Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 23,689,038 | $1.55B | 0.08% | +46,048+0.2% | Added |
| Vanguard Group Inc | 16,481,730 | $1.08B | 0.02% | −233,116−1.4% | Reduced |
| T. Rowe Price Investment Management, Inc. | 13,156,929 | $860.7M | 0.53% | −2,891,792−18.0% | Reduced |
| Capital World Investors | 12,722,728 | $832.3M | 0.11% | +182,540+1.5% | Added |
| BlackRock, Inc. | 10,447,940 | $683.5M | 0.01% | −448,997−4.1% | Reduced |
| Wellington Management Group LLP | 6,588,811 | $431.0M | 0.08% | +243,035+3.8% | Added |
| Bellevue Group AG | 6,244,451 | $408.5M | 8.49% | −1,608,747−20.5% | Reduced |
| State Street Corp | 4,388,651 | $287.1M | 0.01% | −141,747−3.1% | Reduced |
| Deep Track Capital, LP | 3,808,144 | $249.1M | 6.95% | −1,083,400−22.1% | Reduced |
| Geode Capital Management, LLC | 3,066,289 | $200.6M | 0.01% | +175,194+6.1% | Added |
| Tweedy, Browne Co LLC | 2,901,216 | $189.8M | 16.48% | +9,268+0.3% | Added |
| Price T Rowe Associates Inc | 2,729,685 | $178.6M | 0.02% | −396,388−12.7% | Reduced |
| Citadel Advisors LLC | 2,402,065 | $157.1M | 0.13% | +907,084+60.7% | Added |
| Two Sigma Advisers, LP | 2,073,111 | $135.6M | 0.27% | −594,500−22.3% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $129.5M | 1.98% | +1,979,669 | New |
| Two Sigma Investments, LP | 1,575,943 | $103.1M | 0.16% | −212,424−11.9% | Reduced |
| Charles Schwab Investment Management Inc | 1,519,951 | $99.4M | 0.02% | +32,133+2.2% | Added |
| Pictet Asset Management Holding SA | 1,393,124 | $90.5M | 0.09% | +784,484+128.9% | Added |
| American Century Companies Inc | 1,372,225 | $89.8M | 0.05% | +899,476+190.3% | Added |
| Adage Capital Partners GP, L.L.C. | 1,315,000 | $86.0M | 0.14% | −2,485,000−65.4% | Reduced |
| Royal Bank of Canada | 1,226,624 | $80.2M | 0.01% | +426,712+53.3% | Added |
| Morgan Stanley | 1,180,316 | $77.2M | 0.00% | −181,893−13.4% | Reduced |
| UBS Asset Management Americas Inc | 1,154,166 | $75.5M | 0.02% | +363,094+45.9% | Added |
| Macquarie Group Ltd | 1,131,936 | $74.1M | 0.09% | −302,137−21.1% | Reduced |
| Vestal Point Capital, LP | 1,075,000 | $70.3M | 3.19% | +575,000+115.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,059,721 | $69.3M | 0.18% | −291,158−21.6% | Reduced |
| UBS Group AG | 1,046,990 | $68.5M | 0.01% | −482,333−31.5% | Reduced |
| Polar Capital Holdings Plc | 1,033,622 | $67.6M | 0.33% | +33,622+3.4% | Added |
| TD Asset Management Inc | 960,272 | $62.8M | 0.05% | −144,418−13.1% | Reduced |
| Marshall Wace, LLP | 958,829 | $62.7M | 0.07% | +945,729+7,219.3% | Added |
| Artisan Partners Limited Partnership | 890,072 | $58.2M | 0.08% | +535,110+150.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 878,155 | $57.4M | 0.18% | +612,362+230.4% | Added |
| Massachusetts Financial Services Co | 862,593 | $56.4M | 0.02% | +343,409+66.1% | Added |
| Bank of America Corp | 855,295 | $56.0M | 0.00% | −140,595−14.1% | Reduced |
| Northern Trust Corp | 844,943 | $55.3M | 0.01% | +30,693+3.8% | Added |
| Voloridge Investment Management, LLC | 803,047 | $52.5M | 0.18% | −51,587−6.0% | Reduced |
| Millennium Management LLC | 779,570 | $51.0M | 0.04% | −1,869,957−70.6% | Reduced |
| Goldman Sachs Group Inc | 777,570 | $50.9M | 0.01% | −3700.0% | Reduced |
| Ameriprise Financial Inc | 765,822 | $50.1M | 0.01% | +397,703+108.0% | Added |
| Balyasny Asset Management LLC | 760,111 | $49.7M | 0.10% | −8,537−1.1% | Reduced |
| Summit Partners Public Asset Management, LLC | 750,000 | $49.1M | 1.60% | +750,000 | New |
| Bank of Montreal | 747,402 | $48.9M | 0.02% | +264,113+54.6% | Added |
| Nomura Holdings Inc | 733,398 | $48.0M | 0.22% | +701,237+2,180.4% | Added |
| Barclays PLC | 714,048 | $46.7M | 0.02% | +130,782+22.4% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 631,215 | $41.3M | 0.25% | −269,103−29.9% | Reduced |
| D. E. Shaw & Co., Inc. | 630,938 | $41.3M | 0.03% | +630,938 | New |
| Arrowstreet Capital, Limited Partnership | 630,136 | $41.2M | 0.03% | +630,136 | New |
| Candriam Luxembourg S.C.A. | 611,237 | $40.0M | 0.21% | −113,503−15.7% | Reduced |
| Groupama Asset Managment | 561,777 | $37.4M | 0.55% | −99,180−15.0% | Reduced |
| Baker Bros. Advisors LP | 566,798 | $37.1M | 0.27% | +566,798 | New |
| Tang Capital Management LLC | 550,000 | $36.0M | 1.39% | +400,000+266.7% | Added |
| JPMorgan Chase & Co | 544,468 | $35.6M | 0.00% | +149,490+37.8% | Added |
| Eversept Partners, LP | 538,661 | $35.2M | 2.70% | −50,239−8.5% | Reduced |
| Bank of New York Mellon Corp | 532,114 | $34.8M | 0.01% | +4,926+0.9% | Added |
| Invesco Ltd. | 519,070 | $34.0M | 0.01% | +262,835+102.6% | Added |
| Hudson Bay Capital Management LP | 515,000 | $33.7M | 0.20% | −235,000−31.3% | Reduced |
| Renaissance Technologies LLC | 486,714 | $31.8M | 0.04% | +216,000+79.8% | Added |
| Pinnacle Associates Ltd | 481,751 | $31.5M | 0.42% | −12,788−2.6% | Reduced |
| Teacher Retirement System of Texas | 473,945 | $31.0M | 0.12% | −194,328−29.1% | Reduced |
| C WorldWide Group Holding A/S | 426,000 | $27.9M | 0.43% | −24,000−5.3% | Reduced |
| Susquehanna International Group, LLP | 420,950 | $27.5M | 0.04% | +420,950 | New |
| Boone Capital Management LLC | 417,833 | $27.3M | 8.96% | +417,833 | New |
| Nuveen, LLC | 415,618 | $27.2M | 0.01% | +170,533+69.6% | Added |
| Ikarian Capital, LLC | 415,163 | $27.2M | 6.15% | +415,163 | New |
| AXA Investment Managers S.A. | 406,451 | $26.6M | 0.07% | +406,451 | New |
| Squarepoint Ops LLC | 383,792 | $25.1M | 0.05% | +249,397+185.6% | Added |
| BNP Paribas Arbitrage, SA | 383,226 | $25.1M | 0.02% | +205,464+115.6% | Added |
| Jane Street Group, LLC | 365,070 | $23.9M | 0.03% | +365,070 | New |
| Man Group plc | 333,820 | $21.8M | 0.04% | +324,851+3,621.9% | Added |
| Legal & General Group Plc | 319,565 | $20.9M | 0.00% | −84,801−21.0% | Reduced |
| Assenagon Asset Management S.A. | 312,297 | $20.4M | 0.03% | +294,643+1,669.0% | Added |
| Alyeska Investment Group, L.P. | 311,258 | $20.4M | 0.06% | +152,250+95.7% | Added |
| Rhenman & Partners Asset Management AB | 310,000 | $20.3M | 2.24% | +128,000+70.3% | Added |
| Swiss National Bank | 293,100 | $19.2M | 0.01% | +4,500+1.6% | Added |
| Wells Fargo & Company | 285,293 | $18.7M | 0.00% | +75,436+35.9% | Added |
| Sector Gamma AS | 270,963 | $17.7M | 4.40% | −14,879−5.2% | Reduced |
| GW&K Investment Management, LLC | 264,007 | $17.3M | 0.15% | −184,823−41.2% | Reduced |
| Algert Global LLC | 252,281 | $16.5M | 0.28% | +214,191+562.3% | Added |
| Privium Fund Management B.V. | 248,894 | $16.3M | 2.93% | −18,700−7.0% | Reduced |
| Raymond James Financial Inc | 240,424 | $15.7M | 0.01% | +29,832+14.2% | Added |
| Jain Global LLC | 225,739 | $14.8M | 0.19% | +218,544+3,037.4% | Added |
| Orion Investment Co | 224,705 | $14.7M | 4.70% | +7,335+3.4% | Added |
| California Public Employees Retirement System | 215,845 | $14.1M | 0.01% | +13,852+6.9% | Added |
| Trexquant Investment LP | 215,121 | $14.1M | 0.15% | +86,252+66.9% | Added |
| Stifel Financial Corp | 202,628 | $13.3M | 0.01% | +6,271+3.2% | Added |
| Schonfeld Strategic Advisors LLC | 200,839 | $13.1M | 0.09% | −248,367−55.3% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 197,434 | $12.9M | 0.02% | +47,595+31.8% | Added |
| Tocqueville Asset Management L.P. | 193,045 | $12.6M | 0.18% | +5,700+3.0% | Added |
| Great Lakes Advisors, LLC | 186,950 | $12.2M | 0.10% | −212,696−53.2% | Reduced |
| Rhumbline Advisers | 182,061 | $11.9M | 0.01% | +462+0.3% | Added |
| Cinctive Capital Management LP | 173,819 | $11.4M | 0.57% | +173,819 | New |
| Sovran Advisors, LLC | 150,856 | $11.2M | 0.99% | −171,057−53.1% | Reduced |
| Sonora Investment Management Group, LLC | 169,808 | $11.1M | 0.79% | +6,636+4.1% | Added |
| New York State Common Retirement Fund | 168,222 | $11.0M | 0.01% | +81,250+93.4% | Added |
| Sicart Associates LLC | 164,318 | $10.7M | 2.91% | −20,978−11.3% | Reduced |
| Boothbay Fund Management, LLC | 163,462 | $10.7M | 0.28% | +163,462 | New |
| Capricorn Fund Managers Ltd | 162,800 | $10.7M | 3.58% | +162,800 | New |
| Aquatic Capital Management LLC | 159,045 | $10.4M | 0.19% | +959+0.6% | Added |
| Edmond de Rothschild Holding S.A. | 156,690 | $10.3M | 0.16% | −40,910−20.7% | Reduced |
| Citigroup Inc | 155,853 | $10.2M | 0.01% | −185,124−54.3% | Reduced |