Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 333
- −3 vs. Q4 2021
- Shares held
- 125.0M
- +1.76M (+1.4%) vs. Q4 2021
- Total value
- $4.63B
- +$876.1M (+23.4%) vs. Q4 2021
- New holders
- 47
- 107 more added
- Sold out
- 50
- 109 more reduced
5 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,320,886 | $789.7M | 0.06% | +139,384+0.7% | Added |
| Price T Rowe Associates Inc | 14,350,460 | $531.5M | 0.05% | +1,860,180+14.9% | Added |
| Vanguard Group Inc | 12,099,034 | $448.1M | 0.01% | +91,958+0.8% | Added |
| Bellevue Group AG | 9,918,073 | $367.4M | 4.27% | −437,050−4.2% | Reduced |
| BlackRock Inc. | 8,443,843 | $312.8M | 0.01% | −95,439−1.1% | Reduced |
| Clearbridge Investments, LLC | 6,476,033 | $239.9M | 0.18% | +593,051+10.1% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 6,171,308 | $228.6M | 0.95% | −911,948−12.9% | Reduced |
| State Street Corp | 4,030,646 | $149.3M | 0.01% | +124,271+3.2% | Added |
| Camber Capital Management LP | 3,000,000 | $111.1M | 4.02% | +1,610,000+115.8% | Added |
| Tweedy, Browne Co LLC | 2,925,102 | $108.3M | 3.50% | +2,925,102 | New |
| Geode Capital Management, LLC | 1,897,492 | $70.3M | 0.01% | +72,266+4.0% | Added |
| Jacobs Levy Equity Management, Inc | 1,618,267 | $59.9M | 0.40% | +210,879+15.0% | Added |
| First Trust Advisors LP | 1,616,290 | $59.9M | 0.06% | −63,722−3.8% | Reduced |
| Thrivent Financial for Lutherans | 1,561,513 | $57.8M | 0.11% | +27,514+1.8% | Added |
| Citadel Advisors LLC | 1,244,524 | $46.1M | 0.05% | +22,953+1.9% | Added |
| JPMorgan Chase & Co | 1,181,557 | $43.8M | 0.01% | −87,095−6.9% | Reduced |
| Charles Schwab Investment Management Inc | 1,137,827 | $42.1M | 0.01% | +44,388+4.1% | Added |
| Swedbank AB | 1,117,339 | $41.4M | 0.08% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 954,326 | $35.3M | 0.01% | +365,028+61.9% | Added |
| Wells Fargo & Company | 842,284 | $31.2M | 0.01% | +31,318+3.9% | Added |
| TD Asset Management Inc | 820,164 | $30.4M | 0.03% | +77,000+10.4% | Added |
| Norges Bank | 785,561 | $29.1M | 0.01% | −45,658−5.5% | Reduced |
| Two Sigma Investments, LP | 780,256 | $28.9M | 0.09% | +185,371+31.2% | Added |
| Bank of America Corp | 762,158 | $28.2M | 0.00% | +149,323+24.4% | Added |
| Northern Trust Corp | 648,534 | $24.0M | 0.00% | −12,356−1.9% | Reduced |
| Two Sigma Advisers, LP | 611,611 | $22.7M | 0.06% | +114,200+23.0% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 599,616 | $22.2M | 0.01% | −6,286−1.0% | Reduced |
| Nikko Asset Management Americas, Inc. | 599,616 | $21.5M | 0.16% | −6,286−1.0% | Reduced |
| Bank of New York Mellon Corp | 549,247 | $20.3M | 0.00% | −7,330−1.3% | Reduced |
| Pinnacle Associates Ltd | 521,968 | $19.3M | 0.34% | −19,076−3.5% | Reduced |
| Morgan Stanley | 519,477 | $19.2M | 0.00% | +54,592+11.7% | Added |
| Candriam Luxembourg S.C.A. | 499,547 | $18.5M | 0.13% | −437,088−46.7% | Reduced |
| Royal Bank of Canada | 444,502 | $16.5M | 0.00% | −36,146−7.5% | Reduced |
| Nomura Holdings Inc | 394,154 | $15.3M | 0.12% | +21,674+5.8% | Added |
| Assenagon Asset Management S.A. | 357,896 | $13.3M | 0.04% | +309,495+639.4% | Added |
| Dimensional Fund Advisors LP | 353,481 | $13.1M | 0.00% | −33,210−8.6% | Reduced |
| Baillie Gifford & Co | 348,863 | $12.9M | 0.01% | +33,043+10.5% | Added |
| Stifel Financial Corp | 340,566 | $12.6M | 0.02% | −17,382−4.9% | Reduced |
| Barclays PLC | 316,350 | $11.7M | 0.01% | −13,588−4.1% | Reduced |
| Sicart Associates LLC | 304,782 | $11.3M | 2.92% | +22,251+7.9% | Added |
| Dowling & Yahnke LLC | 302,571 | $11.2M | 0.49% | +1500.0% | Added |
| Swiss National Bank | 300,500 | $11.1M | 0.01% | +21,200+7.6% | Added |
| Nuveen Asset Management, LLC | 315,819 | $11.0M | 0.00% | −35,657−10.1% | Reduced |
| California Public Employees Retirement System | 294,815 | $10.9M | 0.01% | +10,391+3.7% | Added |
| Russell Investments Group, Ltd. | 284,130 | $10.5M | 0.02% | +89,985+46.3% | Added |
| Bank of Montreal | 268,497 | $9.58M | 0.01% | +39,090+17.0% | Added |
| Raymond James & Associates | 256,726 | $9.51M | 0.01% | −1,259−0.5% | Reduced |
| Parametric Portfolio Associates LLC | 230,804 | $8.55M | 0.00% | +5,698+2.5% | Added |
| Morningstar Investment Services LLC | 222,681 | $8.00M | 0.09% | +3,249+1.5% | Added |
| Hudson Bay Capital Management LP | 210,000 | $7.78M | 0.11% | −95,000−31.1% | Reduced |
| Altrinsic Global Advisors LLC | 208,158 | $7.71M | 0.27% | −191,234−47.9% | Reduced |
| UBS Asset Management Americas Inc | 206,906 | $7.66M | 0.00% | +23,154+12.6% | Added |
| Pictet Asset Management SA | 206,141 | $7.63M | 0.01% | +23,054+12.6% | Added |
| UBS Group AG | 201,201 | $7.45M | 0.00% | +7,612+3.9% | Added |
| Tang Capital Management LLC | 200,000 | $7.41M | 1.50% | +200,000 | New |
| Majedie Asset Management Ltd | 195,492 | $7.22M | 0.59% | +19,984+11.4% | Added |
| Woodline Partners LP | 192,651 | $7.14M | 0.12% | −218,803−53.2% | Reduced |
| Millennium Management LLC | 191,191 | $7.08M | 0.01% | −1,431,947−88.2% | Reduced |
| Voloridge Investment Management, LLC | 189,556 | $7.02M | 0.04% | −77,289−29.0% | Reduced |
| Sector Gamma AS | 188,439 | $6.98M | 1.52% | −21,098−10.1% | Reduced |
| Credit Suisse AG | 180,626 | $6.69M | 0.01% | +3,859+2.2% | Added |
| Privium Fund Management B.V. | 180,107 | $6.67M | 1.50% | −450,092−71.4% | Reduced |
| Rafferty Asset Management, LLC | 178,794 | $6.62M | 0.04% | −10,845−5.7% | Reduced |
| Tekla Capital Management LLC | 175,680 | $6.51M | 0.23% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 175,568 | $6.50M | 2.62% | −146,998−45.6% | Reduced |
| State Board of Administration of Florida Retirement System | 170,728 | $6.32M | 0.01% | −2,532−1.5% | Reduced |
| California State Teachers Retirement System | 168,362 | $6.24M | 0.01% | −15,642−8.5% | Reduced |
| Tocqueville Asset Management L.P. | 167,505 | $6.20M | 0.09% | −2,900−1.7% | Reduced |
| Legal & General Group Plc | 162,318 | $6.01M | 0.00% | +3,974+2.5% | Added |
| Eversept Partners, LP | 158,806 | $5.88M | 0.54% | −225,983−58.7% | Reduced |
| Sonora Investment Management Group, LLC | 157,261 | $5.83M | 0.66% | +471+0.3% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 157,193 | $5.82M | 0.03% | +44,668+39.7% | Added |
| Private Advisor Group, LLC | 156,968 | $5.81M | 0.04% | +41,226+35.6% | Added |
| BLB&B Advisors, LLC | 149,745 | $5.55M | 0.37% | −1,190−0.8% | Reduced |
| New York State Common Retirement Fund | 146,800 | $5.44M | 0.01% | −7,000−4.6% | Reduced |
| Alps Advisors Inc | 145,615 | $5.39M | 0.06% | −17,809−10.9% | Reduced |
| Invesco Ltd. | 139,992 | $5.18M | 0.00% | +7,750+5.9% | Added |
| Renaissance Technologies LLC | 134,914 | $5.00M | 0.01% | −95,900−41.5% | Reduced |
| Rhumbline Advisers | 133,560 | $4.95M | 0.01% | −6,189−4.4% | Reduced |
| Peregrine Capital Management LLC | 130,320 | $4.83M | 0.11% | −9,401−6.7% | Reduced |
| DekaBank Deutsche Girozentrale | 124,776 | $4.45M | 0.01% | +15,300+14.0% | Added |
| State of Wisconsin Investment Board | 114,451 | $4.24M | 0.01% | +97,397+571.1% | Added |
| Jump Financial, LLC | 109,827 | $4.07M | 0.17% | −10,673−8.9% | Reduced |
| HRT Financial LP | 109,376 | $4.05M | 0.03% | +109,376 | New |
| Gateway Investment Advisers LLC | 99,129 | $3.67M | 0.04% | +14,026+16.5% | Added |
| Bard Financial Services, Inc. | 99,020 | $3.67M | 0.30% | +57,500+138.5% | Added |
| Cubist Systematic Strategies, LLC | 95,530 | $3.54M | 0.03% | −201,652−67.9% | Reduced |
| LPL Financial LLC | 94,553 | $3.50M | 0.00% | +5,887+6.6% | Added |
| BNP Paribas Arbitrage, SA | 90,936 | $3.37M | 0.01% | −215,317−70.3% | Reduced |
| Envestnet Asset Management Inc | 90,871 | $3.37M | 0.00% | −421−0.5% | Reduced |
| International Biotechnology Trust PLC | 154,088 | $3.30M | 1.45% | −201,000−56.6% | Reduced |
| State of New Jersey Common Pension Fund D | 88,879 | $3.29M | 0.01% | −6,355−6.7% | Reduced |
| Allspring Global Investments Holdings, LLC | 87,285 | $3.23M | 0.00% | −11,289−11.5% | Reduced |
| AXA S.A. | 86,300 | $3.20M | 0.01% | −1,600−1.8% | Reduced |
| Davenport & Co LLC | 83,863 | $3.11M | 0.02% | −800−0.9% | Reduced |
| Allianz Asset Management GmbH | 81,830 | $3.03M | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 81,336 | $3.01M | 0.00% | −104,711−56.3% | Reduced |
| PDT Partners, LLC | 80,070 | $2.97M | 0.26% | +12,373+18.3% | Added |
| Public Employees Retirement System of Ohio | 77,666 | $2.88M | 0.01% | −6,995−8.3% | Reduced |
| PFS Investments Inc. | 75,061 | $2.78M | 0.05% | −1,118−1.5% | Reduced |