $3.94M | 0.21% | +46,531+1,500.5% | Added |
| Capital Counsel LLC | 49,580 | $3.93M | 0.15% | 00.0% | Unchanged |
| Toroso Investments, LLC | 49,178 | $3.90M | 0.01% | +14,746+42.8% | Added |
| Worldquant Millennium Advisors LLC | 48,976 | $3.88M | 0.01% | +21,052+75.4% | Added |
| Jones Financial Companies LLLP | 47,442 | $3.85M | 0.00% | +20,719+77.5% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 47,836 | $3.79M | 0.00% | −34,040−41.6% | Reduced |
| Nikko Asset Management Americas, Inc. | 47,656 | $3.78M | 0.05% | −34,040−41.7% | Reduced |
| Public Employees Retirement System of Ohio | 46,862 | $3.72M | 0.01% | +832+1.8% | Added |
| Natixis Advisors, L.P. | 44,728 | $3.55M | 0.00% | +21,007+88.6% | Added |
| Arizona State Retirement System | 43,302 | $3.43M | 0.02% | +1,036+2.5% | Added |
| Aquatic Capital Management LLC | 42,581 | $3.38M | 0.12% | −104,798−71.1% | Reduced |
| Guggenheim Capital LLC | 41,405 | $3.28M | 0.02% | −2,645−6.0% | Reduced |
| Assenagon Asset Management S.A. | 40,927 | $3.25M | 0.00% | +7,254+21.5% | Added |
| J. Goldman & Co LP | 40,366 | $3.20M | 0.11% | −194,894−82.8% | Reduced |
| Jefferies Financial Group Inc. | 38,665 | $3.07M | 0.03% | −20,400−34.5% | Reduced |
| Exchange Traded Concepts, LLC | 38,627 | $3.06M | 0.02% | +4,686+13.8% | Added |
| Vanguard Investments Australia, Ltd. | 38,557 | $3.06M | 0.01% | 00.0% | Unchanged |
| STRS Ohio | 38,166 | $3.03M | 0.01% | +9,384+32.6% | Added |
| Rafferty Asset Management, LLC | 37,648 | $2.99M | 0.01% | −22,660−37.6% | Reduced |
| DCF Advisers, LLC | 37,500 | $2.97M | 0.78% | −18,500−33.0% | Reduced |
| Grandfield & Dodd, LLC | 37,077 | $2.94M | 0.15% | −249−0.7% | Reduced |
| KLP Kapitalforvaltning AS | 37,000 | $2.93M | 0.01% | +3,100+9.1% | Added |
| Entropy Technologies, LP | 36,815 | $2.92M | 0.12% | +9,608+35.3% | Added |
| DeepCurrents Investment Group LLC | 36,212 | $2.87M | 0.10% | +8,790+32.1% | Added |
| ExodusPoint Capital Management, LP | 35,645 | $2.83M | 0.03% | −191,439−84.3% | Reduced |
| Raiffeisen Bank International AG | 35,000 | $2.82M | 0.03% | −1,000−2.8% | Reduced |
| Prudential Financial Inc | 35,338 | $2.80M | 0.00% | +70+0.2% | Added |
| Pathstone Holdings, LLC | 34,004 | $2.70M | 0.01% | +1,169+3.6% | Added |
| Canada Pension Plan Investment Board | 33,300 | $2.64M | 0.00% | +19,200+136.2% | Added |
| Jain Global LLC | 32,931 | $2.61M | 0.03% | +6,646+25.3% | Added |
| Ethic Inc. | 31,679 | $2.51M | 0.03% | +31,679 | New |
| Blair William & Co | 31,606 | $2.51M | 0.01% | −2,251−6.6% | Reduced |
| Trexquant Investment LP | 31,538 | $2.50M | 0.02% | −182,107−85.2% | Reduced |