Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 339
- −4 vs. Q3 2022
- Shares held
- 130.6M
- +4.77M (+3.8%) vs. Q3 2022
- Total value
- $4.93B
- −$630.7M (−11.3%) vs. Q3 2022
- New holders
- 50
- 115 more added
- Sold out
- 54
- 107 more reduced
7 institutions that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,307,519 | $804.8M | 0.08% | +16,360+0.1% | Added |
| Vanguard Group Inc | 13,546,694 | $511.7M | 0.01% | +740,671+5.8% | Added |
| T. Rowe Price Investment Management, Inc. | 11,678,259 | $441.1M | 0.34% | +521,564+4.7% | Added |
| Bellevue Group AG | 9,743,900 | $368.0M | 4.88% | +280,500+3.0% | Added |
| BlackRock Inc. | 9,079,557 | $342.9M | 0.01% | +143,495+1.6% | Added |
| Clearbridge Investments, LLC | 5,425,642 | $204.9M | 0.20% | −348,250−6.0% | Reduced |
| Price T Rowe Associates Inc | 4,292,431 | $162.1M | 0.03% | −504,701−10.5% | Reduced |
| State Street Corp | 4,218,729 | $159.3M | 0.01% | +457,774+12.2% | Added |
| Tweedy, Browne Co LLC | 3,541,136 | $133.7M | 7.12% | +818,148+30.0% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 2,673,538 | $101.0M | 0.88% | −1,039,569−28.0% | Reduced |
| Geode Capital Management, LLC | 2,012,723 | $76.0M | 0.01% | +111,580+5.9% | Added |
| OrbiMed Advisors LLC | 1,993,600 | $75.3M | 1.44% | +1,224,700+159.3% | Added |
| Camber Capital Management LP | 1,925,000 | $72.7M | 2.54% | 00.0% | Unchanged |
| First Trust Advisors LP | 1,780,933 | $67.3M | 0.08% | −296,327−14.3% | Reduced |
| Macquarie Group Ltd | 1,491,687 | $56.3M | 0.07% | +657,646+78.9% | Added |
| Norges Bank | 1,296,647 | $49.0M | 0.01% | +105,896+8.9% | Added |
| Charles Schwab Investment Management Inc | 1,256,268 | $47.4M | 0.02% | +53,922+4.5% | Added |
| Deep Track Capital, LP | 1,205,773 | $45.5M | 1.99% | +1,205,773 | New |
| Renaissance Technologies LLC | 1,178,814 | $44.5M | 0.06% | +311,100+35.9% | Added |
| BVF Inc | 1,121,809 | $42.4M | 1.79% | −1,751,144−61.0% | Reduced |
| Swedbank AB | 1,021,429 | $38.6M | 0.08% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 970,310 | $36.6M | 0.01% | +41,558+4.5% | Added |
| Morgan Stanley | 936,709 | $35.4M | 0.00% | +240,171+34.5% | Added |
| Goldman Sachs Group Inc | 922,411 | $34.8M | 0.01% | −368,154−28.5% | Reduced |
| Thrivent Financial for Lutherans | 919,332 | $34.7M | 0.09% | +10,853+1.2% | Added |
| TD Asset Management Inc | 779,495 | $29.4M | 0.04% | −24,588−3.1% | Reduced |
| Jacobs Levy Equity Management, Inc | 689,721 | $26.1M | 0.18% | +177,746+34.7% | Added |
| Northern Trust Corp | 639,689 | $24.2M | 0.01% | +16,049+2.6% | Added |
| Bank of America Corp | 637,313 | $24.1M | 0.00% | +77,357+13.8% | Added |
| Two Sigma Advisers, LP | 634,911 | $24.0M | 0.07% | −22,600−3.4% | Reduced |
| Wells Fargo & Company | 608,040 | $23.0M | 0.01% | −81,832−11.9% | Reduced |
| Bank of New York Mellon Corp | 573,798 | $21.7M | 0.00% | −5,615−1.0% | Reduced |
| AXA S.A. | 521,570 | $19.7M | 0.07% | +339,214+186.0% | Added |
| Barclays PLC | 507,311 | $19.2M | 0.02% | +2,823+0.6% | Added |
| Royal Bank of Canada | 506,845 | $19.1M | 0.01% | +70,021+16.0% | Added |
| Pinnacle Associates Ltd | 494,750 | $18.7M | 0.41% | −6,140−1.2% | Reduced |
| Allspring Global Investments Holdings, LLC | 488,063 | $18.4M | 0.03% | +481,018+6,827.8% | Added |
| Candriam Luxembourg S.C.A. | 465,700 | $17.6M | 0.12% | +14,349+3.2% | Added |
| Dimensional Fund Advisors LP | 458,444 | $17.3M | 0.01% | −102,484−18.3% | Reduced |
| Assenagon Asset Management S.A. | 441,802 | $16.7M | 0.07% | −10,958−2.4% | Reduced |
| Nomura Holdings Inc | 400,057 | $15.1M | 0.15% | +12,149+3.1% | Added |
| Citadel Advisors LLC | 395,546 | $14.9M | 0.02% | −22,686−5.4% | Reduced |
| Pictet Asset Management SA | 373,586 | $14.1M | 0.02% | +96,609+34.9% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 336,732 | $12.7M | 0.01% | −100,444−23.0% | Reduced |
| Nikko Asset Management Americas, Inc. | 336,732 | $12.7M | 0.18% | −100,444−23.0% | Reduced |
| Baillie Gifford & Co | 333,788 | $12.6M | 0.01% | +8,946+2.8% | Added |
| Qube Research & Technologies Ltd | 330,724 | $12.5M | 0.08% | +319,027+2,727.4% | Added |
| California Public Employees Retirement System | 329,837 | $12.5M | 0.01% | +6,251+1.9% | Added |
| Nuveen Asset Management, LLC | 323,178 | $12.2M | 0.00% | −16,106−4.7% | Reduced |
| Invesco Ltd. | 322,447 | $12.2M | 0.00% | +27,248+9.2% | Added |
| Altrinsic Global Advisors LLC | 319,174 | $12.1M | 0.51% | +157,928+97.9% | Added |
| Swiss National Bank | 308,400 | $11.6M | 0.01% | +5,800+1.9% | Added |
| ExodusPoint Capital Management, LP | 304,390 | $11.5M | 0.18% | +297,973+4,643.5% | Added |
| CI Private Wealth, LLC | 302,677 | $11.4M | 0.04% | +302,677 | New |
| D. E. Shaw & Co., Inc. | 299,231 | $11.3M | 0.02% | +89,786+42.9% | Added |
| Stifel Financial Corp | 269,744 | $10.2M | 0.02% | −30,269−10.1% | Reduced |
| Redmile Group, LLC | 266,187 | $10.1M | 0.41% | −141,472−34.7% | Reduced |
| Schonfeld Strategic Advisors LLC | 265,798 | $10.0M | 0.08% | +58,126+28.0% | Added |
| Sicart Associates LLC | 246,258 | $9.30M | 3.28% | −7,718−3.0% | Reduced |
| Bank of Montreal | 221,978 | $9.21M | 0.01% | −101,551−31.4% | Reduced |
| Eversept Partners, LP | 240,975 | $9.10M | 0.87% | +39,142+19.4% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 230,577 | $8.71M | 0.05% | +1,516+0.7% | Added |
| Man Group plc | 230,525 | $8.71M | 0.03% | +52,928+29.8% | Added |
| Raymond James & Associates | 225,470 | $8.52M | 0.01% | −12,698−5.3% | Reduced |
| Hudson Bay Capital Management LP | 225,000 | $8.50M | 0.10% | +25,200+12.6% | Added |
| Rafferty Asset Management, LLC | 218,979 | $8.27M | 0.07% | +67,005+44.1% | Added |
| Two Sigma Investments, LP | 201,267 | $7.60M | 0.02% | −91,727−31.3% | Reduced |
| Tang Capital Management LLC | 200,000 | $7.55M | 1.10% | 00.0% | Unchanged |
| Jefferies Financial Group Inc. | 197,009 | $7.44M | 0.13% | +197,009 | New |
| BNP Paribas Arbitrage, SA | 191,947 | $7.25M | 0.02% | +59,207+44.6% | Added |
| Fred Alger Management, LLC | 190,353 | $7.19M | 0.04% | +47,831+33.6% | Added |
| Russell Investments Group, Ltd. | 190,298 | $7.19M | 0.01% | +97,978+106.1% | Added |
| Credit Suisse AG | 184,302 | $6.96M | 0.01% | +29,604+19.1% | Added |
| Squarepoint Ops LLC | 181,007 | $6.84M | 0.05% | +88,953+96.6% | Added |
| UBS Asset Management Americas Inc | 175,796 | $6.64M | 0.00% | −103,828−37.1% | Reduced |
| California State Teachers Retirement System | 167,875 | $6.34M | 0.01% | +1,950+1.2% | Added |
| Rhumbline Advisers | 165,163 | $6.24M | 0.01% | +9,449+6.1% | Added |
| Tocqueville Asset Management L.P. | 161,569 | $6.10M | 0.12% | −825−0.5% | Reduced |
| UBS Group AG | 161,471 | $6.10M | 0.00% | +100,161+163.4% | Added |
| Natixis | 159,678 | $6.03M | 0.04% | +25,597+19.1% | Added |
| Sonora Investment Management Group, LLC | 156,115 | $5.90M | 0.54% | −908−0.6% | Reduced |
| State Board of Administration of Florida Retirement System | 155,145 | $5.86M | 0.01% | −8,110−5.0% | Reduced |
| DekaBank Deutsche Girozentrale | 153,000 | $5.70M | 0.02% | +28,224+22.6% | Added |
| BLB&B Advisors, LLC | 148,960 | $5.63M | 0.44% | −110−0.1% | Reduced |
| Privium Fund Management B.V. | 148,807 | $5.56M | 2.11% | 00.0% | Unchanged |
| Sector Gamma AS | 141,373 | $5.34M | 1.22% | −22,850−13.9% | Reduced |
| Parkman Healthcare Partners LLC | 141,115 | $5.33M | 1.42% | −100,830−41.7% | Reduced |
| New York State Common Retirement Fund | 140,500 | $5.31M | 0.01% | −2,400−1.7% | Reduced |
| Kennedy Capital Management, Inc. | 139,181 | $5.26M | 0.15% | −5,614−3.9% | Reduced |
| Peregrine Capital Management LLC | 131,711 | $4.97M | 0.16% | +8,315+6.7% | Added |
| Citigroup Inc | 129,129 | $4.88M | 0.01% | −47,863−27.0% | Reduced |
| State of Wisconsin Investment Board | 128,227 | $4.84M | 0.02% | −1,627−1.3% | Reduced |
| Cubist Systematic Strategies, LLC | 128,070 | $4.84M | 0.04% | +57,662+81.9% | Added |
| Legal & General Group Plc | 127,088 | $4.80M | 0.00% | −1,365−1.1% | Reduced |
| M28 Capital Management LP | 126,300 | $4.77M | 4.55% | +126,300 | New |
| Millennium Management LLC | 115,506 | $4.36M | 0.00% | +96,577+510.2% | Added |
| Eventide Asset Management, LLC | 110,000 | $4.15M | 0.08% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 102,487 | $3.87M | 0.01% | +73,607+254.9% | Added |
| Alberta Investment Management Corp | 101,426 | $3.83M | 0.03% | +101,426 | New |
| Public Sector Pension Investment Board | 98,000 | $3.70M | 0.03% | +98,000 | New |