Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 356
- +9 vs. Q3 2024
- Shares held
- 160.5M
- +3.10M (+2.0%) vs. Q3 2024
- Total value
- $5.61B
- −$692.3M (−11.0%) vs. Q3 2024
- New holders
- 58
- 119 more added
- Sold out
- 49
- 121 more reduced
7 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 22,689,491 | $793.2M | 0.05% | +209,962+0.9% | Added |
| Vanguard Group Inc | 16,472,539 | $575.9M | 0.01% | +1,416,781+9.4% | Added |
| T. Rowe Price Investment Management, Inc. | 14,169,199 | $495.4M | 0.31% | +1,0830.0% | Added |
| BlackRock, Inc. | 11,665,548 | $407.8M | 0.01% | +852,525+7.9% | Added |
| Capital World Investors | 11,465,413 | $400.8M | 0.06% | +3,637,041+46.5% | Added |
| Wellington Management Group LLP | 8,672,148 | $303.2M | 0.06% | −63,639−0.7% | Reduced |
| Bellevue Group AG | 7,868,700 | $275.1M | 5.30% | −5,700−0.1% | Reduced |
| State Street Corp | 5,426,413 | $189.7M | 0.01% | +576,276+11.9% | Added |
| Price T Rowe Associates Inc | 3,826,939 | $133.8M | 0.02% | −383,233−9.1% | Reduced |
| Tweedy, Browne Co LLC | 3,248,863 | $113.6M | 7.66% | −205,813−6.0% | Reduced |
| OrbiMed Advisors LLC | 2,817,347 | $98.5M | 2.05% | +492,900+21.2% | Added |
| Geode Capital Management, LLC | 2,687,248 | $94.0M | 0.01% | +18,890+0.7% | Added |
| Citadel Advisors LLC | 2,165,916 | $75.7M | 0.07% | +1,764,765+439.9% | Added |
| Deep Track Capital, LP | 1,933,928 | $67.6M | 2.53% | −266,072−12.1% | Reduced |
| UBS Group AG | 1,917,608 | $67.0M | 0.02% | +1,749,728+1,042.2% | Added |
| Macquarie Group Ltd | 1,769,743 | $61.9M | 0.08% | −100,063−5.4% | Reduced |
| Norges Bank | 1,714,762 | $59.9M | 0.01% | −312,399−15.4% | Reduced |
| Clearbridge Investments, LLC | 1,618,220 | $56.6M | 0.05% | −84,173−4.9% | Reduced |
| Charles Schwab Investment Management Inc | 1,481,440 | $51.8M | 0.01% | +38,420+2.7% | Added |
| Two Sigma Advisers, LP | 1,349,211 | $47.2M | 0.11% | +16,800+1.3% | Added |
| Morgan Stanley | 1,329,929 | $46.5M | 0.00% | +19,478+1.5% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,080,341 | $37.8M | 0.09% | +300,620+38.6% | Added |
| TD Asset Management Inc | 1,049,990 | $36.7M | 0.03% | −43,000−3.9% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 1,025,260 | $35.8M | 0.30% | −359,009−25.9% | Reduced |
| Two Sigma Investments, LP | 921,439 | $32.2M | 0.07% | +2,362+0.3% | Added |
| Candriam Luxembourg S.C.A. | 849,824 | $29.7M | 0.17% | −98,442−10.4% | Reduced |
| Northern Trust Corp | 840,271 | $29.4M | 0.00% | +97,367+13.1% | Added |
| Hudson Bay Capital Management LP | 821,200 | $28.7M | 0.17% | +54,300+7.1% | Added |
| Marshall Wace, LLP | 812,306 | $28.4M | 0.04% | −1,108,158−57.7% | Reduced |
| Invesco Ltd. | 788,599 | $27.6M | 0.01% | −21,702−2.7% | Reduced |
| Millennium Management LLC | 774,215 | $27.1M | 0.02% | +343,492+79.7% | Added |
| Royal Bank of Canada | 643,192 | $22.5M | 0.00% | −26,957−4.0% | Reduced |
| Camber Capital Management LP | 625,000 | $21.9M | 0.85% | +625,000 | New |
| Pictet Asset Management Holding SA | 620,798 | $21.7M | 0.02% | −682,703−52.4% | Reduced |
| UBS Asset Management Americas Inc | 619,641 | $21.7M | 0.01% | +333,944+116.9% | Added |
| Bank of New York Mellon Corp | 616,071 | $21.5M | 0.00% | +5,178+0.8% | Added |
| J. Goldman & Co LP | 607,499 | $21.2M | 0.75% | −1,917−0.3% | Reduced |
| AXA S.A. | 605,345 | $21.2M | 0.06% | +44,102+7.9% | Added |
| Barclays PLC | 596,072 | $20.8M | 0.01% | −40,960−6.4% | Reduced |
| Vestal Point Capital, LP | 595,000 | $20.8M | 1.23% | +595,000 | New |
| Pinnacle Associates Ltd | 547,642 | $19.1M | 0.26% | +88,663+19.3% | Added |
| Groupama Asset Managment | 517,191 | $18.6M | 0.38% | +101,131+24.3% | Added |
| Great Point Partners LLC | 505,007 | $17.7M | 8.32% | +250,007+98.0% | Added |
| Bank of America Corp | 422,861 | $14.8M | 0.00% | −145,799−25.6% | Reduced |
| JPMorgan Chase & Co | 415,919 | $14.5M | 0.00% | −152,987−26.9% | Reduced |
| Standard Life Aberdeen plc | 401,501 | $14.0M | 0.03% | +98,227+32.4% | Added |
| C WorldWide Group Holding A/S | 400,000 | $14.0M | 0.17% | +100,000+33.3% | Added |
| Ameriprise Financial Inc | 387,448 | $13.5M | 0.00% | −10,450−2.6% | Reduced |
| Goldman Sachs Group Inc | 378,208 | $13.2M | 0.00% | +142,498+60.5% | Added |
| Schonfeld Strategic Advisors LLC | 371,381 | $13.0M | 0.08% | +8,493+2.3% | Added |
| Baker Bros. Advisors LP | 357,915 | $12.5M | 0.13% | +134,445+60.2% | Added |
| Nomura Holdings Inc | 357,255 | $12.5M | 0.07% | −95,814−21.1% | Reduced |
| Tocqueville Asset Management L.P. | 352,140 | $12.3M | 0.19% | −54,730−13.5% | Reduced |
| Wells Fargo & Company | 331,009 | $11.6M | 0.00% | −11,145−3.3% | Reduced |
| Voloridge Investment Management, LLC | 316,943 | $11.1M | 0.04% | −63,698−16.7% | Reduced |
| Bank of Montreal | 312,146 | $10.9M | 0.01% | +98,263+45.9% | Added |
| Nuveen Asset Management, LLC | 290,954 | $10.2M | 0.00% | −13,825−4.5% | Reduced |
| Manufacturers Life Insurance Company, The | 286,279 | $10.0M | 0.01% | −22,668−7.3% | Reduced |
| Jacobs Levy Equity Management, Inc | 281,813 | $9.85M | 0.03% | −368,966−56.7% | Reduced |
| Swiss National Bank | 279,200 | $9.76M | 0.01% | +22,600+8.8% | Added |
| Adage Capital Partners GP, L.L.C. | 275,000 | $9.61M | 0.02% | −225,000−45.0% | Reduced |
| Privium Fund Management B.V. | 266,794 | $9.33M | 2.11% | +16,050+6.4% | Added |
| BNP Paribas Arbitrage, SA | 254,521 | $8.90M | 0.01% | +79,193+45.2% | Added |
| Artisan Partners Limited Partnership | 252,635 | $8.83M | 0.01% | −1,987,820−88.7% | Reduced |
| Siren, L.L.C. | 250,000 | $8.74M | 0.39% | 00.0% | Unchanged |
| CI Private Wealth, LLC | 239,163 | $8.36M | 0.01% | +2,087+0.9% | Added |
| Rafferty Asset Management, LLC | 237,337 | $8.30M | 0.03% | +38,578+19.4% | Added |
| Sector Gamma AS | 235,842 | $8.25M | 2.83% | +25,000+11.9% | Added |
| Aquatic Capital Management LLC | 230,016 | $8.04M | 0.22% | +230,016 | New |
| Kennedy Capital Management, Inc. | 223,278 | $7.81M | 0.17% | +61,202+37.8% | Added |
| Orion Investment Co | 216,000 | $7.55M | 3.03% | −2,525−1.2% | Reduced |
| Eversept Partners, LP | 214,952 | $7.51M | 0.78% | −256,403−54.4% | Reduced |
| Susquehanna Fundamental Investments, LLC | 213,015 | $7.45M | 0.12% | +213,015 | New |
| Rhenman & Partners Asset Management AB | 212,500 | $7.43M | 0.76% | +17,500+9.0% | Added |
| Stifel Financial Corp | 211,493 | $7.39M | 0.01% | +28,988+15.9% | Added |
| Renaissance Technologies LLC | 205,514 | $7.18M | 0.01% | +15,000+7.9% | Added |
| Verition Fund Management LLC | 200,184 | $7.00M | 0.04% | +200,184 | New |
| California Public Employees Retirement System | 192,130 | $6.72M | 0.00% | −19,626−9.3% | Reduced |
| Rhumbline Advisers | 191,893 | $6.71M | 0.01% | −5,049−2.6% | Reduced |
| GW&K Investment Management, LLC | 187,220 | $6.54M | 0.06% | +187,220 | New |
| Sicart Associates LLC | 185,821 | $6.50M | 2.32% | −5,702−3.0% | Reduced |
| Driehaus Capital Management LLC | 180,002 | $6.29M | 0.05% | −49,967−21.7% | Reduced |
| Citigroup Inc | 169,155 | $5.91M | 0.01% | +98,860+140.6% | Added |
| Legal & General Group Plc | 168,080 | $5.88M | 0.00% | +10,793+6.9% | Added |
| Squarepoint Ops LLC | 166,468 | $5.82M | 0.01% | +39,127+30.7% | Added |
| Jane Street Group, LLC | 164,634 | $5.76M | 0.01% | −11,926−6.8% | Reduced |
| Sovran Advisors, LLC | 171,812 | $5.62M | 0.80% | +171,812 | New |
| Sumitomo Mitsui Trust Holdings, Inc. | 156,657 | $5.48M | 0.00% | −39,457−20.1% | Reduced |
| Nikko Asset Management Americas, Inc. | 156,657 | $5.47M | 0.06% | −39,457−20.1% | Reduced |
| State Board of Administration of Florida Retirement System | 152,315 | $5.32M | 0.01% | +1,260+0.8% | Added |
| BLB&B Advisors, LLC | 152,050 | $5.32M | 0.27% | −200−0.1% | Reduced |
| Alyeska Investment Group, L.P. | 150,000 | $5.24M | 0.02% | −18,951−11.2% | Reduced |
| Tang Capital Management LLC | 150,000 | $5.24M | 0.35% | 00.0% | Unchanged |
| Sonora Investment Management Group, LLC | 148,776 | $5.20M | 0.40% | −4,399−2.9% | Reduced |
| Assenagon Asset Management S.A. | 141,917 | $4.96M | 0.01% | +128,619+967.2% | Added |
| California State Teachers Retirement System | 133,902 | $4.68M | 0.01% | +7,722+6.1% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 125,389 | $4.38M | 0.02% | +107,648+606.8% | Added |
| Nicola Wealth Management Ltd. | 87,000 | $4.37M | 0.41% | 00.0% | Unchanged |
| Swedbank AB | 124,237 | $4.34M | 0.01% | −5,136−4.0% | Reduced |
| Woodline Partners LP | 107,610 | $3.76M | 0.03% | +107,610 | New |