Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Adage Capital Partners GP, L.L.C. | 140,000 | $11.1M | 0.02% | −1,175,000−89.4% | Reduced |
| State Board of Administration of Florida Retirement System | 135,878 | $10.7M | 0.02% | −7,656−5.3% | Reduced |
| Aquatic Capital Management LLC | 132,826 | $10.5M | 0.30% | −26,219−16.5% | Reduced |
| Trexquant Investment LP | 132,241 | $10.5M | 0.09% | −82,880−38.5% | Reduced |
| Algert Global LLC | 127,205 | $10.1M | 0.16% | −125,076−49.6% | Reduced |
| Edmond de Rothschild Holding S.A. | 122,190 | $9.67M | 0.14% | −34,500−22.0% | Reduced |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 121,628 | $9.62M | 0.35% | +121,628 | New |
| Balyasny Asset Management LLC | 120,577 | $9.54M | 0.02% | −639,534−84.1% | Reduced |
| Exome Asset Management LLC | 116,515 | $9.22M | 4.55% | −14,501−11.1% | Reduced |
| SEI Investments Co | 115,917 | $9.17M | 0.01% | −3,111−2.6% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 115,293 | $9.12M | 0.04% | −40,497−26.0% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 110,000 | $8.70M | 0.01% | −6,000−5.2% | Reduced |
| Kennedy Capital Management, Inc. | 109,291 | $8.65M | 0.18% | −13,475−11.0% | Reduced |
| Neuberger Berman Group LLC | 108,044 | $8.55M | 0.01% | −6,699−5.8% | Reduced |
| DCF Advisers, LLC | 103,000 | $8.15M | 2.69% | −5,413−5.0% | Reduced |
| Simplex Trading, LLC | 96,647 | $7.65M | 0.22% | −3,559−3.6% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $7.59M | 0.12% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 94,761 | $7.50M | 0.02% | −2,076−2.1% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 93,751 | $7.42M | 0.00% | −21,021−18.3% | Reduced |
| Nikko Asset Management Americas, Inc. | 93,571 | $7.40M | 0.09% | −21,021−18.3% | Reduced |
| Millennium Management LLC | 93,262 | $7.38M | 0.01% | −686,308−88.0% | Reduced |
| HealthInvest Partners AB | 92,377 | $7.31M | 2.33% | +92,377 | New |
| Envestnet Asset Management Inc | 89,919 | $7.11M | 0.00% | +62,410+226.9% | Added |
| Citigroup Inc | 89,340 | $7.07M | 0.00% | −66,513−42.7% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $6.88M | 0.63% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 83,875 | $6.64M | 0.07% | −68,250−44.9% | Reduced |
| Victory Capital Management Inc | 80,729 | $6.39M | 0.00% | +62,518+343.3% | Added |
| Boothbay Fund Management, LLC | 75,562 | $5.98M | 0.16% | −87,900−53.8% | Reduced |
| EFG International AG | 75,276 | $5.96M | 0.12% | +75,276 | New |
| Rafferty Asset Management, LLC | 73,983 | $5.85M | 0.02% | −51,790−41.2% | Reduced |
| Voya Investment Management LLC | 73,760 | $5.84M | 0.01% | −37,829−33.9% | Reduced |
| Erste Asset Management GmbH | 71,800 | $5.74M | 0.05% | 00.0% | Unchanged |
| Hillsdale Investment Management Inc. | 70,900 | $5.61M | 0.15% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 68,191 | $5.40M | 0.00% | +4,314+6.8% | Added |
| Bridgewater Associates, LP | 67,706 | $5.36M | 0.02% | +24,128+55.4% | Added |
| J. Goldman & Co LP | 67,639 | $5.35M | 0.21% | −28,559−29.7% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 66,849 | $5.29M | 0.04% | −2,475−3.6% | Reduced |
| Treasurer of the State of North Carolina | 66,262 | $5.24M | 0.02% | −3,600−5.2% | Reduced |
| BI Asset Management Fondsmaeglerselskab A/S | 62,073 | $4.91M | 0.04% | +62,073 | New |
| BLB&B Advisors, LLC | 61,520 | $4.87M | 0.20% | −57,080−48.1% | Reduced |
| State of New Jersey Common Pension Fund D | 54,783 | $4.33M | 0.02% | −5,034−8.4% | Reduced |
| Creative Planning | 54,774 | $4.33M | 0.00% | +3,300+6.4% | Added |
| PDT Partners, LLC | 54,365 | $4.30M | 0.28% | 00.0% | Unchanged |
| DekaBank Deutsche Girozentrale | 93,807 | $4.30M | 0.01% | 00.0% | Unchanged |
| EAM Investors, LLC | 53,914 | $4.27M | 0.48% | −1,063−1.9% | Reduced |
| Ensign Peak Advisors, Inc | 53,664 | $4.25M | 0.01% | +26,069+94.5% | Added |
| Alpine Global Management, LLC | 53,600 | $4.24M | 0.94% | −2,300−4.1% | Reduced |
| Jefferies Financial Group Inc. | 50,395 | $3.99M | 0.03% | +40,226+395.6% | Added |
| Capital Counsel LLC | 49,605 | $3.92M | 0.15% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 48,921 | $3.87M | 0.01% | +3,701+8.2% | Added |
| Handelsbanken Fonder AB | 47,911 | $3.79M | 0.01% | −4,000−7.7% | Reduced |
| Mariner, LLC | 47,740 | $3.78M | 0.00% | +23,513+97.1% | Added |
| Public Employees Retirement System of Ohio | 47,598 | $3.77M | 0.01% | −947−2.0% | Reduced |
| Atika Capital Management LLC | 47,488 | $3.76M | 0.52% | +25,988+120.9% | Added |
| Quantinno Capital Management LP | 47,378 | $3.75M | 0.01% | +11,263+31.2% | Added |
| Van Eck Associates Corp | 47,102 | $3.73M | 0.00% | −64,717−57.9% | Reduced |
| Lazard Asset Management LLC | 46,402 | $3.67M | 0.01% | −17,389−27.3% | Reduced |
| One Capital Management, LLC | 46,121 | $3.65M | 0.11% | +9,695+26.6% | Added |
| Future Fund LLC | 45,851 | $3.63M | 1.28% | +9,695+26.8% | Added |
| Russell Investments Group, Ltd. | 43,912 | $3.47M | 0.00% | −33,381−43.2% | Reduced |
| Gotham Asset Management, LLC | 43,212 | $3.42M | 0.01% | +11,060+34.4% | Added |
| Arizona State Retirement System | 42,421 | $3.36M | 0.02% | −2,310−5.2% | Reduced |
| China Universal Asset Management Co., Ltd. | 42,394 | $3.35M | 0.26% | +14,455+51.7% | Added |
| Fred Alger Management, LLC | 38,423 | $3.04M | 0.01% | −3,978−9.4% | Reduced |
| West Michigan Advisors, LLC | 38,413 | $3.04M | 0.70% | +38,413 | New |
| Grandfield & Dodd, LLC | 37,821 | $2.99M | 0.17% | +146+0.4% | Added |
| Guggenheim Capital LLC | 37,709 | $2.98M | 0.02% | +2,352+6.7% | Added |
| Stanley-Laman Group, Ltd. | 36,512 | $2.89M | 0.37% | +738+2.1% | Added |
| Bank of Montreal | 36,362 | $2.88M | 0.00% | −711,040−95.1% | Reduced |
| Bamco Inc | 36,000 | $2.85M | 0.01% | +11,000+44.0% | Added |
| Raiffeisen Bank International AG | 35,000 | $2.76M | 0.04% | −15,000−30.0% | Reduced |
| Acadian Asset Management LLC | 34,691 | $2.74M | 0.00% | −75,753−68.6% | Reduced |
| Pathstone Holdings, LLC | 34,304 | $2.71M | 0.01% | +702+2.1% | Added |
| Blair William & Co | 33,788 | $2.67M | 0.01% | −583−1.7% | Reduced |
| KLP Kapitalforvaltning AS | 33,500 | $2.65M | 0.01% | +2,000+6.3% | Added |
| SG Americas Securities, LLC | 33,409 | $2.64M | 0.00% | +28,259+548.7% | Added |
| Calamos Advisors LLC | 33,189 | $2.63M | 0.01% | +7,326+28.3% | Added |
| Lisanti Capital Growth, LLC | 32,789 | $2.59M | 0.61% | −59,335−64.4% | Reduced |
| Susquehanna International Group, LLP | 32,504 | $2.57M | 0.00% | −388,446−92.3% | Reduced |
| Prelude Capital Management, LLC | 32,481 | $2.57M | 0.19% | −4,812−12.9% | Reduced |
| Twin Tree Management, LP | 32,476 | $2.57M | 0.26% | +3,901+13.7% | Added |
| Mutual of America Capital Management LLC | 31,459 | $2.49M | 0.03% | +31,459 | New |
| LPL Financial LLC | 31,069 | $2.46M | 0.00% | +6,606+27.0% | Added |
| PEAK6 LLC | 30,642 | $2.42M | 0.07% | +24,530+401.3% | Added |
| Wolverine Asset Management LLC | 30,515 | $2.41M | 0.03% | +30,515 | New |
| Jane Street Group, LLC | 30,471 | $2.41M | 0.00% | −334,599−91.7% | Reduced |
| Assenagon Asset Management S.A. | 29,316 | $2.32M | 0.00% | −282,981−90.6% | Reduced |
| Kornitzer Capital Management Inc | 29,105 | $2.30M | 0.05% | +29,105 | New |
| Standard Life Aberdeen plc | 28,926 | $2.29M | 0.00% | −58,998−67.1% | Reduced |
| Qsemble Capital Management, LP | 27,579 | $2.18M | 0.18% | +27,579 | New |
| Swedbank AB | 27,253 | $2.16M | 0.00% | +27,253 | New |
| HSBC Holdings PLC | 26,941 | $2.14M | 0.00% | −18,515−40.7% | Reduced |
| Profund Advisors LLC | 26,673 | $2.11M | 0.06% | +741+2.9% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 25,017 | $1.98M | 0.29% | +19,554+357.9% | Added |
| Landscape Capital Management, L.L.C. | 24,155 | $1.91M | 0.13% | −2,407−9.1% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.91M | 0.01% | 00.0% | Unchanged |
| Prudential Financial Inc | 24,008 | $1.90M | 0.00% | +14,664+156.9% | Added |
| Cerity Partners LLC | 23,927 | $1.89M | 0.00% | +23,927 | New |
| Brinker Capital Investments, LLC | 23,574 | $1.86M | 0.01% | +13,612+136.6% | Added |
| Xponance, Inc. | 22,941 | $1.81M | 0.01% | +1,491+7.0% | Added |