Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 326
- −9 vs. Q2 2021
- Shares held
- 121.7M
- −2.53M (−2.0%) vs. Q2 2021
- Total value
- $4.08B
- −$872.0M (−17.6%) vs. Q2 2021
- New holders
- 38
- 108 more added
- Sold out
- 47
- 103 more reduced
3 institutions that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,172,154 | $710.1M | 0.06% | +27,699+0.1% | Added |
| Vanguard Group Inc | 11,800,009 | $395.8M | 0.01% | −855,820−6.8% | Reduced |
| Price T Rowe Associates Inc | 11,737,321 | $393.7M | 0.04% | −521,506−4.3% | Reduced |
| Bellevue Group AG | 9,347,926 | $313.5M | 3.18% | −582,319−5.9% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 8,511,384 | $285.5M | 0.69% | −396,349−4.4% | Reduced |
| BlackRock Inc. | 8,119,853 | $272.3M | 0.01% | −59,813−0.7% | Reduced |
| Clearbridge Investments, LLC | 7,327,322 | $245.8M | 0.18% | +511,721+7.5% | Added |
| State Street Corp | 3,521,314 | $118.1M | 0.01% | +290,363+9.0% | Added |
| Camber Capital Management LP | 2,500,000 | $83.8M | 3.12% | +500,000+25.0% | Added |
| JPMorgan Chase & Co | 2,416,313 | $81.0M | 0.01% | +140,607+6.2% | Added |
| Geode Capital Management, LLC | 1,772,767 | $59.5M | 0.01% | +10,227+0.6% | Added |
| First Trust Advisors LP | 1,680,549 | $56.4M | 0.06% | +158,100+10.4% | Added |
| Thrivent Financial for Lutherans | 1,387,764 | $46.5M | 0.09% | +1,264,397+1,024.9% | Added |
| Rockefeller Capital Management L.P. | 1,332,780 | $44.7M | 0.23% | +8,169+0.6% | Added |
| Jacobs Levy Equity Management, Inc | 1,191,236 | $40.0M | 0.27% | +106,814+9.8% | Added |
| Norges Bank | 1,146,918 | $38.5M | 0.01% | +250,629+28.0% | Added |
| Swedbank AB | 1,117,339 | $37.5M | 0.07% | +640.0% | Added |
| Charles Schwab Investment Management Inc | 1,069,732 | $35.9M | 0.01% | +355,772+49.8% | Added |
| Citadel Advisors LLC | 1,049,857 | $35.2M | 0.04% | +504,377+92.5% | Added |
| Wells Fargo & Company | 853,370 | $28.6M | 0.01% | +11,939+1.4% | Added |
| Candriam Luxembourg S.C.A. | 726,359 | $24.4M | 0.17% | +173,793+31.5% | Added |
| Bank of America Corp | 710,117 | $23.8M | 0.00% | −7,380−1.0% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 685,660 | $23.0M | 0.01% | +161,334+30.8% | Added |
| Nikko Asset Management Americas, Inc. | 675,301 | $22.6M | 0.10% | +166,927+32.8% | Added |
| Northern Trust Corp | 655,421 | $22.0M | 0.00% | −16,152−2.4% | Reduced |
| Nuveen Asset Management, LLC | 628,476 | $21.1M | 0.01% | −94,625−13.1% | Reduced |
| Goldman Sachs Group Inc | 601,836 | $20.2M | 0.01% | −77,593−11.4% | Reduced |
| Bank of New York Mellon Corp | 560,566 | $18.8M | 0.00% | +20,037+3.7% | Added |
| Pinnacle Associates Ltd | 543,226 | $18.2M | 0.34% | +1,884+0.3% | Added |
| Morgan Stanley | 497,936 | $16.7M | 0.00% | −29,673−5.6% | Reduced |
| Royal Bank of Canada | 489,561 | $16.4M | 0.00% | +4,595+0.9% | Added |
| Eversept Partners, LP | 450,501 | $15.1M | 1.21% | +8,501+1.9% | Added |
| Altrinsic Global Advisors LLC | 444,887 | $14.9M | 0.45% | −11,339−2.5% | Reduced |
| Two Sigma Advisers, LP | 432,211 | $14.5M | 0.04% | −93,600−17.8% | Reduced |
| TD Asset Management Inc | 421,964 | $14.2M | 0.01% | +1000.0% | Added |
| Woodline Partners LP | 405,461 | $13.6M | 0.23% | −558,327−57.9% | Reduced |
| Stifel Financial Corp | 376,219 | $12.6M | 0.02% | −1,466−0.4% | Reduced |
| Nomura Holdings Inc | 376,748 | $12.6M | 0.10% | −980−0.3% | Reduced |
| Dimensional Fund Advisors LP | 355,839 | $11.9M | 0.00% | −54,378−13.3% | Reduced |
| Barclays PLC | 330,291 | $11.1M | 0.01% | −33,705−9.3% | Reduced |
| Tekla Capital Management LLC | 322,521 | $10.8M | 0.35% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 314,134 | $10.5M | 0.03% | +7,646+2.5% | Added |
| Dowling & Yahnke LLC | 302,521 | $10.1M | 0.56% | −629−0.2% | Reduced |
| Baillie Gifford & Co | 302,003 | $10.1M | 0.01% | +30,607+11.3% | Added |
| Raymond James & Associates | 301,449 | $10.1M | 0.01% | +7,511+2.6% | Added |
| Sicart Associates LLC | 291,254 | $9.77M | 2.66% | −77,155−20.9% | Reduced |
| California Public Employees Retirement System | 288,128 | $9.66M | 0.01% | −32,552−10.2% | Reduced |
| Millennium Management LLC | 282,854 | $9.49M | 0.01% | −512,988−64.5% | Reduced |
| Swiss National Bank | 279,900 | $9.39M | 0.01% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 265,000 | $8.89M | 0.13% | +80,000+43.2% | Added |
| Sector Gamma AS | 263,870 | $8.85M | 1.77% | +382+0.1% | Added |
| Bank of Montreal | 249,704 | $8.49M | 0.00% | −131,781−34.5% | Reduced |
| New York State Common Retirement Fund | 241,159 | $8.09M | 0.01% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 231,865 | $7.77M | 0.01% | +10,311+4.7% | Added |
| Parametric Portfolio Associates LLC | 231,506 | $7.76M | 0.00% | +11,294+5.1% | Added |
| California State Teachers Retirement System | 225,991 | $7.58M | 0.01% | −17,731−7.3% | Reduced |
| Point72 Asset Management, L.P. | 219,300 | $7.36M | 0.03% | −757,600−77.6% | Reduced |
| Morningstar Investment Services LLC | 214,141 | $7.21M | 0.09% | +4,034+1.9% | Added |
| Tudor Investment Corp Et Al | 201,613 | $6.76M | 0.14% | +101,727+101.8% | Added |
| American Century Companies Inc | 199,346 | $6.69M | 0.00% | −26,834−11.9% | Reduced |
| Credit Suisse AG | 182,662 | $6.13M | 0.00% | +23,477+14.7% | Added |
| UBS Asset Management Americas Inc | 180,665 | $6.06M | 0.00% | +4,324+2.5% | Added |
| Majedie Asset Management Ltd | 175,508 | $5.89M | 0.45% | −8,954−4.9% | Reduced |
| Susquehanna International Group, LLP | 174,166 | $5.84M | 0.01% | −206,300−54.2% | Reduced |
| Squarepoint Ops LLC | 169,865 | $5.70M | 0.04% | +122,120+255.8% | Added |
| Tocqueville Asset Management L.P. | 168,530 | $5.65M | 0.08% | −3,670−2.1% | Reduced |
| Legal & General Group Plc | 167,421 | $5.62M | 0.00% | +41,538+33.0% | Added |
| Sonora Investment Management, LLC | 163,703 | $5.49M | 0.69% | −4,962−2.9% | Reduced |
| State Board of Administration of Florida Retirement System | 161,938 | $5.43M | 0.01% | −2,170−1.3% | Reduced |
| BLB&B Advisors, LLC | 156,200 | $5.24M | 0.35% | −1,290−0.8% | Reduced |
| Balyasny Asset Management LLC | 142,015 | $4.76M | 0.02% | −121,271−46.1% | Reduced |
| Invesco Ltd. | 141,355 | $4.74M | 0.00% | −199,258−58.5% | Reduced |
| Rhumbline Advisers | 138,363 | $4.64M | 0.01% | −1,222−0.9% | Reduced |
| Parkman Healthcare Partners LLC | 136,380 | $4.57M | 1.16% | 00.0% | Unchanged |
| Peregrine Capital Management LLC | 135,787 | $4.55M | 0.09% | −26,741−16.5% | Reduced |
| Pictet Asset Management SA | 135,696 | $4.55M | 0.01% | +135,696 | New |
| UBS Group AG | 132,812 | $4.46M | 0.00% | −22,317−14.4% | Reduced |
| HRT Financial LP | 128,087 | $4.30M | 0.03% | +128,087 | New |
| D. E. Shaw & Co., Inc. | 126,106 | $4.23M | 0.01% | +51,440+68.9% | Added |
| Davenport & Co LLC | 122,303 | $4.10M | 0.03% | +5,340+4.6% | Added |
| Citigroup Inc | 121,064 | $4.06M | 0.00% | −121,059−50.0% | Reduced |
| Caption Management, LLC | 120,993 | $4.06M | 0.27% | +24,986+26.0% | Added |
| DekaBank Deutsche Girozentrale | 107,576 | $3.61M | 0.01% | 00.0% | Unchanged |
| Wolverine Trading, LLC | 106,878 | $3.59M | 0.07% | −4,070−3.7% | Reduced |
| Envestnet Asset Management Inc | 102,422 | $3.44M | 0.00% | +6,702+7.0% | Added |
| Renaissance Technologies LLC | 97,714 | $3.28M | 0.00% | −678,700−87.4% | Reduced |
| Rafferty Asset Management, LLC | 96,737 | $3.25M | 0.02% | +27,965+40.7% | Added |
| Public Employees Retirement System of Ohio | 87,444 | $2.93M | 0.01% | +7,390+9.2% | Added |
| State of New Jersey Common Pension Fund D | 87,216 | $2.92M | 0.01% | +471+0.5% | Added |
| Cubist Systematic Strategies, LLC | 86,754 | $2.91M | 0.04% | −91,388−51.3% | Reduced |
| Sabby Management, LLC | 84,600 | $2.84M | 0.62% | +6,600+8.5% | Added |
| LPL Financial LLC | 83,615 | $2.80M | 0.00% | +24,299+41.0% | Added |
| PFS Investments Inc. | 76,842 | $2.68M | 0.06% | +1,127+1.5% | Added |
| Rhenman & Partners Asset Management AB | 75,000 | $2.52M | 0.18% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 68,451 | $2.30M | 0.00% | −1,352−1.9% | Reduced |
| Jane Street Group, LLC | 64,476 | $2.16M | 0.01% | +18,059+38.9% | Added |
| Guggenheim Capital LLC | 62,637 | $2.10M | 0.01% | +6,501+11.6% | Added |
| AXA S.A. | 57,200 | $1.92M | 0.01% | +57,200 | New |
| Ergoteles LLC | 52,872 | $1.77M | 0.07% | −123,381−70.0% | Reduced |
| AlphaCrest Capital Management LLC | 52,084 | $1.75M | 0.09% | +32,724+169.0% | Added |