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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

Q3 2025 vs. Q2 2025

How the institutions holding Ionis Pharmaceuticals Inc changed between Q2 2025 and Q3 2025.

All holders in Q3 2025All holders in Q2 2025

13F holders of IONS: Q2 2025 compared with Q3 2025
MeasureQ2 2025Of which not filed for Q3 2025Q3 2025Change
Holders3634437+78
Shares168.9M466.5K168.2M−221.1K (−0.1%)
Value$6.67B$18.4M$11.0B+$4.36B (+65.5%)

4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (115)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q3 2025 but not at the end of Q2 2025.

Showing the largest 100 of 115 by value.

Institutions new to IONS in Q3 2025
InstitutionSharesValue% of portfolio
Deerfield Management Company, L.P. (Series C)1,979,669$129.5M1.98%
Summit Partners Public Asset Management, LLC750,000$49.1M1.60%
D. E. Shaw & Co., Inc.630,938$41.3M0.03%
Arrowstreet Capital, Limited Partnership630,136$41.2M0.03%
Baker Bros. Advisors LP566,798$37.1M0.27%
Susquehanna International Group, LLP420,950$27.5M0.04%
Boone Capital Management LLC417,833$27.3M8.96%
Ikarian Capital, LLC415,163$27.2M6.15%
AXA Investment Managers S.A.406,451$26.6M0.07%
Jane Street Group, LLC365,070$23.9M0.03%
Cinctive Capital Management LP173,819$11.4M0.57%
Boothbay Fund Management, LLC163,462$10.7M0.28%
Capricorn Fund Managers Ltd162,800$10.7M3.58%
ExodusPoint Capital Management, LP152,125$9.95M0.14%
Natixis145,286$9.50M0.05%
Lombard Odier Asset Management (Europe) Ltd–$8.96M0.46%
Acadian Asset Management LLC110,444$7.21M0.01%
Amundi101,531$7.01M0.00%
Lisanti Capital Growth, LLC92,124$6.03M1.47%
Hillsdale Investment Management Inc.70,900$4.64M0.14%
Artia Global Partners LP60,176$3.94M0.69%
EAM Investors, LLC54,977$3.54M0.41%
Cubist Systematic Strategies, LLC48,654$3.18M0.04%
Point72 Hong Kong Ltd47,517$3.11M0.14%
Dark Forest Capital Management LP46,092$3.02M0.11%
Bridgewater Associates, LP43,578$2.85M0.01%
Dimensional Fund Advisors LP42,217$2.76M0.00%
LMR Partners LLP37,600$2.46M0.03%
Stanley-Laman Group, Ltd.35,774$2.34M0.33%
Twin Tree Management, LP28,575$1.87M0.09%
Wolverine Trading, LLC27,585$1.77M0.04%
Landscape Capital Management, L.L.C.26,562$1.74M0.11%
Calamos Advisors LLC25,863$1.69M0.01%
Bamco Inc25,000$1.64M0.00%
BlueCrest Capital Management Ltd23,370$1.53M0.09%
Atika Capital Management LLC21,500$1.41M0.12%
Resolute Capital Asset Partners LLC20,000$1.31M0.68%
Dana Investment Advisors, Inc.18,818$1.23M0.04%
Legato Capital Management LLC17,300$1.13M0.12%
Diversified Trust Co15,633$1.02M0.02%
Dynasty Wealth Management, LLC14,341$938.2K0.01%
Allianz Asset Management GmbH11,500$752.3K0.00%
Blueshift Asset Management, LLC11,460$749.7K0.23%
Capstone Investment Advisors, LLC10,402$680.5K0.01%
Baader Bank INC10,228$668.4K0.06%
Gsa Capital Partners LLP10,172$665.0K0.06%
denkapparat Operations GmbH9,968$652.1K0.42%
Thrivent Financial for Lutherans9,962$652.0K0.00%
Empire Financial Management Company, LLC8,000$523.4K0.12%
Stratos Wealth Partners, LTD.7,764$507.9K0.01%
Inceptionr LLC7,621$498.6K0.12%
Cetera Investment Advisers6,873$449.7K0.00%
Swiss Life Asset Management Ltd6,827$446.6K0.00%
AQR Capital Management LLC6,815$438.7K0.00%
Fisher Asset Management, LLC6,210$406.3K0.00%
Summit Trail Advisors, LLC6,205$405.9K0.01%
PEAK6 LLC6,112$399.8K0.01%
Arrowpoint Investment Partners (Singapore) Pte. Ltd.5,463$357.4K0.52%
Edgestream Partners, L.P.5,450$356.5K0.01%
O'Shaughnessy Asset Management, LLC5,297$346.5K0.00%
SG Americas Securities, LLC5,150$337.0K0.00%
Kestra Advisory Services, LLC4,972$325.3K0.00%
Truist Financial Corp4,812$314.8K0.00%
Farallon Capital Management, L.L.C.4,800$314.0K0.00%
Group One Trading, L.P.4,796$313.8K0.01%
Requisite Capital Management, LLC4,734$309.7K0.05%
Credit Agricole S A4,710$308.1K0.00%
CIBC Asset Management Inc4,608$301.5K0.00%
Prospera Financial Services Inc4,581$299.7K0.01%
Coldstream Capital Management Inc4,479$293.0K0.00%
Checchi Capital Advisers, LLC4,233$276.9K0.02%
Pitcairn Co4,075$266.6K0.02%
Prime Capital Investment Advisors, LLC3,934$257.4K0.00%
Regions Financial Corp3,800$248.6K0.00%
Mercer Global Advisors Inc3,747$245.1K0.00%
Nwam LLC3,238$238.2K0.01%
Sanctuary Advisors, LLC3,637$237.9K0.00%
Berkshire Asset Management LLC3,614$236.4K0.01%
Mackenzie Financial Corp3,588$234.7K0.00%
Resources Investment Advisors, LLC.3,588$234.7K0.00%
PharVision Advisers, LLC3,587$234.7K0.13%
Mitchell & Pahl Private Wealth, LLC3,572$233.7K0.10%
Bank of Nova Scotia3,509$229.6K0.00%
Massar Capital Management, LP3,462$226.5K0.08%
EntryPoint Capital, LLC3,458$226.2K0.09%
Victrix Investment Advisors3,400$222.4K0.12%
Anb Bank3,231$211.4K0.09%
Raab & Moskowitz Asset Management LLC3,115$203.8K0.05%
Voleon Capital Management LP3,060$200.2K0.00%
Point72 Europe (London) LLP3,051$199.6K0.01%
Rockefeller Capital Management L.P.2,203$144.1K0.00%
Abich Financial Wealth Management LLC1,708$111.7K0.04%
Root Financial Partners, LLC1,340$87.7K0.01%
Toronto Dominion Bank951$62.2K0.00%
Johnson Financial Group, Inc.670$43.8K0.00%
Quadrant Capital Group LLC616$40.3K0.00%
Quarry LP588$38.5K0.01%
Mather Group, LLC.410$26.8K0.00%
Steigerwald, Gordon & Koch Inc.380$24.9K0.00%
Salomon & Ludwin, LLC332$23.0K0.00%

Sold out (37)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q2 2025 and filed for Q3 2025 without it.

Not filed for Q3 2025 yet (4)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q2 2025 and haven't filed a 13F for Q3 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding IONS in Q2 2025 that haven't filed for Q3 2025
InstitutionShares, Q2 2025Value, Q2 2025
Norges Bank450,254$17.8M
E Fund Management Co., Ltd.16,160$638.5K
Semmax Financial Advisors Inc.79$3.29K
Parkworth Wealth Management, Inc.8$316