Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 339
- −4 vs. Q3 2022
- Shares held
- 130.6M
- +4.77M (+3.8%) vs. Q3 2022
- Total value
- $4.93B
- −$630.7M (−11.3%) vs. Q3 2022
- New holders
- 50
- 115 more added
- Sold out
- 54
- 107 more reduced
7 institutions that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Susquehanna Fundamental Investments, LLC | 93,435 | $3.53M | 0.06% | −60,201−39.2% | Reduced |
| Tekla Capital Management LLC | 87,840 | $3.32M | 0.13% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 82,523 | $3.08M | 0.00% | −6,573−7.4% | Reduced |
| Davenport & Co LLC | 80,617 | $3.04M | 0.03% | −4,246−5.0% | Reduced |
| State of New Jersey Common Pension Fund D | 80,433 | $3.04M | 0.01% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 76,345 | $2.88M | 0.01% | +222+0.3% | Added |
| LPL Financial LLC | 74,099 | $2.80M | 0.00% | −641−0.9% | Reduced |
| Algert Global LLC | 73,547 | $2.78M | 0.15% | +12,610+20.7% | Added |
| Canada Pension Plan Investment Board | 72,900 | $2.75M | 0.00% | +72,900 | New |
| PFS Investments Inc. | 72,125 | $2.72M | 0.05% | −3,077−4.1% | Reduced |
| Voya Investment Management LLC | 70,277 | $2.65M | 0.00% | +20.0% | Added |
| Gotham Asset Management, LLC | 69,896 | $2.64M | 0.07% | +46,656+200.8% | Added |
| Deutsche Bank AG | 66,625 | $2.52M | 0.00% | +1,199+1.8% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 63,000 | $2.38M | 0.01% | −29,700−32.0% | Reduced |
| Guggenheim Capital LLC | 62,159 | $2.35M | 0.02% | +7,190+13.1% | Added |
| Treasurer of the State of North Carolina | 61,302 | $2.31M | 0.01% | +780+1.3% | Added |
| National Bank of Canada | 60,895 | $2.30M | 0.01% | +9,175+17.7% | Added |
| Alliancebernstein L.P. | 58,504 | $2.21M | 0.00% | +402+0.7% | Added |
| Susquehanna International Group, LLP | 57,872 | $2.19M | 0.00% | +17,002+41.6% | Added |
| Ensign Peak Advisors, Inc | 54,891 | $2.07M | 0.00% | +22,576+69.9% | Added |
| Bard Financial Services, Inc. | 53,925 | $2.04M | 0.17% | −33,970−38.6% | Reduced |
| Janus Henderson Group PLC | 53,722 | $2.03M | 0.00% | +30,582+132.2% | Added |
| Duality Advisers, LP | 53,524 | $2.02M | 0.23% | +47,732+824.1% | Added |
| Gateway Investment Advisers LLC | 51,174 | $1.93M | 0.02% | +975+1.9% | Added |
| Erste Asset Management GmbH | 51,300 | $1.92M | 0.04% | 00.0% | Unchanged |
| Intech Investment Management LLC | 50,510 | $1.91M | 0.01% | −6,630−11.6% | Reduced |
| Rhenman & Partners Asset Management AB | 50,000 | $1.89M | 0.20% | 00.0% | Unchanged |
| Trexquant Investment LP | 46,945 | $1.77M | 0.05% | −8,619−15.5% | Reduced |
| SEI Investments Co | 45,941 | $1.74M | 0.00% | +26,812+140.2% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.59M | 0.26% | 00.0% | Unchanged |
| Highland Capital Management, LLC | 40,310 | $1.52M | 0.11% | +1,437+3.7% | Added |
| Capital Counsel LLC | 40,230 | $1.52M | 0.10% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 38,378 | $1.45M | 0.01% | −3,466−8.3% | Reduced |
| Principal Financial Group Inc | 38,322 | $1.45M | 0.00% | −21,947−36.4% | Reduced |
| Tudor Investment Corp Et Al | 36,365 | $1.37M | 0.03% | +15,256+72.3% | Added |
| Arizona State Retirement System | 36,047 | $1.36M | 0.01% | +1,367+3.9% | Added |
| Envestnet Asset Management Inc | 35,429 | $1.34M | 0.00% | −3,835−9.8% | Reduced |
| Magnetar Financial LLC | 34,597 | $1.31M | 0.02% | +34,597 | New |
| Janney Montgomery Scott LLC | 33,058 | $1.25M | 0.00% | +643+2.0% | Added |
| Amalgamated Bank | 32,095 | $1.21M | 0.01% | +503+1.6% | Added |
| Grandfield & Dodd, LLC | 31,474 | $1.19M | 0.09% | +2,403+8.3% | Added |
| Bank of Nova Scotia | 31,000 | $1.17M | 0.00% | +31,000 | New |
| American Century Companies Inc | 30,872 | $1.17M | 0.00% | +20,793+206.3% | Added |
| Virginia Retirement Systems Et Al | 30,800 | $1.16M | 0.01% | +4,200+15.8% | Added |
| Voloridge Investment Management, LLC | 30,709 | $1.16M | 0.01% | +30,709 | New |
| Toronto Dominion Bank | 30,706 | $1.16M | 0.00% | −600−1.9% | Reduced |
| Edgestream Partners, L.P. | 27,393 | $1.03M | 0.12% | +27,393 | New |
| Pinebridge Investments, L.P. | 26,959 | $1.02M | 0.01% | +26,959 | New |
| Raymond James Financial Services Advisors, Inc. | 26,725 | $1.01M | 0.00% | −5,839−17.9% | Reduced |
| Federated Hermes, Inc. | 26,579 | $1.00M | 0.00% | +452+1.7% | Added |
| Great West Life Assurance Co | 26,140 | $993.0K | 0.00% | +9,005+52.6% | Added |
| Walleye Capital LLC | 26,054 | $984.1K | 0.02% | −59,909−69.7% | Reduced |
| STRS Ohio | 25,791 | $974.0K | 0.00% | +8,483+49.0% | Added |
| Dynamic Technology Lab Private Ltd | 25,580 | $966.0K | 0.10% | +25,580 | New |
| Cantor Fitzgerald, L. P. | 22,880 | $864.0K | 0.02% | +22,880 | New |
| Kestra Advisory Services, LLC | 22,413 | $846.5K | 0.01% | −512−2.2% | Reduced |
| Commonwealth Equity Services, LLC | 20,704 | $781.0K | 0.00% | −543−2.6% | Reduced |
| Castle Rock Wealth Management, LLC | 19,385 | $763.4K | 0.34% | −500−2.5% | Reduced |
| Engineers Gate Manager LP | 19,977 | $754.5K | 0.05% | +13,484+207.7% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 19,736 | $745.0K | 0.01% | −1,142−5.5% | Reduced |
| Public Employees Retirement Association of Colorado | 19,604 | $740.0K | 0.00% | 00.0% | Unchanged |
| Echo Street Capital Management LLC | 19,103 | $721.5K | 0.01% | +12,910+208.5% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,697 | $706.2K | 0.00% | +1,963+11.7% | Added |
| Vestmark Advisory Solutions, Inc. | 18,602 | $702.6K | 0.03% | −6,597−26.2% | Reduced |
| Koss-Olinger Consulting, LLC | 18,563 | $701.0K | 0.10% | −17,376−48.3% | Reduced |
| Handelsbanken Fonder AB | 18,511 | $699.0K | 0.00% | 00.0% | Unchanged |
| Xponance, Inc. | 17,710 | $668.9K | 0.01% | +2,170+14.0% | Added |
| Mariner, LLC | 17,542 | $663.0K | 0.00% | +10,401+145.7% | Added |
| Natixis Advisors, L.P. | 16,203 | $612.0K | 0.00% | +385+2.4% | Added |
| American Trust | 15,970 | $603.2K | 0.06% | +15,970 | New |
| Profund Advisors LLC | 15,845 | $598.5K | 0.04% | +368+2.4% | Added |
| Victory Capital Management Inc | 15,787 | $596.3K | 0.00% | −8−0.1% | Reduced |
| Group One Trading, L.P. | 15,463 | $584.0K | 0.02% | +15,463 | New |
| Quantedge Capital Pte Ltd | 15,100 | $570.3K | 0.19% | +15,100 | New |
| Campbell & CO Investment Adviser LLC | 15,018 | $567.2K | 0.14% | +15,018 | New |
| US Bancorp | 14,820 | $559.8K | 0.00% | −1,378−8.5% | Reduced |
| Blair William & Co | 14,644 | $553.1K | 0.00% | −200−1.3% | Reduced |
| ProShare Advisors LLC | 13,903 | $525.1K | 0.00% | −295−2.1% | Reduced |
| AtonRa Partners | 13,875 | $524.1K | 0.67% | −3,753−21.3% | Reduced |
| Franklin Resources Inc | 13,719 | $518.2K | 0.00% | +2,468+21.9% | Added |
| North Star Asset Management Inc | 13,680 | $516.7K | 0.03% | 00.0% | Unchanged |
| Westmount Partners, LLC | 13,462 | $508.5K | 0.26% | +13,462 | New |
| Creative Planning | 13,428 | $507.2K | 0.00% | −464−3.3% | Reduced |
| Ameriprise Financial Inc | 13,331 | $501.0K | 0.00% | −25,372−65.6% | Reduced |
| Bleakley Financial Group, LLC | 13,184 | $498.0K | 0.02% | +13,184 | New |
| Lincoln National Corp | 13,099 | $494.7K | 0.01% | +269+2.1% | Added |
| Storebrand Asset Management AS | 13,062 | $493.4K | 0.00% | 00.0% | Unchanged |
| Caption Management, LLC | 13,000 | $491.0K | 0.08% | +13,000 | New |
| Corton Capital Inc. | 12,638 | $477.3K | 0.39% | +3,215+34.1% | Added |
| Teza Capital Management LLC | 12,624 | $476.8K | 0.09% | +2,376+23.2% | Added |
| Comerica Bank | 11,522 | $459.0K | 0.00% | −17−0.1% | Reduced |
| Van Eck Associates Corp | 12,042 | $455.0K | 0.00% | +10,625+749.8% | Added |
| Illinois Municipal Retirement Fund | 11,866 | $448.0K | 0.01% | +11,866 | New |
| Arden Trust Co | 11,710 | $442.3K | 0.09% | −206−1.7% | Reduced |
| Delphia (USA) Inc. | 11,612 | $438.6K | 0.51% | +2,015+21.0% | Added |
| Brown Advisory Inc | 11,531 | $435.5K | 0.00% | +901+8.5% | Added |
| Jane Street Group, LLC | 11,480 | $433.6K | 0.00% | −9,149−44.4% | Reduced |
| E Fund Management Co., Ltd. | 11,272 | $426.0K | 0.04% | +1,102+10.8% | Added |
| Plancorp, LLC | 11,212 | $423.5K | 0.02% | −43−0.4% | Reduced |
| HighTower Advisors, LLC | 11,166 | $421.0K | 0.00% | +2,301+26.0% | Added |