Ionis Pharmaceuticals Inc
IONS- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
近 90 天，Ionis Pharmaceuticals Inc 內部人申報 1 筆公開市場買進、4 筆賣出；2026 年第 2 季末有 515 家機構在 13F 申報持有，市值合計 $142.6 億；大師中只有方舟投資持有。
2025 年第 4 季 13F 持有人
Ionis Pharmaceuticals Inc 在 2025/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 494
- 較 2025 年第 3 季 +68 家
- 持有股數
- 1.70 億
- 較 2025 年第 3 季 +278.5 萬 (+1.7%)
- 總市值
- $134.6 億
- 較 2025 年第 3 季 +$25.0 億 (+22.8%)
- 新進機構
- 112
- 另有 167 家加碼
- 清倉機構
- 44
- 另有 142 家減碼
另有 11 家機構在 2025 年第 3 季持有、還沒有申報 2025 年第 4 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 IONS 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 515 | $142.6 億 |
| 2026 年第 1 季 | 497 | $129.7 億 |
| 2025 年第 4 季 | 494 | $134.6 億 |
| 2025 年第 3 季 | 437 | $110.1 億 |
| 2025 年第 2 季 | 363 | $66.7 億 |
| 2025 年第 1 季 | 344 | $50.3 億 |
| 2024 年第 4 季 | 356 | $56.1 億 |
| 2024 年第 3 季 | 354 | $63.1 億 |
| 2024 年第 2 季 | 357 | $68.3 億 |
| 2024 年第 1 季 | 361 | $61.7 億 |
| 2023 年第 4 季 | 365 | $72.1 億 |
| 2023 年第 3 季 | 312 | $63.5 億 |
| 2023 年第 2 季 | 305 | $56.0 億 |
| 2023 年第 1 季 | 315 | $46.9 億 |
| 2022 年第 4 季 | 339 | $49.3 億 |
| 2022 年第 3 季 | 350 | $55.9 億 |
| 2022 年第 2 季 | 351 | $46.1 億 |
| 2022 年第 1 季 | 333 | $46.3 億 |
| 2021 年第 4 季 | 341 | $37.5 億 |
| 2021 年第 3 季 | 326 | $40.8 億 |
| 2021 年第 2 季 | 338 | $49.6 億 |
| 2021 年第 1 季 | 365 | $55.5 億 |
2025 年第 4 季持有機構
每家機構持有 Ionis Pharmaceuticals Inc 的股數、市值與佔組合比重；股數變化跟 2025 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 24,072,101 | $19.0 億 | 0.10% | +383,063+1.6% | 加碼 |
| Capital World Investors | 17,961,299 | $14.2 億 | 0.19% | +5,238,571+41.2% | 加碼 |
| Vanguard Group Inc | 16,440,459 | $13.0 億 | 0.02% | −41,271−0.3% | 減碼 |
| BlackRock, Inc. | 10,647,863 | $8.42 億 | 0.01% | +199,923+1.9% | 加碼 |
| T. Rowe Price Investment Management, Inc. | 9,108,019 | $7.21 億 | 0.45% | −4,048,910−30.8% | 減碼 |
| Wellington Management Group LLP | 6,260,325 | $4.95 億 | 0.09% | −328,486−5.0% | 減碼 |
| Bellevue Group AG | 4,802,199 | $3.80 億 | 7.20% | −1,442,252−23.1% | 減碼 |
| State Street Corp | 3,974,865 | $3.14 億 | 0.01% | −413,786−9.4% | 減碼 |
| Geode Capital Management, LLC | 3,148,849 | $2.49 億 | 0.02% | +82,560+2.7% | 加碼 |
| Two Sigma Advisers, LP | 3,052,111 | $2.41 億 | 0.47% | +979,000+47.2% | 加碼 |
| Price T Rowe Associates Inc | 2,987,840 | $2.36 億 | 0.03% | +258,155+9.5% | 加碼 |
| Two Sigma Investments, LP | 2,658,646 | $2.10 億 | 0.31% | +1,082,703+68.7% | 加碼 |
| Tweedy, Browne Co LLC | 2,464,930 | $1.95 億 | 15.74% | −436,286−15.0% | 減碼 |
| JPMorgan Chase & Co | 2,304,792 | $1.82 億 | 0.01% | +1,760,324+323.3% | 加碼 |
| Citadel Advisors LLC | 2,134,636 | $1.69 億 | 0.11% | −267,429−11.1% | 減碼 |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $1.57 億 | 2.01% | 00.0% | 不變 |
| Baker Bros. Advisors LP | 1,791,841 | $1.42 億 | 0.83% | +1,225,043+216.1% | 加碼 |
| Deep Track Capital, LP | 1,700,000 | $1.34 億 | 3.07% | −2,108,144−55.4% | 減碼 |
| American Century Companies Inc | 1,617,106 | $1.28 億 | 0.06% | +244,881+17.8% | 加碼 |
| Charles Schwab Investment Management Inc | 1,541,841 | $1.22 億 | 0.02% | +21,890+1.4% | 加碼 |
| Summit Partners Public Asset Management, LLC | 1,462,706 | $1.16 億 | 3.26% | +712,706+95.0% | 加碼 |
| Pictet Asset Management Holding SA | 1,418,491 | $1.12 億 | 0.11% | +25,367+1.8% | 加碼 |
| UBS Asset Management Americas Inc | 1,388,567 | $1.10 億 | 0.02% | +234,401+20.3% | 加碼 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,352,837 | $1.07 億 | 0.12% | +293,116+27.7% | 加碼 |
| Polar Capital Holdings Plc | 1,333,424 | $1.05 億 | 0.48% | +299,802+29.0% | 加碼 |
| Franklin Resources Inc | 1,321,345 | $1.05 億 | 0.03% | +1,314,752+19,941.6% | 加碼 |
| Invesco Ltd. | 1,269,290 | $1.00 億 | 0.01% | +750,220+144.5% | 加碼 |
| Artisan Partners Limited Partnership | 1,181,416 | $9,346 萬 | 0.14% | +291,344+32.7% | 加碼 |
| Royal Bank of Canada | 1,118,797 | $8,851 萬 | 0.02% | −107,827−8.8% | 減碼 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,076,370 | $8,515 萬 | 0.22% | +198,215+22.6% | 加碼 |
| Arrowstreet Capital, Limited Partnership | 1,063,327 | $8,412 萬 | 0.05% | +433,191+68.7% | 加碼 |
| UBS Group AG | 1,045,041 | $8,267 萬 | 0.02% | −1,949−0.2% | 減碼 |
| Morgan Stanley | 1,019,906 | $8,068 萬 | 0.00% | −160,410−13.6% | 減碼 |
| Nomura Asset Management International Inc. | 864,892 | $6,842 萬 | 0.10% | +864,892 | 新進 |
| Goldman Sachs Group Inc | 855,966 | $6,772 萬 | 0.01% | +78,396+10.1% | 加碼 |
| Nomura Holdings Inc | 848,815 | $6,715 萬 | 0.19% | +115,417+15.7% | 加碼 |
| Northern Trust Corp | 846,718 | $6,698 萬 | 0.01% | +1,775+0.2% | 加碼 |
| Barclays PLC | 842,871 | $6,668 萬 | 0.03% | +128,823+18.0% | 加碼 |
| Massachusetts Financial Services Co | 812,747 | $6,430 萬 | 0.02% | −49,846−5.8% | 減碼 |
| GW&K Investment Management, LLC | 786,668 | $6,223 萬 | 0.54% | +522,661+198.0% | 加碼 |
| Bank of America Corp | 783,579 | $6,199 萬 | 0.00% | −71,716−8.4% | 減碼 |
| TD Asset Management Inc | 773,184 | $6,117 萬 | 0.05% | −187,088−19.5% | 減碼 |
| Groupama Asset Managment | 766,889 | $6,067 萬 | 0.89% | +205,112+36.5% | 加碼 |
| Candriam Luxembourg S.C.A. | 677,629 | $5,361 萬 | 0.27% | +66,392+10.9% | 加碼 |
| Nuveen, LLC | 660,769 | $5,227 萬 | 0.01% | +245,151+59.0% | 加碼 |
| Ameriprise Financial Inc | 598,748 | $4,737 萬 | 0.01% | −167,074−21.8% | 減碼 |
| Voloridge Investment Management, LLC | 584,970 | $4,628 萬 | 0.16% | −218,077−27.2% | 減碼 |
| Eventide Asset Management, LLC | 575,000 | $4,549 萬 | 0.71% | +575,000 | 新進 |
| Tri Locum Partners LP | 557,174 | $4,408 萬 | 5.72% | +557,174 | 新進 |
| Eversept Partners, LP | 538,218 | $4,258 萬 | 2.39% | −443−0.1% | 減碼 |
| Bank of New York Mellon Corp | 537,886 | $4,255 萬 | 0.01% | +5,772+1.1% | 加碼 |
| First Trust Advisors LP | 525,239 | $4,155 萬 | 0.03% | +450,015+598.2% | 加碼 |
| Alyeska Investment Group, L.P. | 481,711 | $3,811 萬 | 0.11% | +170,453+54.8% | 加碼 |
| Hudson Bay Capital Management LP | 475,000 | $3,758 萬 | 0.22% | −40,000−7.8% | 減碼 |
| Pinnacle Associates Ltd | 461,968 | $3,655 萬 | 0.47% | −19,783−4.1% | 減碼 |
| Amundi | 460,947 | $3,647 萬 | 0.01% | +359,416+354.0% | 加碼 |
| Squarepoint Ops LLC | 436,279 | $3,451 萬 | 0.07% | +52,487+13.7% | 加碼 |
| ARK Investment Management LLC大師方舟投資 | 422,968 | $3,346 萬 | 0.22% | −208,247−33.0% | 減碼 |
| Teacher Retirement System of Texas | 422,899 | $3,346 萬 | 0.12% | −51,046−10.8% | 減碼 |
| Boone Capital Management LLC | 417,833 | $3,305 萬 | 10.37% | 00.0% | 不變 |
| C WorldWide Group Holding A/S | 366,000 | $2,895 萬 | 0.51% | −60,000−14.1% | 減碼 |
| Jain Global LLC | 356,259 | $2,818 萬 | 0.28% | +130,520+57.8% | 加碼 |
| Alliancebernstein L.P. | 341,849 | $2,704 萬 | 0.01% | +287,587+530.0% | 加碼 |
| BNP Paribas Arbitrage, SA | 334,608 | $2,647 萬 | 0.02% | −48,618−12.7% | 減碼 |
| D. E. Shaw & Co., Inc. | 332,803 | $2,633 萬 | 0.02% | −298,135−47.3% | 減碼 |
| Legal & General Group Plc | 325,148 | $2,572 萬 | 0.01% | +5,583+1.7% | 加碼 |
| Norges Bank | 320,160 | $2,533 萬 | 0.00% | +320,160 | 新進 |
| Swiss National Bank | 298,500 | $2,361 萬 | 0.01% | +5,400+1.8% | 加碼 |
| Wells Fargo & Company | 280,045 | $2,215 萬 | 0.00% | −5,248−1.8% | 減碼 |
| Zurich Insurance Group Ltd | 261,820 | $2,071 萬 | 0.14% | +261,820 | 新進 |
| Raymond James Financial Inc | 257,210 | $2,035 萬 | 0.01% | +16,786+7.0% | 加碼 |
| Marshall Wace, LLP | 256,933 | $2,033 萬 | 0.02% | −701,896−73.2% | 減碼 |
| New York State Common Retirement Fund | 241,853 | $1,913 萬 | 0.03% | +73,631+43.8% | 加碼 |
| Privium Fund Management B.V. | 240,824 | $1,905 萬 | 3.51% | −8,070−3.2% | 減碼 |
| Davern Capital Partners, LP | 238,477 | $1,887 萬 | 6.10% | +238,477 | 新進 |
| Orion Investment Co | 225,161 | $1,781 萬 | 5.45% | +456+0.2% | 加碼 |
| Renaissance Technologies LLC | 223,607 | $1,769 萬 | 0.03% | −263,107−54.1% | 減碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,574 | $1,737 萬 | 0.03% | +22,140+11.2% | 加碼 |
| Davenport & Co LLC | 217,897 | $1,724 萬 | 0.09% | +155,334+248.3% | 加碼 |
| CI Private Wealth, LLC | 216,438 | $1,712 萬 | 0.02% | +209,848+3,184.3% | 加碼 |
| California Public Employees Retirement System | 213,368 | $1,688 萬 | 0.01% | −2,477−1.1% | 減碼 |
| Tocqueville Asset Management L.P. | 203,730 | $1,612 萬 | 0.24% | +10,685+5.5% | 加碼 |
| Ikarian Capital, LLC | 202,038 | $1,598 萬 | 2.07% | −213,125−51.3% | 減碼 |
| Stifel Financial Corp | 198,863 | $1,573 萬 | 0.01% | −3,765−1.9% | 減碼 |
| Sector Gamma AS | 184,977 | $1,463 萬 | 3.34% | −85,986−31.7% | 減碼 |
| Colony Group, LLC | 181,817 | $1,438 萬 | 0.02% | +181,817 | 新進 |
| Dimensional Fund Advisors LP | 176,035 | $1,393 萬 | 0.00% | +133,818+317.0% | 加碼 |
| Rhumbline Advisers | 175,387 | $1,387 萬 | 0.01% | −6,674−3.7% | 減碼 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 167,657 | $1,326 萬 | 0.01% | +167,657 | 新進 |
| Man Group plc | 166,042 | $1,314 萬 | 0.03% | −167,778−50.3% | 減碼 |
| Sicart Associates LLC | 163,557 | $1,294 萬 | 3.43% | −761−0.5% | 減碼 |
| Rhenman & Partners Asset Management AB | 158,500 | $1,254 萬 | 1.17% | −151,500−48.9% | 減碼 |
| CenterBook Partners LP | 153,949 | $1,218 萬 | 0.60% | +153,949 | 新進 |
| Manufacturers Life Insurance Company, The | 153,241 | $1,211 萬 | 0.01% | +55,218+56.3% | 加碼 |
| Deutsche Bank AG | 149,443 | $1,182 萬 | 0.00% | +60,640+68.3% | 加碼 |
| Great Lakes Advisors, LLC | 149,180 | $1,180 萬 | 0.10% | −37,770−20.2% | 減碼 |
| ADAR1 Capital Management, LLC | 147,130 | $1,164 萬 | 0.87% | +13,312+9.9% | 加碼 |
| Artia Global Partners LP | 144,376 | $1,142 萬 | 1.84% | +84,200+139.9% | 加碼 |
| California State Teachers Retirement System | 144,173 | $1,141 萬 | 0.01% | −939−0.6% | 減碼 |
| Fisher Asset Management, LLC | 141,615 | $1,120 萬 | 0.00% | +135,405+2,180.4% | 加碼 |