Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 24,072,101 | $1.90B | 0.10% | +383,063+1.6% | Added |
| Capital World Investors | 17,961,299 | $1.42B | 0.19% | +5,238,571+41.2% | Added |
| Vanguard Group Inc | 16,440,459 | $1.30B | 0.02% | −41,271−0.3% | Reduced |
| BlackRock, Inc. | 10,647,863 | $842.4M | 0.01% | +199,923+1.9% | Added |
| T. Rowe Price Investment Management, Inc. | 9,108,019 | $720.5M | 0.45% | −4,048,910−30.8% | Reduced |
| Wellington Management Group LLP | 6,260,325 | $495.3M | 0.09% | −328,486−5.0% | Reduced |
| Bellevue Group AG | 4,802,199 | $379.9M | 7.20% | −1,442,252−23.1% | Reduced |
| State Street Corp | 3,974,865 | $314.5M | 0.01% | −413,786−9.4% | Reduced |
| Geode Capital Management, LLC | 3,148,849 | $249.2M | 0.02% | +82,560+2.7% | Added |
| Two Sigma Advisers, LP | 3,052,111 | $241.5M | 0.47% | +979,000+47.2% | Added |
| Price T Rowe Associates Inc | 2,987,840 | $236.4M | 0.03% | +258,155+9.5% | Added |
| Two Sigma Investments, LP | 2,658,646 | $210.3M | 0.31% | +1,082,703+68.7% | Added |
| Tweedy, Browne Co LLC | 2,464,930 | $195.0M | 15.74% | −436,286−15.0% | Reduced |
| JPMorgan Chase & Co | 2,304,792 | $182.3M | 0.01% | +1,760,324+323.3% | Added |
| Citadel Advisors LLC | 2,134,636 | $168.9M | 0.11% | −267,429−11.1% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $156.6M | 2.01% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 1,791,841 | $141.8M | 0.83% | +1,225,043+216.1% | Added |
| Deep Track Capital, LP | 1,700,000 | $134.5M | 3.07% | −2,108,144−55.4% | Reduced |
| American Century Companies Inc | 1,617,106 | $127.9M | 0.06% | +244,881+17.8% | Added |
| Charles Schwab Investment Management Inc | 1,541,841 | $122.0M | 0.02% | +21,890+1.4% | Added |
| Summit Partners Public Asset Management, LLC | 1,462,706 | $115.7M | 3.26% | +712,706+95.0% | Added |
| Pictet Asset Management Holding SA | 1,418,491 | $112.5M | 0.11% | +25,367+1.8% | Added |
| UBS Asset Management Americas Inc | 1,388,567 | $109.8M | 0.02% | +234,401+20.3% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,352,837 | $107.0M | 0.12% | +293,116+27.7% | Added |
| Polar Capital Holdings Plc | 1,333,424 | $105.5M | 0.48% | +299,802+29.0% | Added |
| Franklin Resources Inc | 1,321,345 | $104.5M | 0.03% | +1,314,752+19,941.6% | Added |
| Invesco Ltd. | 1,269,290 | $100.4M | 0.01% | +750,220+144.5% | Added |
| Artisan Partners Limited Partnership | 1,181,416 | $93.5M | 0.14% | +291,344+32.7% | Added |
| Royal Bank of Canada | 1,118,797 | $88.5M | 0.02% | −107,827−8.8% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 1,076,370 | $85.2M | 0.22% | +198,215+22.6% | Added |
| Arrowstreet Capital, Limited Partnership | 1,063,327 | $84.1M | 0.05% | +433,191+68.7% | Added |
| UBS Group AG | 1,045,041 | $82.7M | 0.02% | −1,949−0.2% | Reduced |
| Morgan Stanley | 1,019,906 | $80.7M | 0.00% | −160,410−13.6% | Reduced |
| Nomura Asset Management International Inc. | 864,892 | $68.4M | 0.10% | +864,892 | New |
| Goldman Sachs Group Inc | 855,966 | $67.7M | 0.01% | +78,396+10.1% | Added |
| Nomura Holdings Inc | 848,815 | $67.1M | 0.19% | +115,417+15.7% | Added |
| Northern Trust Corp | 846,718 | $67.0M | 0.01% | +1,775+0.2% | Added |
| Barclays PLC | 842,871 | $66.7M | 0.03% | +128,823+18.0% | Added |
| Massachusetts Financial Services Co | 812,747 | $64.3M | 0.02% | −49,846−5.8% | Reduced |
| GW&K Investment Management, LLC | 786,668 | $62.2M | 0.54% | +522,661+198.0% | Added |
| Bank of America Corp | 783,579 | $62.0M | 0.00% | −71,716−8.4% | Reduced |
| TD Asset Management Inc | 773,184 | $61.2M | 0.05% | −187,088−19.5% | Reduced |
| Groupama Asset Managment | 766,889 | $60.7M | 0.89% | +205,112+36.5% | Added |
| Candriam Luxembourg S.C.A. | 677,629 | $53.6M | 0.27% | +66,392+10.9% | Added |
| Nuveen, LLC | 660,769 | $52.3M | 0.01% | +245,151+59.0% | Added |
| Ameriprise Financial Inc | 598,748 | $47.4M | 0.01% | −167,074−21.8% | Reduced |
| Voloridge Investment Management, LLC | 584,970 | $46.3M | 0.16% | −218,077−27.2% | Reduced |
| Eventide Asset Management, LLC | 575,000 | $45.5M | 0.71% | +575,000 | New |
| Tri Locum Partners LP | 557,174 | $44.1M | 5.72% | +557,174 | New |
| Eversept Partners, LP | 538,218 | $42.6M | 2.39% | −443−0.1% | Reduced |
| Bank of New York Mellon Corp | 537,886 | $42.6M | 0.01% | +5,772+1.1% | Added |
| First Trust Advisors LP | 525,239 | $41.6M | 0.03% | +450,015+598.2% | Added |
| Alyeska Investment Group, L.P. | 481,711 | $38.1M | 0.11% | +170,453+54.8% | Added |
| Hudson Bay Capital Management LP | 475,000 | $37.6M | 0.22% | −40,000−7.8% | Reduced |
| Pinnacle Associates Ltd | 461,968 | $36.5M | 0.47% | −19,783−4.1% | Reduced |
| Amundi | 460,947 | $36.5M | 0.01% | +359,416+354.0% | Added |
| Squarepoint Ops LLC | 436,279 | $34.5M | 0.07% | +52,487+13.7% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 422,968 | $33.5M | 0.22% | −208,247−33.0% | Reduced |
| Teacher Retirement System of Texas | 422,899 | $33.5M | 0.12% | −51,046−10.8% | Reduced |
| Boone Capital Management LLC | 417,833 | $33.1M | 10.37% | 00.0% | Unchanged |
| C WorldWide Group Holding A/S | 366,000 | $29.0M | 0.51% | −60,000−14.1% | Reduced |
| Jain Global LLC | 356,259 | $28.2M | 0.28% | +130,520+57.8% | Added |
| Alliancebernstein L.P. | 341,849 | $27.0M | 0.01% | +287,587+530.0% | Added |
| BNP Paribas Arbitrage, SA | 334,608 | $26.5M | 0.02% | −48,618−12.7% | Reduced |
| D. E. Shaw & Co., Inc. | 332,803 | $26.3M | 0.02% | −298,135−47.3% | Reduced |
| Legal & General Group Plc | 325,148 | $25.7M | 0.01% | +5,583+1.7% | Added |
| Norges Bank | 320,160 | $25.3M | 0.00% | +320,160 | New |
| Swiss National Bank | 298,500 | $23.6M | 0.01% | +5,400+1.8% | Added |
| Wells Fargo & Company | 280,045 | $22.2M | 0.00% | −5,248−1.8% | Reduced |
| Zurich Insurance Group Ltd | 261,820 | $20.7M | 0.14% | +261,820 | New |
| Raymond James Financial Inc | 257,210 | $20.3M | 0.01% | +16,786+7.0% | Added |
| Marshall Wace, LLP | 256,933 | $20.3M | 0.02% | −701,896−73.2% | Reduced |
| New York State Common Retirement Fund | 241,853 | $19.1M | 0.03% | +73,631+43.8% | Added |
| Privium Fund Management B.V. | 240,824 | $19.1M | 3.51% | −8,070−3.2% | Reduced |
| Davern Capital Partners, LP | 238,477 | $18.9M | 6.10% | +238,477 | New |
| Orion Investment Co | 225,161 | $17.8M | 5.45% | +456+0.2% | Added |
| Renaissance Technologies LLC | 223,607 | $17.7M | 0.03% | −263,107−54.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,574 | $17.4M | 0.03% | +22,140+11.2% | Added |
| Davenport & Co LLC | 217,897 | $17.2M | 0.09% | +155,334+248.3% | Added |
| CI Private Wealth, LLC | 216,438 | $17.1M | 0.02% | +209,848+3,184.3% | Added |
| California Public Employees Retirement System | 213,368 | $16.9M | 0.01% | −2,477−1.1% | Reduced |
| Tocqueville Asset Management L.P. | 203,730 | $16.1M | 0.24% | +10,685+5.5% | Added |
| Ikarian Capital, LLC | 202,038 | $16.0M | 2.07% | −213,125−51.3% | Reduced |
| Stifel Financial Corp | 198,863 | $15.7M | 0.01% | −3,765−1.9% | Reduced |
| Sector Gamma AS | 184,977 | $14.6M | 3.34% | −85,986−31.7% | Reduced |
| Colony Group, LLC | 181,817 | $14.4M | 0.02% | +181,817 | New |
| Dimensional Fund Advisors LP | 176,035 | $13.9M | 0.00% | +133,818+317.0% | Added |
| Rhumbline Advisers | 175,387 | $13.9M | 0.01% | −6,674−3.7% | Reduced |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 167,657 | $13.3M | 0.01% | +167,657 | New |
| Man Group plc | 166,042 | $13.1M | 0.03% | −167,778−50.3% | Reduced |
| Sicart Associates LLC | 163,557 | $12.9M | 3.43% | −761−0.5% | Reduced |
| Rhenman & Partners Asset Management AB | 158,500 | $12.5M | 1.17% | −151,500−48.9% | Reduced |
| CenterBook Partners LP | 153,949 | $12.2M | 0.60% | +153,949 | New |
| Manufacturers Life Insurance Company, The | 153,241 | $12.1M | 0.01% | +55,218+56.3% | Added |
| Deutsche Bank AG | 149,443 | $11.8M | 0.00% | +60,640+68.3% | Added |
| Great Lakes Advisors, LLC | 149,180 | $11.8M | 0.10% | −37,770−20.2% | Reduced |
| ADAR1 Capital Management, LLC | 147,130 | $11.6M | 0.87% | +13,312+9.9% | Added |
| Artia Global Partners LP | 144,376 | $11.4M | 1.84% | +84,200+139.9% | Added |
| California State Teachers Retirement System | 144,173 | $11.4M | 0.01% | −939−0.6% | Reduced |
| Fisher Asset Management, LLC | 141,615 | $11.2M | 0.00% | +135,405+2,180.4% | Added |