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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

Q4 2025 vs. Q3 2025

How the institutions holding Ionis Pharmaceuticals Inc changed between Q3 2025 and Q4 2025.

All holders in Q4 2025All holders in Q3 2025

13F holders of IONS: Q3 2025 compared with Q4 2025
MeasureQ3 2025Of which not filed for Q4 2025Q4 2025Change
Holders43711494+68
Shares168.2M720.8K170.2M+2.78M (+1.7%)
Value$11.0B$47.1M$13.5B+$2.50B (+22.8%)

11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (112)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q4 2025 but not at the end of Q3 2025.

Showing the largest 100 of 112 by value.

Institutions new to IONS in Q4 2025
InstitutionSharesValue% of portfolio
Nomura Asset Management International Inc.864,892$68.4M0.10%
Eventide Asset Management, LLC575,000$45.5M0.71%
Tri Locum Partners LP557,174$44.1M5.72%
Norges Bank320,160$25.3M0.00%
Zurich Insurance Group Ltd261,820$20.7M0.14%
Davern Capital Partners, LP238,477$18.9M6.10%
Colony Group, LLC181,817$14.4M0.02%
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main167,657$13.3M0.01%
CenterBook Partners LP153,949$12.2M0.60%
Fideuram - Intesa Sanpaolo Private Banking S.P.A.121,628$9.62M0.35%
HealthInvest Partners AB92,377$7.31M2.33%
EFG International AG75,276$5.96M0.12%
BI Asset Management Fondsmaeglerselskab A/S62,073$4.91M0.04%
West Michigan Advisors, LLC38,413$3.04M0.70%
Mutual of America Capital Management LLC31,459$2.49M0.03%
Wolverine Asset Management LLC30,515$2.41M0.03%
Kornitzer Capital Management Inc29,105$2.30M0.05%
Qsemble Capital Management, LP27,579$2.18M0.18%
Swedbank AB27,253$2.16M0.00%
Cerity Partners LLC23,927$1.89M0.00%
HRT Financial LP22,928$1.81M0.01%
Natixis Advisors, L.P.21,891$1.73M0.00%
Gilder Gagnon Howe & Co LLC19,275$1.52M0.02%
AlphaCentric Advisors LLC18,523$1.47M1.46%
Quantedge Capital Pte Ltd18,500$1.46M0.70%
Elo Mutual Pension Insurance Co18,417$1.46M0.02%
Toroso Investments, LLC17,908$1.42M0.01%
Worldquant Millennium Advisors LLC17,410$1.38M0.01%
J. Safra Sarasin Holding AG17,404$1.38M0.02%
XTX Topco Ltd16,917$1.34M0.04%
M&G Plc14,423$1.14M0.01%
Friedenthal Financial13,115$1.04M0.53%
Lighthouse Investment Partners, LLC13,082$1.03M0.03%
SBI Okasan Asset Management Co.Ltd.12,600$1.01M0.06%
Federation des caisses Desjardins du Quebec12,553$993.1K0.00%
Oppenheimer Asset Management Inc.11,264$891.1K0.01%
Virginia Retirement Systems Et Al10,600$838.6K0.00%
Ares Systematic Credit Ltd9,916$784.5K0.64%
Two Sigma Securities, LLC9,649$763.3K0.10%
Intech Investment Management LLC9,602$759.6K0.01%
Persistent Asset Partners Ltd7,807$617.6K0.30%
Callan Family Office, LLC7,104$562.0K0.01%
PSP Research LLC6,800$537.9K0.47%
North Dakota State Investment Board5,480$433.5K0.02%
Dymon Asia Capital (Singapore) Pte. Ltd.5,350$423.2K0.09%
Captrust Financial Advisors5,293$418.7K0.00%
Vontobel Holding Ltd.5,240$414.5K0.00%
Inspire Advisors, LLC4,851$383.8K0.04%
Skopos Labs, Inc.4,669$373.4K0.02%
AE Wealth Management LLC4,403$348.3K0.00%
Vise Technologies, Inc.4,305$340.6K0.01%
Janney Montgomery Scott LLC4,177$330.0K0.00%
Cambria Investment Management, L.P.3,684$291.4K0.02%
Tudor Investment Corp Et Al3,661$289.6K0.00%
Avanza Fonder AB3,596$284.5K0.01%
Park Avenue Securities LLC3,571$283.0K0.00%
Everhart Financial Group, Inc.3,465$274.1K0.03%
Eurizon Capital SGR S.p.A.3,314$261.4K0.00%
MML Investors Services, LLC3,264$258.2K0.00%
Crossmark Global Holdings, Inc.3,102$245.4K0.00%
Venturi Wealth Management, LLC3,061$242.2K0.01%
Argent Trust Co3,018$238.8K0.01%
National Asset Management, Inc.2,975$235.3K0.01%
Cambridge Investment Research Advisors, Inc.2,957$234.0K0.00%
Norden Group LLC2,935$232.2K0.02%
HB Wealth Management, LLC2,922$231.2K0.00%
Impact Partnership Wealth, LLC2,905$229.8K0.03%
Axxcess Wealth Management, LLC2,877$227.6K0.00%
Campbell & CO Investment Adviser LLC2,784$220.2K0.01%
Clearbridge Investments, LLC2,715$214.8K0.00%
Montis Financial, LLC2,700$213.6K0.04%
Kerntke Otto McGlone Wealth Management Group2,695$213.2K0.15%
IFG Advisory, LLC2,678$211.9K0.01%
Motley Fool Asset Management LLC2,630$208.1K0.01%
Employees Retirement System of Texas1,354$107.0K0.00%
SRS Capital Advisors, Inc.774$61.2K0.00%
Clear Street Markets LLC748$59.2K0.01%
Elequin Capital LP711$56.2K0.01%
Los Angeles Capital Management LLC700$51.9K0.00%
Laurel Wealth Advisors LLC600$47.5K0.01%
Hilton Head Capital Partners, LLC599$47.4K0.03%
Wellington-Altus USA Inc.351$27.8K0.02%
Brown Brothers Harriman & Co341$27.0K0.00%
Walleye Capital LLC325$25.7K0.00%
Sound Income Strategies, LLC286$21.8K0.00%
SageView Advisory Group, LLC215$17.0K0.00%
MH & Associates Securities Management Corp200$15.8K0.01%
Zions Bancorporation, National Association188$14.9K0.00%
Basecamp Wealth Advisors LLC185$14.6K0.00%
Strategic Wealth Partners, Ltd.150$11.9K0.00%
Torren Management, LLC137$10.8K0.01%
Garner Asset Management Corp115$9.10K0.00%
LRI Investments, LLC110$8.70K0.00%
Kemnay Advisory Services Inc.71$5.62K0.00%
Triumph Capital Management50$3.96K0.00%
Activest Wealth Management32$2.53K0.00%
First Horizon Corp25$1.98K0.00%
Aspect Partners, LLC20$1.58K0.00%
Keating Financial Advisory Services, Inc.16$1.27K0.00%
Aster Capital Management (DIFC) Ltd15$1.19K0.00%

Sold out (44)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of IONS in Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
Macquarie Group Ltd1,131,936$74.1M
Vestal Point Capital, LP1,075,000$70.3M
Tang Capital Management LLC550,000$36.0M
Schonfeld Strategic Advisors LLC200,839$13.1M
Sovran Advisors, LLC150,856$11.2M
Capricorn Fund Managers Ltd162,800$10.7M
Lombard Odier Asset Management (Europe) Ltd–$8.96M
Great Point Partners LLC80,000$5.23M
NJ State Employees Deferred Compensation Plan42,000$2.75M
Entropy Technologies, LP32,925$2.15M
Bayesian Capital Management, LP24,715$1.62M
BlueCrest Capital Management Ltd23,370$1.53M
Resolute Capital Asset Partners LLC20,000$1.31M
Diversified Trust Co15,633$1.02M
Fieldview Capital Management, LLC13,523$884.7K
Capstone Investment Advisors, LLC10,402$680.5K
Gsa Capital Partners LLP10,172$665.0K
Empire Financial Management Company, LLC8,000$523.4K
Edgestream Partners, L.P.5,450$356.5K
Requisite Capital Management, LLC4,734$309.7K
Brevan Howard Capital Management LP4,516$295.4K
Perbak Capital Partners LLP4,426$289.5K
Pitcairn Co4,075$266.6K
Massar Capital Management, LP3,462$226.5K
EntryPoint Capital, LLC3,458$226.2K
Victrix Investment Advisors3,400$222.4K
Ci Investments Inc.1,453$95.0K
Wexford Capital LP1,192$78.0K
Itau Unibanco Holding S.A.1,121$73.3K
Toronto Dominion Bank951$62.2K
Johnson Financial Group, Inc.670$43.8K
Mather Group, LLC.410$26.8K
Storebrand Asset Management AS271$17.7K
Union Bancaire Privee, UBP SA265$17.0K
Wealthspire Advisors, LLC245$16.0K
Advisory Services Network, LLC238$15.5K
Pacifica Partners Inc.150$9.87K
GPS Wealth Strategies Group, LLC119$7.79K
Principal Securities, Inc.111$7.26K
Ameritas Advisory Services, LLC87$5.69K
Clear Investment Research, LLC71$4.64K
Heartwood Wealth Advisors LLC21$1.37K
Key Financial Inc19$1.25K
Ronald Blue Trust, Inc.10$654

Not filed for Q4 2025 yet (11)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding IONS in Q3 2025 that haven't filed for Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
AXA Investment Managers S.A.406,451$26.6M
Sonora Investment Management Group, LLC169,808$11.1M
Cubist Systematic Strategies, LLC48,654$3.18M
Point72 Hong Kong Ltd47,517$3.11M
Wolverine Trading, LLC27,585$1.77M
Point72 (DIFC) Ltd15,698$1.03M
Point72 Europe (London) LLP3,051$199.6K
Abich Financial Wealth Management LLC1,708$111.7K
AllSquare Wealth Management LLC198$13.0K
Creekmur Asset Management LLC100$6.54K
Hemington Wealth Management42$2.00K