Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2023
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 315
- −18 vs. Q4 2022
- Shares held
- 131.1M
- +517.1K (+0.4%) vs. Q4 2022
- Total value
- $4.69B
- −$238.7M (−4.8%) vs. Q4 2022
- New holders
- 34
- 87 more added
- Sold out
- 52
- 128 more reduced
6 institutions that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 21,436,334 | $766.1M | 0.07% | +128,815+0.6% | Added |
| Vanguard Group Inc | 13,975,790 | $499.5M | 0.01% | +429,096+3.2% | Added |
| T. Rowe Price Investment Management, Inc. | 13,064,047 | $466.9M | 0.33% | +1,385,788+11.9% | Added |
| Bellevue Group AG | 9,511,900 | $340.0M | 4.93% | −232,000−2.4% | Reduced |
| BlackRock Inc. | 8,982,246 | $321.0M | 0.01% | −97,311−1.1% | Reduced |
| Clearbridge Investments, LLC | 5,391,581 | $192.7M | 0.18% | −34,061−0.6% | Reduced |
| State Street Corp | 4,068,334 | $145.4M | 0.01% | −150,395−3.6% | Reduced |
| Price T Rowe Associates Inc | 3,934,951 | $140.6M | 0.02% | −357,480−8.3% | Reduced |
| Tweedy, Browne Co LLC | 3,541,046 | $126.6M | 6.89% | −900.0% | Reduced |
| Deep Track Capital, LP | 2,834,069 | $101.3M | 4.31% | +1,628,296+135.0% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 2,637,192 | $94.3M | 0.65% | −36,346−1.4% | Reduced |
| BVF Inc | 2,560,761 | $91.5M | 3.35% | +1,438,952+128.3% | Added |
| OrbiMed Advisors LLC | 2,124,500 | $75.9M | 1.50% | +130,900+6.6% | Added |
| Geode Capital Management, LLC | 2,069,950 | $74.0M | 0.01% | +57,227+2.8% | Added |
| Camber Capital Management LP | 1,925,000 | $68.8M | 2.35% | 00.0% | Unchanged |
| First Trust Advisors LP | 1,638,943 | $58.6M | 0.07% | −141,990−8.0% | Reduced |
| Macquarie Group Ltd | 1,493,903 | $53.4M | 0.06% | +2,216+0.1% | Added |
| Charles Schwab Investment Management Inc | 1,186,393 | $42.4M | 0.01% | −69,875−5.6% | Reduced |
| Norges Bank | 1,132,691 | $40.5M | 0.01% | −163,956−12.6% | Reduced |
| Pictet Asset Management SA | 1,113,042 | $39.8M | 0.05% | +739,456+197.9% | Added |
| JPMorgan Chase & Co | 1,057,395 | $37.8M | 0.00% | +87,085+9.0% | Added |
| Morgan Stanley | 1,003,009 | $35.8M | 0.00% | +66,300+7.1% | Added |
| Swedbank AB | 961,674 | $34.4M | 0.07% | −59,755−5.9% | Reduced |
| Thrivent Financial for Lutherans | 932,540 | $33.3M | 0.08% | +13,208+1.4% | Added |
| TD Asset Management Inc | 817,308 | $29.2M | 0.04% | +37,813+4.9% | Added |
| Northern Trust Corp | 658,466 | $23.5M | 0.00% | +18,777+2.9% | Added |
| Renaissance Technologies LLC | 636,314 | $22.7M | 0.03% | −542,500−46.0% | Reduced |
| Bank of America Corp | 632,644 | $22.6M | 0.00% | −4,669−0.7% | Reduced |
| Wells Fargo & Company | 626,150 | $22.4M | 0.01% | +18,110+3.0% | Added |
| Bank of New York Mellon Corp | 566,095 | $20.2M | 0.00% | −7,703−1.3% | Reduced |
| Jacobs Levy Equity Management, Inc | 536,688 | $19.2M | 0.12% | −153,033−22.2% | Reduced |
| AXA S.A. | 520,868 | $18.6M | 0.06% | −702−0.1% | Reduced |
| Royal Bank of Canada | 495,957 | $17.7M | 0.01% | −10,888−2.1% | Reduced |
| Pinnacle Associates Ltd | 490,655 | $17.5M | 0.36% | −4,095−0.8% | Reduced |
| Barclays PLC | 458,817 | $16.4M | 0.02% | −48,494−9.6% | Reduced |
| Dimensional Fund Advisors LP | 442,885 | $15.8M | 0.01% | −15,559−3.4% | Reduced |
| Goldman Sachs Group Inc | 422,098 | $15.1M | 0.00% | −500,313−54.2% | Reduced |
| Candriam Luxembourg S.C.A. | 445,197 | $14.6M | 0.10% | −20,503−4.4% | Reduced |
| Nomura Holdings Inc | 401,323 | $14.3M | 0.14% | +1,266+0.3% | Added |
| Allspring Global Investments Holdings, LLC | 377,211 | $13.5M | 0.02% | −110,852−22.7% | Reduced |
| Two Sigma Advisers, LP | 345,811 | $12.4M | 0.03% | −289,100−45.5% | Reduced |
| Liontrust Investment Partners LLP | 337,601 | $12.1M | 0.18% | +337,601 | New |
| Baillie Gifford & Co | 332,659 | $11.9M | 0.01% | −1,129−0.3% | Reduced |
| Altrinsic Global Advisors LLC | 322,281 | $11.5M | 0.45% | +3,107+1.0% | Added |
| Invesco Ltd. | 315,720 | $11.3M | 0.00% | −6,727−2.1% | Reduced |
| Nuveen Asset Management, LLC | 313,865 | $11.2M | 0.00% | −9,313−2.9% | Reduced |
| Hudson Bay Capital Management LP | 305,800 | $10.9M | 0.12% | +80,800+35.9% | Added |
| CI Private Wealth, LLC | 305,286 | $10.9M | 0.03% | +2,609+0.9% | Added |
| Eversept Partners, LP | 303,369 | $10.8M | 0.97% | +62,394+25.9% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 297,469 | $10.6M | 0.01% | −39,263−11.7% | Reduced |
| California Public Employees Retirement System | 282,326 | $10.1M | 0.01% | −47,511−14.4% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 278,758 | $9.96M | 0.05% | +48,181+20.9% | Added |
| Swiss National Bank | 275,900 | $9.86M | 0.01% | −32,500−10.5% | Reduced |
| Nikko Asset Management Americas, Inc. | 297,469 | $9.83M | 0.11% | −39,263−11.7% | Reduced |
| Stifel Financial Corp | 269,831 | $9.64M | 0.01% | +870.0% | Added |
| ExodusPoint Capital Management, LP | 265,330 | $9.48M | 0.11% | −39,060−12.8% | Reduced |
| Man Group plc | – | $8.95M | 0.03% | – | – |
| Credit Suisse AG | 242,071 | $8.65M | 0.01% | +57,769+31.3% | Added |
| Bank of Montreal | 213,931 | $7.65M | 0.00% | −8,047−3.6% | Reduced |
| Sicart Associates LLC | 210,698 | $7.53M | 2.93% | −35,560−14.4% | Reduced |
| Rafferty Asset Management, LLC | 203,887 | $7.29M | 0.05% | −15,092−6.9% | Reduced |
| Balyasny Asset Management LLC | 203,466 | $7.27M | 0.02% | +203,466 | New |
| Raymond James & Associates | 200,954 | $7.18M | 0.01% | −24,516−10.9% | Reduced |
| Tang Capital Management LLC | 200,000 | $7.15M | 1.07% | 00.0% | Unchanged |
| Citigroup Inc | 184,973 | $6.61M | 0.01% | +55,844+43.2% | Added |
| Privium Fund Management B.V. | 182,773 | $6.53M | 2.19% | +33,966+22.8% | Added |
| Kennedy Capital Management, Inc. | 182,425 | $6.52M | 0.19% | +43,244+31.1% | Added |
| UBS Asset Management Americas Inc | 176,733 | $6.32M | 0.00% | +937+0.5% | Added |
| Rhumbline Advisers | 176,685 | $6.32M | 0.01% | +11,522+7.0% | Added |
| California State Teachers Retirement System | 165,180 | $5.90M | 0.01% | −2,695−1.6% | Reduced |
| Tocqueville Asset Management L.P. | 162,480 | $5.81M | 0.11% | +911+0.6% | Added |
| DekaBank Deutsche Girozentrale | 165,000 | $5.72M | 0.01% | +12,000+7.8% | Added |
| State Board of Administration of Florida Retirement System | 155,145 | $5.54M | 0.01% | 00.0% | Unchanged |
| Sonora Investment Management Group, LLC | 152,833 | $5.46M | 0.48% | −3,282−2.1% | Reduced |
| Citadel Advisors LLC | 151,523 | $5.42M | 0.01% | −244,023−61.7% | Reduced |
| Parkman Healthcare Partners LLC | 151,161 | $5.40M | 1.17% | +10,046+7.1% | Added |
| Peregrine Capital Management LLC | 149,247 | $5.33M | 0.15% | +17,536+13.3% | Added |
| BLB&B Advisors, LLC | 148,960 | $5.32M | 0.40% | 00.0% | Unchanged |
| Sector Gamma AS | 146,441 | $5.23M | 1.27% | +5,068+3.6% | Added |
| Legal & General Group Plc | 140,718 | $5.03M | 0.00% | +13,630+10.7% | Added |
| Twinbeech Capital LP | 136,967 | $4.90M | 0.10% | +136,967 | New |
| New York State Common Retirement Fund | 134,000 | $4.79M | 0.01% | −6,500−4.6% | Reduced |
| M28 Capital Management LP | 126,300 | $4.51M | 5.10% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 115,251 | $4.12M | 0.01% | −12,976−10.1% | Reduced |
| Squarepoint Ops LLC | 113,400 | $4.05M | 0.03% | −67,607−37.4% | Reduced |
| Eventide Asset Management, LLC | 110,000 | $3.93M | 0.07% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 108,248 | $3.87M | 0.01% | +5,761+5.6% | Added |
| UBS Oconnor LLC | 107,489 | $3.84M | 0.09% | +107,489 | New |
| Jane Street Group, LLC | 103,901 | $3.71M | 0.01% | +92,421+805.1% | Added |
| Russell Investments Group, Ltd. | 103,476 | $3.70M | 0.01% | −86,822−45.6% | Reduced |
| Alberta Investment Management Corp | 101,426 | $3.62M | 0.04% | 00.0% | Unchanged |
| UBS Group AG | 100,946 | $3.61M | 0.00% | −60,525−37.5% | Reduced |
| BNP Paribas Arbitrage, SA | 99,115 | $3.54M | 0.01% | −92,832−48.4% | Reduced |
| Public Sector Pension Investment Board | 98,000 | $3.50M | 0.03% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 95,885 | $3.43M | 0.01% | +95,885 | New |
| Agf Management Ltd | 94,625 | $3.38M | 0.02% | +94,625 | New |
| Tekla Capital Management LLC | 87,840 | $3.14M | 0.12% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 86,651 | $3.10M | 0.00% | −212,580−71.0% | Reduced |
| Davenport & Co LLC | 80,617 | $2.88M | 0.02% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 80,433 | $2.87M | 0.01% | 00.0% | Unchanged |