Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Skandinaviska Enskilda Banken AB (publ) | 155,790 | $10.2M | 0.04% | +96,164+161.3% | Added |
| ExodusPoint Capital Management, LP | 152,125 | $9.95M | 0.14% | +152,125 | New |
| Natixis | 145,286 | $9.50M | 0.05% | +145,286 | New |
| California State Teachers Retirement System | 145,112 | $9.49M | 0.01% | +80.0% | Added |
| State Board of Administration of Florida Retirement System | 143,534 | $9.39M | 0.02% | −10,361−6.7% | Reduced |
| Lombard Odier Asset Management (Europe) Ltd | – | $8.96M | 0.46% | – | New |
| ADAR1 Capital Management, LLC | 133,818 | $8.75M | 0.87% | −14,643−9.9% | Reduced |
| Exome Asset Management LLC | 131,016 | $8.57M | 5.66% | +9,900+8.2% | Added |
| Rafferty Asset Management, LLC | 125,773 | $8.23M | 0.03% | −18,997−13.1% | Reduced |
| Kennedy Capital Management, Inc. | 122,766 | $8.03M | 0.18% | −9,279−7.0% | Reduced |
| SEI Investments Co | 119,028 | $7.79M | 0.01% | +20,680+21.0% | Added |
| BLB&B Advisors, LLC | 118,600 | $7.76M | 0.33% | −32,950−21.7% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 116,000 | $7.59M | 0.01% | 00.0% | Unchanged |
| Sumitomo Mitsui Trust Holdings, Inc. | 114,772 | $7.51M | 0.00% | −24,967−17.9% | Reduced |
| Neuberger Berman Group LLC | 114,743 | $7.51M | 0.01% | +120+0.1% | Added |
| Nikko Asset Management Americas, Inc. | 114,592 | $7.49M | 0.07% | −25,147−18.0% | Reduced |
| Van Eck Associates Corp | 111,819 | $7.32M | 0.01% | +38,202+51.9% | Added |
| Voya Investment Management LLC | 111,589 | $7.30M | 0.01% | +47,072+73.0% | Added |
| Acadian Asset Management LLC | 110,444 | $7.21M | 0.01% | +110,444 | New |
| DCF Advisers, LLC | 108,413 | $7.09M | 2.69% | +16,663+18.2% | Added |
| Amundi | 101,531 | $7.01M | 0.00% | +101,531 | New |
| Simplex Trading, LLC | 100,206 | $6.55M | 0.14% | +60,568+152.8% | Added |
| Manufacturers Life Insurance Company, The | 98,023 | $6.41M | 0.01% | +14,637+17.6% | Added |
| State of Wisconsin Investment Board | 96,837 | $6.34M | 0.01% | +143+0.1% | Added |
| J. Goldman & Co LP | 96,198 | $6.29M | 0.24% | −51,484−34.9% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $6.28M | 0.10% | +3,060+3.3% | Added |
| Lisanti Capital Growth, LLC | 92,124 | $6.03M | 1.47% | +92,124 | New |
| DekaBank Deutsche Girozentrale | 93,807 | $5.99M | 0.01% | 00.0% | Unchanged |
| Deutsche Bank AG | 88,803 | $5.81M | 0.00% | +3,525+4.1% | Added |
| Standard Life Aberdeen plc | 87,924 | $5.75M | 0.01% | −318,770−78.4% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $5.69M | 0.51% | 00.0% | Unchanged |
| Great Point Partners LLC | 80,000 | $5.23M | 2.19% | −420,000−84.0% | Reduced |
| Russell Investments Group, Ltd. | 77,293 | $5.06M | 0.01% | +68,028+734.2% | Added |
| First Trust Advisors LP | 75,224 | $4.92M | 0.00% | +18,705+33.1% | Added |
| Hillsdale Investment Management Inc. | 70,900 | $4.64M | 0.14% | +70,900 | New |
| Erste Asset Management GmbH | 71,800 | $4.61M | 0.04% | +20,500+40.0% | Added |
| Treasurer of the State of North Carolina | 69,862 | $4.57M | 0.01% | −2,725−3.8% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 69,324 | $4.54M | 0.04% | +9,601+16.1% | Added |
| Janus Henderson Group PLC | 63,877 | $4.18M | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 63,791 | $4.17M | 0.01% | +3,042+5.0% | Added |
| Davenport & Co LLC | 62,563 | $4.09M | 0.02% | −2,280−3.5% | Reduced |
| Artia Global Partners LP | 60,176 | $3.94M | 0.69% | +60,176 | New |
| State of New Jersey Common Pension Fund D | 59,817 | $3.91M | 0.01% | +899+1.5% | Added |
| Alpine Global Management, LLC | 55,900 | $3.66M | 0.75% | +30,463+119.8% | Added |
| PDT Partners, LLC | 54,365 | $3.56M | 0.22% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 54,262 | $3.55M | 0.00% | +2,205+4.2% | Added |
| EAM Investors, LLC | 54,977 | $3.54M | 0.41% | +54,977 | New |
| Handelsbanken Fonder AB | 51,911 | $3.40M | 0.01% | +8,700+20.1% | Added |
| Creative Planning | 51,474 | $3.37M | 0.00% | −1,815−3.4% | Reduced |
| Capital Counsel LLC | 49,605 | $3.25M | 0.12% | −600−1.2% | Reduced |
| Raiffeisen Bank International AG | 50,000 | $3.21M | 0.04% | −6,754−11.9% | Reduced |
| Cubist Systematic Strategies, LLC | 48,654 | $3.18M | 0.04% | +48,654 | New |
| Public Employees Retirement System of Ohio | 48,545 | $3.18M | 0.01% | +301+0.6% | Added |
| Point72 Hong Kong Ltd | 47,517 | $3.11M | 0.14% | +47,517 | New |
| Dark Forest Capital Management LP | 46,092 | $3.02M | 0.11% | +46,092 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 45,220 | $2.96M | 0.01% | +1,605+3.7% | Added |
| Great West Life Assurance Co | 46,128 | $2.96M | 0.00% | −373−0.8% | Reduced |
| HSBC Holdings PLC | 45,456 | $2.95M | 0.00% | −62,838−58.0% | Reduced |
| Arizona State Retirement System | 44,731 | $2.93M | 0.02% | +691+1.6% | Added |
| Bridgewater Associates, LP | 43,578 | $2.85M | 0.01% | +43,578 | New |
| Fred Alger Management, LLC | 42,401 | $2.77M | 0.01% | +32,937+348.0% | Added |
| Dimensional Fund Advisors LP | 42,217 | $2.76M | 0.00% | +42,217 | New |
| NJ State Employees Deferred Compensation Plan | 42,000 | $2.75M | 0.30% | 00.0% | Unchanged |
| Grandfield & Dodd, LLC | 37,675 | $2.46M | 0.14% | +445+1.2% | Added |
| LMR Partners LLP | 37,600 | $2.46M | 0.03% | +37,600 | New |
| Prelude Capital Management, LLC | 37,293 | $2.44M | 0.19% | −2,130−5.4% | Reduced |
| Verition Fund Management LLC | 37,196 | $2.43M | 0.01% | −195,491−84.0% | Reduced |
| One Capital Management, LLC | 36,426 | $2.38M | 0.08% | +6,561+22.0% | Added |
| Future Fund LLC | 36,156 | $2.37M | 0.83% | +6,561+22.2% | Added |
| Quantinno Capital Management LP | 36,115 | $2.36M | 0.01% | +18,573+105.9% | Added |
| Stanley-Laman Group, Ltd. | 35,774 | $2.34M | 0.33% | +35,774 | New |
| Guggenheim Capital LLC | 35,357 | $2.31M | 0.02% | −5,500−13.5% | Reduced |
| Blair William & Co | 34,371 | $2.25M | 0.01% | −3,520−9.3% | Reduced |
| Pathstone Holdings, LLC | 33,602 | $2.20M | 0.01% | +2,843+9.2% | Added |
| Entropy Technologies, LP | 32,925 | $2.15M | 0.16% | +3,473+11.8% | Added |
| Gotham Asset Management, LLC | 32,152 | $2.10M | 0.01% | +17,873+125.2% | Added |
| KLP Kapitalforvaltning AS | 31,500 | $2.06M | 0.01% | 00.0% | Unchanged |
| Twin Tree Management, LP | 28,575 | $1.87M | 0.09% | +28,575 | New |
| Granite Investment Partners, LLC | 28,033 | $1.83M | 0.10% | −15,148−35.1% | Reduced |
| China Universal Asset Management Co., Ltd. | 27,939 | $1.83M | 0.15% | −4,027−12.6% | Reduced |
| Ensign Peak Advisors, Inc | 27,595 | $1.81M | 0.00% | −25,725−48.2% | Reduced |
| Envestnet Asset Management Inc | 27,509 | $1.80M | 0.00% | +13,965+103.1% | Added |
| Wolverine Trading, LLC | 27,585 | $1.77M | 0.04% | +27,585 | New |
| Landscape Capital Management, L.L.C. | 26,562 | $1.74M | 0.11% | +26,562 | New |
| Profund Advisors LLC | 25,932 | $1.70M | 0.06% | −2,927−10.1% | Reduced |
| Calamos Advisors LLC | 25,863 | $1.69M | 0.01% | +25,863 | New |
| Engineers Gate Manager LP | 25,779 | $1.69M | 0.02% | −7,339−22.2% | Reduced |
| Bamco Inc | 25,000 | $1.64M | 0.00% | +25,000 | New |
| Bayesian Capital Management, LP | 24,715 | $1.62M | 0.33% | +8,115+48.9% | Added |
| Daiwa Securities Group Inc. | 24,701 | $1.62M | 0.01% | −1,440−5.5% | Reduced |
| LPL Financial LLC | 24,463 | $1.60M | 0.00% | −409−1.6% | Reduced |
| Mariner, LLC | 24,227 | $1.58M | 0.00% | −12,687−34.4% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.58M | 0.01% | 00.0% | Unchanged |
| BlueCrest Capital Management Ltd | 23,370 | $1.53M | 0.09% | +23,370 | New |
| Atika Capital Management LLC | 21,500 | $1.41M | 0.12% | +21,500 | New |
| Xponance, Inc. | 21,450 | $1.40M | 0.01% | −1,304−5.7% | Reduced |
| Nicollet Investment Management, Inc. | 20,408 | $1.33M | 0.44% | −339−1.6% | Reduced |
| Resolute Capital Asset Partners LLC | 20,000 | $1.31M | 0.68% | +20,000 | New |
| Dana Investment Advisors, Inc. | 18,818 | $1.23M | 0.04% | +18,818 | New |
| Victory Capital Management Inc | 18,211 | $1.19M | 0.00% | −305−1.6% | Reduced |