Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 7 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 24,556,637 | $1.84B | 0.10% | +484,536+2.0% | Added |
| Capital World Investors | 21,186,369 | $1.59B | 0.22% | +3,225,070+18.0% | Added |
| BlackRock, Inc. | 10,442,476 | $784.1M | 0.01% | −205,387−1.9% | Reduced |
| Vanguard Portfolio Management LLC | 7,808,902 | $586.4M | 0.03% | +7,808,902 | New |
| Vanguard Capital Management LLC | 7,118,330 | $534.5M | 0.01% | +7,118,330 | New |
| Wellington Management Group LLP | 6,391,816 | $480.0M | 0.09% | +131,491+2.1% | Added |
| T. Rowe Price Investment Management, Inc. | 6,159,027 | $462.5M | 0.32% | −2,948,992−32.4% | Reduced |
| Two Sigma Investments, LP | 5,857,629 | $439.8M | 0.37% | +3,198,983+120.3% | Added |
| Geode Capital Management, LLC | 3,984,332 | $305.2M | 0.02% | +835,483+26.5% | Added |
| State Street Corp | 3,995,564 | $300.0M | 0.01% | +20,699+0.5% | Added |
| Royal Bank of Canada | 3,801,815 | $285.5M | 0.05% | +2,683,018+239.8% | Added |
| Price T Rowe Associates Inc | 3,025,251 | $227.2M | 0.03% | +37,411+1.3% | Added |
| JPMorgan Chase & Co | 2,363,567 | $171.4M | 0.01% | +58,775+2.6% | Added |
| Tweedy, Browne Co LLC | 2,275,625 | $170.9M | 13.57% | −189,305−7.7% | Reduced |
| Artisan Partners Limited Partnership | 2,058,308 | $154.6M | 0.25% | +876,892+74.2% | Added |
| Baker Bros. Advisors LP | 2,047,727 | $153.8M | 0.88% | +255,886+14.3% | Added |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $148.7M | 1.75% | 00.0% | Unchanged |
| Deep Track Capital, LP | 1,950,000 | $146.4M | 3.02% | +250,000+14.7% | Added |
| Bellevue Group AG | 1,818,665 | $136.6M | 3.25% | −2,983,534−62.1% | Reduced |
| Goldman Sachs Group Inc | 1,699,847 | $127.6M | 0.02% | +843,881+98.6% | Added |
| American Century Companies Inc | 1,663,803 | $124.9M | 0.06% | +46,697+2.9% | Added |
| Charles Schwab Investment Management Inc | 1,583,266 | $118.9M | 0.02% | +41,425+2.7% | Added |
| Franklin Resources Inc | 1,575,023 | $118.3M | 0.03% | +253,678+19.2% | Added |
| UBS Asset Management Americas Inc | 1,475,632 | $110.8M | 0.02% | +87,065+6.3% | Added |
| Pictet Asset Management Holding SA | 1,434,995 | $107.1M | 0.11% | +16,504+1.2% | Added |
| Summit Partners Public Asset Management, LLC | 1,404,033 | $105.4M | 4.88% | −58,673−4.0% | Reduced |
| Invesco Ltd. | 1,277,358 | $95.9M | 0.01% | +8,068+0.6% | Added |
| Millennium Management LLC | 1,051,506 | $79.0M | 0.06% | +958,244+1,027.5% | Added |
| Morgan Stanley | 1,026,509 | $77.1M | 0.00% | +6,603+0.6% | Added |
| Vanguard Fiduciary Trust Co | 1,024,377 | $76.9M | 0.02% | +1,024,377 | New |
| Citadel Advisors LLC | 942,534 | $70.8M | 0.05% | −1,192,102−55.8% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 907,533 | $68.1M | 0.08% | −445,304−32.9% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 874,089 | $65.6M | 0.15% | −202,281−18.8% | Reduced |
| Northern Trust Corp | 868,179 | $65.2M | 0.01% | +21,461+2.5% | Added |
| Bank of America Corp | 840,598 | $63.1M | 0.00% | +57,019+7.3% | Added |
| Polar Capital Holdings Plc | 829,511 | $62.3M | 0.27% | −503,913−37.8% | Reduced |
| Groupama Asset Managment | 824,540 | $61.9M | 0.90% | +57,651+7.5% | Added |
| UBS Group AG | 808,443 | $60.7M | 0.01% | −236,598−22.6% | Reduced |
| Nomura Asset Management International Inc. | 785,281 | $59.0M | 0.10% | −79,611−9.2% | Reduced |
| GW&K Investment Management, LLC | 779,349 | $58.5M | 0.52% | −7,319−0.9% | Reduced |
| Arrowstreet Capital, Limited Partnership | 737,859 | $55.4M | 0.03% | −325,468−30.6% | Reduced |
| Squarepoint Ops LLC | 695,276 | $52.2M | 0.11% | +258,997+59.4% | Added |
| Voloridge Investment Management, LLC | 672,858 | $50.5M | 0.20% | +87,888+15.0% | Added |
| Massachusetts Financial Services Co | 666,116 | $50.0M | 0.02% | −146,631−18.0% | Reduced |
| Ameriprise Financial Inc | 660,144 | $49.6M | 0.01% | +61,396+10.3% | Added |
| Nuveen, LLC | 648,496 | $48.7M | 0.01% | −12,273−1.9% | Reduced |
| Eversept Partners, LP | 632,100 | $47.5M | 3.13% | +93,882+17.4% | Added |
| Eventide Asset Management, LLC | 575,000 | $43.2M | 0.71% | 00.0% | Unchanged |
| TD Asset Management Inc | 529,954 | $39.8M | 0.03% | −243,230−31.5% | Reduced |
| Teacher Retirement System of Texas | 523,932 | $39.3M | 0.16% | +101,033+23.9% | Added |
| Bank of New York Mellon Corp | 514,617 | $38.6M | 0.01% | −23,269−4.3% | Reduced |
| Perceptive Advisors LLC | 504,000 | $37.8M | 0.75% | +504,000 | New |
| Boone Capital Management LLC | 500,522 | $37.6M | 11.51% | +82,689+19.8% | Added |
| Candriam Luxembourg S.C.A. | 484,053 | $36.3M | 0.19% | −193,576−28.6% | Reduced |
| BNP Paribas Arbitrage, SA | 479,460 | $36.0M | 0.02% | +144,852+43.3% | Added |
| Alyeska Investment Group, L.P. | 473,150 | $35.5M | 0.10% | −8,561−1.8% | Reduced |
| First Trust Advisors LP | 468,363 | $35.2M | 0.03% | −56,876−10.8% | Reduced |
| Neuberger Berman Group LLC | 443,272 | $33.3M | 0.03% | +335,228+310.3% | Added |
| Pinnacle Associates Ltd | 436,457 | $32.8M | 0.42% | −25,511−5.5% | Reduced |
| D. E. Shaw & Co., Inc. | 429,599 | $32.3M | 0.03% | +96,796+29.1% | Added |
| Alliancebernstein L.P. | 400,669 | $31.7M | 0.01% | +58,820+17.2% | Added |
| Davern Capital Partners, LP | 386,903 | $29.1M | 7.97% | +148,426+62.2% | Added |
| C WorldWide Group Holding A/S | 366,000 | $27.5M | 0.59% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 350,414 | $26.3M | 0.04% | +108,561+44.9% | Added |
| Capital Research Global Investors | 323,015 | $24.3M | 0.00% | +323,015 | New |
| Renaissance Technologies LLC | 305,549 | $22.9M | 0.04% | +81,942+36.6% | Added |
| Swiss National Bank | 304,500 | $22.9M | 0.01% | +6,000+2.0% | Added |
| Hudson Bay Capital Management LP | 295,100 | $22.2M | 0.13% | −179,900−37.9% | Reduced |
| Legal & General Group Plc | 294,679 | $22.1M | 0.01% | −30,469−9.4% | Reduced |
| Privium Fund Management B.V. | 290,024 | $21.8M | 4.53% | +49,200+20.4% | Added |
| Barclays PLC | 289,874 | $21.8M | 0.01% | −552,997−65.6% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 288,716 | $21.7M | 0.17% | −134,252−31.7% | Reduced |
| TimesSquare Capital Management, LLC | 275,674 | $20.7M | 0.35% | +275,674 | New |
| Dimensional Fund Advisors LP | 267,215 | $20.1M | 0.00% | +91,180+51.8% | Added |
| California Public Employees Retirement System | 255,485 | $19.2M | 0.01% | +42,117+19.7% | Added |
| HRT Financial LP | 252,250 | $18.9M | 0.05% | +229,322+1,000.2% | Added |
| Zurich Insurance Group Ltd | 239,645 | $18.0M | 0.14% | −22,175−8.5% | Reduced |
| Davenport & Co LLC | 238,238 | $17.9M | 0.10% | +20,341+9.3% | Added |
| J. Goldman & Co LP | 235,260 | $17.7M | 0.82% | +167,621+247.8% | Added |
| Raymond James Financial Inc | 235,121 | $17.7M | 0.01% | −22,089−8.6% | Reduced |
| ExodusPoint Capital Management, LP | 227,084 | $17.1M | 0.17% | +143,209+170.7% | Added |
| Orion Investment Co | 225,015 | $16.9M | 5.38% | −146−0.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,652 | $16.5M | 0.03% | +780.0% | Added |
| Tocqueville Asset Management L.P. | 219,220 | $16.5M | 0.24% | +15,490+7.6% | Added |
| Handelsbanken Fonder AB | 213,911 | $16.1M | 0.05% | +166,000+346.5% | Added |
| Trexquant Investment LP | 213,645 | $16.0M | 0.12% | +81,404+61.6% | Added |
| Jump Financial, LLC | 206,675 | $15.5M | 0.23% | +206,675 | New |
| Stifel Financial Corp | 196,703 | $14.8M | 0.01% | −2,160−1.1% | Reduced |
| CI Private Wealth, LLC | 196,599 | $14.8M | 0.02% | −19,839−9.2% | Reduced |
| Jane Street Group, LLC | 191,818 | $14.4M | 0.02% | +161,347+529.5% | Added |
| Wells Fargo & Company | 189,853 | $14.3M | 0.00% | −90,192−32.2% | Reduced |
| HSBC Holdings PLC | 185,967 | $14.0M | 0.01% | +159,026+590.3% | Added |
| California State Teachers Retirement System | 176,485 | $13.3M | 0.01% | +32,312+22.4% | Added |
| Rhumbline Advisers | 173,440 | $13.0M | 0.01% | −1,947−1.1% | Reduced |
| Sector Gamma AS | 169,468 | $12.7M | 3.00% | −15,509−8.4% | Reduced |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 167,657 | $12.6M | 0.01% | 00.0% | Unchanged |
| Colony Group, LLC | 165,544 | $12.4M | 0.01% | −16,273−9.0% | Reduced |
| ADAR1 Capital Management, LLC | 160,338 | $12.0M | 0.72% | +13,208+9.0% | Added |
| Deutsche Bank AG | 159,891 | $12.0M | 0.00% | +10,448+7.0% | Added |
| Sicart Associates LLC | 159,412 | $12.0M | 3.07% | −4,145−2.5% | Reduced |