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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2025

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
437
+78 vs. Q2 2025
Shares held
168.2M
−221.1K (−0.1%) vs. Q2 2025
Total value
$11.0B
+$4.36B (+65.5%) vs. Q2 2025
New holders
115
136 more added
Sold out
37
116 more reduced

4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 437 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ3 2025: $11.0B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.

Institutions holding IONS in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Truvestments Capital LLC1$490.00%00.0%Unchanged
American Capital Advisory, LLC2$1310.00%+2New
Clearstead Advisors, LLC3$1970.00%−6,997−100.0%Reduced
IMA Wealth, Inc.5$3270.00%00.0%Unchanged
Cornerstone Planning Group LLC5$3710.00%−7−58.3%Reduced
Kayne Anderson Rudnick Investment Management LLC7$4580.00%00.0%Unchanged
True Wealth Design, LLC7$4580.00%00.0%Unchanged
Essential Partners LLC7$4580.00%+7New
Ronald Blue Trust, Inc.10$6540.00%+10New
CIBC Private Wealth Group, LLC11$7200.00%+9+450.0%Added
Rakuten Securities, Inc.11$7200.00%+11New
Rothschild Investment LLC13$8500.00%+3+30.0%Added
Quaker Wealth Management, LLC14$9160.00%00.0%Unchanged
Mascoma Wealth Management LLC14$9160.00%00.0%Unchanged
Fortitude Family Office, LLC17$1.11K0.00%00.0%Unchanged
Cromwell Holdings LLC18$1.18K0.00%00.0%Unchanged
Key Financial Inc19$1.25K0.00%00.0%Unchanged
TFC Financial Management21$1.37K0.00%00.0%Unchanged
Heartwood Wealth Advisors LLC21$1.37K0.00%+21New
Horizon Investments, LLC22$1.44K0.00%+7+46.7%Added
Bruce G. Allen Investments, LLC23$1.50K0.00%00.0%Unchanged
Global Retirement Partners, LLC23$1.50K0.00%+7+43.8%Added
Principia Wealth Advisory, LLC26$1.70K0.00%+1+4.0%Added
Raffa Wealth Management, LLC28$1.83K0.00%00.0%Unchanged
Hantz Financial Services, Inc.36$2.00K0.00%00.0%Unchanged
Hemington Wealth Management42$2.00K0.00%−2−4.5%Reduced
Cheviot Value Management, LLC28$2.06K0.00%00.0%Unchanged
South State Corp.33$2.16K0.00%−18−35.3%Reduced
Rossby Financial, LCC34$2.24K0.00%00.0%Unchanged
Highline Wealth Partners LLC38$2.49K0.00%00.0%Unchanged
CoreCap Advisors, LLC45$2.94K0.00%00.0%Unchanged
Sachetta, LLC45$2.94K0.00%00.0%Unchanged
FIL Ltd47$3.08K0.00%+47New
Crewe Advisors LLC48$3.14K0.00%+48New
Bell Investment Advisors, Inc61$3.99K0.00%00.0%Unchanged
Leonteq Securities AG63$4.12K0.00%00.0%Unchanged
Private Wealth Management Group, LLC65$4.25K0.00%00.0%Unchanged
WPG Advisers, LLC70$4.58K0.00%00.0%Unchanged
Clear Investment Research, LLC71$4.64K0.01%00.0%Unchanged
Assetmark, Inc75$4.91K0.00%00.0%Unchanged
Orion Capital Management LLC80$5.23K0.00%00.0%Unchanged
TD Private Client Wealth LLC80$5.23K0.00%+36+81.8%Added
Ameritas Advisory Services, LLC87$5.69K0.00%−59−40.4%Reduced
Massmutual Trust Co FSB89$5.82K0.00%−14−13.6%Reduced
Quent Capital, LLC98$6.41K0.00%+98New
Creekmur Asset Management LLC100$6.54K0.00%00.0%Unchanged
Smartleaf Asset Management LLC104$6.67K0.00%+104New
Principal Securities, Inc.111$7.26K0.00%+48+76.2%Added
Bogart Wealth, LLC118$7.72K0.00%00.0%Unchanged
GPS Wealth Strategies Group, LLC119$7.79K0.00%00.0%Unchanged
Spire Wealth Management125$8.18K0.00%00.0%Unchanged
Bessemer Group Inc133$9.00K0.00%+94+241.0%Added
Wealth Preservation Advisors, LLC150$9.81K0.01%00.0%Unchanged
Pacifica Partners Inc.150$9.87K0.00%00.0%Unchanged
Bayforest Capital Ltd154$10.1K0.00%+154New
AllSquare Wealth Management LLC198$13.0K0.01%00.0%Unchanged
Atlantic Union Bankshares Corp200$13.1K0.00%00.0%Unchanged
Umb Bank N A200$13.1K0.00%+200New
Harbour Investments, Inc.210$13.7K0.00%+10+5.0%Added
Global Trust Asset Management, LLC218$14.3K0.01%00.0%Unchanged
Westside Investment Management, Inc.231$15.2K0.00%00.0%Unchanged
Advisory Services Network, LLC238$15.5K0.00%+238New
Parkside Financial Bank & Trust240$15.7K0.00%−198−45.2%Reduced
Covestor Ltd246$16.0K0.01%−59−19.3%Reduced
Wealthspire Advisors, LLC245$16.0K0.00%+245New
MTM Investment Management, LLC258$16.9K0.01%00.0%Unchanged
Union Bancaire Privee, UBP SA265$17.0K0.00%00.0%Unchanged
SBI Securities Co., Ltd.267$17.5K0.00%+10+3.9%Added
MAI Capital Management267$17.5K0.00%−159−37.3%Reduced
Storebrand Asset Management AS271$17.7K0.00%00.0%Unchanged
NBC Securities, Inc.273$17.9K0.00%+273New
Strategic Advocates LLC287$18.8K0.00%+287New
Capital Advisors, Ltd. LLC295$19.0K0.00%00.0%Unchanged
Eastern Bank300$19.6K0.00%00.0%Unchanged
Global X Japan Co., Ltd.321$21.0K0.00%+62+23.9%Added
Salomon & Ludwin, LLC332$23.0K0.00%+332New
Golden State Wealth Management, LLC376$24.6K0.00%+250+198.4%Added
Steigerwald, Gordon & Koch Inc.380$24.9K0.00%+380New
ORG Wealth Partners, LLC400$26.2K0.01%00.0%Unchanged
Mather Group, LLC.410$26.8K0.00%+410New
Quest Partners LLC453$29.6K0.00%−382−45.7%Reduced
AdvisorNet Financial, Inc469$30.7K0.00%+41+9.6%Added
Farther Finance Advisors, LLC566$37.0K0.00%+133+30.7%Added
Quarry LP588$38.5K0.01%+588New
Archer Investment Corp600$39.3K0.01%00.0%Unchanged
Quadrant Capital Group LLC616$40.3K0.00%+616New
Huntington National Bank654$42.8K0.00%−141−17.7%Reduced
Johnson Financial Group, Inc.670$43.8K0.00%+670New
Meeder Asset Management Inc713$46.6K0.00%+614+620.2%Added
EverSource Wealth Advisors, LLC827$54.1K0.00%−274−24.9%Reduced
Allworth Financial LP840$55.0K0.00%+100+13.5%Added
Sterling Capital Management LLC898$58.7K0.00%−64−6.7%Reduced
Toronto Dominion Bank951$62.2K0.00%+951New
Sunbelt Securities, Inc.1,014$66.3K0.00%00.0%Unchanged
Steward Partners Investment Advisory, LLC1,069$69.9K0.00%−152−12.4%Reduced
IFP Advisors, Inc1,070$70.0K0.00%+166+18.4%Added
Larson Financial Group LLC1,110$72.6K0.00%+83+8.1%Added
Itau Unibanco Holding S.A.1,121$73.3K0.00%−3−0.3%Reduced
Wexford Capital LP1,192$78.0K0.02%−3,557−74.9%Reduced
Manchester Capital Management LLC1,248$81.6K0.01%00.0%Unchanged