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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q2 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
515
+21 vs. Q1 2026
Shares held
179.7M
+7.19M (+4.2%) vs. Q1 2026
Total value
$14.3B
+$1.30B (+10.0%) vs. Q1 2026
New holders
67
199 more added
Sold out
46
162 more reduced

3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 515 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ2 2026: $14.3B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.

Institutions holding IONS in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Evolution Advisers, Inc.2$00.00%+2New
Activest Wealth Management1$790.00%+1New
Medallion Wealth Advisors, LLC1$790.00%+1New
Walleye Capital LLC2$1590.00%−65,947−100.0%Reduced
Manchester Capital Management LLC2$1590.00%−3−60.0%Reduced
3 Factor Indexing, LLC2$1590.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC2$1590.00%+2New
Wealth Enhancement Trust Services, Inc.2$1590.00%+2New
Cornerstone Planning Group LLC5$2700.00%−5−50.0%Reduced
SHP Wealth Management4$3170.00%+4New
Downshift Financial, LLC4$3170.00%+4New
American Capital Advisory, LLC6$4760.00%−1−14.3%Reduced
Kayne Anderson Rudnick Investment Management LLC7$5550.00%00.0%Unchanged
Essential Partners LLC7$5550.00%00.0%Unchanged
True Wealth Design, LLC7$5560.00%00.0%Unchanged
Hughes Financial Services, LLC8$6340.00%+2+33.3%Added
Planning Strategies Inc.8$6340.00%+8New
Valley National Advisers Inc11$8730.00%+11New
Signature Equity Partners, LLC12$9510.00%+12New
Rothschild Investment LLC13$1.03K0.00%00.0%Unchanged
Mascoma Wealth Management LLC14$1.11K0.00%00.0%Unchanged
Cape Investment Advisory, Inc.14$1.11K0.00%+14New
South State Corp.14$1.11K0.00%00.0%Unchanged
Whipplewood Advisors, LLC15$1.19K0.00%00.0%Unchanged
Cornerstone Financial Management LLC15$1.19K0.00%00.0%Unchanged
Quaker Wealth Management, LLC15$1.19K0.00%00.0%Unchanged
MJT & Associates Financial Advisory Group, Inc.15$1.19K0.00%+15New
Fortitude Family Office, LLC17$1.35K0.00%00.0%Unchanged
Clearstead Advisors, LLC19$1.51K0.00%+7+58.3%Added
NBT Bank N A20$1.59K0.00%00.0%Unchanged
Transamerica Financial Advisors, Inc.21$1.67K0.00%−12−36.4%Reduced
TFC Financial Management21$1.67K0.00%00.0%Unchanged
Bryn Mawr Trust Co22$1.74K0.00%+22New
Bruce G. Allen Investments, LLC23$1.82K0.00%00.0%Unchanged
Horizon Investments, LLC26$2.06K0.00%−22−45.8%Reduced
Cheviot Value Management, LLC28$2.22K0.00%00.0%Unchanged
Raffa Wealth Management, LLC28$2.22K0.00%00.0%Unchanged
Quarry LP29$2.30K0.00%+29New
Principia Wealth Advisory, LLC32$2.54K0.00%00.0%Unchanged
Cromwell Holdings LLC34$2.70K0.00%+16+88.9%Added
Hantz Financial Services, Inc.36$3.00K0.00%00.0%Unchanged
Highline Wealth Partners LLC38$3.01K0.00%00.0%Unchanged
Sachetta, LLC47$3.73K0.00%+2+4.4%Added
TD Waterhouse Canada Inc.48$3.80K0.00%00.0%Unchanged
Triumph Capital Management50$3.96K0.00%00.0%Unchanged
Hilton Head Capital Partners, LLC55$4.36K0.00%−298−84.4%Reduced
Bell Investment Advisors, Inc61$4.84K0.00%00.0%Unchanged
First Horizon Corp62$4.92K0.00%+6+10.7%Added
Private Wealth Management Group, LLC65$5.15K0.00%00.0%Unchanged
Truvestments Capital LLC70$5.53K0.00%+69+6,900.0%Added
Meeder Asset Management Inc72$5.71K0.00%−80−52.6%Reduced
Leonteq Securities AG73$5.79K0.00%00.0%Unchanged
Rossby Financial, LCC74$5.87K0.00%00.0%Unchanged
Orion Capital Management LLC80$6.34K0.00%00.0%Unchanged
Ameriflex Group, Inc.87$6.90K0.00%+87New
Keating Financial Advisory Services, Inc.88$6.98K0.00%−2−2.2%Reduced
Bessemer Group Inc94$7.00K0.00%00.0%Unchanged
Massmutual Trust Co FSB90$7.14K0.00%−53−37.1%Reduced
Basecamp Wealth Advisors LLC98$7.77K0.00%−87−47.0%Reduced
TD Private Client Wealth LLC98$7.77K0.00%+18+22.5%Added
Danske Bank A/S100$7.93K0.00%00.0%Unchanged
Main Street Group, LTD100$7.93K0.00%00.0%Unchanged
Spire Wealth Management101$8.01K0.00%−24−19.2%Reduced
WPG Advisers, LLC103$8.17K0.00%+33+47.1%Added
Quent Capital, LLC105$8.32K0.00%+6+6.1%Added
LRI Investments, LLC110$8.72K0.00%00.0%Unchanged
Action Point Financial Planning, LLC118$9.12K0.00%+118New
Bogart Wealth, LLC123$9.75K0.00%00.0%Unchanged
SBI Securities Co., Ltd.132$10.5K0.00%−29−18.0%Reduced
Silver Grove Financial Group, Inc.143$11.3K0.01%+143New
Strategic Wealth Partners, Ltd.150$11.9K0.00%00.0%Unchanged
United Financial Planning Group LLC158$12.5K0.01%00.0%Unchanged
Tower Research Capital LLC (TRC)185$14.7K0.00%−4,281−95.9%Reduced
Aster Capital Management (DIFC) Ltd190$15.1K0.00%−360−65.5%Reduced
MH & Associates Securities Management Corp200$15.9K0.01%00.0%Unchanged
Atlantic Union Bankshares Corp200$15.9K0.00%00.0%Unchanged
LifeSteps Financial, Inc.200$15.9K0.01%+200New
CX Institutional203$16.0K0.00%+1+0.5%Added
Covestor Ltd196$16.0K0.01%+14+7.7%Added
Owl Creek Wealth Partners LLC210$16.7K0.00%+40+23.5%Added
Global Trust Asset Management, LLC213$16.9K0.01%−5−2.3%Reduced
Zions Bancorporation, National Association214$17.0K0.00%+37+20.9%Added
Cedar Mountain Advisors, LLC223$17.7K0.00%00.0%Unchanged
FIL Ltd227$18.0K0.00%+62+37.6%Added
Westside Investment Management, Inc.231$18.3K0.00%00.0%Unchanged
Harvest Fund Management Co., Ltd234$19.0K0.00%00.0%Unchanged
Umb Bank N A245$19.4K0.00%+30+14.0%Added
Caitong International Asset Management Co., Ltd248$19.7K0.00%+241+3,442.9%Added
Trust Co250$19.8K0.00%+250New
Parkside Financial Bank & Trust254$20.1K0.00%−4−1.6%Reduced
MTM Investment Management, LLC258$20.5K0.01%00.0%Unchanged
E Fund Management (Hong Kong) Co., Ltd.260$20.6K0.01%+65+33.3%Added
SMA Capital LLC260$20.6K0.01%+260New
Steigerwald, Gordon & Koch Inc.265$21.0K0.00%−30−10.2%Reduced
Nomura Asset Management Co Ltd270$21.4K0.00%+270New
NBC Securities, Inc.273$21.6K0.00%00.0%Unchanged
Global X Japan Co., Ltd.279$22.1K0.00%+151+118.0%Added
Capital Advisors, Ltd. LLC295$23.0K0.00%00.0%Unchanged
Eastern Bank300$23.8K0.00%00.0%Unchanged
Wellington-Altus USA Inc.317$23.8K0.02%00.0%Unchanged